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Translational Lung Research Center Heidelberg

Mark O. Wielpütz, M.D.

Resident in Radiology, Department of Diagnostic and Interventional Radiology

Head of Junior Research Group for Structural and Functional Airway Imaging (JRG-SFI)

 

Department of Diagnostic and Interventional Radiology

Heidelberg University Hospital

Im Neuenheimer Feld 110
69120 Heidelberg


Phone:+49 (0)6221 56-6410

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Research Interests:

  • Functional imaging of airway disease
  • Lung Perfusion imaging by MRI and DECT
  • Computerized image analysis
  • Computer-aided diagnosis CAD
  • Imaging of mouse models for airway disease

Short CV

2002-2008Medical School: University of Erlangen-Nuremberg, Germany, and the University of Sydney, Australia
2009Dissertation (M.D.), University of Erlangen-Nuremberg
Since 2009
Clinical training in Radiology at the Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg
Since 2012Junior Research Group Leader: Structural and Functional Airway Imaging; German Center for Lung Research (DZL) and Translational Lung Research Center Heidelberg (TLRC)
2012Principal Investigator, German Center for Lung Research (DZL) and Translational Lung Research Center Heidelberg (TLRC)

Honours & Awards

2005Sofie-Wallner-Preis for Cancer Research
2006Member of Leonardo Elite Kolleg, University of Erlangen-Nuremberg
2014
Christiane Herzog Foundation Research Award for Cystic Fibrosis Research

Projects

The JRG-SFI focuses on the structural and functional imaging of the airways. New methods will be developed for the imaging of epithelial function to allow a more direct quantification of regional airway function in health and disease.

  1. An established mouse model for cystic fibrosis (CF) lung disease, but possibly also for chronic-obstructive pulmonary disease (COPD), the β-ENaC-transgenic mouse, will be subject to functional imaging methods. This project will be conducted in close cooperation with Prof. Dr. M. Mall. Especially Magnetic Resonance Imaging and Volumetric Computed Tomography will be developed toward an outcome measure for interventional trials in this mouse model.
  2. Dual-energy computed tomography (DECT), will be the main focus in a cooperative project together with Dr. W. Stiller, a physicist at the Department of Radiology in Heidelberg. This innovative method has the potential for quantitative imaging of regional lung perfusion, and thus airway function. To accomplish this task, it will be necessary to develop new models for lung perfusion and to adapt these to the conditions of DECT imaging
  3. Morpho-functional MRI of cystic fibrosis lung disease
  4. CAD of pulmonary nodules
  5. ArtiCHEST(R) - artifical chest phantom
  6. Opens external link in new windowCOSYCONET

Team

Scientific staff

Dr. rer. nat. Oliver Weinheimer, Ph.D.

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Dr. med. Bertram Jobst 

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Dr. med. Jan Müller

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PhD students

Jens Hansen, Dipl.-Phys.

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M.D. Students

Diana Bardarova

Mila Garbeva

Mila Trauth

Jacek Wroblewski

  

Technical Assistant

Julia Schliebus

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Selected Publications

  1. M. O. Wielpütz, M. Eichinger, O. Weinheimer, S. Ley, M. A. Mall, M. Wiebel, A. Bischoff, H.-U. Kauczor, C. P. Heußel and M. Puderbach (2012). “Automatic airway analysis on multidetector computed tomography in cystic fbrosis – correlation with pulmonary function testing.” J Thorac Imaging published ahead of print
  2. M. O. Wielpütz, M. Eichinger, Z. Zhou, K. Leotta, S. Hirtz, S. H. Bartling, W. Semmler, H.-U. Kauczor, M. Puderbach and M. A. Mall (2011). “In vivo monitoring of cystic fibrosis-like lung disease in mice by volumetric computed tomography.” Eur Respir J 38(5):1060-70
  3. M. Eichinger, D.-E. Optazaite, A. Kopp-Schneider, C. Hintze, J. Biederer, A. Niemann, M. A. Mall, M. O. Wielpütz, H.-U. Kauczor and M. Puderbach (2011). Morphologic and functional scoring of cysic fibrosis lung disease using MRI.“ Eur J Radiol 38(5):1060-70)
  4. R. Lopez-Benítez, M. O. Wielpütz, M. G. H. Bryant, Tom Ganten, G. M. Richter, N. Flach and P. J. Hallscheidt (2011). Percutaneous Treatment of Biliary Cast Syndrome After Orthotopic Liver Transplantation: Comparison of Mechanical Versus Hydraulic Rheolytic Cast Extraction.Cardiovasc Intervent Radiol 34(5):998-1005
  5. M. O. Wielpütz, I.-H. Lee, S. Boulkroun, N. Farman, D. I. Cook, C. Korbmacher and R. Rauh (2007). “(NDRG2) stimulates amiloride-sensitive Na+ currents in Xenopus laevis oocytes and Fisher Rat Thyroid cells.” J Biol Chem 282(38), 28264-28273

 

 

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