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Dr. rer. nat. Radhika Puttagunta

Leitung: 

Experimentelle Paraplegiologie - Neuroregeneration 

 

E-Mail:

radhika.puttagunta@med.uni-heidelberg.de

 

Kontakt:

Klinik für Paraplegiologie
Department Orthopädie, Unfallchirurgie und Paraplegiologie
Universitätsklinikum Heidelberg
Schlierbacher Landstraße 200 a
69118 Heidelberg

 

Wissenschaftliche Schwerpunkte:

    • Regeneration im zentralen und peripheren Nervensystem
    • Neuronale Programme für axonales Wachstum
    • Zelltransplantation mit Neurotrophe Faktoren und Gentherapie
    • Biomaterialien
    • Mechanismen neuropathischer Schmerzen nach spinalem Trauma

     

    Curriculum Vitae

    Studium und Promotion

      • 1994-1998  Studium der Molekularen Zellbiologie an der University of Michigan-Ann Arbor, USA; B.Sc und M.Sc
      • 1999-2002  Studium der Genetik an der University of Wisconsin-Madison, USA; M.Sc
      • 2002  Lehrbescheinigung in Undergraduate Education from the Teaching and Learning Scholarship program, Universität von Wisconsin-Madison, USA
      • 2002-2006  Dissertation in Genetik an der University of Wisconsin-Madison, USA; PhD, Prof. Tomas Prolla, “The role of mitochondrial heat shock protein 70kD in mammalian stress resistance”
      • 2017 Baden-Württemberg Zertifikat für Hochschuldiddaktik

         

        Beruflicher und Wissenschaftlicher Werdegang

        • 2007-2013  Postdoktorandin, Laboratory for NeuroRegeneration and Repair, Hertie Institut für Hirnforschung, Universität Tübingen
        • 2014-2016  Stellv. Gruppenleiterin und Ober Postdoktorandin, Laboratory for NeuroRegeneration and Repair, Hertie Institut für Hirnforschung, Universität Tübingen
        • 2014-2016  Klassenkoordinatorin und Dozentin, “Neuroregeneration and Neuro-tissue engineering”, Graduate Training Centre of Neuroscience, Universität Tübingen
        • Seit 2016  Gruppenleiterin der Experimentellen Paraplegiologie / Neuroregeneration, Klinik für Paraplegiologie des Departments Orthopädie, Unfallchirurgie und Paraplegiologie, des Universitätsklinikums Heidelberg

        Publikationen

        Joshi Y.$, Soria M.$, Quadrato G., Inak G., Zhou L., Hervera A., Rathore K., Elnagger M., Cucchiarini M., Marine J., Puttagunta R. and Di Giovanni S. (2015). The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury. Brain, Jul;138(Pt 7):1843-62. Link to article.

         

        Lindner R., Puttagunta R., Nguyen T. and Di Giovanni S. (2014). DNA methylation temporal profiling following peripheral versus central nervous system axotomy. Scientific Data 1. Article number 140038. ​Link to article.

         

        Puttagunta R.$, Tedeschi A.$, Soria M.G., Hervera A., Lindner R., Rathore K.I., Gaub P., Joshi Y., Nguyen T., Schmandke A., Laskowski C.J., Boutillier A.-L., Bradke F. and Di Giovanni S. (2014). PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system. Nature Communications 5: 3527. Link to article.

         

        Lindner R., Puttagunta R. and Di Giovanni S. (2013). Epigenetic regulation of axon outgrowth and regeneration in CNS injury: the first steps forward. Neurotherapeutics. 10(4): 771-81. . Link to article.

         

        Puttagunta R. and Di Giovanni S. (2011). Retinoic acid signaling in axonal regeneration. Frontiers in Molecular Neuroscience. 4: 59. Link to article.

         

        Puttagunta R., Schmandke A., Floriddia E., Gaub P., Fomin N., Ghyselinck N. and Di Giovanni S. (2011). RA-RARß counteracts myelin-dependent inhibition of neurite outgrowth via Lingo-1 repression. The Journal of Cell Biology. 193(7): 1147-56. Link to article.

         

        Gaub P., Tedeschi A., Puttagunta R., Nguyen T., Schmandke A. and Di Giovanni S. (2010). HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation. Cell Death and Differentiation. 17(9): 1392-408. Link to article.

         

        Tedeschi A., Nguyen T., Puttagunta R., Gaub P. and Di Giovanni S. (2009). A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regeneration. Cell Death and Differentiation. 16(4): 543-54. Link to article.

         

        Bomar J.M., Benke P.J., Slattery E.L., Puttagunta R., Taylor L.P., Seong E., Nystuen A., Chen W., Albin R.L., Patel P.D., Kittles R.A., Sheffield V.C. and Burmeister M. (2003). Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse. Nature Genetics. 35(3): 264-9. Link to article.

         

        Puttagunta R., Gordon L.A., Meyer G.E., Kapfhamer D., Lamerdin J.E., Kantheti P., Portman K.M., Chung W.K., Jenne D.E., Olsen AS. and Burmeister M. (2000). Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Genome Research. 10(9): 1369-80. Link to article.

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