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Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Volkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schafer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londono JEC, Meder B, Freichel M, Grone HJ, Most P, Muller OJ, Herzig S, Furlong EEM, Katus HA, Backs J. A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway. Nat Med. 2018;24:62-72

Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Grone HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A. Inhibition of endothelial notch signaling impairs fatty acid transport and leads to metabolic and vascular remodeling of the adult heart. Circulation. 2018

Siede D, Rapti K, Gorska AA, Katus HA, Altmuller J, Boeckel JN, Meder B, Maack C, Volkers M, Muller OJ, Backs J, Dieterich C. Identification of circular rnas with host gene-independent expression in human model systems for cardiac differentiation and disease. J Mol Cell Cardiol. 2017;109:48-56

Seyler C, Scherer D, Kopple C, Kulzer M, Korkmaz S, Xynogalos P, Thomas D, Kaya Z, Scholz E, Backs J, Karle C, Katus HA, Zitron E. Role of plasma membrane-associated akaps for the regulation of cardiac ik1 current by protein kinase a. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:493-503

Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW. G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. PLoS One. 2017;12:e0182110

Neef S, Heijman J, Otte K, Dewenter M, Saadatmand AR, Meyer-Roxlau S, Antos CL, Backs J, Dobrev D, Wagner M, Maier LS, El-Armouche A. Chronic loss of inhibitor-1 diminishes cardiac ryr2 phosphorylation despite exaggerated camkii activity. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:857-862

Meder B, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Frese K, Lai A, Nietsch R, Scheiner C, Mester S, Bordalo DM, Amr A, Dietrich C, Pils D, Siede D, Hund H, Bauer A, Holzer DB, Ruhparwar A, Mueller-Hennessen M, Weichenhan D, Plass C, Weis T, Backs J, Wuerstle M, Keller A, Katus HA, Posch AE. Epigenome-wide association study identifies cardiac gene patterning and a novel class of biomarkers for heart failure. Circulation. 2017;136:1528-1544

Dewenter M, von der Lieth A, Katus HA, Backs J. Calcium signaling and transcriptional regulation in cardiomyocytes. Circ Res. 2017;121:1000-1020

Dewenter M, Neef S, Vettel C, Lammle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A. Calcium/calmodulin-dependent protein kinase ii activity persists during chronic beta-adrenoceptor blockade in experimental and human heart failure. Circ Heart Fail. 2017;10:e003840

Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schafer M, Wurtz CM, Neef S, Voigt N, Baczko I, Varro A, Muller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T. Nucleoside diphosphate kinase-c suppresses camp formation in human heart failure. Circulation. 2017;135:881-897

Sawall S, Franke D, Kirchherr A, Beckendorf J, Kuntz J, Maier J, Kraupner A, Backs J, Briel A, Kachelriess M. In vivo quantification of myocardial infarction in mice using micro-ct and a novel blood pool agent. Contrast Media Mol Imaging. 2017;2017:2617047

Spaich S, Zelniker T, Endres P, Stiepak J, Uhlmann L, Bekeredjian R, Chorianopoulos E, Giannitsis E, Backs J, Katus HA, Preusch MR. Fibroblast growth factor 23 (fgf-23) is an early predictor of mortality in patients with cardiac arrest. Resuscitation. 2016;98:91-96

Scherer D, Seyler C, Xynogalos P, Scholz EP, Thomas D, Backs J, Andrassy M, Volkers M, Karle CA, Katus HA, Zitron E. Inhibition of cardiac kir current (ik1) by protein kinase c critically depends on pkcbeta and kir2.2. PLoS One. 2016;11:e0156181

Schafer M, Oeing CU, Rohm M, Baysal-Temel E, Lehmann LH, Bauer R, Volz HC, Boutros M, Sohn D, Sticht C, Gretz N, Eichelbaum K, Werner T, Hirt MN, Eschenhagen T, Muller-Decker K, Strobel O, Hackert T, Krijgsveld J, Katus HA, Berriel Diaz M, Backs J, Herzig S. Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia. Mol Metab. 2016;5:67-78

Saddouk FZ, Sun LY, Liu YF, Jiang M, Singer DV, Backs J, Van Riper D, Ginnan R, Schwarz JJ, Singer HA. Ca2+/calmodulin-dependent protein kinase ii-gamma (camkiigamma) negatively regulates vascular smooth muscle cell proliferation and vascular remodeling. FASEB J. 2016;30:1051-1064

Kreusser MM, Lehmann LH, Wolf N, Keranov S, Jungmann A, Grone HJ, Muller OJ, Katus HA, Backs J. Inducible cardiomyocyte-specific deletion of cam kinase ii protects from pressure overload-induced heart failure. Basic Res Cardiol. 2016;111:65

Zhang M, Hagenmueller M, Riffel JH, Kreusser MM, Bernhold E, Fan J, Katus HA, Backs J, Hardt SE. Calcium/calmodulin-dependent protein kinase ii couples wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy. Hypertension. 2015;65:335-344

Spinelli AM, Liu Y, Sun LY, Gonzalez-Cobos JC, Backs J, Trebak M, Singer HA. Smooth muscle camkiidelta promotes allergen-induced airway hyperresponsiveness and inflammation. Pflugers Arch. 2015;467:2541-2554

Spaich S, Katus HA, Backs J. Ongoing controversies surrounding cardiac remodeling: Is it black and white-or rather fifty shades of gray? Front Physiol. 2015;6:202

Mollova MY, Katus HA, Backs J. Regulation of camkii signaling in cardiovascular disease. Front Pharmacol. 2015;6:178

Werfel S, Jungmann A, Lehmann L, Ksienzyk J, Bekeredjian R, Kaya Z, Leuchs B, Nordheim A, Backs J, Engelhardt S, Katus HA, Muller OJ. Rapid and highly efficient inducible cardiac gene knockout in adult mice using aav-mediated expression of cre recombinase. Cardiovasc Res. 2014;104:15-23

Weinreuter M, Kreusser MM, Beckendorf J, Schreiter FC, Leuschner F, Lehmann LH, Hofmann KP, Rostosky JS, Diemert N, Xu C, Volz HC, Jungmann A, Nickel A, Sticht C, Gretz N, Maack C, Schneider MD, Grone HJ, Muller OJ, Katus HA, Backs J. Cam kinase ii mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury. EMBO Mol Med. 2014;6:1231-1245

Lehmann LH, Worst BC, Stanmore DA, Backs J. Histone deacetylase signaling in cardioprotection. Cell Mol Life Sci. 2014;71:1673-1690

Lehmann LH, Stanmore DA, Backs J. The role of endothelin-1 in the sympathetic nervous system in the heart. Life Sci. 2014;118:165-172

Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Luscher TF, Schneider MD, Parlato R, Grone HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Essential role of sympathetic endothelin a receptors for adverse cardiac remodeling. Proc Natl Acad Sci U S A. 2014;111:13499-13504

Kreusser MM, Lehmann LH, Keranov S, Hoting MO, Oehl U, Kohlhaas M, Reil JC, Neumann K, Schneider MD, Hill JA, Dobrev D, Maack C, Maier LS, Grone HJ, Katus HA, Olson EN, Backs J. Cardiac cam kinase ii genes delta and gamma contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy. Circulation. 2014;130:1262-1273

Kreusser MM, Backs J. Integrated mechanisms of camkii-dependent ventricular remodeling. Front Pharmacol. 2014;5:36

Fredman G, Ozcan L, Spolitu S, Hellmann J, Spite M, Backs J, Tabas I. Resolvin d1 limits 5-lipoxygenase nuclear localization and leukotriene b4 synthesis by inhibiting a calcium-activated kinase pathway. Proc Natl Acad Sci U S A. 2014;111:14530-14535

Dybkova N, Wagner S, Backs J, Hund TJ, Mohler PJ, Sowa T, Nikolaev VO, Maier LS. Tubulin polymerization disrupts cardiac beta-adrenergic regulation of late ina. Cardiovasc Res. 2014;103:168-177

Scott JA, Klutho PJ, El Accaoui R, Nguyen E, Venema AN, Xie L, Jiang S, Dibbern M, Scroggins S, Prasad AM, Luczak ED, Davis MK, Li W, Guan X, Backs J, Schlueter AJ, Weiss RM, Miller FJ, Anderson ME, Grumbach IM. The multifunctional ca(2)(+)/calmodulin-dependent kinase iidelta (camkiidelta) regulates arteriogenesis in a mouse model of flow-mediated remodeling. PLoS One. 2013;8:e71550

Ozcan L, Cristina de Souza J, Harari AA, Backs J, Olson EN, Tabas I. Activation of calcium/calmodulin-dependent protein kinase ii in obesity mediates suppression of hepatic insulin signaling. Cell Metab. 2013;18:803-815

Neef S, Sag CM, Daut M, Baumer H, Grefe C, El-Armouche A, DeSantiago J, Pereira L, Bers DM, Backs J, Maier LS. While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in camkiidelta-ko mice. J Mol Cell Cardiol. 2013;59:107-116

Liesz A, Zhou W, Na SY, Hammerling GJ, Garbi N, Karcher S, Mracsko E, Backs J, Rivest S, Veltkamp R. Boosting regulatory t cells limits neuroinflammation in permanent cortical stroke. J Neurosci. 2013;33:17350-17362

Hohl M, Wagner M, Reil JC, Muller SA, Tauchnitz M, Zimmer AM, Lehmann LH, Thiel G, Bohm M, Backs J, Maack C. Hdac4 controls histone methylation in response to elevated cardiac load. J Clin Invest. 2013;123:1359-1370

Hamdani N, Krysiak J, Kreusser MM, Neef S, Dos Remedios CG, Maier LS, Kruger M, Backs J, Linke WA. Crucial role for ca2(+)/calmodulin-dependent protein kinase-ii in regulating diastolic stress of normal and failing hearts via titin phosphorylation. Circ Res. 2013;112:664-674

Haas J, Frese KS, Park YJ, Keller A, Vogel B, Lindroth AM, Weichenhan D, Franke J, Fischer S, Bauer A, Marquart S, Sedaghat-Hamedani F, Kayvanpour E, Kohler D, Wolf NM, Hassel S, Nietsch R, Wieland T, Ehlermann P, Schultz JH, Dosch A, Mereles D, Hardt S, Backs J, Hoheisel JD, Plass C, Katus HA, Meder B. Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Mol Med. 2013;5:413-429

Sun Q, Sattayakhom A, Backs J, Stremmel W, Chamulitrat W. Role of myocyte enhancing factor 2b in epithelial myofibroblast transition of human gingival keratinocytes. Exp Biol Med (Maywood). 2012;237:178-185

Spaich S, Will RD, Just S, Spaich S, Kuhn C, Frank D, Berger IM, Wiemann S, Korn B, Koegl M, Backs J, Katus HA, Rottbauer W, Frey N. F-box and leucine-rich repeat protein 22 is a cardiac-enriched f-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo. Circ Res. 2012;111:1504-1516

Scott JA, Xie L, Li H, Li W, He JB, Sanders PN, Carter AB, Backs J, Anderson ME, Grumbach IM. The multifunctional ca2+/calmodulin-dependent kinase ii regulates vascular smooth muscle migration through matrix metalloproteinase 9. Am J Physiol Heart Circ Physiol. 2012;302:H1953-1964

Ozcan L, Wong CC, Li G, Xu T, Pajvani U, Park SK, Wronska A, Chen BX, Marks AR, Fukamizu A, Backs J, Singer HA, Yates JR, 3rd, Accili D, Tabas I. Calcium signaling through camkii regulates hepatic glucose production in fasting and obesity. Cell Metab. 2012;15:739-751

Muller OJ, Katus HA, Backs J. Macrovascular disease in diabetes: Is the mouse a suitable model? Exp Clin Endocrinol Diabetes. 2012;120:194-196

Kuhn C, Frank D, Dierck F, Oehl U, Krebs J, Will R, Lehmann LH, Backs J, Katus HA, Frey N. Cardiac remodeling is not modulated by overexpression of muscle lim protein (mlp). Basic Res Cardiol. 2012;107:262

Wagner S, Ruff HM, Weber SL, Bellmann S, Sowa T, Schulte T, Anderson ME, Grandi E, Bers DM, Backs J, Belardinelli L, Maier LS. Reactive oxygen species-activated ca/calmodulin kinase iidelta is required for late i(na) augmentation leading to cellular na and ca overload. Circ Res. 2011;108:555-565

Sag CM, Kohler AC, Anderson ME, Backs J, Maier LS. Camkii-dependent sr ca leak contributes to doxorubicin-induced impaired ca handling in isolated cardiac myocytes. J Mol Cell Cardiol. 2011;51:749-759

Li W, Li H, Sanders PN, Mohler PJ, Backs J, Olson EN, Anderson ME, Grumbach IM. The multifunctional ca2+/calmodulin-dependent kinase ii delta (camkiidelta) controls neointima formation after carotid ligation and vascular smooth muscle cell proliferation through cell cycle regulation by p21. J Biol Chem. 2011;286:7990-7999

Just S, Berger IM, Meder B, Backs J, Keller A, Marquart S, Frese K, Patzel E, Rauch GJ, Tubingen Screen C, Katus HA, Rottbauer W. Protein kinase d2 controls cardiac valve formation in zebrafish by regulating histone deacetylase 5 activity. Circulation. 2011;124:324-334

Berry JM, Le V, Rotter D, Battiprolu PK, Grinsfelder B, Tannous P, Burchfield JS, Czubryt M, Backs J, Olson EN, Rothermel BA, Hill JA. Reversibility of adverse, calcineurin-dependent cardiac remodeling. Circ Res. 2011;109:407-417

Backs J, Worst BC, Lehmann LH, Patrick DM, Jebessa Z, Kreusser MM, Sun Q, Chen L, Heft C, Katus HA, Olson EN. Selective repression of mef2 activity by pka-dependent proteolysis of hdac4. J Cell Biol. 2011;195:403-415

Backs J, Stein P, Backs T, Duncan FE, Grueter CE, McAnally J, Qi X, Schultz RM, Olson EN. The gamma isoform of cam kinase ii controls mouse egg activation by regulating cell cycle resumption. Proc Natl Acad Sci U S A. 2010;107:81-86

Kristen AV, Schuhmacher B, Strych K, Lossnitzer D, Friederich HC, Hilbel T, Haass M, Katus HA, Schneider A, Streitberger KM, Backs J. Acupuncture improves exercise tolerance of patients with heart failure: A placebo-controlled pilot study. Heart. 2010;96:1396-1400

Xu L, Lai D, Cheng J, Lim HJ, Keskanokwong T, Backs J, Olson EN, Wang Y. Alterations of l-type calcium current and cardiac function in camkii{delta} knockout mice. Circ Res. 2010;107:398-407

Toischer K, Rokita AG, Unsold B, Zhu W, Kararigas G, Sossalla S, Reuter SP, Becker A, Teucher N, Seidler T, Grebe C, Preuss L, Gupta SN, Schmidt K, Lehnart SE, Kruger M, Linke WA, Backs J, Regitz-Zagrosek V, Schafer K, Field LJ, Maier LS, Hasenfuss G. Differential cardiac remodeling in preload versus afterload. Circulation. 2010;122:993-1003

Moresi V, Williams AH, Meadows E, Flynn JM, Potthoff MJ, McAnally J, Shelton JM, Backs J, Klein WH, Richardson JA, Bassel-Duby R, Olson EN. Myogenin and class ii hdacs control neurogenic muscle atrophy by inducing e3 ubiquitin ligases. Cell. 2010;143:35-45

Timmins JM, Ozcan L, Seimon TA, Li G, Malagelada C, Backs J, Backs T, Bassel-Duby R, Olson EN, Anderson ME, Tabas I. Calcium/calmodulin-dependent protein kinase ii links er stress with fas and mitochondrial apoptosis pathways. J Clin Invest. 2009;119:2925-2941

Sag CM, Wadsack DP, Khabbazzadeh S, Abesser M, Grefe C, Neumann K, Opiela MK, Backs J, Olson EN, Brown JH, Neef S, Maier SK, Maier LS. Calcium/calmodulin-dependent protein kinase ii contributes to cardiac arrhythmogenesis in heart failure. Circ Heart Fail. 2009;2:664-675

Backs J, Backs T, Neef S, Kreusser MM, Lehmann LH, Patrick DM, Grueter CE, Qi X, Richardson JA, Hill JA, Katus HA, Bassel-Duby R, Maier LS, Olson EN. The delta isoform of cam kinase ii is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A. 2009;106:2342-2347

Kreusser MM, Buss SJ, Krebs J, Kinscherf R, Metz J, Katus HA, Haass M, Backs J. Differential expression of cardiac neurotrophic factors and sympathetic nerve ending abnormalities within the failing heart. J Mol Cell Cardiol. 2008;44:380-387

Backs J, Backs T, Bezprozvannaya S, McKinsey TA, Olson EN. Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase ii responsiveness by oligomerization with histone deacetylase 4. Mol Cell Biol. 2008;28:3437-3445

Streitberger K, Steppan J, Maier C, Hill H, Backs J, Plaschke K. Effects of verum acupuncture compared to placebo acupuncture on quantitative eeg and heart rate variability in healthy volunteers. J Altern Complement Med. 2008;14:505-513

Zhang T, Kohlhaas M, Backs J, Mishra S, Phillips W, Dybkova N, Chang S, Ling H, Bers DM, Maier LS, Olson EN, Brown JH. Camkiidelta isoforms differentially affect calcium handling but similarly regulate hdac/mef2 transcriptional responses. J Biol Chem. 2007;282:35078-35087

Potthoff MJ, Wu H, Arnold MA, Shelton JM, Backs J, McAnally J, Richardson JA, Bassel-Duby R, Olson EN. Histone deacetylase degradation and mef2 activation promote the formation of slow-twitch myofibers. J Clin Invest. 2007;117:2459-2467

Kreusser MM, Haass M, Buss SJ, Hardt SE, Gerber SH, Kinscherf R, Katus HA, Backs J. Injection of nerve growth factor into stellate ganglia improves norepinephrine reuptake into failing hearts. Hypertension. 2006;47:209-215

Song K, Backs J, McAnally J, Qi X, Gerard RD, Richardson JA, Hill JA, Bassel-Duby R, Olson EN. The transcriptional coactivator camta2 stimulates cardiac growth by opposing class ii histone deacetylases. Cell. 2006;125:453-466

Olson EN, Backs J, McKinsey TA. Control of cardiac hypertrophy and heart failure by histone acetylation/deacetylation. Novartis Found Symp. 2006;274:3-12; discussion 13-19, 152-155, 272-156

Kristen AV, Kreusser MM, Lehmann L, Kinscherf R, Katus HA, Haass M, Backs J. Preserved norepinephrine reuptake but reduced sympathetic nerve endings in hypertrophic volume-overloaded rat hearts. J Card Fail. 2006;12:577-583

Buss SJ, Backs J, Kreusser MM, Hardt SE, Maser-Gluth C, Katus HA, Haass M. Spironolactone preserves cardiac norepinephrine reuptake in salt-sensitive dahl rats. Endocrinology. 2006;147:2526-2534

Backs J, Song K, Bezprozvannaya S, Chang S, Olson EN. Cam kinase ii selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. J Clin Invest. 2006;116:1853-1864

Backs J, Olson EN. Control of cardiac growth by histone acetylation/deacetylation. Circ Res. 2006;98:15-24

Backs J, Bresch E, Lutz M, Kristen AV, Haass M. Endothelin-1 inhibits the neuronal norepinephrine transporter in hearts of male rats. Cardiovasc Res. 2005;67:283-290

Zugck C, Lossnitzer D, Backs J, Kristen A, Kinscherf R, Haass M. Increased cardiac norepinephrine release in spontaneously hypertensive rats: Role of presynaptic alpha-2a adrenoceptors. J Hypertens. 2003;21:1363-1369

Haunstetter A, Schulze Icking B, Backs J, Kruger C, Haass M. Differential effects of acidosis, high potassium concentrations, and metabolic inhibition on noradrenaline release and its presynaptic muscarinic regulation. Pharmacol Res. 2002;45:221-228

Backs J, Haunstetter A, Gerber SH, Metz J, Borst MM, Strasser RH, Kubler W, Haass M. The neuronal norepinephrine transporter in experimental heart failure: Evidence for a posttranscriptional downregulation. J Mol Cell Cardiol. 2001;33:461-472

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