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Zentrale Tel.: 06221-560
Translational Lung Research Center Heidelberg

Alexander Dalpke, M.D.

Professor of Medical Microbiology and Infection and Immunity


Department of Infectious Diseases, Medical Microbiology and Hygiene
Heidelberg University Hospital
Im Neuenheimer Feld 324
69120 Heidelberg

Phone:+49 6221 56-38173
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Research Interests:

  • Immune functions of airway epithelium
  • Microbiome analysis in CF patients
  • Innate Immunity
  • Signal transduction

 

 

Curriculum Vitae

1992-1998Medical School, Georg-August University Göttingen
1998-1999First-year resident, Hospital Alfeld, Internal Medicine
1999-2004Post-doc and Research Assistant, Inst. of Medical Microbiology, Philipps-University Marburg
2005Group Leader, Dept. of Hygiene and Med. Microbiology, Heidelberg
Since 2006Professor (W3) for Medical Microbiology and Infection and Immunity, Dept. of Infectious Diseases - Medical Microbiology and Hygiene, University Heidelberg
Since 2013Deputy Medical Director, Dept. of Infectious Diseases, Medical Microbiology and Hygiene
Since 2014Principal Investigator, Translational Lung Research Center Heidelberg (TLRC) and German Center for Lung Research (DZL)

 

 

Speciality certification

1998Graduation (MD), Med. Microbiology, Center of Hygiene and Human Genetics, University Göttingen
2004Habilitation, University lecturer for infection and immunity, Philipps University Marburg
2006Specialist in immunology (“Fachimmunologe DGfI”, German Society for Immunology)
2011Certified for microbiology, virology and epidemiology of infections

 

 

Honours & Awards

1993-1998Scholarship of the “Cusanuswerk” for the promotion of highly talented students
2001Poster award, 32. Annual meeting of the German Society of Immunology, Dresden
2003Poster award Biochemical Society, Focused Meeting "Toll-Like Receptors", Horsham, UK
2004Martin-Stolze-Award, Vereinigung der Mitteldeutschen Urologen, "Antineoplastic activity of immunostimulating DNA"

Memberships/Committee Assignments

2004-2007Member of the DFG priority program SP1110 „Innate Immunity“
2006-2009Member of the SFB405 “Immunetolerance and its disturbances“, project B18
since 2007Member of “Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology”
2008-2011Speaker of the Postgraduate Program “Differential activation and integration of signaling modules within the immune system”
2011-2015Member of the SFB938 “Environment specific control of immunological reactivity”, project E
2012-2015Coordinator Teaching&Education Activities, DZIF, Heidelberg site

 

 

Projects

  1. Immune functions of airway epithelium

    It has been shown that the activity of innate immune cells can be shaped by the local microenvironment within specific organs. We analyze immunemodulatory effects of bronchial epithelial cells on local myeloid cells that limit the reactivity and activation under homeostatic, steady-state conditions. We assign to airway epithelial cells an important role in the regulation of organ-specific immune responses.

  2. Microbiome analysis in cystic fibrosis (CF) patients
    We study CF lung microbiome using next generation sequencing techniques aiming to answer different questions about CF microbiome resilience, antibiotic treatment effect and possible dysbiosis induced by exacerbation.

  3. Innate Immunity
    We are studying activation and inhibition of cells of the innate immune system. One topic of our research centers on the recognition of microbial nucleic acids by pattern recognition receptors. We try to elucidate principles that enable Toll-like receptors to differentiate foreign, microbial from self nucleic acids.

  4. Signal transduction

    While the mechanisms of activation of innate immune receptors are nowadays increasingly recognized it is still less clear how immune reactions are turned off again. A further focus of my lab is signal termination and here we specifically analyze a group of proteins termed suppressor of cytokine signaling proteins (SOCS). We focus on a new, unanticipated role of SOCS-1 within the cell nucleus.

Team

Post-doctoral fellows

Dr. Michael Weitnauer

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Dr. Sébastien Boutin

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Scientist

Dr. Tatjana Eigenbrod

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PhD studend

Isabel Freund

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Vedrana Mijosek

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Jana Zimmer

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Volker Kloess

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Medical Student

Nathalie Ng Kuet Leong

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Julia Kanorek

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Technical Assistant

Suzan Allam

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Rene Karayilan

 

 

Selected Publications

  1. Mijošek V, Lasitschka F, Warth A, Zabeck H, Dalpke AH, Michael Weitnauer (2016): Endoplasmic Reticulum Stress Is a Danger Signal Promoting Innate Inflammatory Responses in Bronchial Epithelial Cells. J Innate Immun, 8(5):464-478

  2. Weitnauer M, Mijošek V, Dalpke AH (2016): Control of local immunity by airway epithelial cells. Mucosal Immunol. 9: 287-298

  3. Weitnauer M, Schmidt L, Ng Kuet Leong N, Muenchau S, Lasitschka F, Eckstein V, Hübner S, Tuckermann J and Dalpke AH (2014): Bronchial epithelial cells induce alternatively activated dendritic cells dependent on glucocorticoid receptor signaling. J Immunol, 193(3):1475-1484.

  4. Hidmark A, von Saint Paul A, Dalpke AH (2012). Cutting Edge: TLR13 is a receptor for bacterial RNA. J Immunol. 189(6): 2717-21

  5. Gehrig S, Eberle ME, Botschen F, Rimbach K, Eberle F, Eigenbrod T, Kaiser S, Holmes WM, Erdmann VA, Sprinzl M, Bec G, Keith G, Dalpke AH* and Helm M* (2012). Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity. J Exp Med 209 (2): 225-233, *equal contribution

  6. Schmidt LM, Belvisi MG, Bode KA, Bauer J, Schmidt C, Suchy MT, Tsikas D, Scheuerer J, Lasitschka F, Gröne HJ and Dalpke AH (2011). Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells. J Immunol. 186(4): 2095-2105

  7. Baetz A, Koelsche C, Strebovsky J, Heeg K, Dalpke AH (2008). Identification of a nuclear localization signal in suppressor of cytokine signaling 1 (SOCS1). FASEB J 22(12): 4296-4305

  8. Mayer AK, Muehmer M, Mages J, Gueinzius K, Hess C, Heeg K, Bals R, Lang R and Dalpke AH (2007). Differential recognition of Toll-like receptor dependent microbial ligands in human bronchial epithelial cells: Implications for pattern recognition at non-sterile mucosal surfaces. J. Immunol. 178(5): 3134-3142

  9. Bartz H, Avalos NM, Baetz A, Heeg K and Dalpke AH (2006). Involvement of Suppressors of Cytokine Signaling in Toll-like receptor-mediated block of dendritic cell differentiation. Blood 108(13): 4102-4108

  10. Bätz A, Frey M, Heeg K and Dalpke AH (2004). Suppressor of cytokine signaling (SOCS) proteins indirectly regulate Toll-like receptor signaling in innate immune cells. J. Biol. Chem. 279(52): 54708-54715
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