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Translational Lung Research Center Heidelberg

Carsten Schultz, Ph.D., PD

Group Leader and Senior Scientist

Cell Biology & Biophysics Unit

EMBL Heidelberg
Meyerhofstr. 1

69117 Heidelberg


Phone: +49 (0)6221 3878210

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Research Interests

  • Developing and applying chemical btools to study lung disease
  • Novel probes to monitor enzyme activities in cystic fibrosis and COPD
  • Proceeding from cell models to intact organisms and patients
  • Novel tools to manipulate and perturb intracellular signalling networks

Short CV

1979-1986 Study of Chemistry and Diploma Thesis at the University of Bremen, Germany
1989Dissertation (Ph.D.) at the University of Bremen
1989Researcher at the University of Bremen
1990Postdoctoral Fellow, Dept. of Pharmacology, School of Medicine, University of California, San Diego, USA
1992Project Assistant, Dept. of Pharmacology, School of Medicine, University of California, San Diego, USA
1993 Habilitation Fellow at the University of Bremen
1996 Researcher at the University of Bremen
1997 Habilitation in Organic Chemistry, University of Bremen
2000   Group Leader, MPI Molecular Physiology, Dortmund, Germany
2001 Group Leader, Gene Expression Unit, EMBL Heidelberg, Germany
2005 Member of the Molecular Medicine Partnership Unit (MMPU), Heidelberg          
2008 Senior Scientist, Cell Biology & Biophysics Unit, EMBL Heidelberg

Honours & Awards

1993 Habilitation stipend, German Research Foundation (DFG)
2005 Piet Van Duijn Lecture, Int. Fed. of Soc. Histochemistry and Cytochemistry, The Netherlands
2012 Heidelberg Molecular Life Science Award 2012, shared with Michael Brunner      

Projects

COPD/Cystic Fibrosis

  1. Development of protease probes relevant to lung inflammation. Tests in model cells, the CF mouse model of the Mall group and in patient cells.
  2. Sampling and testing of samples from CF and COPD patients, treatment with above mentioned probes and subjecting the probes to automated microscopy.
  3. Testing of macrophage elastase prodrugs in the CF mouse model of the Mall group.

COPD/Lung Cancer

  1. Development of protease probes relevant to cancer. Tests in model cells and grafted mouse models.
  2. Development of bimodal probes for simultaneous MRI and fluorescence imaging.
  3. Development of tools to noninvasively activate signalling events downstream of the membrane receptor level (within LungSysII).

Team

Technical Assistant

Rainer Müller, Ph.D.

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Post-doctoral fellows

Vibor Laketa, Ph.D.

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Sabine Reither, Ph.D.

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Devaraj Subramanian, Ph.D.

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Per Haberkant, Ph.D.

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Andre Nadler, Ph.D.

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Dmytro Yushchenko, Ph.D.

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Hai-Yu Hu, Ph.D.

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Gopal Datta, Ph.D.

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PhD studentsgehrig@embl.de

 

Suihan Feng

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Tilman Plass

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Doris Höglinger

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Verena Rickert-Zacharias

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Frank Stein

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Selected Publications

  1. Lukinavičius, G., Umezawa, K., Olivier, N., Honigmann, A., Yang, G., Plass, T., Mueller, V., Reymond, L., Correa, I. R., Luo, Z.-G., Schultz, C., Lemke, E., Heppenstall, P., Eggeling, C., Johnsson, K. A near-infrared fluorophore for live-cell superresolution microscopy of cellular proteins, Nat. Chem. (2013) accepted.
  2. Rutkowska, A., Schultz, C. Protein tango: the toolbox to capture interacting partners. Angew. Chem. Int. Ed. 51, 8166–8176 (2012). DOI: 10.1002/anie.2012 01717
  3. Cobos-Correa, A., Stein, F., Schultz, C. Target-activated prodrugs for the auto-regulated inhibition of MMP12. ACS Med. Chem. Lett. 3, 653–657 (2012). DOI: 10.1021/ml3001193
  4. Gehrig, S., Mall M. A., Schultz, C. Spatially resolved monitoring of neutrophil elastase activity with ratiometric fluorescent reporters. Angew. Chem. Int. Ed. 51, 6258-6261 (2012).
  5. Johannesson, B., Hirtz, S., Schatterny, J., Schultz, C., Mall M. A. CFTR modifies onset and mortality of chronic obstructive lung disease in βENaC-overexpressing mice. PLoS ONE 7, e44059 (2012). doi:10.1371/journal.pone.0044059.
  6. Lemke, E. A., Schultz, C. Principles for designing fluorescent sensors and reporters. Nat. Chem. Biol. 7, 480-483 (2011).Rutkowska, A., Haering, C. H., Schultz, C. A FlAsH-based cross-linker to study protein interactions in living cells. Angew. Chem. Int. Ed. 50, 12655-12658 (2011)
  7. Plass, T., Köhler, C., Schultz, C., Lemke, E. Genetically encoded copper free click chemistry.  Angew. Chem. Int. Ed. 50, 3878-3881 (2011).
  8. Mentel, M., V. Laketa, V., Subramanian, D., Gillandt, H., Schultz, C. Photoactivatable and cell membrane-permeant phosphatidylinositol 3,4,5-trisphosphate. Angew. Chem. Int. Ed. 50, 3811-3814 (2011).
  9. Mall, M. A., Button, B., Johannesson, B., Zhou, Z., Livraghi, A., Caldwell, R. A., Schubert, S., Schultz, C., O’Neal, W., Pradervand, S., Hummler, E., Rossier, B. C., Grubb, B., Boucher, R. C. Airway surface liquid volume regulation determines different airway phenotypes in liddle's compared to βENAC-overexpressing mice. J. Biol. Chem. 285, 26945-55 (2010).
  10. Schultz, C. Challenges in studying phospholipid signaling. Nat. Chem. Biol. 6, 473-475 (2010).
  11. Subramanian, D., Laketa, V., Müller, R., Tischer, C., Zarbakhsh, S., Pepperkok, R., Schultz, C. Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells. Nat. Chem. Biol. 6, 324-326 (2010).
  12. Cobos-Correa, A., Trojanek, J. Diemer, S., Mall, M. A., Schultz, C. MMP12 activity in pulmonary inflammation visualized by a membrane-targeted fluorescent reporter. Nat. Chem. Biol. 5, 628-630 (2009).
  13. Laketa, V., Zarbakhsh, S., Mortier, E., Subramanian, D., Brumbaugh, J., Dinkel, C., Zimmermann, P., Pepperkok, R., Schultz, C. Membrane-permeant phosphoinositide derivatives as modulators of growth factor signaling and neurite outgrowth. Chem. Biol. 16, 1190-1196 (2009).
  14. Neef, A. B., Schultz, C. Selective fluorescent labeling of lipids in living cells. Angew. Chem. Int. Ed. 48, 1498-1500 (2009).
  15. Yudushkin, I. A., Schleifenbaum, A., Neel, B. J., Schultz, C., Bastiaens, P. I. H. Imaging the enzyme-substrate intermediate reveals functional subpopulations of the tyrosine phosphatase PTP1B in living cells. Science 315, 115-119 (2007)
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