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Translational Lung Research Center Heidelberg

Diffuse Parenchymal Lung Disease

Diffuse Parenchymal Lung Diseases (DPLD) are a heterogeneous group of more than 100 different entities characterized by inflammation and/or fibrosis of the pulmonary interstitium that share similar pathomechanistic principles. Progression of the disease results in impaired oxygen transfer and scarring within the lung. Our ability to analyze these diseases continues to improve but treatment options are still limited.


The diffuse parenchymal lung diseases are divided into fours groups:


Group 1 is associated with known causes, e.g. drugs or connective tissue diseases.

Group 2 comprises idiopathic (ILD) interstitial pneumonias and idiopathic pulmonary fibrosis (IPF) is the most common disease of this type.

Group 3 compromises granulomateous diseases, e.g. sarcoidosis and hypersensitivity pneumonitis.

Group 4 comprises other forms, e.g. alveolar proteinosis, lymphangioleiomyomatosis.

At the TLRC we pursue a multidisciplinary translational approach to DPLD research, ranging from molecular biology, novel animal models through to clinical trials and healthcare research.


Research Groups

this section is under development

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