Medizinische Ausbildung

Qualifikationen

Beruflicher Werdegang

Deutschland

England (United Kingdom)

Kanada

United States of America

Mitgliedschaft in Fachkommissionen

Mitgliedschaft in folgenden akademischen Gesellschaften

Publikationen

Auszug der Research & Invited Articles, Monographs and Editorials ab dem Jahr 2000 (Stand: Februar 2007):

• Voso MT, Pantel G, Weis M, Schmidt P, Martin S, Moos M, Ho AD, Haas R, Hohaus S.  In vivo depletion of B cells using a combination of high-dose cytosine arabinoside/mitoxantrone and rituximab for autografting in patients with non-Hodgkin's lymphoma.  Br J Haematol 109:729-735, 2000
• Nierhoff D, Horvath HC, Mytilineos J, Golling M, Bud O, Klar E, Opelz G, Voso MT, Ho AD, Haas R, Hohaus S. Microchimerism in bone-marrow-derived CD34+ cells of patients after liver transplantation.  Blood 96:763-767, 2000
• Fiehn C, Wettschureck N, Krauthoff A, Haas R, Ho AD. Bone marrow-derived cells as carriers of recombinant immunomodulatory cytokine genes to lymphoid organs. Cancer Gene Ther 7:1105-1112, 2000
• Schneeweiss A, Hensel M, Goerner R, Khbeis T, Hohaus S, Egerer G, Solomayer E, Haas R, Grischke EM, Bastert G, Ho AD.  Comparison of double and triple high-dose chemotherapy with autologous blood stem cell transplantation in patients with metastatic breast cancer.  Stem Cells 19:151-160, 2001
• Hensel M, Breitbart A, Ho AD.  Autologous hematopoietic stem-cell transplantation for Behcet's disease with pulmonary involvement. N Engl J Med 344: 69, 2001
• Möhler TM, Neben K, Benner A, Egerer G, Krasniqi F, Ho AD, Goldschmidt H.  Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy.
• Blood 8:3846-3848, 2001
• Harter C, Salwender HJ, Bach A, Egerer G, Goldschmidt, Ho AD.  Catheter-related infection and thrombosis of the internal jugular vein in hematologic-oncologic patients undergoing chemotherapy: a prospective comparison of silver-coated and uncoated catheters.  Cancer 94:245-251, 2002
• Hensel M, Schneeweiss A, Sinn HP, Egerer G, Kornacker M, Solomayer E, Haas R, Bastert G, Ho AD.  Stem cell dose and tumorbiologic parameters as prognostic markers for patients with metastatic breast cancer undergoing high-dose chemotherapy with autologous blood stem cell support. Stem Cells 20:32-40, 2002
• Hensel M, Egerer G, Schneeweiss A, Goldschmidt H, Ho AD.  Quality of life and rehabilitation in social and professional life after autologous stem cell transplantation.  Ann Oncology 13:209-217, 2002
• Frühauf S, Srbic K, Seggewiss R, Topaly J, Ho AD. Functional characterization of podia formation in normal and malignant hematopoietic cells.  J Leukoc Biol. 71:425-32, 2002
• Punzel M, Zhang T, Liu D, Eckstein V, Ho AD.  Functional analysis of initial cell divisions defines the subsequent fate of individual human CD34+CD38- cells.  Experimental Hematology 30:464-472, 2002
• Hensel M, Schneeweiss A, Sinn HP, Egerer G, Solomayer E, Haas R, Bastert G, Ho AD.  P53 is the strongest predictor of survival in high-risk primary breast cancer patients undergoing high-dose chemotherapy with autologous blood stem cell support. Int J Cancer 100:290-296, 2002
• Krämer A, Neben K, Ho AD.  Centrosome replication, genomic instability and cancer.  Leukemia 16:767-775, 2002
• Abdallah A, Egerer G, Weber-Nordt RM, Körbling M, Haas R, Ho AD. Long-term outcome in acute myelogenous leukemia autografted with mafosfamide-purged marrow in a single institution:  adverse events and incidence of secondary myelodysplasia. Bone Marrow Transplantation 30:15-22, 2002
• Schneeweiss A, Hensel M, Sinn P, Khbeis T, Haas R, Bastert G, Ho AD. Characteristics associated with long-term progression-free survival following high-dose chemotherapy in metastatic breast cancer and influence of chemotherapy dose.  Ann Oncol. 13:679-688, 2002
• Görner M, Kordelas I, Thalheimer M, Luft T. Pfeiffer S, Ustaoglu F, Punzel M, Weber-Nordt R, Moos M, Goldschmidt H, Ho AD.  Stable mixed chimerism after T cell-depleted allogeneic hematopoietic stem cell transplantation using conditioning with low-dose total body irradiation and fludarabine.  Bone Marrow Transplant. 29:621-624, 2002
• Krämer A, Schultheis B, Bergmann J, Willer A, Hegenbart U, Ho AD, Goldschmidt H, Hehlmann R.  Alterations of the cyclin D1/pRb/p16INK4A pathway in multiple myeloma.  Leukemia 16:1844-1851, 2002
• Viardot A, Möller P, Högel J, Werner K, Mechtersheimer G, Ho AD, Ott G, Barth TFE, Siebert R, Gesk S, Schlegelberger B, Döhner H, Bentz M.  Clinicopathologic correlations of genomic gains and losses in follicular lymphoma.  J Clin Oncology  20:4523-4530, 2002
• Neben K, Giesecke C, Schweizer S, Ho AD, Kramer A.  Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile.  Blood 101:289-291, 2003
• Neben K, Mytilineos J, Moehler TM, Preiss A, Kraemer A, Ho AD, Opelz G, Goldschmidt H. Polymorphisms of the tumor necrosis factor-alpha gene promoter predict for outcome after thalidomide therapy in relapsed and refractory multiple myeloma. Blood 100:2263-2265, 2002
• Egerer G, Goldschmidt H, Zoz M, Ho AD.  Autologous bone marrow transplantation in adult patients with acute lymhoblastic leukemia. Leukemia & Lymphoma 44:9 14, 2003
• Laufs S, Gentner B, Nagy KZ, Jauch A, Benner A, Naundorf S, Kuehlcke K, Schiedlmeier B, Ho AD, Zeller WJ, Fruehauf S.  Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells.  Blood 101:2191-2198, 2003
• Punzel M, Liu D, Zhang T, Eckstein V, Miesala K, Ho AD.  The symmetry of initial divisions of human hematopoietic progenitors is altered only by the cellular microenvironment. Exper Hematol 31:339-347, 2003
• Ho AD, Punzel M.  Hematopoietic stem cells:  can old cells learn new tricks?  J Leukocyte Biology 73:547-555, 2003
• Seggewiss R, Buss EC, Herrmann D, Goldschmidt H, Ho AD, Frühauf S.  Kinetics of peripheral blood stem cell mobilization following G-CSF-supported chemotherapy. Stem Cells 21:568-574, 2003
• Schneeweiss A, Sinn HP, Ehemann V, Khbeis T, Neben K, Krause U, Ho AD, Bastert G, Krämer K.  Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression.  Int J Cancer 107:346-352, 2003
• Luft T, Moos M, Goldschmidt H, Ho AD, Görner M.  Dissociation of putative graft-versus-haematopoiesis and graft-versus-myeloma effects in patients with rapidly progressive multiple myeloma.  Brit J Haematol 123:646-653, 2003
• Fruehauf S, Topaly J, Schad M, Paschka P, Gschaidmeier H, Zeller WJ, Hochhaus A, Ho AD.  Imatinib restores expression of CD62L in BCR-ABL-positive cells.
• J Leukoc Biol. 73:600-603, 2003
• Hensel M, Kornacker M, Yammeni S, Egerer G, Ho AD.  Disease activity and pretreatment, rather than hypogammaglobulinaemia, are major risk factors for infectious complications in patients with chronic lymphocytic leukaemia.  Brit J Haematol. 122:600-606, 2003
• Krämer A, Schweizer S, Neben K, Giesecke C, Kalla J, Katzenberger T, Benner A, Müller-Hermelink HK, Ho AD, Ott G.  Centrosome aberrations as a possible mechanism for chromosomal instability in non-Hodgkin's lymphoma. Leukemia 17:2207-2213, 2003
• Neben K, Tews B, Wrobel G, Hahn M, Kokocinski F, Giesecke C, Krause U, Ho AD, Kramer A, Lichter P.  Gene expression patterns in acute myeloid leukemia correlate with centrosome aberrations and numerical chromosome changes.  Oncogene 23:2379-2384, 2004
• Kasper B, Lehnert T, Bernd L, Mechtersheimer G, Goldschmidt H, Ho AD, Egerer G.  Autografting for sarcoma – High-dose chemotherapy with autologous peripheral blood stem cell transplantation for bone and soft-tissue sarcomas.  Bone Marrow Transplantation 34: 37-41, 2004
• Wagner W, Ansorge A, Wirkner U, Eckstein V, Schwager C, Blake J, Miesala K, Selig J, Saffrich R, Ansorge W, Ho AD.  Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis. Blood 104:675-686, 2004
• Luft T, Marakovsky E, Schnurr M, Knebel K, Kirsch M, Görner M, Skoda R, Ho AD, Nawroth P, Bierhaus A. Tuning the volume of the immune response: strength and persistence of stimulation determine migration and cytokine secretion of dendritic cells. Blood 104:1066-1074, 2004
• Lowe B, Willand L, Eich W, Zipfel S, Ho AD, Herzog W, Fiehn C.  Psychiatric comorbidity and work disability in patients with inflammatory rheumatic diseases.  Psychosom Med. 66:395-402, 2004
• Möhler TM, Hillengass J, Goldschmidt H, Ho AD.  Antiangiogenic therapy in hematologic malignancies. Curr Pharm Des. 10:1221-1234, 2004
• Leo E, Scheuer L, Schmidt-Wolf IGH, Kerowgan M, Schmitt C, Leo A, Tanja B, Kraemer A, Mey U, Benner A, Parwaresch R, Ho AD.  Significant thrombocytopenia associated with the addition of rituximab to a combination of fludarabine and cyclophosphamide in the treatment of relapsed follicular lymphoma.   Eur J Haematol 73:251-257, 2004
• Schneeweiss A, Diel I, Hensel M, Kaul S, Sinn HP, Unnebrink K, Rudlowski C, Lauschner I, Schuetz F, Egerer G, Haas R, Ho AD, Bastert G. Micrometastatic bone marrow cells at diagnosis have no impact on survival of primary breast cancer patients with extensive axillary lymph node involvement treated with stem cell-supported high-dose chemotherapy.  Ann Oncol 15:1627-1632, 2004
• Perz JB, Schönland SO, Hundemer M, Kristen AV, Dengler TJ, Zeier M, Linke RP, Ho AD,   High-dose melphalan with autologous stem cell transplantation after VAD induction chemotherapy for treatment of amyloid light chain amyloidosis: a single centre prospective phase II study.  Brit J Haematol 127:543-551, 2004
• Reusch U, Le Gall F, Hensel M, Moldenhauer G, Ho AD, Little M, Kipriyanov SM. Effect of tetravalent bispecific CD19xCD3 recombinant antibody construct and CD28 costimulation on lysis of malignant B cells from patients with chronic lymphocytic leukemia by autologous T cells.  Int J Cancer 112:509-518, 2004
• Mei S, Ho AD, Mahlknecht U. Role of histone deacetylase inhibitors in the treatment of cancer.  Int J Oncol. 25:1509-1519, 2004
• Niemeyer P, Krause U, Fellenberg J, Kasten P, Seckinger A, Ho AD, Simank HG.  Evaluation of mineralized collagen and alpha-tricalcium phosphate as scaffolds for tissue engineering of bone using human mesenchymal stem cells.  Cells Tissues Organs 177:68-78, 2004
• Ho AD. Kinetics and symmetry of divisions of hematopoietic stem cells. Exp Hematol 33:1-8, 2005
• Munder M, Mollinedo F, Calafat J, Canchado J, Gil-Lamaignere C, Fuentes JM, Luckner C, Doschko G, Soler G, Eichmann K, Müller FM, Ho AD, Goerner M, Modolell M. Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood 105:2549-2556, 2005
• Choi C, Witzens M, Bueur M, Feuerer M, Sommerfeldt N, Trojan A, Ho AD, Schirrmacher V, Goldschmidt H, Beckhove P. Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma.  Blood 105:2132-2134, 2005
• Kornacker M, Luft T, Ho AD, Schaefer HJ.  Thrombotic microangiopathy after combined autografting-allografting for multiple myeloma - report of three cases.
• Eur J Haematol. 74:250-253, 2005
• Frühauf S, Buss EC, Topaly J, Kreipe HH, Ho AD.  Myeloablative conditioning in myelofibrosis using i.v. treosulfan and autologous peripheral blood progenitor cell transplantation with high doses of CD34+ cells results in hematologic responses - follow-up of three patients.  Haematologica 90:ECR08, 2005
• Raab MS, Cremer FW, Breitkreutz IN, Gerull S, Luft T, Benner A, GoernerM, Ho AD, Goldschmidt H, Moos M.  Molecular monitoring of tumour load kinetics predicts disease progression after non-myeloablative allogeneic stem cell transplantation in multiple myeloma.  Ann Oncol. 16:611-617, 2005
• Nikendei C, Schilling T, Nawroth P, Hensel M, Ho AD, Schwenger V, Zeier M, Herzog W, Schellberg D, Katus HA, Dengler T, Stremmel W, Müller M, Jünger J.  Integrated skills laboratory concept for undergraduate training in internal medicine.  Dtsch Med Wochenschr. 130: 1133-1138, 2005
• Kasper B, Ho AD, Egerer G.  Is there an indication for high-dose chemotherapy in the treatment of bone and soft-tissue sarcoma? Oncology 68:115-121, 2005
• Krämer A, Neben K, Ho AD.  Centrosome aberrations in hematological malignancies.  Cell Biol Int. 29:375-383, 2005
• Ho AD, Wagner W, Mahlknecht U.  Stem cells and ageing.  EMBO Rep. 2005 Jul;6 Suppl 1:S35-38
• Bochtler T, Hensel M, Lorenz HM, HoAD, Mahlknecht U. Chronic lymphocytic leukaemia and concomitant relapsing polychondritis: a report on one treatment for the combined manifestation of two diseases.  Rheumatology (Oxford) 44:1199, 2005
• Wagner W, Laufs S, Blake J, Schwager C, Wu X, Zeller JW, Ho AD, Fruehauf S.  Retroviral integration sites correlate with expressed genes in hematopoietic stem cells. Stem Cells 23:1050-1058, 2005
• Wagner W, Saffrich R, Wirkner U, Eckstein V, Blake J, Ansorge A, Schwager C, Wein F, Miesala K, Ansorge W, Ho AD.  Hematopoietic progenitor cells and cellular microenvironment - Behavioral and molecular changes upon interaction.  Stem Cells 23:1180-1191, 2005
• Hensel M, Villalobos M, Kornacker M, Krasniqi F, Ho AD. Pentostatin/cyclophosphamide with or without Rituximab: An effective regimen for patients with Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma.  Clin Lymphoma Myeloma 6:131-135, 2005

Auszug der Research & Invited Articles, Monographs and Editorials (1997 - 1999)

• Moskowitz CH, Stiff P, Gordon MS, McNiece I, Ho AD , Costa JJ, Broun ER, Bayer RA, Wyres M, Hill J, Jelaca-Maxwell K, Nichols CR, Brown SL, Nimer SD, and Gabrilove J: Recombinant methionyl human stem cell factor and filgrastim for peripheral blood progenitor cell mobilization and transplantation in non-Hodgkin's lymphoma patients--results of a phase I/II trial. Blood 89(9):3136-3147, 1997
• Gervaix A, Schwarz L, Law P, Ho AD , Looney D, Lane T, Wong-Staal F. Gene therapy targeting peripheral blood CD34+ hematopoietic stem cells of HIV-infected individuals. Human Gene Therapy 8:2229-2238, 1997
• Glück S, Ross AA, Layton TJ, Ostrander AB, Goldstein LC, Porter K, Ho AD : Decrease in tumor cell contamination and progenitor cell yield in leukapheresis products after consecutive cycles of chemotherapy for breast cancer treatment. Biology of Blood and Marrow Transplantation 3:316-323, 1997
• Li X, Gervaix A, Kang D, Law P, Spector SA, Ho AD , Wong-Staal F: Gene therapy targeting cord blood-derived CD34+ cells from HIV-exposed infants: preclinical studies. Gene Therapy 5:233-239,1998
• Sinclair AM, Agrawal YP, Elbar E, Agrawal R, Ho AD and Levine F: Interaction of vesicular stomatitis virus-G pseudotyped retrovirus with CD34+ and CD34+CD38- hematopoietic progenitor cells. Gene Therapy 4:918-927, 1997
• Huang S, Law P, Young D, Ho AD : Candidate hematopoietic stem cells from fetal tissues, umbilical cord blood versus adult bone marrow and mobilized peripheral blood. Exp Hematol 26:1162-1171, 1998
• Bashey A, Shephard S, Frankel W, Wang-Rodriguez J, Cahill T, Chamberlain M, Mason JR, Ho AD , Corringham RE. Induction of molecular remission by donor peripheral blood leukocyte therapy in patients relapsing with extramedullary blastic phase chronic myeloid leukemia after allogeneic bone marrow transplantation. Onkology Reports. 5:281-285, 1998
• Poeschla E, Gilbert J, Li Xinqiang, Huang S, Ho AD , Wong-Staal, F: Identification of a human immunodeficiency virus type 2 (HIV-2) encapsidation determinant and transduction of nondividing human cells by HIV-2-based lentivirus vectors. J Virol 72(8):6527-6536, 1998
• McLaughlin P, Grillo-Lopez J, Link BK, Levy R, Czuczman MS, Williams ME, Heyman MR, Bence-Bruckler I, White CA, Cabanillas F, Jain V, Ho AD , Lister J, Wey K, Shen D, Dallaire BK: Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncology 16(8):2825-2833, 1998
• Ho AD , Huang S, Law P: Hematopoietic progenitor cells derived from fetal tissues, umbilical cord blood, adult bone marrow and mobilized peripherald blood. Cancer Research Therapy and Control, 7:49-56, 1998.
• Lane TA, Ho AD , Bashey A, Peterson S, Young D, Mason JR and Law P: Mobilization of blood-derived stem and progenitor cells in normal subjects by granulocyte-macrophage- and granulocyte-colony-stimulating factors. Transfusion 39:39-47, 1999
• Law P, Lane TA, Gervaix A, Looney D, Schwarz L, Young D, Ramos S, Wong-Staal F, Recktenwald D, Ho AD : Mobilization of peripheral blood progenitor cells from human immunodeficiency virus-infected individuals. Exp Hematol 27:147-154, 1999
• Kasper B, Fruehauf S, Schiedlmeier B, Buchdunger E, Ho AD , Zeller WJ: Favorable therapeutic index of a p210BCR-ABL-specific tyrosine kinase inhibitor; activity on lineage-committed and primitive chronic myelogenous leukemia progenitors. Cancer Chemother Pharmacol 44: 433-438, 1999
• Huang S, Law P, Francis K, Palsson BO, Ho AD : Symmetry of initial cell divisions among primitive hematopoietic progenitors is independet of ontogenic age and regulatory molecules. Blood 94:2595-2604, 1999
• Huang S, Chen Z, Yu JF, Young D, Bashey A, Ho AD : Correlation betwen IL-3 receptor expression and growth potential of human CD34+ hematopoietic cells from different tissues. Stem Cells 17: 265-272, 1999

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