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Mechanisms of myocardial remodeling and heart failure

The research focus of the group is the identification of novel signaling mechanisms governing myocardial remodeling and cardiac myocyte growth occuring following pathological stimuli such as aortic stenosis and myocardial infarction. In order to examine these regulatory mechanisms we use an integrative approach employing functional and molecular characterization of in vivo models as well as culture of isolated cardiac myocytes. Thematically, we are working on dissecting the mechanisms how GSK-3β acts as a negative regulator of myocardial hypertrophy. In this context we currently investigate the potential role of Wnt-signaling for myocardial remodeling.

Team "Hardt-Lab"
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