zurück zur Startseite
Zentrale Tel.: 06221-560
SFB 1118

Overview project areas and subprojects

 

A-projects 

Identify and describe those pathways that are dysregulated in diabetes and lead to increased formation and accumulation of reactive metabolites and associated post-translational modifications. 

 

B-projects 

Determine the mechanism of action of reactive metabolites in the development and progression of later diabetic complications.

  

C-projects 

Identify pathways controlled which can reduce or prevent the formation, accumulation and subsequent biological consequences of reactive metabolites and associated post-translational modifications in diabetes.

 

 

Project

Title

Research Areas

Principal Investigator, Institute(s), Location(s)

A01

Post-translational modification of transcriptional co-factors through reactive metabolites in the promotion of diabetic late complications

Medicine

Biology

Molecular biology

Herzig

Institute for Diabetes and Cancer IDC
Helmholtz Center Munich, Munich /
Joint Heidelberg-IDC Translational Diabetes Program
Heidelberg University Hospital, Heidelberg

A02

Iron overload as a cause and consequence of the reactive metabolites-induced diabetic late complications

Medicine

Biochemistry

Cell biology

Muckenthaler

Medical Faculty HD

Department of Internal
Medicine I and Clinical Chemistry, Heidelberg

A03

Regulation of MG detoxification via Glo1 and its physiological impact

Biochemistry

Developmental biology

Teleman

German Cancer Research Center (DKFZ) Heidelberg

A04

The Importance of Enzymatic Regulation of Methylglyoxal Metabolism in Diabetic Neuropathy

Medicine

Biochemistry

 

Fleming / Nawroth

Medical Faculty HD

Department of Internal
Medicine I and Clinical Chemistry, Heidelberg

B01

Reactive metabolite induced posttranslational protein modifications and its influence on blood vessel formation and functionh

Vascular biology,
Vascular signal transduction,
Model organism zebrafish

Kroll

Medical Faculty MA,

CBTM Mannheim

B02

Role of TRPC and TRPM channels in reactive metabolites induced development of late diabetic complications

Medicine

Pharmacology and Toxicology

Freichel

Institute of  Pharmacology

Heidelberg

B03

The role of CaMKII for diabetic nephropathy

Experimental

Medicine

Backs/Müller

Medical Faculty HD, Internal Medicine III, Heidelberg

B04

Regulation of endothelial aquaporin-1 channels by reactive glucose metabolites

– project closed –

Medicine

Nephrology

 

Schwenger

new affiliation:
Klinikum Stuttgart – Katharinenhospital
Klinik für Nieren- u. Hochdruckkrankheiten
Transplantationszentrum Stuttgart

B05

In vivo characterization of the role of reactive metabolites in diabetic neuropathy using MRI techniques- from bed to benchside and back

Physics

Medical physics

Radiology

Heiland / Bendszus

Medical Faculty HD

Neuroradiology

B06

Functional roles and mechanisms of ROS-dependent sumoylation in diabetic neuropathy

Pharmaceutical technology

Pharmakology and Toxicology /

Biotechnology

Kuner / Agarwal

Institute of Pharmacology, Heidelberg

C03

Glucose and reactive metabolites in the diabetic retina -
Approaches to the prevention of vasoregression

Medicine

Endocrinology

Hammes

Medical Faculty MA, Medical Clinic V, Mannheim

C04

Reactive metabolites in the progression of the diabetic tubulopathy and its association to mitochondrial dysfunction und lipid droplets

Pathology

Biochemistry

 

Hoffmann/ Gröne

Medical research Center, Medical Faculty MA and German Cancer Research Center (DKFZ), Division of Cellular and Molecular Pathology Heidelberg

C05

Regulation of carnosine-metabolism by reactive metabolites in diabetic nephropathye

Medicine

Biology

Cell biology/

Pediatrics

Peters / Schmitt

Centre of Pediatrics and Youth Medicine Heidelberg

C06

The role of ATIC at the interface between cellular repair and damage caused by reactive metabolites

Medicine

Endocrinology

Nawroth / Mendler

Medical Faculty HD

Department of Internal
Medicine I and Clinical Chemistry, Heidelberg

S01

Analytical Platform

LC-MS/MS Core Facility

 

 

Fleming

Medical Faculty HD,

Department of Internal
Medicine I and Clinical Chemistry, Heidelberg

S02

Pathological and Biomaterial Platform

Biomaterialbank

 

 

Herpel

Institute of Pathology Heidelberg

Z

Central tasks

 

 

Nawroth

Medical Faculty HD

Department of Internal
Medicine I and Clinical Chemistry, Heidelberg

Select languageSelect language
Print Diese Seite per E-Mail weiterempfehlen