Studien

Rahbari NN, Lordick F, Fink C, Bork U, Stange A, Jager D, Luntz SP, Englert S, Rossion I, Koch M, Buchler MW, Kieser M, Weitz J.
Resection of the primary tumour versus no resection prior to systemic therapy in patients with colon cancer and synchronous unresectable metastases (UICC stage IV): SYNCHRONOUS - A randomised controlled multicentre trial (ISRCTN30964555).
BMC Cancer. 2012 Apr 5;12(1):142

Neben K, Lokhorst HM, Jauch A, Bertsch U, Hielscher T, van der Holt B, Salwender H, Blau IW, Weisel K, Pfreundschuh M, Scheid C, Dührsen U, Lindemann W, Schmidt-Wolf IG, Peter N, Teschendorf C, Martin H, Haenel M, Derigs HG, Raab MS, Ho AD, van de Velde H, Hose D, Sonneveld P, Goldschmidt H.
Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17p.
Blood. 2012 Jan 26;119(4):940-8. Epub 2011 Dec 8.

Heger U, Voss S, Knebel P, Doerr-Harim C, Neudecker J, Schuhmacher C, Faist E, Diener MK, Kieser M, Seiler CM, Büchler MW
Prevention of abdominal wound infection (PROUD trial, DRKS00000390): study protocol for a randomized controlled trial.
Trials. 2011 Nov 21;12:245

Diener MK, Seiler CM, Rossion I, Kleeff J, Glanemann M, Butturini G, Tomazic A, Bruns CJ, Busch OR, Farkas S, Belyaev O, Neoptolemos JP, Halloran C, Keck T, Niedergethmann M, Gellert K, Witzigmann H, Kollmar O, Langer P, Steger U, Neudecker J, Berrevoet F, Ganzera S, Heiss MM, Luntz SP, Bruckner T, Kieser M, Büchler MW.
Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial.
Lancet. 2011 Apr 30; 337(9776): 1514-22 

Christoph Bartl, Dirk Stengel, Thomas Bruckner, Inga Rossion, Steffen Luntz, Christoph Seiler, Florian Gebhard
Open reduction and internal fixation versus casting for highly comminuted and intra-articular fractures of the distal radius (ORCHID): protocol for a randomized clinical multi-center trial 
Trials 2011 March 22

Loffler T, Seiler CM, Rossion I, Kijak T, Thombusch O, Hodina R, Kruger M, Simon T, Bruckner T, Kieser M, Buchler MW, Weitz J, Group HT.
HAnd-suture versus STApling for Closure of Loop Ileostomy: HASTA-Trial: a study rationale and design for a randomized controlled trial.
Trials. 2011 Feb 8;12(1):34.

Brenner H, Chang-Claude J, Seiler CM, Rickert A, Hoffmeister M.
Protection from colorectal cancer after colonoscopy: a population-based, case-control study.
Ann Intern Med. 2011 Jan 4;154(1):22-30.

Fischer L, Seiler CM, Broelsch CE, de Hemptinne B, Klempnauer J, Mischinger HJ, Gassel HJ, Rokkjaer M, Schauer R, Larsen PN, Tetens V, Büchler MW.
Hemostatic efficacy of TachoSil in liver resection compared with argon beam coagulator treatment: an open, randomized, prospective, multicenter, parallel-group trial. 
Surgery. 2011 Jan;149(1):48-55. Epub 2010 Apr 10.    

Michael Bernhard, Konrad-Martin Schultz, Stefan Hofer, Christian Hainer, Vassil Gegouskov, Eike Martin, Matthias Karck, Johann Motsch, Markus A. Weigand, Steffen P. Luntz, Christoph Lichtenstern 
MIF and markers of the inflammatory response following cardiac surgery under extracorporeal circulation
Applied Cardiopulmonary Pathophysiology Vol. 14, 2-2010; 115-123

Markus K Diener, Thomas Bruckner, Pietro Contin, Christopher Halloran, Matthias Glanemann, Hans Jurgen Schlitt, Joachim Mossner, Meinhard Kieser, Jens Werner, Markus W Buchler  and Christoph M Seiler 
ChroPac-Trial: Duodenum-preserving pancreatic head resection versus pancreatoduodenectomy for chronic pancreatitis. Trial protocol of a randomised controlled multicentre trialTrials 2010 April 29; 11:47

Fischer L, Bruckner T, Müller-Stich BP, Höer J, Knaebel HP, Büchler MW, Seiler CM.
Variability of surgical knot tying techniques: do we need to standardize?
Langenbecks Arch Surg. 2010 Apr;395(4):445-50. Epub 2009 Dec 16.

Funke S, Timofeeva M, Risch A, Hoffmeister M, Stegmaier C, Seiler CM, Brenner H, Chang-Claude J.
Genetic polymorphisms in GST genes and survival of colorectal cancer patients treated with chemotherapy.
Pharmacogenomics. 2010 Jan;11(1):33-41.

Seiler CM
Prospective randomized single-blinded trial of endoscopic stenting for chronic pancreatitis
Clin Trials 2009 Oct;6(5):464; discussion 465-6

Petra Baumann, Hardy Schuhmacher, Johannes Hüsing, Stefffen Luntz, Hanns-Peter Knaebel
A randomized, controlled, prospective trial to evaluate the haemostatic effect of Lyostypt versus Surgicel in arterial bypass anastomosis: "COBBANA" trial 
Trials 2009 Sept 29, 10:91

Seiler CM, Bruckner T, Diener MK, Büchler MW
Response to the Letter to the Editor: "Suture Materials and Techniques for Midline Abdominal Closure" by Dr. Tetsuji Fujita
Ann Surg 2009 Aug 27 [Epub ahead of print]

Bruns H, Rahbari NN,  Löffler T, Diener MK, Seiler CM, GlanemannM, Butturini G, Schuhmacher C, Rossion I, Büchler MW, Junghans T, DISPACT Trial Group
Perioperative management in distal pancreatectomy: results of a survey in 23 European participating centres of the DISPACT trial and a review of literature
Trials. 2009 Jul 26; 10:58

Seiler CM, Deckert A, Diener MK, Knaebel HP, Weigand MA, Victor N, Büchler MW
Midline versus transverse incision in major abdominal surgery: a randomized, double-blind equivalance trial (POVATI: ISRCTN60734227)
Ann Surg. 2009 Jun; 249(6):913-20

Seiler CM, Bruckner T, Diener MK, Papyan A, Golcher H, Seidlmayer C, Franck A, Kieser M, Büchler MW, Knaebel HP. 
Interrupted or Continuous Slowly Absorbable Sutures For Closure of Primary Elective Midline Abdominal Incisions: A Multicenter Randomized Trial (INSECT: ISRCTN24023541)
Ann Surg. 2009 Apr; 249(4):576-82

Diener MK, Knaebel HP, Witte St, Büchler MW, Seiler CM and the DISPACT Trial Group (2007)
DISPACT: A randomized controlled trial to compare two different surgical techniques of Distal Pancreatectomy: Study rationale and design (ISRCTN 18452029)
Clinical Trials 2008; 5; 534

Martinez-Torres F, Menon S, Victor N, Jenetzky E, Jensen K, Schielke E, Schmutzhard E, de Gans J, Chung CH, Luntz S, Hacke W, Meyding-Lamadé U; GACHE Investigators
Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]
BMC Neurol. 2008 Oct 29, 8:40

van Gelder T, Silva HT, de Fijter JW, Budde K, Kuypers D, Tyden G, Lohmus A, Sommerer C, Hartmann A, Le Meur Y, Oellerich M, Holt DW, Tönshoff B, Keown P, Campbell S, Mamelok RD
Comparing mycophenolate mofetil regimens for de novo renal transplant recipients: the fixed-dose concentration-controlled trial
Transplantation 2008 Oct 27;86(8):1043-51

Fischer L, Baumann P, Hüsing J, Seidlmayer C, Albertsmeier M, Franck A, Luntz S, Seiler CM, Knaebel HP
A historically controlled, single-arm, multi-centre, prospective trial to evaluate the safety and efficacy of MonoMax suture material for abdominal wall closure after primary midline laparotomy. ISSAAC-Trial [NCT005725079]
BMC Surg. 2008 Jul 21; 8:21

Jüttler E, Schwab S, Schmiedek P, Unterberg A, Hennerici M, Woitzik J, Witte S, Jenetzky E, Hacke W; DESTINY Study group
Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY): a randomized, controlled trial.
Stroke 2007 Sep;38(9):2518-25.

Schlosser K, Veit JA, Witte St, Fernandez E, Victor N, Knaebel H-P, Seiler CM, Rothmund M
Comparison of total parathyroidectomy without autotransplantation and without thymectomy versus total parathyroidectomy with autotransplantation and with thymectomy for secondary hyperparathyroidism: TOPAR PILOT-Trial
Trials, 2007 September 18; 8:22

Warady BA, Feneberg R, Verrina E, Flynn JT, Müller-Wiefel DE, Besbas N, Zurowska A, Aksu N, Fischbach M, Sojo E, Donmez O, Sever L, Sirin A, Alexander SR, Schaefer F; IPPR.
Peritonitis in children who receive long-term peritoneal dialysis: a prospective evaluation of therapeutic guidelines
J Am Soc Nephrol. 2007 Jul;18(7):2172-9

Seiler CM, Kellmeyer P, Kienle P, Buchler MW, Knaebel HP, the INSECT Study Group
Assessment of the ethical review process for non-pharmalogical multicentre studies in Germany on the basis of a randomised surgical trial
J Med Ethics 2007 Feb; 33 (2): 113-8

Seiler CM, Fröhlich BE, Veit JA, Gazyakan E, Wente MN, Knauer C, Deckert A, Witte S, Victor N, Büchler MW, Knaebel HP and the CLIVIT Study Group (2006)
Protocol design and current status of CLIVIT: A randomized controlled multicenter relevance trial comparing clips versus ligatures in thyroid surgery (ISRCTN 96901396)
Trials. 2006 Sep 1;7(1):27 

Chung CH, Freiberger A, Kalkum M, Luntz SP, Shakur H, Seiler CM.
CRASH2 in Germany [ISRCTN 86750102].
Trials. 2006 Jun 21;7:22 

Knebel P, Frohlich B, Knaebel HP, Kienle P, Luntz S, Buchler M, Seiler C. (2006)
Comparison of Venae Sectio vs. modified Seldinger Technique for Totally Implantable Access Ports; Portas-trial [ISRCTN:52368201].
Trials. 2006 Jun 8;7:20

Koninger J, Seiler CM, Wente MN, Reidel MA, Gazayakan E, Mansmann U, Muller MW, Friess H, Buchler MW (2006)
Duodenum preserving pancreatectomy in chronic pancreatitis: Design of a randomized controlled trial comparing two surgical techniques [ISRCTN50638764].
Trials. 2006 May 8;7:12.

Hesse C, Luntz SP, Siedler H, Unnebrink K, Mikus G, de Bruijn M, Zondag E, de Vries M, Seibert-Grafe M, Haefeli WE
Kinetics and dynamics of the peripheral neurokinin-1 receptor antagonist SLV317 in healthy individuals
BR J Clin Pharmacol. 2006 Apr;61(4):414-9

Knaebel HP, Kirschner MH, Reidel MA, Büchler MW, Seiler CM (2006)
Operative standardization in randomized controlled surgical trials. Meeting of the INSECT trial.
Chirurg. 2006 Mar;77(3):267-72. German.  

Hesse C, Siedler H, Luntz SP, Arendt BM, Goerlich R, Fricker R, Heer M, Haefeli WE
Modulation of endothelial and smooth muscle function by bed rest and hypoenergetic, low-fat nutrition
J Appl Physiol. 2005 Dec;99(6):2196-203

Luntz SP, Unnebrink K, Seibert-Grafe M, Bunzendahl H, Kraus TW, Büchler MW, Klar E, Schemmer P.
HEGPOL: randomized, placebo controlled, multicenter, double-blind clinical trial to investigate hepatoprotective effects of glycine in the postoperative phase of liver transplantation [ISRCTN69350312]
BMC Surg. 2005 Aug 17;5:18

Knaebel HP, Koch M, Sauerland S, Diener MK, Büchler MW, Seiler CM and the INSECT-Study Group of the Study Centre of the German Surgical Society (2005)
Interrupted or continuous slowly absorbable sutures – Design of a multi-centre randomized controlled trial to evaluate abdominal closure techniques- INSECT-Trial [ISRCTN 24023541].
BMC Surg. 2005 Mar 8;5(1):3 

Reidel MA, Knaebel HP, Seiler CM, Knauer C, Motsch J, Victor N, Buchler MW. 
Postsurgical pain outcome of vertical and transverse abdominal incision: design of a randomized controlled equivalence trial [ISRCTN60734227].
BMC Surg. 2003 Nov 13;3:9.