Angewandte Tumorbiologie
Pathologie

Ausgewählte Publikationen

2013

 

  • Lee J, Ballikaya S, Schönig K, Ball CR, Glimm H, Kopitz J, Gebert J.bTransforming growth factor beta receptor 2 (TGFBR2) changes sialylation in the microsatellite unstable (MSI) Colorectal cancer cell line HCT116. PLoS One. 2013;8(2):e57074. PubMed Abstract
  • Aretz S, Krohne TU, Kammerer K, Warnken U, Hotz-Wagenblatt A, Bergmann M, Stanzel BV, Kempf T, Holz FG, Schnölzer M, Kopitz J. In-depth mass spectrometric mapping of the human vitreous proteome. Proteome Sci. 2013 May 20;11(1):22. PubMed Abstract
  • Kopitz J, Fik Z, André S, Smetana K Jr, Gabius HJ. Single-site mutational engineering and following monoPEGylation of the human lectin galectin-2: effects on ligand binding, functional aspects, and clearance from serum.  Mol Pharm. 2013 May 6;10(5):2054-61. PubMed Abstract
  • Schütt F, Aretz S, Auffahrt GU, Kopitz J. Rolle des Energiestoffwechsels im retinalen Pigmentepithel. Ophthalmologe. 2013 Apr;110(4):346-52. PubMed Abstract
  • Plaschke K, Hauth S, Jansen C, Bruckner T, Schramm C, Karck M, Kopitz J. The influence of preoperative serum anticholinergic activity and other risk factors for the development of postoperative cognitive dysfunction after cardiac surgery. J Thorac Cardiovasc Surg. 2013 Mar;145(3):805-11. PubMed PMID: 24054023. PubMed Abstract  
  • Kloor M, Staffa L, Ahadova A, von Knebel Doeberitz M.  Clinical significance of microsatellite instability in colorectal cancer. Langenbecks Arch Surg. 2013 Sep 19. [Epub ahead of print] PubMed Abstract
  • Reuschenbach M, von Knebel Doeberitz M. Diagnostic tests for the detection of human papillomavirus-associated cervical lesions. Curr Pharm Des. 2013;19 (8):1358-70. PubMed Abstract 
  • Bauer K, Nelius N, Reuschenbach M, Koch M, Weitz J, Steinert G, Kopitz J, Beckhove P, Tariverdian M, von Knebel Doeberitz M, Kloor M. T cell responses against microsatellite instability-induced frameshift peptides and influence of regulatory T cells in colorectal cancer. Cancer Immunol Immunother. 2013 Jan;62 (1): 27-37.  PubMed Abstract
  • von Knebel Doeberitz M, Kloor M. Towards a vaccine to prevent cancer in Lynch syndrome patients. Fam Cancer. 2013 Jun;12(2):307-12. PubMed Abstract
  • Reuschenbach M, Roos J, Panayotopoulos D, Baldus SE, Schnürch HG, Berger A, Petry KU, Dürst M, Seiz M, von Knebel Doeberitz M, Hampl M; on behalf of the German Study Group for Colposcopy. Characterization of Squamous Cell Cancers of the Vulvar Anterior Fourchette by Human Papillomavirus, p16INK4a, and p53. J Low Genit Tract Dis. 2013 Jul;17 (3):289-297. PubMed Abstract
  • Capper D, Voigt A, Bozukova G, Ahadova A, Kickingereder P, von Deimling A, von Knebel Doeberitz M, Kloor M. BRAF V600E-specific immunohistochemistry for the exclusion of Lynch syndrome in MSI-H colorectal cancer. Int J Cancer 2013 Oct 1;133(7):1624-30. PubMed Abstract
  • Kloor M. [Pathogenesis of microsatellite-unstable colorectal cancer : Evaluation of new diagnostic and therapeutic options]. Pathologe. 2013 Nov;34 Suppl 2:277-81. PubMed Abstract

 

2012

 

  • Reuschenbach M, Vinokurova S, von Knebel Doeberitz M. Ätiologie des Zervixkarzinoms und dessen Vorstufen. Onkologe. 2012;18:9-19.

  • Reuschenbach M, Seiz M, von Knebel DC, Vinokurova S, Duwe A, Ridder R, Sartor H, Kommoss F, Schmidt D, von Knebel Doeberitz  M. Evaluation of cervical cone biopsies for coexpression of p16INK4a and Ki-67 in epithelial cells. Int J Cancer 2012 Jan 15;130(2):388-94. Opens external link in new windowPubMed Abstract

  • Reuschenbach M, von Knebel Doeberitz M.Diagnostic  tests for the detection of human papillomavirus-associated cervical lesions. Curr Pharm Des. 2013;19(8):1358-70. PubMed Abstract
  • Bauer K, Nelius N, Reuschenbach M, Koch M, Weitz J, Steinert G, Kopitz J, Beckhove P, Tariverdian M, von Knebel Doeberitz M, Kloor M. T cell responses against microsatellite instability-induced frameshift peptides and influence of regulatory T cells in colorectal cancer. Cancer Immunol Immunother. 2013 Jan;62(1):27-37. PubMed Abstract
  • Reuschenbach M, Sommerer C, Hartschuh W, Zeier M, von Knebel Doeberitz  M, Kloor M. Absence of mismatch repair deficiency-related microsatellite instability in non-melanoma skin cancer. J Invest Dermatol. 2012 Feb;132(2):491-3. PubMed Abstract
  • Kloor M, Huth C, Voigt AY, Benner A, Schirmacher P, von Knebel Doeberitz M, Bläker H. Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study. Lancet Oncol. 2012 Jun;13(6):598-606. PubMed Abstract
  • Huth C, Kloor M, Voigt AY, Bozukova G, Evers C, Gaspar H, Tariverdian M, Schirmacher P, von Knebel Doeberitz M, Bläker H. The molecular basis of EPCAM expression loss in Lynch syndrome-associated tumors. Mod Pathol. 2012 Jun;25(6):911-6. PubMed Abstract
  • Chaiwongkot A, Vinokurova S, Pientong C, Ekalaksananan T, Kongyingyoes B, Kleebkaow P, Chumworathayi B, Patarapadungkit N, Reuschenbach M, von Knebel Doeberitz M. Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions. Int J Cancer 2013 May 1;132(9):2087-9 PubMed Abstract
  • Gebert J, Kloor M, Lee J, Lohr M, André S, Wagner R, Kopitz J, Gabius HJ.Colonic carcinogenesis along different genetic routes: glycophenotyping of tumor cases separated by microsatellite instability/stability. Histochem Cell Biol. 2012 Aug;138(2):339-50. PubMed Abstract
  • Lee J, Li L, Gretz N, Gebert J, Dihlmann S. Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers. Oncogene. 2012 Mar 8;31(10):1242-53. PubMed Abstract
  • Kopitz J, Ballikaya S, André S, Gabius HJ.Ganglioside GM1/ galectin-dependent growth regulation in human neuroblastoma cells: special properties of bivalent galectin-4 and significance of linker length for ligand selection. Neurochem Res. 2012 Jun;37(6):1267-76. PubMed Abstract
  • Plaschke K, Bent F, Rosenhagen C, Wagner S, Hofer S, Kopitz J. The inhibitory in-vitro effect of high-dose levosimendan on platelet function may be mediated through its action as a phosphodiesterase inhibitor. Coronary Artery Dis. 2012 May;23(3):215-220. PubMed Abstract
  • Plaschke K, Hauth S, Jansen C, Bruckner T, Schramm C, Karck M, Kopitz J.The influence of preoperative serum anticholinergic activity and other risk factors for the development of postoperative cognitive dysfunction after cardiac surgery. J Thorac Cardiovasc Surg. 2013 Mar;145(3):805-11. PubMed Abstract
  • Schütt F, Aretz S, Auffarth GU, Kopitz J. Moderately reduced ATP levels promote oxidative stress and debilitate autophagic and phagocytic capacities in human RPE cells. Invest Ophthalmol Vis Sci. 2012 Aug 9;53(9):5354-61. PubMed Abstract
  • von Knebel Doeberitz M, Reuschenbach M, Schmidt D, Bergeron C.Biomarkers for  cervical cancer screening: the role of p16(INK4a) to highlight transforming HPV infections. Expert Rev Proteomics. 2012 Apr;9(2):149-63. PubMed Abstract
  • Tikidzhieva A, Benner A, Michel S, Formentini A, Link KH, Dippold W, von Knebel Doeberitz M, Kornmann M, Kloor M. Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results ofthe FOGT-4 trial. Br J Cancer. 2012 Mar 13;106(6):1239-45. PubMed Abstract
  • von Knebel Doeberitz M, Vinokurova S, Reuschenbach M. Monogr Virol. Concepts of Biomarker Development. Monogr  Virol. Basel, Karger, 2012(28): 99-108.
  • von Knebel Doeberitz M. Humane Papillomviren (HPV). In: Impfkompendium (Hrsg.: Spiess, Heininger, Jilg). Thieme Verlag 7. Auflage 2012, 169-173.

 

2011

 

  • Reuschenbach M, Vinokurova S, von Knebel Doeberitz M. [HPV-associated carcinomas of the female genital tract : Molecular mechanisms of development]. Pathologe. 2011 Nov;32(6):451-60. German.
    PubMed Abstract.
  • Vinokurova S, von Knebel Doeberitz M. Differential methylation of the HPV 16 upstream regulatory region during epithelial differentiation and neoplastic transformation. PLoS One. 2011;6(9):e24451. Epub 2011 Sep 7.
    PubMed Abstract.
  • Bauer K, Michel S, Reuschenbach M, Nelius N, von Knebel Doeberitz M, Kloor M. Dendritic cell and macrophage infiltration in microsatellite-unstable and microsatellite-stable colorectal cancer. Fam Cancer. 2011  2011 Sep;10(3):557-65.
    PubMed abstract.
  • Bergmann M, Holz F, Kopitz J. Lysosomal stress and lipid peroxidation products induce VEGF-121 and VEGF-165 expression in ARPE-19 cells. Graefes Arch Clin Exp Ophthalmol. 2011 Oct;249(10):1477-83. Epub 2011 Apr 21.
    PubMed Abstract.
  • Plaschke K, Bergmann M, Kopitz J. Ginkgo extract EGb 761(®) shields from slowly accumulating neurodegenerative-like changes in a newly developed cell culture model induced by the combined action of low doses of antimycin A1 and 2-deoxy-D: -glucose. J Neural Transm. 2011 Aug;118(8):1247-54. Epub 2011 Apr 9.
    PubMed abstract.
  • Reuschenbach M, Tran T, Faulstich F, Hartschuh W, Vinokurova S, Kloor M, Krautkrämer E, Zeier M, von Knebel Doeberitz M, Sommerer C. High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients andimmunocompetent patients. Br J Cancer. 2011 Apr 12;104(8):1334-41.
    PubMed abstract.
  • Kloor M, Voigt AY, Schackert HK, Schirmacher P, von Knebel Doeberitz M, Bläker H. Analysis of EPCAM Protein Expression in Diagnostics of Lynch Syndrome. J Clin Oncol.  2011 Jan 10;29(2):223-7. Epub 2010 Nov 29.
    PubMed abstract.

 

2010

          • Reuschenbach M, Clad A, von Knebel Doeberitz C, Wentzensen N, Rahmsdorf J, Schaffrath F, Griesser H, Freudenberg N, von Knebel Doeberitz M. Performance of p16INK4a-cytology, HPV mRNA, and HPV DNA testing to identify high grade cervical dysplasia in women with abnormal screening results. Gynecol Oncol. 2010 Oct;119(1):98-105.
            PubMed abstract.
          • Kloor M, Michel S, von Knebel Doeberitz M. Immune evasion of microsatellite unstable colorectal cancers. Int J Cancer. 2010 Sep 1;127(5):1001-10. Review.
            PubMed abstract.
          • Kopitz J, Bergmann M, Gabius HJ. How adhesion/growth-regulatory galectins-1 and -3 attain cell specificity: case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane. IUBMB Life. 2010 Aug;62(8):624-8.
            PubMed abstract.
          • Grabe N, Lahrmann B, Pommerencke T, von Knebel Doeberitz M, Reuschenbach M, Wentzensen N. A virtual microscopy system to scan, evaluate and archive biomarker enhanced cervical cytology slides. Cell Oncol. 2010;32(1-2):109-19.
            PubMed abstract.
          • Reuschenbach M, Kloor M, Morak M, Wentzensen N, Germann A, Garbe Y, Tariverdian M, Findeisen P, Neumaier M, Holinski-Feder E, von Knebel Doeberitz M. Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with Lynch syndrome. Fam Cancer. 2010 Jun;9(2):173-9.
            PubMed abstract.
          • Patsos G, Germann A, Gebert J, Dihlmann S. Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells. Int J Cancer. 2010 Apr 15;126(8):1838-49.
            PubMed abstract.
          • von Knebel Doeberitz M. Screening for cancer. Int J Cancer. 2010 Mar 1;126(5):1037-8. No abstract available.
          • Krohne TU, Kaemmerer E, Holz FG, Kopitz J. Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action. Exp Eye Res. 2010 Feb;90(2):261-6. Epub 2009 Nov 4.
            PubMed abstract.
          • Michel S, Kloor M, Singh S, Gdynia G, Roth W, von Knebel Doeberitz M, Schirmacher P, Bläker H. Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation. Mol Carcinog. 2010 Feb;49(2):175-82.
            PubMed abstract.
          • Woerner SM, Yuan YP, Benner A, Korff S, von Knebel Doeberitz M, Bork P. SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology. Nucleic Acids Res. 2010 Jan;38(Database issue):D682-9.
            PubMed abstract.
          • von Knebel Doeberitz M, Reuschenbach M. [Human papillomaviruses in the pathogenesis of intraepithelial neoplasia (AIN) and carcinoma of the anus.] Hautarzt. 2010 Jan;61(1):13-20. German.
            PubMed abstract.

          2009

                • Michel S, Linnebacher M, Alcaniz J, Voss M, Wagner R, Dippold W, Becker C, von Knebel Doeberitz M, Ferrone S, Kloor M. Lack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes. Int J Cancer. 2009 Dec 9;127(4):889-898.
                  PubMed abstract.
                • Reuschenbach M, von Knebel Doeberitz M, Wentzensen N. A systematic review of humoral immune responses against tumor antigens. Cancer Immunol Immunother 2009 Oct;58(10):1535-44.
                  PubMed abstract.
                • Kloor M. Lymphocyte infiltration and prognosis in colorectal cancer. Lancet Oncol. 2009 Sep;10(9):840-1. No abstract available.
                • Knebel Doeberitz M, Vinokurova S. Host factors in HPV-related carcinogenesis: cellular mechanisms controlling HPV infections. Arch Med Res. 2009 Aug;40(6):435-42. No abstract available.
                  • Patsos G, André S, Roeckel N, Gromes R, Gebert J, Kopitz J, Gabius HJ. Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile. Glycobiology 2009 Jul;19(7):726-34.
                    PubMed abstract.
                  • Halama N, Michel S, Kloor M, Zoernig I, Pommerencke T, von Knebel Doeberitz M, Schirmacher P, Weitz J, Grabe N, Jäger D. The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy.
                    Cancer Immun 2009 Feb 19;9:1.
                    PubMed abstract.
                  • Roeckel N, Woerner SM, Kloor M, Yuan YP, Patsos G, Gromes R, Kopitz J, Gebert, J. High frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability. Cancer Res 2009 Jan 1;69(1):292-9.
                    PubMed abstract.

                   

                  2008

                   

                  • Michel S, Benner A, Tariverdian M, Wentzensen N, Hoefler P, Pommerencke T, Grabe N, von Knebel Doeberitz M, Kloor M. High density of Foxp3 positive T cells infiltrating colorectal cancers with microsatellite instability. Br J Cancer 2008 Dec 2;99(11):1867-73.
                    PubMed abstract.
                  • Reuschenbach M, Waterboer T, Wallin KL, Einenkel J, Dillner J, Hamsikova E, Eschenbach D, Zimmer H, Heilig B, Kopitz J, Pawlita M, von Knebel Doeberitz M, Wentzensen N. Characterization of humoral immune responses against p16, p53, HPV16 E6 and HPV16 E7 in patients with HPV-associated cancers. Int J Cancer 2008 Dec 1;123(11):2626-31.
                    PubMed abstract.
                  • Nehls K, Vinokurova S, Schmidt D, Kommoss F, Reuschenbach M, Kisseljov F, Einenkel J, von Knebel Doeberitz M, Wentzensen, N. p16 methylation does not affect protein expression in cervical carcinogenesis. Eur J Cancer 2008 Nov;44(16):2496-505.
                    PubMed abstract.
                  • Gurrola-Díaz CM, Suárez-Rincón AE, Vázquez-Camacho G, Buonocunto-Vázquez G, Rosales-Quintana S, Wentzensen N, von Knebel Doeberitz M.  P16INK4a immunohistochemistry improves the reproducibility of the histological diagnosis of cervical intraepithelial neoplasia in cone biopsies. Gynecol Oncol 2008 Oct;111(1):120-4.
                    PubMed abstract.
                  • Vinokurova S, Wentzensen N, Kraus I, Klaes R, Driesch C, Melsheimer P, Kisseljov F, Duerst M, Schenider A, von Knebel Doeberitz M. Type dependent frequency of human papillomavirus genomes in cervical cancer lesions. Cancer Res 2008; 68 (1): 307-313
                    PubMed abstract.
                    • Schwitalle Y, Kloor M, Eiermann S, Linnebacher M, Kienle P, Knaebel HP, Tariverdian M, Benner A, von Knebel Doeberitz M. Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers. Gastroenterology 2008
                      PubMed abstract.
                    • Wentzensen N, du Bois A, Kommoss S, Pfisterer J, von Knebel Doeberitz M, Schmidt D, Kommoss F. No metastatic cervical adenocarcinomas in a series of p16INK4a-positive mucinous or endometrioid advanced ovarian carcinomas: an analysis of the AGO Ovarian Cancer Study Group. Int J Gynecol Pathol 2008 Jan;27 (1): 18-23
                      PubMed abstract.
                    • Korff S, Woerner SM, Yuan YP, Bork P, von Knebel Doeberitz M and Gebert J. Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability. BMC Cancer 2008, 8:329.
                      PubMed abstract.

                     

                    2007

                     

                    • Woerner SM, Kloor M, Schwitalle Y, Youmans H, von Knebel Doeberitz M, Gebert J and Dihlmann S. The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers. Genes Chromosomes Cancer 2007 Dec;46(12):1080-9.
                      PubMed abstract. see also at Seltarbase.
                    • Gassler N, Roth W, Funke B, Schneider A, Herzog F, Tischendorf JJ, Grund K, Penzel R, Bravo IG, Mariadason J, Ehemann V, Sykora J, Haas TL, Walczak H, Ganten T, Zentgraf H, Erb P, Alonso A, Autschbach F, Schirmacher P, Knüchel R, Kopitz J. Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing. Gastroenterology 2007 Aug;133(2):587-98.
                      PubMed abstract.
                    • Wentzensen N, von Knebel Doeberitz, M.: Biomarkers in cervical cancer screening. Dis Markers 2007 23(4):315-330.
                      PubMed abstract.
                    • Kloor M, Michel S, Buckowitz B, Ruschoff J, Buttner R, Holinski-Feder E, Dippold W, Wagner R, Tariverdian M, Benner A, Schwitalle Y, Kuchenbuch B, von Knebel Doeberitz M. Beta2-microglobulin mutations in microsatellite unstable colorectal tumors. Int J Cancer 2007 Jul 15;121(2):454-8.
                      PubMed abstract. see also at Seltarbase.
                    • Eckert A, Kloor M, Giersch A, Ahmadi R, Herold-Mende C, Hampl JA, Heppner FL, Zoubaa S, Holinski-Feder E, Pietsch T, Wiestler OD, von Knebel Doeberitz M, Roth W, Gebert J. Microsatellite instability in pediatric and adult high-grade gliomas. Brain Pathol 2007 Apr;17(2):146-50.
                      PubMed abstract.
                    • Kaemmerer E, Schutt F, Krohne TU, Holz FG, Kopitz J. Effects of lipid peroxidation-related protein modifications on RPE lysosomal functions and POS phagocytosis. Invest Ophthalmol Vis Sci 2007 Mar;48(3):1342-7.
                      PubMed abstract.
                    • Wentzensen N., Braumann U.-D., Einenkel J., Horn L.C., von Knebel Doeberitz M., Löffler M., Kuska J.P.:  Combined Serial Section-Based 3D Reconstruction of Cervical Carcinoma Invasion Using H&E/p16INK4a/CD3 Alternate Staining. Cytometry Part A 71A: 327-333
                      PubMed abstract.
                    • Wentzensen N, Bergeron C, Cas F, Vinokurova S, von Knebel Doeberitz, M.:  Triage of women with ASCUS and LSIL cytology: use of qualitative assessment of p16INK4a positive cells to identify patients with high-grade cervical intraepithelial neoplasia. Cancer 2007 111(1):58-66.
                      PubMed abstract.
                    • Hampl M, Wentzensen N, Vinokurova S, von Knebel Doeberitz M, Poremba C, Bender HG et al. Comprehensive analysis of 130 multicentric intraepithelial female lower genital tract lesions by HPV typing and p16 expression profile. J Cancer Res Clin Oncol 2007 133(4):235-245.
                      PubMed abstract.

                     

                    2006

                     

                    • Wentzensen N, Hampl M, Herkert M, Reichert A, Trunk MJ, Poremba C, Ridder R, von Knebel Doeberitz M.: Identification of high-grade cervical dysplasia by the detection of p16INK4a in cell lysates obtained from cervical samples. Cancer 2006; 107(9):2307-13.
                      PubMed abstract.
                    • Wentzensen N, Bergeron C, Cas F, Vinokurova S, von Knebel Doeberitz M: Triage of women with ASCUS and LSIL cytology: use of qualitative assessment of p16INK4a positive cells to identify patients with high-grade cervical intraepithelial neoplasia. Cancer 2006; 111 (1) 58-66
                      PubMed abstract.
                    • German HNPCC Consortium; Muller A, Beckmann C, Westphal G, Bocker Edmonston T, Friedrichs N, Dietmaier W, Brasch FE, Kloor M, Poremba C, Keller G, Aust DE, Fass J, Buttner R, Becker H, Ruschoff J. Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study. Int J Colorectal Dis 2006, 21(7):632-41.
                      PubMed abstract.
                    • Woerner SM, Kloor M, von Knebel Doeberitz M, Gebert JF. Microsatellite instability in the development of DNA mismatch repair deficient tumors. Cancer Biomarkers 2006, 2(1-2), 69-86.
                    • von Knebel Doeberitz M. Is progression of HPV-infected cells within the cervical epithelium linked to modified interaction with the extracellular matrix: a potential role of the 67 kd non-integrin laminin receptor 67LR Acta Cytol 2006 (50)  (1) Suppl. 1-2
                      PubMed abstract.
                    • Baehring J, Sutter C, Kadmon M, von Knebel Doeberitz M, Gebert J. A 'Nonsense' Mutation Leads to Aberrant Splicing of hMLH1 in a German Hereditary Non-polyposis Colorectal Cancer Family. Fam Cancer 2006, 5(2), 195-9.
                      PubMed abstract.
                    • Kloor M, Schwitalle Y, von Knebel Doeberitz M, Wentzensen N. Tetranucleotide repeats in coding regions: no evidence for involvement in EMAST carcinogenesis. J Mol Med 2006 Jan 17, 1-5
                      PubMed abstract.

                     

                    2005

                    • Wentzensen N, Bergeron C, Cas F, Eschenbach D, Vinokurova S, von Knebel Doeberitz M. Evaluation of a nuclear score for p16INK4a-stained cervical squamous cells in liquid-based cytology samples. Cancer 2005 Dec 25;105(6):461-7.
                      PubMed abstract.
                    • Findeisen P, Kloor M, Merx S, Sutter C, Woerner SM, Dostmann N, Benner A, Dondog B, Pawlita M, Dippold W, Wagner R, Gebert J, von Knebel Doeberitz M. T25 Repeat in the 3' Untranslated Region of the CASP2 Gene: A Sensitive and Specific Marker for Microsatellite Instability in Colorectal Cancer. Cancer Res 2005 Sept 15, 65(18), 8072-8078.
                      PubMed abstract. see also at Seltarbase.
                    • Kloor M, von Knebel Doeberitz M, Gebert JF. Molecular testing for microsatellite instability and its value in tumor characterization. Expert Rev Mol Diagn 2005 Jul, 5(4), 599-611.
                      PubMed abstract.
                    • Kloor M, Becker C, Benner A, Woerner SM, Gebert J, Ferrone S, von Knebel Doeberitz M. Immunoselective pressure and human leukocyte antigen class I antigen machinery defects in microsatellite unstable colorectal cancers. Cancer Res 2005 Jul 15, 65(14): 6418-24.
                      PubMed abstract. see also at Seltarbase.
                    • Dihlmann S, Kloor M, Fallsehr C, von Knebel Doeberitz M. Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells. Carcinogenesis 2005 Sep;26(9):1503-12.
                      PubMed abstract.
                    • Buckowitz A, Knaebel HP, Benner A, Blaker H, Gebert J, Kienle P, von Knebel Doeberitz M, Kloor M. Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases. Br J Cancer 2005 May 9, 92(9), 1746-53.
                      PubMed abstract.
                    • Woerner SM, Kloor M, Mueller A, Rueschoff J, Friedrichs N, Buettner R, Buzello M, Kienle P, Knaebel HP, Kunstmann E, Pagenstecher C, Schackert HK, Moeslein G, Vogelsang H, von Knebel Doeberitz M, Gebert JF, and the German HNPCC Consortium. Microsatellite Instability of Selective Target Genes in HNPCC-Associated Colon Adenomas. Oncogene 2005, Apr 7, 25(15), 2525-2535.
                      PubMed abstract.

                     

                    2004

                     

                    • Kloor M, Sutter C, Wentzensen N, Cremer FW, Buckowitz A, Keller M, von Knebel Doeberitz M, Gebert J. A large MSH2 Alu insertion mutation causes HNPCC in a German kindred. Hum Genet 2004 Oct, 115(5), 432-8.
                      PubMed abstract.
                    • Vinokurova S, Wentzensen N, Einenkel J, Klaes R, Ziegert C, Melsheimer P, Sartor H, Horn Lars-Christian, Höchel, M, von Knebel Doeberitz M.: Clonal History of Papillomavirus-Induced Dysplasia in rthe Female Lower Genitale Tract. Journal of the National Cancer Institute 97 (24), 1816-1821
                      PubMed abstract.
                    • Wang SS, Trunk M, Schiffman M, Herrero R, Sherman M.E, Burk RD, Hildesheim A, Bratti MC, Wright T, Rodriguez AC, Chen S, Reichert A, von Knebel Doeberitz C, Ridder R, von Knebel Doeberitz M. Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica. Cancer Epidemiol. Biomarkers Prev 2004; 13: 1355-1360.
                      PubMed abstract.
                    • Trunk MJ, Dallenbach-Hellweg G, Ridder R, Petry KU, Ikenberg H, Schneider V, von Knebel Doeberitz M. Morphologic characteristics of p16INK4a-positive cells in cervical cytology samples. Acta Cytol 2004; 48: 771-782.
                      PubMed abstract.
                    • Melsheimer P, Vinokurova S, Wentzensen N, Bastert G, von Knebel Doeberitz M. DNA aneuploidy and integration of human papillomavirus type 16 e6/e7 oncogenes in intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix uteri. Clin Cancer Res 2004; 10:  3059-3063.
                      PubMed abstract.
                    • Wentzensen N, Vinokurova S, von Knebel Doeberitz M. Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract, Cancer Res 2004, Jun 64(11), 3878-84
                      PubMed abstract.
                    • Wentzensen N, von Knebel Doeberitz M. Virale Kanzerogenese von Kopf-Hals-Tumoren, Der Pathologe 2004, Feb 25(1), 21-30
                      PubMed abstract.
                    • Schwitalle Y, Linnebacher M, Ripberger E, Gebert J, von Knebel Doeberitz M. Immunogenic peptides generated by frameshift mutations in DNA mismatch repair-deficient cancer cells. Cancer Immun 2004, Nov 25, 4:14
                      PubMed abstract.
                    • Koesters R, Linnebacher M, Coy JF, Germann A, Schwitalle Y, Findeisen P, von Knebel Doeberitz M. WT1 is a tumor-associated antigen in colon cancer that can be recognized by in vitro stimulated cytotoxic T cells. Int J Cancer 2004, 109(3), 385-92
                      PubMed abstract.

                     

                    2003

                     

                    • Ziegert C, Wentzensen N, Vinokurova S, Kisseljov F, Einenkel J, Hoeckel M, von Knebel Doeberitz M. A Comprehensive Analysis of HPV Integration Loci in Anogenital Lesions Combining Transcript and Genome Based Amplification Techniques. Oncogene 2003, Jun 19, 22(25), 3977-3984
                      PubMed abstract.
                    • Ridder R, Wentzensen N, von Knebel Doeberitz M. Biomarker in der Differenzialdiagnostik von HPV-assoziierten Läsionen, Der Gynäkologe 2003, Apr, 36(4), 323-330
                      PubMed abstract.
                    • Woerner SM, Benner A, Sutter C, Schiller M, Keller G, Yuan, Y.P, Bork P, von Knebel Doeberitz M, Gebert, JF. Carcinogenesis of MSI-H Cancer of the Colorectum Stomach and Endometrium. Real Common Target Genes and Bystander Genes. Oncogene 2003, Apr 17, 22(15), 2226-2235.
                      PubMed abstract. see also at Seltarbase.
                    • Bonk T, Humeny A, Gebert J, Sutter C, von Knebel Doeberitz M, Becker CM. MALDI-TOF-MS based detection of coding microsatellite instability. A novel diagnostic approach to mismatch repair deficient hereditary nonpolyposis (HNPCC) and sporadic colecteral cancer. Clin Chem 2003 Apr, 49(4), 552-561.
                      PubMed abstract.
                    • Ripberger E, Linnebacher M, Schwitalle Y, Gebert J, von Knebel Doeberitz M. Identification of an HLA-A0201-restricted CTL epitope generated by a tumor-specific frameshift mutation in a coding microsatellite of the OGT gene. J Clin Immunol 2003, 23(5), 415-423
                      PubMed abstract.
                    • Schütt F, Bergmann M, Holz FG, Kopitz J. Identification of proteins modified by malondialdehyde, 4-hydroxynonenal or advanced glycation endproducts in lipofuscin of human retinal pigment epithelium. Invest Ophthalmol Vis Sci 2003 Aug, 44(8), 3663-8
                      PubMed abstract.
                    • Kopitz J, Andre S, von Reitzenstein C, et al. Homodimeric Galectin-7 (p53-Induced Gene 1) is a Negative Growth Regulator for Human Neuroblastoma Cells. Oncogene 2003 Sep 18, 22(40), 6277-88
                      PubMed abstract.
                    Select languageSelect language
                    Print Mail