Molecular Medicine Partnership Unit

 

Recent Publications

Opens external link in new windowIron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by IRPs.
Sanchez, M., B. Galy, B. Schwanhaeusser, J. Blake, T. Bähr-Ivacevic, V. Benes, M. Selbach, M.U. Muckenthaler and M.W. Hentze.
Blood 118: e168-79, Nov 2011

 

Opens external link in new windowThe liver-specific microRNA miR-122 controls systemic iron homeostasis in mice.
Castoldi M, Vujić Spasić M, Altamura S, Elmén J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmüller U, Fleming RE, Longerich T, Gröne HJ, Benes V, Kauppinen S, Hentze MW, Muckenthaler MU.
J Clin Invest. 2011 Apr 1;121(4):1386-96

 

Opens external link in new windowSnapShot: protein-protein interaction networks.
Seebacher J. and Gavin A.C.
Cell 2011 March 18;144, 1000

 

Opens external link in new windowp38 MAPK controls prothrombin expression by regulated RNA 3' end processing.
Danckwardt S, Gantzert AS, Macher-Goeppinger S, Probst HC, Gentzel M, Wilm M, Gröne HJ, Schirmacher P, Hentze MW, Kulozik AE.
Mol Cell. 2011 Feb 4;41(3):298-310. 

 

Opens external link in new windowTwo to tango: regulation of mammalian iron metabolism
Hentze, M.W., M.U. Muckenthaler, B. Galy and C. Camaschella.
Cell 142, 24-38, 2010

 

Opens external link in new windowAirway surface liquid volume regulation determines different airway phenotypes in liddle's compared to {beta}ENAC-overexpressing mice 
Mall MA, Button B, Johannesson B, Zhou Z, Livraghi A, Caldwell RA, Schubert SC, Schultz C, O'Neal WK, Pradervand S, Hummler E, Rossier BC, Grubb BR, Boucher RC.
J Biol Chem. 2010 Aug 27;285(35):26945-55. Epub 2010 Jun 21

 

Opens external link in new windowSelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology
Woerner SM, Yuan YP, Benner A, Korff S, von Knebel Doeberitz M, Bork P
Nucleic Acids Res. 2010 Jan; 38 (Database issue)

 

Opens external link in new windowSMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression
Mleczko-Sanecka, K., G. Casanovas, A. Ragab, K. Breitkopf, M. Boutros, S. Dooley, M.W. Hentze and M.U. Muckenthaler.
Blood115, 2657-2665, 2010

 

Opens external link in new windowMembrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation 
Cobos-Correa A, Trojanek JB, Diemer S, Mall MA, Schultz C. 
Nat Chem Biol. 2009 Sep;5(9):628-30. Epub 2009 Aug 2.

 

Opens external link in new windowDisassembly of exon junction complexes by PYM
Gehring N.H., S. Lamprinaki, A.E. Kulozik, M.W. Hentze. 
Cell. 2009 May 1;137(3):536-48.

 

Opens external link in new windowDetecTiff: A novel image analysis routine for high content screening microscopy 
Gilbert D, Meinhof T, Pepperkok R, Runz H., 
J. Biomol Screen. 2009 Sept;14(8):944-55. Epub 2009 Jul 29

 

Opens external link in new windowIdentification of cholesterol-regulating genes by targeted RNAi-screening
Bartz F, Kern L, Erz D, Zhu M, Gilbert D, Meinhof T, Wirkner U, Erfle H, Muckenthaler M, Pepperkok R, Runz H, 
Cell Metab. 2009 Jul;10(1):63-75

 

Opens external link in new windowThe hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay
Gehring N.H., S. Lamprinaki, M.W. Hentze, A.E. Kulozik. 
PLoS Biol. 2009 May 26;7(5):e1000120. Epub 2009 May 26.

 

Opens external link in new windowBone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD
Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU. 
J Mol Med. 2009 May;87(5):471-80. Epub 2009 Feb 20

 

Opens external link in new windowHigh frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability
Roeckel N, Woerner SM, Kloor M, Yuan YP, Patsos G, Gromes R, Kopitz J, Gebert, J. 
Cancer Res 2009; 69(1):292-9.

 

Opens internal link in current windowFor more publications go to each Research Group

 

 

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