| Forschung Höhenmedizin |
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Diese Arbeitsgruppe steht unter der Leitung von Prof. Bärtsch, der seit 1984 in Feldstudien in der Margherita-Hütte (Walliser Alpen, 4559 m ü. M.) Fragen zur Pathophysiologie, Therapie und Prophylaxe der akuten Bergkrankheit und des Höhenlungenödems untersucht.
Arbeitsgruppe
Aktuelle Projekte
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Wichtigste Publikationen
Originalarbeiten
Kallenberg K, Dehnert C, Dörfler A, Schellinger PD, Bailey DM, Knauth M, Bärtsch P.
Microhemorrages in nonfatal high-altitude cerebral edema
J Cereb Blood Flow Metab 2008;28:1635-42.
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Kallenberg K, Bailey DM, Christ S, Mohr A, Roukens R, Menold E, Steiner T, Bärtsch P, Knauth M.
Magnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sickness.
J Cereb Blood Flow Metab 2007;27:1064-1071.
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Bailey DM, Roukens R, Knauth M, Kallenberg K, Christ S, Mohr A, Genius J, Storch-Hagenlocher B, Meisel F, McEneny J, Young IS, Steiner T, Hess K, Bärtsch P.
Free radical-mediated damage to barrier function is not associated with altered brain morphology in high-altitude headache.
J Cereb Blood Flow Metab 2006;26:99-111
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Dehnert C, Risse F, Ley S, Kuder TA, Buhmann R, Puderbach M, Menold E, Mereles D, Kauczor H-U, Bärtsch P, Fink C.
Magnetic resonance imaging of uneven pulmonary perfusion in hypoxia in humans.
Am J Respir Crit Care Med 2006;174:1132-1138.
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Maggiorini M, Brunner-La Rocca H-P, Peth S, Fischler M, Böhm T, Bernheim A, Kiencke S, Bloch KE, Dehnert C, Naeije R, Lehmann T, Bärtsch P, Mairbäurl H.
Both tadalafil and dexamethasone may reduce the incidence of high-altitude pulmonary edema.
Ann Intern Med 2006;145:497-506.
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Berger M, Hesse C, Dehnert C, Siedler H, Kleinbongard P, Bardenheuer HJ, Kelm M, Bärtsch P, Haefeli WE.
Hypoxia impairs systemic endothelial function in individuals prone to high-altitude pulmonary edema.
Am J Respir Crit Care Med 2005;172:763-767.
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Swenson ER, Maggiorini M, Mongovin S, Gibbs JSR, Greve I,
Maibäurl H, Bärtsch P. Pathogenesis of high-altitude pulmonary edema: Inflammation is not an etiologic factor.
JAMA 2002;287:2228-2235.
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Grünig E, Mereles D, Hildebrandt W, Swenson ER, Kübler W, Kuecherer H, Bärtsch P.
Stress doppler echocardiography for identification of susceptibility to high altitude pulmonary edema.
J Am Coll Cardiol 2000;35:980-987.
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Scherrer U, Vollenweider L, Delabays A, Savcic M, Eichenberger U, Kleger G-R, Firkrle A, Ballmer P, Nicod P, Bärtsch P.
Inhaled nitric oxide for high-altitude pulmonary edema.
N Engl J Med 1996;334:624-629.
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Bärtsch P, Merki B, Hofstetter D, Maggiorini M, Kayser B, Oelz O.
Treatment of acute mountain sickness by simulated descent: A randomised controlled trial.
Br Med J 1993;306:1098-1101.
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Bärtsch P, Maggiorini M, Ritter M, Noti C, Vock P, Oelz O.
Prevention of high-altitude pulmonary edema by nifedipine.
N Engl J Med 1991;325:1284-1289.
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Bärtsch P, Baumgartner RW, Waber U, Maggiorini M, Oelz O.
Comparison of carbon-dioxide-enriched, oxygen-enriched, and normal air in treatment of acute mountain sickness.
Lancet 1990;336:772-775.
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Oelz O, Ritter M, Jenni R, Maggiorini M, Waber U, Vock P, Bärtsch P.
Nifedipine for High Altitude Pulmonary Oedema.
Lancet 1989;2(8674):1241-1244.
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Reviews
Bärtsch P, Gibbs JSR.
Effect of altitude on the heart and the lungs.
Circulation 2007;116:2191-2202.
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Bärtsch P, Mairbäurl H, Maggiorini M, Swenson E.
Physiological aspects of high-altitude pulmonary edema.
J Appl Physiol 2005;98:1101-10.
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Bärtsch P, Bailey D, Berger M, Knauth M, Baumgartner M.
Acute mountain sickness: Controversies and advances.
High Alt Med Biol 2004;5:110-124.
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Bärtsch P, Roach R.
Acute mountain sickness and high-altitude cerebral edema.
In: Hornbein, T. F.; Schoene, R., eds. High altitude - an exploration of human adaptation. New York: Marcel Dekker Inc.; 2001. pp. 731-776.
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Bärtsch P.
High Altitude Pulmonary Edema.
Respiration 1997;64:435-443.
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Editorials
Bärtsch P.
How thrombogenic is hypoxia?
JAMA 2006;295:2297-2299.
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Bärtsch P.
Platelet activation with exercise and risk of cardiac events.
Lancet 1999;354:1747-1748.
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