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Translational Lung Research Center Heidelberg

News archive before 2015

April 2014: New Method for Detecting Early Lung Disease in Infants and Preschool Children with Cystic Fibrosis

TLRC scientists publish breakthrough method for non-invasive early diagnosis of pulmonary changes in infants and young children with cystic fibrosis. Initiates file downloadRead more ...

February 2013: New therapeutic approach to severe asthma

-  As featured on Opens external link in new windowpage 7 of the February Newsletter from the BMBF, DZL Researchers, led by Prof. Dr. Marcus A. Mall at the University of Heidelberg, have found that a specific polymorphism in the 3' UTR of the chloride channel SLC26A9 occurs more frequently in asthmatics than in healthy subjects.  The SLC26A9 polymorphism associated with asthma leads to reduced protein expression in vitro. Ion channels such as SLC26A9 are believed to be critical for the dilution of mucus secretions via a process called osmosis.  Researchers hypothesize that asthmatics bearing this polymorphism may have lower levels of SLC26A9 protein which in turn may contribute to their disease. "We have found a very specific point of attack for new asthma drugs," says Professor Dr. Mall.  These therapies may also help patients with Cystic Fibrosis, an incurable lung disease.  Cystic Fibrosis patients also have abnormally thick mucus secretions and may benefit from therapies which help thin mucus.  The findings were published in the Opens external link in new windowJournal of Clinical Investigation.

November 2011: The Translational Lung Research Center Heidelberg (TLRC) is part of the newly established German Center for Lung Research (DZL)

The DZL has the mission of using translational research to combat widespread lung diseases. Prof. Marcus A. Mall, head of the Division of Pulmonology & and Allergy and Cystic Fibrosis Center at Heidelberg University Hospital is director of the TLRC and member of the Executive Board of the DZL. For more information please see the Opens external link in new windowpress release (in German) from Heidelberg University Hospital.

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