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Translational Lung Research Center Heidelberg

Ekkehard Grünig, M.D.

Professor for Internal Medicine at Heidelberg University

Head, Centre for Pulmonary Hypertension

Thoraxklinic at Heidelberg University Hospital
Amalienstr. 5

69126 Heidelberg

Tel.: 06221/396 8053
Fax: 06221/396 1209

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Research Interests:

  • Pulmonar hypertension
  • Genetics
  • Exercise training and rehabilitation
  • Echocardiography

Curriculum Vitae

1984-1987Research Fellow, Children's Hospital, University of Mainz, Germany
1988-1990Doctoral Candidate, Department of Cardiology, University of Heidelberg, Germany
1990-2003Internship, Residency, Consultant for Internal Medicine and Cardiology, University of Heidelberg, Germany
2004-2007Ass. Prof. for Internal Medicine, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany, Senior Physician
2008-Professor at the University of Heidelberg
2011-Head of the Division for Pulmonary Hypertension of the University of Heidelberg
2014-Principal Investigator of the Translational Lung Research Center Heidelberg (TLRC) and the German Center for lung Research (DZL)

 

 

Memberships/Committee Assignments

2003Member of the German PH-Registry Advisory Board
2002-2005Co-Coordinator of the European trial ”early diagnosis and genetics of primary pulmonary hypertension”
2003 
Task Force of Genetics of Pulmonary arterial hypertension, World Congress, Venice
2003 
Interdisciplinary working group for pulmonary hypertension of the German Society of Cardiology, Pneumology, and Cardiology for Children
2003 
Member of Task Force of the German Guidelines for Pulmonary Hypertension
2006 
Elected Member of the Steering-Committee of the European Project “Pulmotension”
2006
Elected Speaker of the Pulmonary Hypertension Working Group of the German Society of Cardiology
since 2008
Elected Speaker of the Working Group on Pulmonary Hypertension for Austria, Switzerland, Germany. In Germany, the working group is associated with the German Society of Cardiology, Pneumology and Pediatric Cardiology
2010Co-Speaker of the Pulmonary Hypertension Working Group of the German Society of Cardiology
2010Member of the task force of the German comment to the "European Guidelines for the diagnosis and treatment of pulmonary hypertension”
2012Steering Committee member of the CompERA-study
2012-2014Elected Speaker of the Pulmonary Hypertension Working Group of the German Society of Cardiology

 

 

Honours & Awards

1999

1st poster price for the supported project of the Medical Faculty Heidelberg, together with PD Dr. Bart Janssen, Institute of Human Genetics, Heidelberg
2005René-Baumgart award of the coworkers/working group Derliz Mereles, Nicola Ehlken and Sandra Kreuscher for their work „Exercise and Respiratory Training Improve Exercise Capacity and Quality of Life in Patients with Severe Chronic Pulmonary Hypertension“
2008Quality promotion award of Baden-Württemberg for "Training in Severe Pulmonary Hypertension"

 

 

Projects

  1. Effect of training in pulmonary hypertension in right ventricular contractile reserve
  2. Epigenetic effects of training in pulmonary hypertension
  3. Early identification and treatment of boderline PAH in systemic sclerosis
  4. Genetics of heritable pulmonary arterial hypertension

Team

Physicians

Dr. Benjamin Egenlauf

Tel.:+49(0)6221 396 8078

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Dr. Satenik Harutyunova

Tel.: +49(0)6221 396 8025

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Consultants

Dr. Christian Nagel

Tel.: +49(0)6221 396 8063

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Study coordinator / biometrician

BSc Nicola Benjamin

Tel.: +49(0)6221 396 8076

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Microbiologist

Dr. Christina Eichstaedt

Tel.: +49(0)6221 396 1221

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Ph-Nurses

Andrea Servatius

Tel.: +49(0)6221 396 8083

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Alisa Eisert

Tel.: +49(0)6221 396 8235

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Study Nurses

Lena Geiger

Tel.: +49(0)6221 396 8230

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Eva-Maria Heier

Tel.: +49(0)6221 396 8234

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Katharina Ziegler

Tel.: +49(0)6221 396 8236

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Selected Publications

  1. Ghofrani HA, Galiè N, Grimminger F, Grünig E, Humbert M, Jing ZC, Keogh AM, Langleben D, Kilama MO, Fritsch A, Neuser D, Rubin LJ; PATENT-1 Study Group. Riociguat for the treatment of pulmonary arterial hypertension. N Engl J Med. 2013;369(4):330-40.
  2. Ghofrani HA, D'Armini AM, Grimminger F, Hoeper MM, Jansa P, Kim NH, Mayer E, Simonneau G, Wilkins MR, Fritsch A, Neuser D, Weimann G, Wang C; CHEST-1 Study Group. Riociguat for the treatment of chronic thromboembolic pulmonary hypertension. N Engl J Med. 2013;369(4):319-29.
  3. Pulido T, Adzerikho I, Channick RN, Delcroix M, Galiè N, Ghofrani HA, Jansa P, Jing ZC, Le Brun FO, Mehta S, Mittelholzer CM, Perchenet L, Sastry BK, Sitbon O,  Souza R, Torbicki A, Zeng X, Rubin LJ, Simonneau G; SERAPHIN Investigators. Macitentan and morbidity and mortality in pulmonary arterial hypertension. N Engl J Med. 2013;369(9):809-18.
  4. Grünig E, Tiede H, Enyimayew EO, Ehlken N, Seyfarth HJ, Bossone E, D'Andrea A, Naeije R, Olschewski H, Ulrich S, Nagel C, Halank M, Fischer C. Assessment and Prognostic Relevance of Right Ventricular Contractile Reserve in Patients with Severe Pulmonary Hypertension. Circulation. 2013; 128(18):2005-15.
  5. Hoeper MM, Barst RJ, Bourge RC, Feldman J, Frost AE, Galié N, Gómez-Sánchez MA, Grimminger F, Grünig E, Hassoun PM, Morrell NW, Peacock AJ, Satoh T, Simonneau G, Tapson VF, Torres F, Lawrence D, Quinn DA, Ghofrani HA. Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study. Circulation. 2013;127(10):1128-38.
  6. Grünig E, Weissmann S, Ehlken N, Fijalkowska A, Fischer C, Fourme T, Galié N, Ghofrani A, Harrison RE, Huez S, Humbert M, Janssen B, Kober J, Koehler R, Machado RD, Mereles D, Naeije R, Olschewski H, Provencher S, Reichenberger F, Retailleau K, Rocchi G, Simonneau G, Torbicki A, Trembath R, Seeger W. Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxia. Circulation. 2009;119(13):1747-57.
  7. Dehnert C, Bärtsch P, Grünig E, Mereles D. High-altitude pulmonary edema and  patent foramen ovale. JAMA. 2007;297(13):1432.
  8. Mereles D, Ehlken N, Kreuscher S, Ghofrani S, Hoeper MM, Halank M, Meyer FJ, Karger G, Buss J, Juenger J, Holzapfel N, Opitz C, Winkler J, Herth FF, Wilkens H, Katus HA, Olschewski H, Grünig E. Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension. Circulation. 2006;114(14):1482-9.
  9. Machado RD, Aldred MA, James V, Harrison RE, Patel B, Schwalbe EC, Gruenig E, Janssen B, Koehler R, Seeger W, Eickelberg O, Olschewski H, Elliott CG, Glissmeyer E, Carlquist J, Kim M, Torbicki A, Fijalkowska A, Szewczyk G, Parma J, Abramowicz MJ, Galie N, Morisaki H, Kyotani S, Nakanishi N, Morisaki T, Humbert M, Simonneau G, Sitbon O, Soubrier F, Coulet F, Morrell NW, Trembath RC. Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension. Hum Mutat. 2006;27(2):121-32.
  10. Grünig E, Janssen B, Mereles D, Barth U, Borst MM, Vogt IR, Fischer C, Olschewski H, Kuecherer HF, Kübler W. Abnormal pulmonary artery pressure response in asymptomatic carriers of primary pulmonary hypertension gene. Circulation. 2000;102(10):1145-50.
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