Selected publications of the Lanzer group

 

Most recent (last 5 years)

 

Jida M, Sanchez CP, Urgin K, Ehrhardt K, Mounien S, Geyer A, Elhabiri M, Lanzer M, Davioud-Charvet E (2017) A Redox-Active Fluorescent pH Indicator for Detecting Plasmodium falciparum Strains with Reduced Responsiveness to Quinoline Antimalarial Drugs. ACS infectious diseases 3: 119-131

                  

Waldecker M, Dasanna AK, Lansche C, Linke M, Srismith S, Cyrklaff M, Sanchez CP, Schwarz US, Lanzer M (2017) Differential time-dependent volumetric and surface area changes and delayed induction of new permeation pathways in P. falciparum-infected hemoglobinopathic erythrocytes. Cell Microbiol 19

 

Urgin K, Jida M, Ehrhardt K, Muller T, Lanzer M, Maes L, Elhabiri M, Davioud-Charvet E (2017) Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties. Molecules 22

 

Pegoraro S, Duffey M, Otto TD, Wang Y, Rosemann R, Baumgartner R, Fehler SK, Lucantoni L, Avery VM, Moreno-Sabater A, Mazier D, Vial HJ, Strobl S, Sanchez CP, Lanzer M (2017) SC83288 is a clinical development candidate for the treatment of severe malaria. Nature communications 8: 14193

 

Rhiel M, Bittl V, Tribensky A, Charnaud SC, Strecker M, Muller S, Lanzer M, Sanchez C, Schaeffer-Reiss C, Westermann B, Crabb BS, Gilson PR, Kulzer S, Przyborski JM (2016) Trafficking of the exported P. falciparum chaperone PfHsp70x. Scientific reports 6: 36174

 

Przyborski JM, Nyboer B, Lanzer M (2016) Ticket to ride: export of proteins to the Plasmodium falciparum-infected erythrocyte. Mol Microbiol 101: 1-11 Helms G, Dasanna AK, Schwarz US, Lanzer M (2016) Modeling cytoadhesion of Plasmodium falciparum-infected erythrocytes and leukocytes-common principles and distinctive features. FEBS Lett 590: 1955-1971

 

Ehrhardt K, Deregnaucourt C, Goetz AA, Tzanova T, Gallo V, Arese P, Pradines B, Adjalley SH, Bagrel D, Blandin S, Lanzer M, Davioud-Charvet E (2016) The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites. Antimicrob Agents Chemother 60: 5146-5158  

 

Staudacher V, Djuika CF, Koduka J, Schlossarek S, Kopp J, Buchler M, Lanzer M, Deponte M (2015) Plasmodium falciparum antioxidant protein reveals a novel mechanism for balancing turnover and inactivation of peroxiredoxins. Free radical biology & medicine 85: 228-236

 

Petersen I, Gabryszewski SJ, Johnston GL, Dhingra SK, Ecker A, Lewis RE, de Almeida MJ, Straimer J, Henrich PP, Palatulan E, Johnson DJ, Coburn-Flynn O, Sanchez C, Lehane AM, Lanzer M, Fidock DA (2015) Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter. Mol Microbiol 97: 381-395

  

Rieger H, Yoshikawa HY, Quadt K, Nielsen MA, Sanchez CP, Salanti A, Tanaka M, and Lanzer M (2015) Cytoadhesion of Plasmodium falciparum-infected erythrocytes to chondroitin-4-sulfate is cooperative and shear enhanced. Blood 125: 383-391

     

Kilian N, Srismith S, Dittmer M, Ouermi D, Bisseye C, Simpore J, Cyrklaff M, Sanchez CP, and Lanzer M (2015) Hemoglobin S and C affect protein export in Plasmodium falciparum-infected erythrocytes. Biology open 

          

Rug M, Cyrklaff M, Mikkonen A, Lemgruber L, Kuelzer S, Sanchez CP, Thompson J, Hanssen E, O'Neill M, Langer C, Lanzer M, Frischknecht F, Maier AG, and Cowman AF (2014) Export of virulence proteins by malaria-infected erythrocytes involves remodelling of host actin cytoskeleton. Blood 124: 3459-3468   

       

Sanchez CP, Liu CH, Mayer S, Nurhasanah A, Cyrklaff M, Mu J, Ferdig MT, Stein WD, and Lanzer M (2014) A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. PLoS genetics 10: e1004382

 

Summers RL, Dave A, Dolstra TJ, Bellanca S, Marchetti RV, Nash MN, Richards SN, Goh V, Schenk RL, Stein WD, Kirk K, Sanchez CP, Lanzer M, and Martin RE (2014) Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter. Proc Natl Acad Sci U S A 111: E1759-1767

 

Geiger C, Compaore G, Coulibaly B, Sie A, Dittmer M, Sanchez C, Lanzer M, and Janisch T (2014) Substantial increase in mutations in the genes pfdhfr and pfdhps puts sulphadoxine-pyrimethamine-based intermittent preventive treatment for malaria at risk in Burkina Faso. Tropical medicine & international health : TM & IH 19: 690-697

  

Plaimas K, Wang Y, Rotimi SO, Olasehinde G, Fatumo S, Lanzer M, Adebiyi E, König R. (2013) Computational and experimental analysis identified 6-diazo-5-oxonorleucine as a potential agent for treating infection by Plasmodium falciparum. Infect Genet Evol 20:389-95.  

              

Djuika CF, Fiedler S, Schnölzer M, Sanchez C, Lanzer M, Deponte M. (2013) Plasmodium falciparum antioxidant protein as a model enzyme for a special class of glutaredoxin/glutathione-dependent peroxiredoxins. Biochim Biophys Acta 1830(8):4073-90.   

 

Ehrhardt, K., Davioud-Charvet, E., Ke, H., Vaidya, A. B., Lanzer, M. and Deponte, M. (2013). The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain. Antimicrob Agents Chemother 57(5): 2114-2120.

   

Geiger, C., Agustar, H. K., Compaore, G., Coulibaly, B., Sie, A., Becher, H., Lanzer, M. and Janisch, T. (2013). Declining malaria parasite prevalence and trends of asymptomatic parasitaemia in a seasonal transmission setting in north-western Burkina Faso between 2000 and 2009--2012. Malar J 12(1): 27.

    

Sanchez, C. P., Pfahler, J., Del Portillo, H. A. and Lanzer, M. (2013). Transient transfection of Plasmodium vivax blood-stage parasites. Methods Mol Biol 923: 151-159.

        

Schrader, F. C., Glinca, S., Sattler, J. M., Dahse, H. M., Afanador, G. A., Prigge, S. T., Lanzer, M., Mueller, A. K., Klebe, G. and Schlitzer, M. (2013). Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents. ChemMedChem 8(3): 442-461.

     

Kilian N, Dittmer M, Cyrklaff M, Ouermi D, Bisseye C, Simpore J, Frischknecht F, Sanchez CP, Lanzer M. (2012) Hemoglobin S and C affect the motion of Maurer's clefts in P. falciparum-infected erythrocytes. Cell Microbiol. Dec 26 

Cyrklaff, M., Sanchez, C.P., Frischknecht, F., and Lanzer, M. (2012) Host actin remodeling and protection from malaria by hemoglobinopathies. Trends Parasitol. Nov;28(11):479-485              

Lanfranchi, D.A., Belorgey, D., Müller, T., Vezin, H., Lanzer, M., Davioud-Charvet, E. (2012) Exploring the trifluoromenadione core as a template to design antimalarial redox-active agents interacting with glutathione reductase. Org Biomol Chem. Jun 28;10(24):4795-806.

 

 

 


  

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DZIF Press Release

(6 Feb. 2017):

Successful preclinical tests for new agent against severe malaria  

 

See also the article in Nature Communications by Pegoraro et al.