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Translational Lung Research Center Heidelberg

Prof. Dr. Roland Eils

Division Head “Theoretical Bioinformatics” (DKFZ) and Ordinarius of Bioinformatics and Functional Genomics (Heidelberg University), Acting Director BioQuant

DKFZ
Im Neuenheimer Feld 267
69120 Heidelberg

Phone:+49 6221 54-51290
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Research Interests:

  • Genome and Epigenome Sequencing Approaches
  • Integration of Tools from Mathematical Modeling, Image analysis and Informatics into Life Science Research
  • Systems Biology of Cellular Death Pathways
  • Advanced Life Cell Imaging and Automated Image Processing

Curriculum Vitae

1996-1997Guest researcher at the Institut Albert Bonniot, Université Grenoble, France (Host: Prof. M. Robert-Nicoud, Faculty of medicine).
1997-1999Head of the biocomputing group „Structure and function in cell biology“, IWR, Heidelberg University, Germany
2000Head of the Biofuture junior group „Intelligent bioinformatics systems“ at the German Cancer Research Center (dkfz)
Since 2002Head of division „Theoretical Bioinformatics“ at the German Cancer Research Center (dkfz), Heidelberg
2002Appointed director of department “Bioinformatics and Functional Genomics” and full professor (C4) at Heidelberg University
Since 2006/2011Founding / Acting director of BIOQUANT- Centre for Quantitative Biology, Heidelberg University (~250 scientists in 20 research groups).
2010-2011Visiting Professor at Harvard Medical School, Harvard University



Speciality certification

1984-1990Mathematics and Computer Science, RWTH Aachen (M.Sc. (Diplom), first class)
1988-1990Southeast Asian Languages, Universities of Bonn and Cologne
1990-1992Southeast Asian Languages, Universitas Padjadjaran, Bandung, Indonesia
Oct. 1992- Sept. 1995Ph.D. study at University of Heidelberg (Ruprecht-Karl-Universität Heidelberg); Specialization: Mathematics and Scientific Computing (PhD in Mathematics, first class)

 

 

Memberships/Committee Assignments

2007-2012Coordinator of the Helmholtz Alliance on Systems Biology (50 million € for five six years, program initiated by Helmholtz prize awarded to Roland Eils)
Since 2008-2011 Speaker of BMBF funded program FORSYS - German Research Units for Systems Biology
Since 2009/2011Co-coordinator (together with Peter Lichter) of the German PedBrain consortium within the International Cancer Genome Consortium (ICGC), Coordination of Data Management and Analysis for two further contributions to the ICGC
2012-2014Coordinator Helmholtz Initiative on Synthetic Biology



Honours & Awards

June 1999BioFuture prize from the German Ministry for Education and Research (approx. 1.2 million €; most prestigious German prize for young researchers in the life sciences)
2002/2003 Nominated for full professor positions (C4) at University of Giessen, University of Bonn (both not realized) and Heidelberg University
2005Microsoft Research Award “Computational tools for advancing science”
2005Award for new innovative research by Helmholtz Association: “Systems Biology of Complex Diseases”
2006Nominated for full professor positions at the University of Manchester and University College Dublin (the latter combined with directorship of the Centre for Complex Adaptive Systems); both not realized
2011Nominated for Program Director and Full Professor for Quantitative Biology at Cold Spring Harbor Laboratory, New York
2014HMLS (Heidelberg Molecular Life Sciences) Investigator Award

 

 

Projects

Epigenetic reprogramming by environmental exposure and consequence for disease riskEpigenetic mechanisms have emerged as potential links between prenatal environmental exposure and increased disease risk later in life. Based on the unique LINA-mother-child cohort (Junge et al., 2014 Clinical Immunology; Weisse et al., 2013 Allergy), which is managed by our collaboration partners at the UFZ in Leipzig  we study epigenetic changes induced by maternal environmental exposure at base pair resolution by mapping DNA methylation, histone modifications and transcription in expectant mothers and newborn children. Based on longitudinal whole genome bisulfite sequencing we study the induction of DNA methylation changes in mothers and childen through maternal exposure or other factors such as Vitamin D levels (Junge et al., 2015 Journal of Allergy and Clinical Immunology). We have shown that those changes are conserved over years of life and might contribute to disease risks later in life. The observed differential methylation leads to multiple, regulatory interactions with distal genes. We also observe that epigenetic deregulation is associated with an increased risk for lung disease in children.

 

Junge, K.M., Bauer, T., Geissler, S., Hirche, F., Thurmann, L., Bauer, M., Trump, S., Bieg, M., Weichenhan, D., Gu, L., Mallm, J.P., Ishaque, N., Mucke, O., Roder, S., Herberth, G., Diez, U., Borte, M., Rippe, K., Plass, C., Hermann, C., Stangl, G.I., Eils, R., & Lehmann, I. (2015). Increased vitamin D levels at birth and in early infancy increase offspring allergy risk-evidence for involvement of epigenetic mechanisms. Journal of Allergy and Clinical Immunology. doi: 10.1016/j.jaci.2015.06.040

 

Junge, K.M., Hornig, F., Herberth, G., Roder, S., Kohajda, T., Rolle-Kampczyk, U., von Bergen, M., Borte, M., Simon, J.C., Heroux, D., Denburg, J.A., & Lehmann, I. (2014). The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy. Clinical Immunology, 152(1-2), 68-76. doi: 10.1016/j.clim.2014.02.013

 

Weisse, K., Winkler, S., Hirche, F., Herberth, G., Hinz, D., Bauer, M., Roder, S., Rolle-Kampczyk, U., von Bergen, M., Olek, S., Sack, U., Richter, T., Diez, U., Borte, M., Stangl, G.I., & Lehmann, I. (2013). Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. Allergy, 68(2), 220-228. doi: 10.1111/all.12081

 

 

Patents

Puplication No.Publications DateInventor/ApplicantTitle
202014003175.428.05.2015Eils, GladilinMikropresse zur Hochdurchsatzerfassung von mechanischen Zelleigenschaften
PCT/EP2014/071155not yet publishedNiopek, Eils, et al.Non-ribosomal protein synthesis pigment fusion peptides
EP 15186957.5not yet publishedEils, Liesche, BeaudouinDEATH RECEPTOR-BASED SELECTION MARKER

 

 

Team

Further Information Opens external link in new windowhere

Selected Publications

  1. Junge, K.M., Bauer, T., Geissler, S., Hirche, F., Thurmann, L., Bauer, M., Trump, S., Bieg, M., Weichenhan, D., Gu, L., Mallm, J.P., Ishaque, N., Mucke, O., Roder, S., Herberth, G., Diez, U., Borte, M., Rippe, K., Plass, C., Hermann, C., Stangl, G.I., Eils, R., & Lehmann, I.@ (2015). Increased vitamin D levels at birth and in early infancy increase offspring allergy risk-evidence for involvement of epigenetic mechanisms. Journal of Allergy and Clinical Immunology. doi: 10.1016/j.jaci.2015.06.040
  2.  Gu, L., Frommel, S.C., Oakes, C.C., (…), Eils, R. @, Plass, C. @, & Santoro, R. @ (2015). BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence. Nature Genetics , 47. doi:10.1038/ng.3165
  3. Niopek, D., Benzinger, D., Roensch, J., Draebing, T., Wehler, P., Eils, R.@, & Di Ventura, B.@ (2014). Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells. Nature Communications, 5. doi: 10.1038/ncomms5404
  4. Kallenberger, S. M., Beaudouin, J., Claus, J., Fischer, C., Sorger, P. K., Legewie, S., & Eils, R.@ (2014). Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis. Science Signaling, 7(316), ra23-. doi: 10.1126/scisignal.2004738
  5. Jäger, N., Schlesner, M., Jones, D. T. W., (…), & Eils, R.@ (2013). Hypermutation of the inactive X chromosome is a frequent event in cancer. Cell, 155 1-15, 201. doi: 10.1016/j.cell.2013.09.042
  6. Jones, D. T., Hutter, B., Jäger, N., (…)., Eils, R.@, Lichter, P@., the International Cancer Genome Consortium PedBrain Tumor, P., & Pfister, S. M. (2013). Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nature Genetics, 45(8), 927-932. doi: 10.1038/ng.2682
  7. Jones, D. T. W., Jäger, N., (…)., Eils, R.@, Pfister, S. @ M., & Lichter, P. @ (2012). Dissecting the genomic complexity underlying medulloblastoma. Nature, 488(7409), 100-105. doi: 10.1038/Nature11284
  8. Neumann, L., Pforr, C., Beaudouin, J., Pappa, A., Fricker, N., Krammer, P. H., Lavrik, I. N., & Eils, R.@ (2010). Dynamics within the CD95 death-inducing signaling complex decide life and death of cells. Molecular Systems Biology, 6, 352. doi: 10.1038/msb.2010.6
  9. Busch, H., Camacho-Trullio, D., Rogon, Z., Breuhahn, K., Angel, P., Eils, R.@, & Szabowski, A.@ (2008). Gene network dynamics controlling keratinocyte migration. Molecular Systems Biology, 4, 199. doi: 10.1038/msb.2008.36
  10. Bacher, C.P., Guggiari, M., Brors, B., Augui, S., Clerc, P., Avner, P., Eils, R.@, and Heard, E. @ (2006). Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Nature Cell Biology 8, 293-299. doi: 10.1038/ncb1365
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