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Allgemein-, Viszeral- & Transplantationschirurgie

PancoBank platform

Biobank at the European Pancreas Centre (EPZ/Surgery Heidelberg)

Stellvertret. Leiterin:
Dr. Miriam Schenk

 

Technical Management:
Markus Fischer

FFPE-Tissues Biobanking:
Karin Ruf

Cryobanking (Tissues und Biofluides):
Monika Meinhardt

OP-Room Duty:

Markus Fischer

Contact for Cooperation inquires:
Prof. Dr. Oliver Strobel
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Established by Prof. M. W. Büchler in 2002, the Biobank of European Pancreas Centre currently contains over 10.000 biospecimens and is a member of Opens internal link in current windowBMBH-Consortium.

The STARLims-managed collection of tissues and biofluids serves a broad spectrum of intra- and extramural research activities, particularly genome-wide screening programs. To accelerate clinical translation of our findings, we developed PancoBank-infrastructure which integrates two units.

The first unit is an Amazon-like platform enabling standardized web-based registration of the suitable samples, their management, quality assessment, and distribution. It allows to perorm remote searches of the database by cooperating partners and provides them with HE-stained images and information about cellular composition of collected tissue samples—one of the most crucial aspects in the interpretation of the molecular profiles. This unit was developed in the framework of German-wide translational genomic network PaCaNet (NGFNPlus program funded by BMBF, Opens external link in new windowwww.ngfn-pacanet.de).

The second unit of the PancoBank utilizes developed by DKFZ iCHIP-technology (Opens external link in new windowwww.services.ichip.de), to store and to link PID-protected clinico-pathological records to the data delivered via own research activities or by various cooperating partners (see below). The information includes qualitative (images) and quantitative data sets such as whole genome sequencing or measurements of mRNA, miRNA, SNPs, proteins and antibodies. These sets are used to elucidate molecular signatures associated with pancreatic pathogenesis and enabling stratification of the patients for novel treatments.


Cooperation partners

  • EPZ-Outpatient clinic (Prof. Thilo Hackert, Dr. Christine Tjaden, Ulf Hinz)
  • Institute of Pathology, University Hospital Heidelberg

    • BMBH-team (Biomaterial Bank Heidelberg; Prof. Peter  Schirmacher)
    • PD Dr. Esther Herpel and Dr. Matthias Gaida

  • DKFZ  (German Cancer Research Center), Heidelberg

    • PancoBank-iCHIP and Bioinformatics: PD Dr. Esther Herpel and Dr. Matthias Gaida
    • Genomics, proteomics, mRNA and miRNA profiling: Dr. Andrea Bauer and Dr. Jörg Hoheisel; Division of Functional Genome Analysis
    • GWAS studies: Dr. Federico Canzian, Genomic Epidemiology Group
    • Whole genome profiling: HIPO (Heidelberger Institute of Personalized Oncology); NCT

  • University Hospital Marburg: PD Dr. Malte Buchholz and Prof. Dr. Thomas M. Gress, Gastroenterology, University Hospital Marburg

  • University Hospital Tübingen: Prof. Dr. Bence Sipos, Institute of Pathology, General pathology, University Hospital Tübingen


Selected Publications

  • Wolpin, BM et al. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nature Genetics 46, 994-1000 (2014)

  • Schultz, NA et al. Diagnostic and Prognostic Impact of Circulating YKL-40, IL-6, and CA 19.9 in Patients with Pancreatic Cancer. PLoS One 8, e67059 (2013)

  • Gress, TM et al. Differentiation of multiple types of pancreatico-biliary tumors by molecular analysis of clinical specimens. J Mol Med 90, 457-464 (2012)

  • Bauer, AS et al. Diagnosis of pancreatic ductal adenocarcinoma and chronic pancreatitis by measurement of microRNA abundance in blood and tissue. PLoS One 7, e34151 (2012)

  • Rizzato, C et al. Pancreatic cancer susceptibility Loci and their role in survival. PLoS One 6, e27921 (2011)

  • Keller, A et al. Toward the blood-borne miRNome of human diseases. Nat Methods 8, 841-843 (2011)

  • Alhamdani, MS et al. Single-step procedure for the isolation of proteins at near-native conditions from mammalian tissue for proteomic analysis on antibody microarrays. J Proteome Res 9, 963-971 (2010)

  • Ceyhan, GO et al. Pancreatic Neuropathy and Neuropathic Pain - A comprehensive pathomorphological  study of 546 Cases. Gastroenterology 136, 177-186 (2009)


 

Financial Support

 
Opens external link in new windowHeidelberger Stiftung ChirurgieBMBF programs NGFNplus (PaCaNet; 2008-2013)E:med (PancStrat; 2013-2016)

 

European Union ERA-NET (Transcan; 2015-2017)


 

 

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Leitung


Dr. Nathalia A. Giese


Im Neuenheimer Feld 110
69120 Heidelberg
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