|November 2014 EMBL Press Release|
Scientists from the MMPU group HIV-1 formation and its inhibition have obtained the first structure of the immature form of HIV at a high enough resolution to pinpoint exactly where each building block sits in the virus. The study, published online in Nature, reveals that the building blocks of the immature form of HIV are arranged in a surprising way.
Press Release EMBL
Press Release Heidelberg University Hospital
|December 2013, EMBL&cetera newsletter|
MMPU on a mission
Many medical research-related questions were discussed at the 12th public MMPU Research Day in Heidelberg.
|February 2013, EMBL&cetera newsletter|
Top clinicians join as MMPU fellows
Three top-level clinician scientists have been awarded the first Heidelberg Research Center for Molecular Medicine (HRCMM) Career Development Fellowships (CDF).
|February 2013 EMBL Press Release|
Zeroing in on heart disease
Innovative strategy pinpoints genes underlying cardiovascular disease risk.
Studies screening the genome of hundreds of thousands of individuals have linked more than 100 regions in the genome to the risk of developing cardiovascular disease. Researchers from EMBL and the University of Heidelberg are taking these results one step further by pinpointing the exact genes that could have a role in the onset of the disease. Their findings are published today in the Public Library of Science (PLoS) Genetics.
Universitätsklinikum Heidelberg Pressemitteilung
Two additional MMPU Group leaders receive ERC Advanced Grants: Rohini Kuner, PI of the MMPU group “Chronic Pain” and Matthias Hentze, PI of the MMPU groups “Blood Diseases “ and “ Iron Homeostasis”. ERC Advanced Grants allow exceptional established research leaders to pursue ground-breaking, high-risk projects that open new directions in their respective research fields or other domains.
Three further groups joined the MMPU: Anne-Claude Gavin (EMBL Heidelberg) and Anthony Ho (Department of Internal Medicine V: Hematology, Oncology and Rheumatology, Heidelberg University Medical Center) study early warning signals of aging, John Briggs (EMBL, Heidelberg) and Hans-Georg Kräusslich (Department of Infectious Diseases, Virology, Heidelberg University Medical Center) look how to interfere with the assembly and maturation of infectious HIV-1, and Paul Heppenstall (EMBL Monterotondo) and Rohini Kuner (Institute of Pharmacology, Heidelberg University Medical Center) search for molecular mediators of chronic pain. The MMPU now consists of eight international teams with more than 70 scientists from across the world.
Two MMPU groups moved into common space provided by the University of Heidelberg, the Otto-Meyerhof-Zentrum (OMZ), Im Neuenheimer Feld 350. The OMZ was built in 2001 and serves as additional building for medical research groups from the Heidelberg University Medical Center with a strong focus on interdisciplinarity. Otto Meyerhof, a German physician and biochemist, was awarded the Nobel Prize in Medicine in 1922 for his work on muscle metabolism.
Peer Bork received an ERC Advanced Grant for his proposal ‘Cancerbiome’ which pioneers research into microbial communities associated with cancer. The European Research Council (ERC) is the EU funding body that implements the specific FP7 Programme ‘Ideas’.
|June 2011 EMBL&cetera newsletter|
From patient to bench and back
Valuable insights presented by members from the 5 research groups and 6 invited guest speakers at the 8th public research day held at the ZMBH.
|April 2011 University Hospital Heidelberg press release|
Kleinste Nukleinsäurestückchen regulieren Schlüsselhormon des Eisenstoffwechsels
Novel insights into the role of miRNAs .The liver-specific microRNA miR-122 controls hepcidin, the key hormone that regulates systemic iron homeostasis in mice. Work of the group “ Iron Homeostasis” in collaboration with 2 groups of the Medical Faculty of the University of Heidelberg and from the DKFZ was published in Journal of Clinical Investigations.
|April 2011 EMBL press release|
What's your gut type?
Bakterien-WG im Darm
Peer Bork, EMBL, co-heading the MMPU group “Cancer Early Detection”, and his collaborators in the international MetaHIT consortium, have found that humans harbour three different types of gut microbial communities. The story, published in Nature, has been covered by far more than 100 newspapers around the world, for example in the New York Times.
|February 2011, EMBL press release|
Blood-clotting protein linked to cancer and septicaemia
Scientists of the group " Diseases of mRNA metabolism" have discovered how stressed cells boost the production of the key blood-clotting factor, thrombin. Their work, published in Molecular Cell, shows how cancer cells may be taking advantage of this process, and opens new possibilities for fighting back against cancer and septicaemia.
|December 2010, EMBL&cetera newsletter|
Perspectives for Translational Medicine in Heidelberg
The MMPU contributed to the 625 year celebrations of Heidelberg University by organizing a special one day symposium to build bridges between medicine and molecular research to strengthen state-of-the-art translational medicine.
|17 November 2010 Press Release University Hospital Heidelberg|
Symposium Translationale Medizin: vom Labor zum Patienten - ein Brückenschlag von der Grundlagenforschung in die Klinik.
|June 2010, EMBL&cetera newsletter|
Feet of strength
MMPU 4U – 4 MMPU PIs participated at the Heidelberg Half- Marathon. “Feet of strength” were needed to run Heidelberg’s grueling hills and dales.
December 2009, EMBL&cetera newsletter
The 5th public Research Day took place at the new Advanced Training Centre (ATC) at EMBL. Members of each group as well as one guest speaker presented their recent findings.
2 August 2009, EMBL press release
7 July 2009, EMBL press release
7 July 2009, Informationsdienst Wissenschaft
|June 2009, EMBL&cetera newsletter|
Biology goes green
The Molecular Medicine Partnership Unit (MMPU) of EMBL and Heidelberg University has uncovered the first step in the recycling of a crucial molecular tag that ensures correct translation, helping protect against genetic diseases.
16 April 2009, FAZ.NET