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Allgemeine Psychiatrie
Zentrum für Psychosoziale Medizin

 Cognitive Neuropsychiatry

Welcome to the Cognitive Neuropsychiatrie working group

Head: PD Dr. med. Robert Christian Wolf 
[// deutsch]

The working group uses a combination of neuropsychological methods together with a multimodal neuroimaging approach to characterise the functional brain circuits underlying cognitive processes in healthy control subjects as well as cognitive impairment and psychopathology in patients with neuropsychiatric disorders and at-risk individuals.

Specifically, we aim at understanding the neural mechanisms of cognitive dysfunction in major (neuro)psychiatric disorders using magnetic resonance imaging (MRI) techniques, such as high-resolution structural imaging, diffusion tensor imaging (DTI), functional magnetic resonance (fMRI) and MRI perfusion imaging. A specific scientific interest is the characterization of functional brain networks during cognitive processing by means of functional and effective connectivity analysis techniques. In previous studies, we have investigated the structural and functional neuroanatomy underlying attention, working memory processing, executive function and inhibition in healthy controls, individuals with dyslexia and in patients with depression, schizophrenia, ADHD and Huntington’s disease. Longitudinal studies were conducted in order to characterise treatment-associated changes in brain activation in patients with schizophrenia, as well as disease-related changes in cognition, brain structure and function in clinically presymptomatic carriers of the HD gene mutation.

Ongoing studies aim at characterising intrinsic (”resting state”) brain connectivity and cerebral blood flow in patients with schizophrenia, major depressive disorder and bipolar disorder in order to identify potential targets and markers for psychopharmacological and psychotherapeutical treatment options and outcome.


Half-time post-doctoral position available from November 2013


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