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Translational Lung Research Center Heidelberg

Dr. Wolfram Stiller

Dr. sc. hum. Wolfram Stiller, Physicist (Dipl.-Phys.)
Senior research fellow and section head “Physics & Methods”


Department of Diagnostic and Interventional Radiology (DIR)
Heidelberg University Hospital
Im Neuenheimer Feld 110
69120 Heidelberg

Phone:+49 6221 56-37240
Fax: +49 6221 56-6434

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Research Interests:

  • Physico-technical properties of computed tomography (CT)
  • Monte-Carlo (MC) simulation of radiation transport problems & dose distributions
  • Optimization of image quality & radiation exposure in CT
  • Functional CT-imaging
  • Quantitative CT-imaging methods, e.g. Dual-energy CT (DECT)



Curriculum Vitae

1997 – 2000Undergraduate/graduate studies in Physics, University of Kaiserslautern, Germany
2000 – 2002Graduate studies in Physics, Ludwig-Maximilians-University (LMU) Munich, Germany
2003 – 2004Postgraduate research fellow, Max-Planck-Institute for Physics (Werner-Heisenberg-Institute), Munich, Germany
2004 – 2008Postgraduate research fellow (Ph.D. student), Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ) Heidelberg, Germany
2008 - 2010Postdoctoral research fellow, Department of Radiology, German Cancer Research Center (DKFZ) Heidelberg, Germany
01/2009 - 11/2012Project leader (PI) “Reduction of Radiation Exposure Caused by Computed Tomography Examinations (02NUK008G)", BMBF Collaboration Project “Innovative Methods for the Optimization of Radiological Applications in Biomedical Imaging”
since 2010Senior research fellow & section head "Physics & Methods", Department of Diagnostic and Interventional Radiology (DIR), University Hospital Heidelberg, Germany
07/2012 - 06/2017Project leader (PI) "Innovative Imaging of Tissue Perfusion (R02)", Transregional Collaborative Research Center (SFB/TRR 125) "Cognition-guided Surgery", University Hospital Heidelberg, German Cancer Research Center (DKFZ) Heidelberg, Karlsruhe Institute of Technology (KIT), Germany
since 12/2013Principal Investigator (PI) of the "Imaging" platform, Translational Lung Research Center Heidelberg (TLRC) and German Center for Lung Research (DZL), Germany



Speciality Certification

10/2007Certificate "Medical Physics for Physicists (DGMP)" according to the subject catalog of the German Association of Medical Physics (DGMP), Academy for Professional Scientific Development, Ruprecht-Karls-University Heidelberg, Germany
12/2008Certificate in qualified technical knowledge of radiation protection (Fachkunde im Strahlenschutz): "Fachkundegruppe R7 nach der Richtlinie Fachkunde nach der Röntgenverordnung vom 27. Mai 2003“ according to §18a(1) Röntgenverordnung (RöV)
07/2012Certificate „Allgemeiner Prüfer-/Prüfarztkurs – Rahmenbedingungen und Durchführung klinischer Studien“, Center for Coordination of Clinical Studies (KKS) at the University Hospital Heidelberg, Germany



Honours & Awards

2011“Trainee Research Prize“ in the category “Physics/Fellow“, Radiological Society of North America (RSNA), Chicago, USA: “A Theoretical Model for Calculating MDCT Beam-shaping Filter Geometry: Comparison of Calculated Attenuation Profiles and Monte-Carlo Simulated Transmission Spectra to Measurements”
2013“Young Investigator Scholarship”, 3rd World Congress of Thoracic Imaging (WCTI), Seoul, Korea: “Thoracic imaging with low-dose MDCT at low tube voltages using iterative image reconstruction: Where is the limit of diagnostic confidence compared to the clinical standard?“
2013“Best Scientific Presentation Award” (“Cum Laude”), 3rd World Congress of Thoracic Imaging (WCTI), Seoul, Korea: “Thoracic imaging with low-dose MDCT at low tube voltages using iterative image reconstruction: Where is the limit of diagnostic confidence compared to the clinical standard?“



Memberships/Committee Assignments

since 2011Member of the German Radiological Society (DRG)
since 2011Member of the European Society of Radiology (ESR)
since 2013Member of the German-Japanese Radiological Affiliation (GJRA)
since 12/2014Official representative of the European Society of Radiology (ESR) with regard to research in the field of radiation protection in medicine
since 02/2016Member of the “Radiation Protection Subcommittee” within the “Quality, Safety & Standards Committee” of the European Society of Radiology (ESR)
since 01/2017Member of the "Physics" section of the "Scientific Editorial Board" of the radiological journal "European Radiology"




Ph.D. students


Dipl.-Tech. Math. Stephan Skornitzke

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M.Sc. Biomedical Engineering Andrea Steuwe




Technical Assistant


Martin Finke


Selected Publications

  1. Steuwe A, Geisbüsch P, Schulz CJ, Böckler D, Kauczor HU, Stiller W. “Comparison of radiation exposure associated with intraoperative cone-beam computed tomography (CBCT) and follow-up multi detector-row computer tomography (MDCT) for evaluating endovascular aortic repair procedures.“ J Endovasc Ther 2016; 23(4): 583-92. doi: 10.1177/1526602816649588.
  2. Pahn G, Skornitzke S, Schlemmer HP, Kauczor HU, Stiller W. “Toward standardized quantitative image quality (IQ) assessment in computed tomography (CT): A comprehensive framework for automated and comparative IQ analysis based on ICRU Report 87.” Phys Med 2016; 32(1): 104-15. doi: 10.1016/j.ejmp.2015.09.017.
  3. Stiller W, Skornitzke S, Fritz F, Klauß M, Hansen J, Pahn G, Grenacher L, Kauczor HU. “Correlation of Quantitative Dual-energy CT Iodine Maps and Abdominal CT-perfusion Measurements: Are Single-acquisition DECT Iodine Maps More Than a Reduced-Dose Surrogate of Conventional CT Perfusion?” Invest Radiol 2015; 50(10): 703-8. doi: 10.1097/RLI.0000000000000176.
  4. Nattenmüller J, Hosch W, Nguyen TT, Skornitzke S, Jöres A, Grenacher L, Kauczor HU, Sommer C, Stiller W. “Hypodense liver lesions in patients with hepatic steatosis: Do we profit from dual-energy computed tomography?” Eur Radiol 2015; 25(12): 3567-76. doi: 10.1007/s00330-015-3772-6.
  5. Skornitzke S, Fritz F, Klauß M, Pahn G, Hansen J, Hirsch J, Grenacher L, Kauczor HU, Stiller W. “Qualitative and quantitative evaluation of rigid and deformable motion correction algorithms using dual-energy CT images in view of application to CT perfusion measurements in abdominal organs affected by breathing motion,” Br J Radiol 2015; 88(1046): 20140683. doi: 10.1259/bjr.20140683.
  6. Stiller W, Veloza S, Kauczor HU. Attenuation-based Dynamic CT Beam-shaping Filtration in Dependence of Fan and Projection Angle: Evaluation of a New Method for Radiation Exposure Reduction by Monte-Carlo Simulation of Spatial Dose Distribution. In: Yu, B., Ed., IEEE Nucl Sci Conf R 2012 Nov; 2625-2632.
  7. Stiller W, Schwarzwaelder, CB, Sommer CM, Veloza S, Radeleff BA, Kauczor HU. Dual-energy, standard and low-kVp contrast-enhanced CT-cholangiography: A comparative analysis of image quality and radiation exposure. Eur J Radiol 2012 Jul; 81(7): 1405-1412.
  8. Bartling SH, Dinkel J, Stiller W, Grasruck M, Madisch I, Trnka D, Kauczor HU, Semmler W, Gupta R, Kießling F. Intrinsic respiratory gating in small animal CT. Eur Radiol 2008 Jul; 18(7): 1375-1384.
  9. Bartling SH, Stiller W, Grasruck M, Schmidt B, Peschke P, Semmler W, Kießling F. Retrospective motion-gating in small animal CT of mice and rats. Invest Radiol 2007 Oct; 42(10): 704–714.
  10. Stiller W, Kobayashi M, Koike K, Stampfl U, Richter G, Semmler W, Kießling F. Initial experience with a novel low-dose micro-CT system / [Erste Erfahrungen mit einem neuen Niedrigdosis-Mikro-CT]. Fortschr Röntgenstr 2007 Jul; 179(7): 669–676.
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