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Translational Lung Research Center Heidelberg

Ursula Klingmüller, Ph.D.

Professor of Systems Biology of Signal Transduction
Head of the Division Systems Biology of Signal Transduction, German Cancer Research Center (DKKFZ)
Scientific Co-coordinator of the Disease Area Lung Cancer of the German Center for Lung Research (DZL)
   
Division of Systems Biology of Signal Transduction
German Cancer Research Center (DKFZ)
Im Neuenheimer Feld 280
69120 Heidelberg
Tel: +49 (0) 6221 42-4481
Fax: +49 (0) 6221 42-4488
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Research Interests:

  • Systems biology of signal transduction
  • Quantitative analysis of information processing
  • Identification of key regulatory mechanisms
  • Prediction of strategies for effective intervention in cancer

 

 

Short CV

1985Bachelor of Science, University of Bayreuth, Germany
1988Diploma in molecular biology, cell biology and virology, University of Heidelberg, Germany
1992Graduate studies at the University of Heidelberg, Doctoral Thesis (summa cum laude), Center for Molecular Biology Heidelberg (ZMBH)
1992-1993Postdoctoral fellow, Harvard Medical School, Boston, USA
1993-1996Postdoctoral Fellow, Whitehead Institute for Biomedical Research, Cambridge, USA  
1996-2003Group leader of an independent junior group (Hans-Spemann-Laboratories), Max-Planck-Institute for Immunbiology, Freiburg, Germany
2000Habilitation and Venia Legendi in Molecular Biology and Genetics, University of Freiburg, Germany
2003-2007Leader of the Boveri-Group ‘Systems Biology of Signal Transduction’, German Cancer Research Center (DKFZ), Heidelberg, Germany
2004Venia Legendi in Cell Biology, University of Heidelberg, Germany
2007–Head of the division ‘Systems Biology of Signal Transduction’, German Cancer Research Center (DKFZ), Heidelberg, Germany
2011-W3 Professor - Systems Biology of Signal Transduction, University of Heidelberg, Germany
2012-Principal Investigator of the Translational Lung Research Center Heidelberg (TLRC) and the German Center for Lung Research (DZL)

 

 

Honours & Awards

1997FEBS Anniversary Prize
2004R. Eils, U. Klingmüller, O. Wiestler, E. Wanker,. A.-P. Zeng, R. Balling. ‘Systems Biology of Complex Diseases’ Ideenwettbewerb Helmholtz Association
2007-Board of Trustees German Cancer Research Center (DKFZ), Member of board of directors of the DKFZ-ZMBH Alliance

 

 

Memberships/Committee Assignments

2012-Elected Member of the  German Research Foundation (DFG) "Hinterzartner Kreis"

Projects

Current research activities cover three main topics:

  1. Unraveling principal mechanisms of erythropoietin (Epo) mediated cellular decisions in the hematopoietic system. Our aim is to develop strategies for the establishment of an integrative mathematical model comprising signal transduction, gene regulation and physiological responses of Epo in hematopoietic system and to unravel general design principles controlling cellular decisions. This knowledge will enable the design of strategies for the targeted expansion of erythroid progenitor cells to counteract anemia.

  2. Bridging from the cellular to the whole organ level during liver regeneration. Within the network Virtual Liver we are currently establishing integrative models addressing pathway crosstalk, regulation through microRNAs and cell-cell communication. A main goal of the Virtual Liver is to link data-based mathematical models across scales to establish a reliable framework to quantitatively predict physiological responses of the liver.

  3. Insights into altered regulation in lung cancer and prediction of strategies for efficient intervention. In the CancerSys network LungSysII and the DZL we are addressing the dynamics of signaling pathways at the cell population and single cell level in close collaboration with clinicians and partners from companies. This will be performed in lung cancer cell lines representative for key alterations observed in lung cancer, which are cultivated either in monolayer, as spheroid or xenograft. By integrating dynamic pathway models, spatio-temporal models and multi-scale models, our aim is to link the extent of pathway activation to migratory and proliferative decisions and thereby unravel mechanisms promoting early spread in lung cancer.

Team

Post-doctoral fellows
Dr. Marcel Schilling
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Dr. Sofia Depner
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Dr. Lorenza D`Alessandro
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Dr. Agustin Rodriguez
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Dr. Fransziska Herrmann
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Dr. Stephanie Müller
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Dr. Marie-Christine Wagner
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PhD Students
Lorenz Adlung
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Svantje Braun
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Sajib Chakraborty
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Dmytro    Dvornikov
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Xiaoyun Huang
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Nao Iwamoto
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Frédérique Kok
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Philippe Lucarelli    
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Ruth Merkle
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Florian Salopiata    
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Tibor Szekeres    
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Katharina Waldow    
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Technical and IT Support
Markus Stepath
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Technical Assistants
Susen Lattermann    
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Sandra Manthey    
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Secretariat
Martina Kegel
Phone: +49 (0) 6221 42–4486    
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Selected Publications

  1. Swameye, I., Müller, T. G., Timmer, J., Sandra, O., and Klingmüller, U., Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by data-based dynamic modeling. Proc. Natl. Acad. Sci. USA (2003), 100:1028-33.

  2. Schilling, M., Maiwald, T., Hengl, S., Winter, D., Kolch, W., Lehmann, W. D., Timmer, J., and Klingmüller, U., Combined Theoretical and Experimental Analysis Links Isoform-specific MAP-kinase Signaling to Cellular Decisions. Molecular Systems Biology (2009), 5:334.

  3. Becker, V., Schilling, M., Bachmann, J., Baumann, U., Raue, A., Maiwald, T., Timmer, J., and Klingmüller, U., Covering a Broad Dynamic Range – Information Processing at the Erythropoietin Receptor. Science (2010) 328(5984):1404-1408.

  4. Bachmann, J., Raue, A., Schilling, M., Boehm, ME., Kreutz, C., Kaschek, D., Busch, H., Gretz, N., Lehmann, WD., Timmer, J., Klingmüller, U. Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Molecular Systems Biology (2011) 7, Art.Nr. 516.

  5. Raia, V., Schilling, M., Böhm, M., Hahn, B., Kowarsch, A., Raue, A., Sticht, C., Bohl, S., Saile, M., Möller, P., Gretz, N., Timmer, J., Theis, F., Lehmann, WD., Lichter, P., and Klingmüller, U. Dynamic Mathematical Modeling of IL13-induced Signaling in Hodgkin and Primary Mediastinal B-cell Lymphoma Allows Prediction of Therapeutic Targets. Cancer Research (2011), 71(3), 693-704
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