Stem Cells in Development and Disease 12th and 13th of July 2013

Steam cells

Dear Colleagues,

On behalf of the Steering Committee of the Collaborative Research Center (Sonderforschungsbereich) 873 “Maintenance and Differentiation of Stem Cells in Development and Disease”, may I extend a cordial invitation to you to join us at the upcoming symposium to be held from July 12 to July 13, 2013 at the Kommunikationszentrum, German Cancer Research Center, Heidelberg, Germany.

The main theme of the conference is on “Stem Cells in Development and Disease” and serves as an interactive forum for basic researchers and clinician scientists from academic institutions as well as from the biomedical industry in the field of stem cell technology.

The Collaborative Research Center, SFB873, was established in July 2010. The goal of the SFB873 is to define the regulatory principles underlying the balance between stem cell maintenance and differentiation in diverse organisms on a mechanistic level. By comparing divergent and conserved modules of stem cell control across the kingdoms of life, our SFB will fundamentally advance the understanding of the principles and molecular mechanisms that control stem cell function during development, homeostasis, injury repair and disease.

We look forward to welcoming you to Heidelberg!

Anthony D. Ho,
Professor and Chair,
Department of Medicine V
Ruprecht-Karls-University Heidelberg

Program Friday, July 12th, 2013

08:15 Opening
Anthony D. HO
Spokesperson SFB 873
08:20 - 08:30Greetings
Vice-rector, Heidelberg University - Germany

Chairman of the Management Board and Scientific Director, German Cancer Research Center (DKFZ), Heidelberg - Germany
Session 1Pluripotency
Chairpersons: Jan LOHMANN,
08:30 - 09:30Key Note Lecture
Introduction: Jan LOHMANN
MIT, Cambridge, Massachusetts – USA
Stem Cells, Reprogramming, Therapy:
Promise, Problems, Reality
09:30 - 09:45Takashi HIIRAGI
EMBL, Heidelberg - Germany
Symmetry Breaking in the Mouse
09:45 - 10:10Linheng LI
Stowers Institute for Medical Research, Kansas City – USA
Niche, Signaling and Epigenetic Regulation of Stem Cells
10:10 - 10:35Niels GEIJSEN
Hubrecht Institute, Utrecht - The Netherlands
Dazl‘in Germ Cells and Embryonic Stem Cells
10:35 - 11:15Coffee Break



Session 2Signaling
Chairpersons: Ingrid LOHMANN,
11:15 - 11:30Christof NIEHRS
DKFZ, Heidelberg - Germany
Mitotic Wnt Signalling
11:30 - 11:55 Mariann BIENZ
MRC Laboratory of Molecular Biology, Cambridge - UK
Wnt Signalosomes and Degradasomes
11:55 - 12:10 Thomas HOLSTEIN
Centre for Organismal Studies (COS), Heidelberg – Germany
Wnt Signaling and the Evolution of
Stem Cells
12:10 - 12:25Herbert STEINBEISSER
Institute of Human Genetics,
Medical Faculty, Heidelberg – Germany
IGF/Wnt Interactions in Cell Differentiation
12:25 - 13:30Lunch



Session 3Differentiation
Chairpersons: Ana MARTIN-VILLALBA, Bruce EDGAR
13:30 - 13:55Oliver BRÜSTLE
Institute for Reconstructive Neurobiology, Bonn – Germany
Differentiating Human Pluripotent Stem Cells for Neurological Disease Modeling
13:55 - 14:20Magdalena GÖTZ
Helmholtz Center, Munich - Germany
Novel Factors Regulating Neural Stem Cell Differentiation and Brain Size
14:20 - 14:45Lukas SOMMER
Anatomical Institute, Zurich - Switzerland
Neural Crest Stem Cells in Development and Tumor Formation
14:45 - 15:00Jochen WITTBRODT
COS, Heidelberg – Germany
Retinal Stem Cells in Growth and Regeneration
15:00 - 15:30Coffee Break



Session 4Stem Cell Niche
Chairpersons: Marieke ESSERS,
15:30 - 15:55Xi LI
Stowers Institute for Medical Research, Kansas City - USA
Targeting Quiescent and Active Cancer Stem Cells in Adenoma
15:55 - 16:10Michael BOUTROS
Cell and Molecular Biology,
Mannheim – Germany
Mechanisms of Wnt Secretion
16:10 - 16:35Paul FRENETTE
Albert Einstein College of Medicine,
New York - USA
Microenvironmental Control of Stem
Cell Behaviour
16:35 - 16:50Jan LOHMANN
COS, Heidelberg - Germany
A Novel Regulator of Plant Stem Cell
16:50 - 17:15

Thomas BOSCH
Zoological Institute, Kiel - Germany
Stem Cell Decision Making in Hydra

17:15 - 17:30 Petra BOUKAMP
DKFZ, Heidelberg - Germany
The Niche Guarantees Human Epidermal Stem Cell Maintenance and Function
17:30Social event
Open end

Program Saturday, July 13th, 2013

Session 5Haematopoesis
Chairpersons: Claudia SCHOLL,
Andreas TRUMPP
08:30 - 08:45Hans-Reimer RODEWALD
DKFZ, Heidelberg – Germany
Stem Cell Activity and Lineage Output in
Unperturbed Hematopoiesis
08:45 - 09:10Tariq ENVER
University College, London – UK
Transcriptional Control of Normal and
Leukemic Haematopoiesis
09:10 - 09:25Hellmut AUGUSTIN
DKFZ, Heidelberg – Germany
Regulation of Hematopoietic Stem Cell
Quiescence and Mobilization through the
Angiopoietin / Tie System
09:25 - 09:50Karl WELTE
Medical School, Hannover - Germany
Leukemogenesis in Congenital Bone
Marrow Failure Syndromes
09:50 - 10:15Martin ZENKE
Institute for Biomedical Technologies,
Aachen - Germany
From Hematopoietic Stem Cells towards
Antigenpresenting Dendritic Cells
10:15 - 11:00Coffee Break



Session 6Stem Cells and Cancer
Chairpersons: Petra BOUKAMP,
11:00 - 11:25Dominique BONNET
London Research Institute, London - UK
New Insights into Human Hematopoietic
Stem Cells and Their Niche
11:25 - 11:40Anthony D. HO
Department of Medicine,
Heidelberg – Germany
Heterogeneity of Human Leukemia Stem
Cells - Does It Matter?
11:40 - 11:55Jochen UTIKAL
Clinic for Dermatology, Venereology and
Allergiology, Mannheim - Germany
Induced Pluripotent Cancer Cells
11:55 - 12:10Andreas TRUMPP
DKFZ, Heidelberg – Germany
Leukemic and Metastasis Stem Cells
12:10 – 13:10Key Note Lecture
Introduction: Anthony D. HO

University of Arkansas for Medical
Sciences, Little Rock / Arkansas – USA
My Journey with Myeloma – from No Cure
to Cure with Stem Cells
13:10 - 13:30Awarding Ceremony
Faculty Medal of the Faculty of
Medicine Heidelberg
Claus R. BARTRAM, Dean of the Medical
Faculty, Heidelberg University



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Conference Location

German Cancer Research Center (DKFZ)
Center of Communications
Im Neuenheimer Feld 280
69120 Heidelberg

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