HomepageResearch Interests
- Developing and applying chemical btools to study lung disease
- Novel probes to monitor enzyme activities in cystic fibrosis and COPD
- Proceeding from cell models to intact organisms and patients
- Novel tools to manipulate and perturb intracellular signalling networks
Short CV
| 1979-1986 | Study of Chemistry and Diploma Thesis at the University of Bremen, Germany |
| 1989 | Dissertation (Ph.D.) at the University of Bremen |
| 1989 | Researcher at the University of Bremen |
| 1990 | Postdoctoral Fellow, Dept. of Pharmacology, School of Medicine, University of California, San Diego, USA |
| 1992 | Project Assistant, Dept. of Pharmacology, School of Medicine, University of California, San Diego, USA |
| 1993 | Habilitation Fellow at the University of Bremen |
| 1996 | Researcher at the University of Bremen |
| 1997 | Habilitation in Organic Chemistry, University of Bremen |
| 2000 | Group Leader, MPI Molecular Physiology, Dortmund, Germany |
| 2001 | Group Leader, Gene Expression Unit, EMBL Heidelberg, Germany |
| 2005 | Member of the Molecular Medicine Partnership Unit (MMPU), Heidelberg |
| 2008 | Senior Scientist, Cell Biology & Biophysics Unit, EMBL Heidelberg |
Honours & Awards
| 1993 | Habilitation stipend, German Research Foundation (DFG) |
| 2005 | Piet Van Duijn Lecture, Int. Fed. of Soc. Histochemistry and Cytochemistry, The Netherlands |
| 2012 | Heidelberg Molecular Life Science Award 2012, shared with Michael Brunner |
Projects
COPD/Cystic Fibrosis
- Development of protease probes relevant to lung inflammation. Tests in model cells, the CF mouse model of the Mall group and in patient cells.
- Sampling and testing of samples from CF and COPD patients, treatment with above mentioned probes and subjecting the probes to automated microscopy.
- Testing of macrophage elastase prodrugs in the CF mouse model of the Mall group.
COPD/Lung Cancer
- Development of protease probes relevant to cancer. Tests in model cells and grafted mouse models.
- Development of bimodal probes for simultaneous MRI and fluorescence imaging.
- Development of tools to noninvasively activate signalling events downstream of the membrane receptor level (within LungSysII).
Team
Technical Assistant
Rainer Müller, Ph.D.
Post-doctoral fellows
Vibor Laketa, Ph.D.
Sabine Reither, Ph.D.
Devaraj Subramanian, Ph.D.
Per Haberkant, Ph.D.
Andre Nadler, Ph.D.
Dmytro Yushchenko, Ph.D.
Hai-Yu Hu, Ph.D.
Gopal Datta, Ph.D.
PhD studentsgehrig@embl.de
Suihan Feng
Tilman Plass
Doris Höglinger
Verena Rickert-Zacharias
Frank Stein
Selected Publications
- Lukinavičius, G., Umezawa, K., Olivier, N., Honigmann, A., Yang, G., Plass, T., Mueller, V., Reymond, L., Correa, I. R., Luo, Z.-G., Schultz, C., Lemke, E., Heppenstall, P., Eggeling, C., Johnsson, K. A near-infrared fluorophore for live-cell superresolution microscopy of cellular proteins, Nat. Chem. (2013) accepted.
- Rutkowska, A., Schultz, C. Protein tango: the toolbox to capture interacting partners. Angew. Chem. Int. Ed. 51, 8166–8176 (2012). DOI: 10.1002/anie.2012 01717
- Cobos-Correa, A., Stein, F., Schultz, C. Target-activated prodrugs for the auto-regulated inhibition of MMP12. ACS Med. Chem. Lett. 3, 653–657 (2012). DOI: 10.1021/ml3001193
- Gehrig, S., Mall M. A., Schultz, C. Spatially resolved monitoring of neutrophil elastase activity with ratiometric fluorescent reporters. Angew. Chem. Int. Ed. 51, 6258-6261 (2012).
- Johannesson, B., Hirtz, S., Schatterny, J., Schultz, C., Mall M. A. CFTR modifies onset and mortality of chronic obstructive lung disease in βENaC-overexpressing mice. PLoS ONE 7, e44059 (2012). doi:10.1371/journal.pone.0044059.
- Lemke, E. A., Schultz, C. Principles for designing fluorescent sensors and reporters. Nat. Chem. Biol. 7, 480-483 (2011).Rutkowska, A., Haering, C. H., Schultz, C. A FlAsH-based cross-linker to study protein interactions in living cells. Angew. Chem. Int. Ed. 50, 12655-12658 (2011)
- Plass, T., Köhler, C., Schultz, C., Lemke, E.
Genetically encoded copper free click chemistry. Angew. Chem. Int. Ed. 50, 3878-3881 (2011). - Mentel, M., V. Laketa, V., Subramanian, D., Gillandt, H., Schultz, C. Photoactivatable and cell membrane-permeant phosphatidylinositol 3,4,5-trisphosphate. Angew. Chem. Int. Ed. 50, 3811-3814 (2011).
- Mall, M. A., Button, B., Johannesson, B., Zhou, Z., Livraghi, A., Caldwell, R. A., Schubert, S., Schultz, C., O’Neal, W., Pradervand, S., Hummler, E., Rossier, B. C., Grubb, B., Boucher, R. C. Airway surface liquid volume regulation determines different airway phenotypes in liddle's compared to βENAC-overexpressing mice. J. Biol. Chem. 285, 26945-55 (2010).
- Schultz, C. Challenges in studying phospholipid signaling. Nat. Chem. Biol. 6, 473-475 (2010).
- Subramanian, D., Laketa, V., Müller, R., Tischer, C., Zarbakhsh, S., Pepperkok, R., Schultz, C. Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells. Nat. Chem. Biol. 6, 324-326 (2010).
- Cobos-Correa, A., Trojanek, J. Diemer, S., Mall, M. A., Schultz, C. MMP12 activity in pulmonary inflammation visualized by a membrane-targeted fluorescent reporter. Nat. Chem. Biol. 5, 628-630 (2009).
- Laketa, V., Zarbakhsh, S., Mortier, E., Subramanian, D., Brumbaugh, J., Dinkel, C., Zimmermann, P., Pepperkok, R., Schultz, C. Membrane-permeant phosphoinositide derivatives as modulators of growth factor signaling and neurite outgrowth. Chem. Biol. 16, 1190-1196 (2009).
- Neef, A. B., Schultz, C. Selective fluorescent labeling of lipids in living cells. Angew. Chem. Int. Ed. 48, 1498-1500 (2009).
- Yudushkin, I. A., Schleifenbaum, A., Neel, B. J., Schultz, C., Bastiaens, P. I. H. Imaging the enzyme-substrate intermediate reveals functional subpopulations of the tyrosine phosphatase PTP1B in living cells. Science 315, 115-119 (2007)
