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Projekt K - Platten/Wick

Opens external link in new windowConstitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR.

Litzenburger UM, Opitz CA, Sahm F, Rauschenbach KJ, Trump S, Winter M, Ott M, Ochs K, Lutz C, Liu X, Anastasov N, Lehmann I, Höfer T, von Deimling A, Wick W, Platten M.

Oncotarget. 2014 Feb 28;5(4):1038-51.
Opens external link in new windowmTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy.

Weiler M, Blaes J, Pusch S, Sahm F, Czabanka M, Luger S, Bunse L, Solecki G, Eichwald V, Jugold M, Hodecker S, Osswald M, Meisner C, Hielscher T, Rübmann P, Pfenning PN, Ronellenfitsch M, Kempf T, Schnölzer M, Abdollahi A, Lang F, Bendszus M, von Deimling A, Winkler F, Weller M, Vajkoczy P, Platten M, Wick W.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):409-14. doi:
10.1073/pnas.1314469111. Epub 2013 Dec 23.

Opens external link in new windowThe endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress.

Sahm F, Oezen I, Opitz CA, Radlwimmer B, von Deimling A, Ahrendt T, Adams S, Bode HB, Guillemin GJ, Wick W, Platten M.

Cancer Res. 2013 Apr 2.

Opens external link in new windowAn endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. (PubMed)


Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, Schumacher T, Jestaedt L, Schrenk D, Weller M, Jugold M, Guillemin GJ, Miller CL, Lutz C, Radlwimmer B, Lehmann I, von Deimling A, Wick W, Platten M.


Nature. 2011 Oct 5;478(7368):197-203. doi: 10.1038/nature10491.





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