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Zentrale Tel.: 06221-560
Translational Lung Research Center Heidelberg

Christoph Plass, Ph.D.

German Cancer Research Center (DKFZ)
Im Neuenheimer Feld 280

69120 Heidelberg, Germany

Phone:+49 6221 423300

 

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Research Interests:

  • Epigenetics
  • Epigenomics
  • Lung Cancer
  • Leukemia, Head and Neck Cancer

Curriculum Vitae

1982-1987Diploma, University of Berlin, Germany
1988-1993Ph.D., University of Lübeck, Germany
1993-1996Postdoc, Roswell Park Cancer Institute, Buffalo, NY, USA
1996-1997Cancer Research Scientist, Roswell Park Cancer Institute, Buffalo, NY, USA
1997-2002Assistant Professor, The Ohio State University, Columbus, USA
2002-2005Associate Professor, The Ohio State University, Columbus, USA
2005-2007Professor, The Ohio State University, Columbus, USA
since 2007Professor and Head of Department, German Cancer Research Center (DKFZ), Heidelberg, Germany

 

 

Memberships/Committee Assignments

2009German cancer aid expert committee "Clinical research, basic research"
2011Coordinator of DFG SPP 1463 Program (German Research Foundation - DFG)

 

 

Honours & Awards

2002 - 2005V-Foundation Translational Award
2002 - 2007Leukemia Lymphoma Society of America Scholar
2003Honorary Faculty of the Mirrors Honors Society
2005Elected Fellow, American Association for the Advancement of Science (AAAS)
2006Barbara J. Bonner Chair in Lung Cancer
2007Stohlman Scholar, Leukemia Lymphoma Society of America

 

 

Projects

  1. Identifying early epigenetic predictors of breast cancer risk and their etiology determinants - EpiMARK (BMBF)
  2. Priority Area 1463 - Epigenetic Regulation of Normal Hematopoiesis and its dysregulation in myeloid neoplasia (DFG)
  3. Coordination and Administration of Priority Area 1463 (DFG)
  4. CancerTelSys - Identifying cancer telomere maintenance networks for diagnosis, patient stratification an therapy response prediction (BMBF)
  5. Understanding and overcoming resistance to apoptosis and therapy (Helmholtz)
  6. Epigenetic markers in AML: demethylating substances as monotherapy and in combination with conventional chemotherapy (Deutsche Krebshilfe)
  7. Virtual institute - German Center for Cardiovascular Research (BMBF)
  8. The Genomes of Early Onset Prostate Cancer (BMBF)
  9. CancerEpiSys – Integrative analysis of epigenetic networks that determine the chronic lymphocytic leukemia disease state (BMBF)

Team

Senior Scientist

Dr. Yassen Assenov

Tel.:+49(0)6221 423322

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Dr. Daniel Lipka

Tel.:+49(0)6221 423322

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Dr. Christopher Oakes

Tel.:+49(0)6221 423316

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Dr. Dieter Weichenhan

Tel.:+49(0)6221 423305

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Postdoc

Dr. Annika Baude

Tel.: +49(0)6224 423337

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Dr. Michael Daskalakis

Tel.: +49(0)6224 423322

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Dr. Tania Witte

Tel.: +49(0)6224 423337

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Technical Assistant

Marion Bähr

Tel.: +49(0)6224 423327

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Monika Helf

Tel.: +49(0)6224 423327

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Oliver Mücke

Tel.: +49(0)6224 423327

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PhD Student

Olga Bogatyrova

Tel.: +49(0)6224 423322

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Justyna Wierzbinska

Tel.: +49(0)6224 423337

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Selected Publications

  1. Costello JF, Frühwald MC, Smiraglia DJ, Rush L, Robertson GP, Gao X, Wright F, Feramisco JD, Peltomäki P, Lang JC, Schuller DE, Yu L, Bloomfield C, Caligiuri M, Yates A, Nishikawa R, Su Huang H-J, Petrelli NJ, Zhang X, O’Dorisio MS, Held WA, Cavenee WK, Plass C. Aberrant CpG island methylation has non-random and tumor type specific patterns. Nature Genetics, 25:132-138, 2000.

  2. Raval A, Tanner S, Byrd J, Angerman E, Perko J, Chen S-S, Grever M, Lucas D, Matkovic J, Lin T, Kipps T, Murry F, Weisenburger D, Sanger W, Lynch J, Watson P, Jansen M, Yoshinaga Y, Rosenquist R, de Jong P, Coggill P, Beck S, Lynch H, de la Chapelle A, Plass C. Down-regulation of death associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell, 129:879-890, 2007.

  3. Claus R, Lucas DM, Stilgenbauer S, Ruppert AS, Yu L, Zucknick M, Mertens D, Bühler A, Oakes CC, Larson RA, Kay NE, Jelinek DF, Kipps TJ, Rassenti LZ, Gribben JG, Döhner H, Heerema NA, Marcucci G, Plass C, Byrd JC. Quantitative DNA Methylation Analysis Identifies a Single CpG Dinucleotide Important for ZAP-70 Expression and Predictive of Prognosis in Chronic Lymphocytic Leukemia. Journal of Clinical Oncology, 30:2483-2491, 2012.

  4. Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, Konermann C, Pfaff E, Tönjes M, Sill M, Bender S, Kool M, Zapatka M, Becker N, Zucknick M, Hielscher T, Liu XY, Fontebasso AM, Ryzhova M, Albrecht S, Jacob K, Wolter M, Ebinger M, Schuhmann MU, van Meter T, Frühwald MC, Hauch H, Pekrun A, Radlwimmer B, Niehues T, von Komorowski G, Dürken M, Kulozik AE, Madden J, Donson A, Foreman NK, Drissi R, Fouladi M, Scheurlen W, von Deimling A, Monoranu C, Roggendorf W, Herold-Mende C, Unterberg A, Kramm CM, Felsberg J, Hartmann C, Wiestler B, Wick W, Milde T, Witt O, Lindroth AM, Schwartzentruber J, Faury D, Fleming A, Zakrzewska M, Liberski PP, Zakrzewski K, Hauser P, Garami M, Klekner A, Bognar L, Morrissy S, Cavalli F, Taylor MD, van Sluis P, Koster J, Versteeg R, Volckmann R, Mikkelsen T, Aldape K, Reifenberger G, Collins VP, Majewski J, Korshunov A, Lichter P, Plass C*, Jabado N*, Pfister SM* (*joint corresponding authors). Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell, 22:425-437, 2012.

  5. Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann D, Dyckhoff G, Herold-Mende C, Grummt I*, Niehrs C*, Plass C* (*joint corresponding authors). Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A. Molecular Cell, 55:604-614, 2014
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