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Molecular Medicine Partnership Unit

 

JCF - Junior Career Fellowship

This Fellowship is awarded for a period of 12 months to support medical students with ambitions in particular in molecular medicine. Integrated into one of the Opens internal link in current windoweight MMPU groups, selected fellows will have the opportunity to conduct a challenging project for their MD thesis and to start networking with internationally renowned scientists and physicians.

Open MD positions in MMPU labs can be found on this page: Opens internal link in current windowCalls

 

 

Our successful JCF awardees 2018 are:

 

 

Tamara Kempter

Tamara is an MD student at Heidelberg University working on pediatric T-cell acute lymphoblastic leukemia (T-ALL) in the group of Andreas Kulozik (Children’s Hospital, Department of Pediatric Oncology, Hematology, Immunology and Pulmonology).

The aim of her project is to validate subclonal mutations in TP53 as a prognostic biomarker of fatal childhood T-ALL relapse. The validation of the prognostic value of TP53 may have substantial implications for the early identification of high-risk patients and for the development of future personalized and risk-adapted therapy.

Email: kempter@stud.uni-heidelberg.de

 

 

 

Paul Naser

Paul is an MD student at Heidelberg University working on top-down modulation of chronic pain in the the group of Rohini Kuner at the Institute of Pharmacology.

The aim of his project is to identify cholinergic circuits involved in the percept of pain and investigate their plasticity over pain chronicity.

Email: paul.naser@pharma.uni-heidelberg.de

 

 

 

Our successful JCF awardees 2017 are:

 

 

Nicole Fritsch

Nicole Fritsch

Nicole is an MD student at the University of Heidelberg working on iron refractory iron deficiency anemia (IRIDA) in the group of Martina Muckenthaler (Children's Hospital, Department of Pediatric Oncology, Hematology and Immunology).

The aim of her project is to characterize the functional consequence of new mutations identified by exome sequencing that hallmark a novel form of IRIDA.

Email: n.fritsch@stud.uni-heidelberg.de

 

 

Christiane Höper

Christiane is an MD student at Heidelberg University studying pain caused by tumor-nerve interaction in the group of Rohini Kuner at the Institute of Pharmacology.

The aim of her project is to identify molecular mechanisms that mediate nerve invasion of cancer cells to investigate consequences for metastasis, prognosis and pain in patients suffering from ductal adenocarcinoma of the pancreas (PDAC). 

Email: C.Hoeper@stud.uni-heidelberg.de

 

 

Our successful JCF awardees 2016 are:

 

 

Caroline von Knebel Doeberitz

Caroline is an MD student at the University of Heidelberg and works on pediatric T-cell acute lymphoblastic leukemia (T-ALL) in the group of Opens external link in new windowAndreas Kulozik (Children’s Hospital, Department of Pediatric Oncology, Hematology, Immunology and Pulmonology.)

The aim of her project is to identify mechanisms that drive progression of pediatric T-ALL to relapse using bioinformatics to investigate mutational spectra in early precursor leasons, primary tumor and relapsing disease upon treatment.

Email: C.Knebel@stud.uni-heidelberg.de

 

 

 

Carl Maximilian Thielmann

Carl Maximilian Thielmann

Carl Maximilian is an MD student at Heidelberg University working on the effects of Iron accumulation in tumor associated macrophages (TAMs) in the group of Opens external link in new windowMartina Muckenthaler (Children's Hospital, Department of Pediatric Oncology, Hematology and Immunology).

The aim of his project is to understand consequences of accumulated iron in TAMs and implications on cancer prognosis and progression.

Email: thielmann@stud.uni-heidelberg.de

 

 

 

Oscar Retana

Oscar A. Retana R.

Oscar is an MD student at Heidelberg University in the group of Opens external link in new windowRohini Kuner (Institute of Pharmacology) studying pain related neural networks.

The aim of his project is to couple molecular activity markers with the expression of DREADDs and optogenetic technology, in order to determine the identity and function of pain coding neurons in the prefrontal cortex.

Oscar is intergrated into the Opens external link in new windowHBIGS program.

Email: oscar.retana@pharma.uni-heidelberg.de

 

 

 

Our successful JCF awardees 2015 are:

 

 

Carolin Escherich

Carolin Escherich

Carolin is an MD student at the University of Heidelberg and works on expression changes of selected TRPV1 interacting molecules in chronic pain states in the group of Opens external link in new windowJan Siemens (Heidelberg University Medical Center, Pharmacology Institute).

The aim of her project is to elucidate the candidate’s role in TRPV1 modulation, an important prerequisite to identify new targets for pharmacotherapy in the pain pathway.

Email: Opens window for sending emailcarolin.escherich@pharma.uni-heidelberg.de

 

 

 

Florian de Molière

Florian de Molière

Florian is an MD student at the University of Heidelberg and works on the effect of oncogenes on chemokine signalling in collective cell migration in the group of Opens external link in new windowDarren Gilmour (EMBL).

The aim of his project is to understand whether collectively migrating cancer cells reactivate the signalling mechanisms that normally allow collective motion during organ development.

Email: florian.moliere@embl.de

 

 

 

Pia-Elena Frey

Pia-Elena Frey

Pia-Elena is an MD student at the University of Heidelberg and works on pediatric T-cell acute lymphoblastic leukemia (T-ALL) in the group of Opens external link in new windowAndreas Kulozik (Children’s Hospital, Department of Pediatric Oncology, Hematology, Immunology and Pulmonology.)

The aim of her project is to functionally analyse genes that influence the development of childhood T-ALL.

Pia-Elena is intergrated into the Opens external link in new windowHBIGS program.

Email: Opens window for sending emailpia-elena.frey@med.uni-heidelberg.de

 

 

 

Our successful JCF awardees 2014/2015 are:

 

 

Nikolai Schmeer

Nikolai Schmeer

Nikolai is an MD student at Heidelberg University working on Hereditary Hemochromatosis in the group of Opens external link in new windowMartina Muckenthaler (Children´s Hospital, Department of Pediatric Oncology, Hematology and Immunology).

The aim of his project is to reveal novel components of the hepatocytic iron-sensing complex scaffolded by the hemochromatosis-associated proteins HFE, TfR2 and HJV, upstream activators of the master iron-regulatory hormone hepcidin. This may shed light on new signaling pathways and molecular mechanisms involved in the control of systemic iron homeostasis.

Email:Opens window for sending emailNikolai.Schmeer@med.uni-heidelberg.de

Publication:

Imatinib and spironolactone suppress hepcidin expression.
Mleczko-Sanecka K, da Silva AR, Call D, Neves J, Schmeer N, Damm G, Seehofer D, Muckenthaler MU.
Haematologica. 2017 Jul;102(7):1173-1184. doi: 10.3324/haematol.2016.162917. Epub 2017 Apr 6.PMID:28385785

 

 

 

Andreas Simmelbauer

Andreas Simmelbauer

Andreas is an MD student at Heidelberg University working on Iron Metabolism in the group of Opens external link in new windowMartina Muckenthaler (Children´s Hospital, Department of Pediatric Oncology, Hematology and Immunology).

The aim of his project is to reveal novel pathways in the treatment of malaria and atherosclerosis by understanding the complex key role of iron metabolism during these pathological occurrences.

Email:Opens window for sending emailandreas.simmelbauer@med.uni-heidelberg.de

 

 

 

Andreas Sonnen

Andreas Sonnen

Andreas is an MD student at the University of Heidelberg and works in the groups of Opens external link in new windowJohn Briggs (EMBL) and Opens external link in new windowHans-Georg Kräusslich (University Hospital Heidelberg) applying cryo-electron microscopy and cryo-tomography to study membrane proteins and protein/membrane interactions.

The aim of his project is to determine the structure of mechanosensitive channels and of other medically relevant membrane proteins.

Email:Opens window for sending emailAndreas.Sonnen@embl.de

Publications:

New hardware and workflows for semi-automated correlative cryo-fluorescence and cryo-electron microscopy/tomography.
Schorb M, Gaechter L, Avinoam O, Sieckmann F, Clarke M, Bebeacua C, Bykov YS, Sonnen AF, Lihl R, Briggs JA.
J Struct Biol. 2016 Jun 28. pii: S1047-8477(16)30135-6. doi: 10.1016/j.jsb.2016.06.020. PMID: 27368127

A saposin-lipoprotein nanoparticle system for membrane proteins.
Frauenfeld J, Löving R, Armache JP, Sonnen AF, Guettou F, Moberg P, Zhu L, Jegerschöld C, Flayhan A, Briggs JA, Garoff H, Löw C, Cheng Y, Nordlund P.
Nat Methods. 2016 Apr;13(4):345-51. doi: 10.1038/nmeth.3801. Epub 2016 Mar 7. PMID: 26950744

 

 

 

Our successful JCF awardees 2014 are:

 

 

David Santos

David C. d. Santos

David is an MD student at the University of Heidelberg and works on pediatric T-cell acute lymphoblastic leukemia (T-ALL) in the group of Opens external link in new windowAndreas Kulozik (Children’s Hospital, Department of Pediatric Oncology, Hematology, Immunology and Pulmonology.)

The aim of his project is to find characteristic genetic lesions that contribute to leukemogenesis and to investigate the influence of their pathways on the development of malignancy.

David is integrated into the Opens external link in new windowHBIGS program.

 

Email: Opens window for sending emailcordas@stud.uni-heidelberg.de

 

 

 

Stephan Spahn

Stephan Spahn

Stephan is an MD student at Heidelberg University and works on cystic fibrosis in the group of Opens external link in new windowMarcus Mall (Translational Lung Research Center Heidelberg / Department of Pediatric Oncology, Hematology, Immunology and Pulmonology). The aim of his project is to a elucidate the molecular pathways involved in the activation and pharmacological regulation of SLC26A9, a recently identified epithelial chloride channel in the lung that might serve as a novel molecular target in cystic fibrosis and other chronic obstructive lung diseases.

Stephan is integrated into the Opens external link in new windowHBIGS program.

 

Email: Opens window for sending emailStephan.Spahn@med.uni-heidelberg.de

 

 

Maximilian Stich

Maximilian Stich

Maximilian is an MD student at Heidelberg University and works on cancer epigenetics in the group of Opens external link in new windowMagnus von Knebel Doeberitz (Department of Applied Tumor Biology, Institute of Pathology). The aim of his project is to reverse specific methylation patterns in HPV-triggered carcinoma cells that are linked to tumor initiation, progression and immune evasion.
Maximilian is integrated into the Opens external link in new windowHBIGS program.

 

Email: Opens window for sending emailmaximilian.stich@med.uni-heidelberg.de

Publication:

5-aza-2'-deoxycytidine (DAC) treatment downregulates the HPV E6 and E7 oncogene expression and blocks neoplastic growth of HPV-associated cancer cells.
Stich M, Ganss L, Puschhof J, Prigge ES, Reuschenbach M, Guiterrez A, Vinokurova S, von Knebel Doeberitz M.
Oncotarget. 2016 Jul 16. doi: 10.18632/oncotarget.10631. [Epub ahead of print]
PMID: 27447977

 

 

 

 

 

Our successful JCF awardees 2013 are:

 

 

Juliane Eilers

Juliane Eilers

Juliane is an MD student at Heidelberg University and works on pediatric T-ALL ( T-cell acute lymphoblastic leukemia) in the Opens external link in new windowgroup of Andreas Kulozik (Children’s Hospital, Department of Pediatric Oncology, Hematology, Immunology and Pulmonology). The aim of her project is to understand the pathways involved in leukemogenesis and to find prognostic markers for childhood T-ALL.
Juliane is integrated into the Opens external link in new windowHBIGS program.

E-mail: Opens window for sending emailJuliane.Eilers@med.uni-heidelberg.de

Publication:

Pediatric T-lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation.
Kunz JB, Rausch T, Bandapalli OR, Eilers J, Pechanska P, Schuessele S, Assenov Y, Stütz AM, Kirschner-Schwabe R, Hof J, Eckert C, von Stackelberg A, Schrappe M, Stanulla M, Koehler R, Avigad S, Elitzur S, Handgretinger R, Benes V, Weischenfeldt J, Korbel JO, Muckenthaler MU, Kulozik AE.
Haematologica. 2015 Aug 20. pii: haematol.2015.129692. [Epub ahead of print] PMID: 26294725

 

 

 

 

Aenne Solvejg Thormählen

Aenne Solvejg Thormählen

Aenne is an MD student at Heidelberg University and works on myocardial infarction. She joined the Opens external link in new windowgroup of Heiko Runz (Institute of Human Genetics) in spring 2013 for her MD-thesis and uses cell-based assays to characterize rare coding genetic variants for their possible influence on blood lipid levels and the risk of cholesterol-associated cardiovascular diseases.
Aenne is integrated into the Opens external link in new windowHBIGS program.

 

E-mail: Opens window for sending emailaenne.thormaehlen@arcor.de

Publications:

Systematic Cell-Based Phenotyping of Missense Alleles.
Thormählen AS, Runz H
.
Methods Mol Biol. 2017;1601:215-228. doi: 10.1007/978-1-4939-6960-9_17.PMID:28470529

 

Systematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case for LDLR and Myocardial Infarction.
Thormaehlen AS, Schuberth C, Won HH, Blattmann P, Joggerst-Thomalla B, Theiss S, Asselta R, Duga S, Merlini PA, Ardissino D, Lander ES, Gabriel S, Rader DJ, Peloso GM, Pepperkok R, Kathiresan S, Runz H. PLoS Genet. 2015 Feb 3;11(2):e1004855. doi: 10.1371/journal.pgen.1004855. eCollection 2015 Feb.PMID:25647241

 

 

 

 

Varun Venkataramani

Varun Venkataramani

Varun is an MD student at Heidelberg University in the Opens external link in new windowgroup of Rohini Kuner (Institute of Pharmacology) and the aim of his project is to find new mechanisms of cancer-nerve-interaction in the context of perineural invasion in pain associated with pancreatic cancer.
He wants to elucidate these mechanisms with the help of in-vitro and in-vivo models of perineural invasion as well as human biopsies from pancreatic cancer. To investigate the ultrastructure of perineural invasion he makes use of correlative light- and electron- microscopy (3D-SEM, confocal microscopy and 3D-STORM).
Varun is integrated into the Opens external link in new windowHBIGS program.

 

E-mail: Opens window for sending emailvarun.venkataramani@pharma.uni-heidelberg.de

 

 

 

 

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The Heidelberg Research Center for Molecular Medicine is part of the Opens external link in new windowExcellence Initiative II of the Heidelberg University.

 

 

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