Publikationen

A self-taught artificial agent for multi-physics computational model personalization.

Neumann D, Mansi T, Itu L, Georgescu B, Kayvanpour E, Sedaghat-Hamedani F, Amr A, Haas J, Katus H, Meder B, Steidl S, Hornegger J, Comaniciu D.

Med Image Anal. 2016 Apr 21. pii: S1361-8415(16)30021-4. doi: 10.1016/j.media.2016.04.003.

 

 

Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.

Eden M, Meder B, Völkers M, Poomvanicha M, Domes K, Branchereau M, Marck P, Will R, Bernt A, Rangrez A, Busch M; German Mouse Clinic Consortium, Hrabě de Angelis M, Heymes C, Rottbauer W, Most P, Hofmann F, Frey N.

Nat Commun. 2016 Apr 28;7:11317. doi: 15.13155/ncomms11317.

 

 

miRTargetLink-miRNAs, Genes and Interaction Networks.

Hamberg M, Backes C, Fehlmann T, Hart M, Meder B, Meese E, Keller A.

Int J Mol Sci. 2016 Apr 14;17(4). pii: E564. doi: 10.3390/ijms17040564.

 

 

Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress.

Scheid LM, Mosqueira M, Hein S, Kossack M, Juergensen L, Mueller M, Meder B, Fink RH, Katus HA, Hassel D.

Cardiovasc Res. 2016 Mar 24. pii: cvw066.

 

 

Distribution of miRNA expression across human tissues.

Ludwig N, Leidinger P, Becker K, Backes C, Fehlmann T, Pallasch C, Rheinheimer S, Meder B, Stähler C, Meese E, Keller A.

Nucleic Acids Res. 2016 Feb 25. pii: gkw116.

 

 

Deep characterization of blood cell miRNomes by NGS.

Schwarz EC, Backes C, Knörck A, Ludwig N, Leidinger P, Hoxha C, Schwär G, Grossmann T, Müller SC, Hart M, Haas J, Galata V, Müller I, Fehlmann T, Eichler H, Franke A, Meder B, Meese E, Hoth M, Keller A.

Cell Mol Life Sci. 2016 Feb 13.

 

 

Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity.

Gast M, Schroen B, Voigt A, Haas J, Kuehl U, Lassner D, Skurk C, Escher F, Wang X, Kratzer A, Michalik K, Papageorgiou A, Peters T, Loebel M, Wilk S, Althof N, Prasanth KV, Katus H, Meder B, Nakagawa S, Scheibenbogen C, Schultheiss HP, Landmesser U, Dimmeler S, Heymans S, Poller W.

J Mol Cell Biol. 2016 Jan 27. pii: mjw003.

 

 

Validating Alzheimer's disease micro RNAs using next-generation sequencing.

Keller A, Backes C, Haas J, Leidinger P, Maetzler W, Deuschle C, Berg D, Ruschil C, Galata V, Ruprecht K, Stähler C, Würstle M, Sickert D, Gogol M, Meder B, Meese E.

Alzheimers Dement. 2016 Jan 22. pii: S1552-5260(15)03036-8. doi: 10.1016/j.jalz.2015.12.012.

 

 

Bias in High-Throughput Analysis of miRNAs and Implications for Biomarker Studies.

Backes C, Sedaghat-Hamedani F, Frese K, Hart M, Ludwig N, Meder B, Meese E, Keller A.

Anal Chem. 2016 Feb 16;88(4):2088-95. doi: 10.1021/acs.analchem.5b03376. Epub 2016 Jan 27.

 

 

Prioritizing and selecting likely novel miRNAs from NGS data.

Backes C, Meder B, Hart M, Ludwig N, Leidinger P, Vogel B, Galata V, Roth P, Menegatti J, Grässer F, Ruprecht K, Kahraman M, Grossmann T, Haas J, Meese E, Keller A.

Nucleic Acids Res. 2016 Apr 7;44(6):e53. doi: 10.1093/nar/gkv1335. Epub 2015 Dec 3.

 

 

 

From Single Variants to Protein Cascades: MULTISCALE MODELING OF SINGLE NUCLEOTIDE VARIANT SETS IN GENETIC DISORDERS.

Mueller SC, Sommer B, Backes C, Haas J, Meder B, Meese E, Keller A.

J Biol Chem. 2016 Jan 22;291(4):1582-90. doi: 10.1074/jbc.M115.695247. Epub 2015 Nov 24.

 

 

Double-Stranded Ligation Assay for the Rapid Multiplex Quantification of MicroRNAs.

Hofmann S, Huang Y, Paulicka P, Kappel A, Katus HA, Keller A, Meder B, Stähler CF, Gumbrecht W.

Anal Chem. 2015 Dec 15;87(24):12104-11. doi: 10.1021/acs.analchem.5b02850. Epub 2015 Dec 2.

 

 

Pathway-based variant enrichment analysis on the example of dilated cardiomyopathy.

Backes C, Meder B, Lai A, Stoll M, Rühle F, Katus HA, Keller A.

Hum Genet. 2016 Jan;135(1):31-40. doi: 10.1007/s00439-015-1609-7. Epub 2015 Nov 7.

 

 

 

Next-generation sequencing identifies altered whole blood microRNAs in neuromyelitis optica spectrum disorder which may permit discrimination from multiple sclerosis.

Keller A, Leidinger P, Meese E, Haas J, Backes C, Rasche L, Behrens JR, Pfuhl C, Wakonig K, Gieß RM, Jarius S, Meder B, Bellmann-Strobl J, Paul F, Pache FC, Ruprecht K.

J Neuroinflammation. 2015 Oct 31;12:196. doi: 10.1186/s12974-015-0418-1.

 

Determined to Fail-the Role of Genetic Mechanisms in Heart Failure.
Kayvanpour E, Katus HA, Meder B.
Curr Heart Fail Rep. 2015 Aug 2.

 

Biomarker Changes after Strenuous Exercise Can Mimic Pulmonary Embolism and Cardiac Injury-A Metaanalysis of 45 Studies.
Sedaghat-Hamedani F, Kayvanpour E, Frankenstein L, Mereles D, Amr A, Buss S, Keller A, Giannitsis E, Jensen K, Katus HA, Meder B.
Clin Chem. 2015 Aug 3. pii: clinchem.2015.240796.

 

Towards Personalized Cardiology: Multi-Scale Modeling of the Failing Heart.
Kayvanpour E, Mansi T, Sedaghat-Hamedani F, Amr A, Neumann D, Georgescu B, Seegerer P, Kamen A, Haas J, Frese KS, Irawati M, Wirsz E, King V, Buss S, Mereles D, Zitron E, Keller A, Katus HA, Comaniciu D, Meder B.
PLoS One. 2015 Jul 31;10(7):e0134869. doi: 10.1371/journal.pone.0134869. eCollection 2015.

 

So rare we need to hunt for them: reframing the ethical debate on incidental findings.
Schuol S, Schickhardt C, Wiemann S, Bartram CR, Tanner K, Eils R, Meder B, Richter D, Glimm H, von Kalle C, Winkler EC.
Genome Med. 2015 Jul 30;7(1):83. doi: 10.1186/s13073-015-0198-3. eCollection 2015.

 
Influence of Next-Generation Sequencing and Storage Conditions on miRNA Patterns Generated from PAXgene Blood.
Backes C, Leidinger P, Altmann G, Wuerstle M, Meder B, Galata V, Mueller SC, Sickert D, Stähler C, Meese E, Keller A.
Anal Chem. 2015 Aug 10.

 

BALL-SNP: combining genetic and structural information to identify candidate non-synonymous single nucleotide polymorphisms.
Mueller SC, Backes C, Kalinina OV, Meder B, Stöckel D, Lenhof HP, Meese E, Keller A.
Genome Med. 2015 Jul 1;7(1):65. doi: 10.1186/s13073-015-0190-y. eCollection 2015.

 

miFRame: analysis and visualization of miRNA sequencing data in neurological disorders.
Backes C, Haas J, Leidinger P, Frese K, Großmann T, Ruprecht K, Meder B, Meese E, Keller A.
J Transl Med. 2015 Jul 14;13:224. doi: 10.1186/s12967-015-0594-x.

 

RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish.
Frese KS, Meder B, Keller A, Just S, Haas J, Vogel B, Fischer S, Backes C, Matzas M, Köhler D, Benes V, Katus HA, Rottbauer W.
J Cell Sci. 2015 Aug 15;128(16):3030-40. doi: 10.1242/jcs.166850. Epub 2015 Jun 26.

 

Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients.
Garnier S, Hengstenberg C, Lamblin N, Dubourg O, De Groote P, Fauchier L, Trochu JN, Arbustini E, Esslinger U, Barton PJ, Meder B, Katus H, Frese K, Komajda M, Cook SA, Isnard R, Tiret L, Villard E, Charron P.
Int J Cardiol. 2015 Jun 15;189:105-7. doi: 10.1016/j.ijcard.2015.04.003. Epub 2015 Apr 1. No abstract available.

 

The current role of next-generation DNA sequencing in routine care of patients with hereditary cardiovascular conditions: a viewpoint paper of the European Society of Cardiology working group on myocardial and pericardial diseases and members of the European Society of Human Genetics.
Mogensen J, van Tintelen JP, Fokstuen S, Elliott P, van Langen IM, Meder B, Richard P, Syrris P, Caforio AL, Adler Y, Anastasakis A, Gimeno JR, Klingel K, Linhart A, Imazio M, Pinto Y, Newbery R, Schmidtke J, Charron P.
Eur Heart J. 2015 Jun 7;36(22):1367-70. doi: 10.1093/eurheartj/ehv122. Epub 2015 Apr 5. Review. No abstract available.

 

Pathogenicity prediction of non-synonymous single nucleotide variants in dilated cardiomyopathy.
Mueller SC, Backes C, Haas J The Inheritance Study Group, Katus HA, Meder B, Meese E, Keller A.
Brief Bioinform. 2015 Jan 30. pii: bbu054.

 

MicroRNA in vitro diagnostics using immunoassay analyzers.
Kappel A, Backes C, Huang Y, Zafari S, Leidinger P, Meder B, Schwarz H, Gumbrecht W, Meese E, Staehler CF, Keller A.
Clin Chem. 2015 Apr;61(4):600-7. doi: 10.1373/clinchem.2014.232165. Epub 2015 Jan 23.

 

New insights into the genetics of glioblastoma multiforme by familial exome sequencing.
Backes C, Harz C, Fischer U, Schmitt J, Ludwig N, Petersen BS, Mueller SC, Kim YJ, Wolf NM, Katus HA, Meder B, Furtwängler R, Franke A, Bohle R, Henn W, Graf N, Keller A, Meese E.
Oncotarget. 2015 Mar 20;6(8):5918-31.

 

Robust image-based estimation of cardiac tissue parameters and their uncertainty from noisy data.
Neumann D, Mansi T, Georgescu B, Kamen A, Kayvanpour E, Amr A, Sedaghat-Hamedani F, Haas J, Katus H, Meder B, Hornegger J, Comaniciu D.
Med Image Comput Comput Assist Interv. 2014;17(Pt 2):9-16.

 

miRNAs can be generally associated with human pathologies as exemplified for miR-144.
Keller A, Leidinger P, Vogel B, Backes C, ElSharawy A, Galata V, Mueller SC, Marquart S, Schrauder MG, Strick R, Bauer A, Wischhusen J, Beier M, Kohlhaas J, Katus HA, Hoheisel J, Franke A, Meder B, Meese E.
BMC Med. 2014 Dec 3;12:224. doi: 10.1186/s12916-014-0224-0.

 

Effects of β-blocker therapy on electrocardiographic and echocardiographic characteristics of left ventricular noncompaction.
Li J, Franke J, Pribe-Wolferts R, Meder B, Ehlermann P, Mereles D, Andre F, Abdelrazek MA, Merten C, Schweizer PA, Becker R, Katus HA, Thomas D.
Clin Res Cardiol. 2015 Mar;104(3):241-9. doi: 10.1007/s00392-014-0778-z. Epub 2014 Oct 21.

 

Assessment of myocardial deformation with cardiac magnetic resonance strain imaging improves risk stratification in patients with dilated cardiomyopathy.
Buss SJ, Breuninger K, Lehrke S, Voss A, Galuschky C, Lossnitzer D, Andre F, Ehlermann P, Franke J, Taeger T, Frankenstein L, Steen H, Meder B, Giannitsis E, Katus HA, Korosoglou G.
Eur Heart J Cardiovasc Imaging. 2015 Mar;16(3):307-15. doi: 10.1093/ehjci/jeu181. Epub 2014 Sep 21.

 

Atlas of the clinical genetics of human dilated cardiomyopathy. Haas J, Frese KS, Peil B, Kloos W, Keller A, Nietsch R, Feng Z, Müller S, Kayvanpour E, Vogel B, Sedaghat-Hamedani F, Lim WK, Zhao X, Fradkin D, Köhler D, Fischer S, Franke J, Marquart S, Barb I, Li DT, Amr A, Ehlermann P, Mereles D, Weis T, Hassel S, Kremer A, King V, Wirsz E, Isnard R, Komajda M, Serio A, Grasso M, Syrris P, Wicks E, Plagnol V, Lopes L, Gadgaard T, Eiskjær H, Jørgensen M, Garcia-Giustiniani D, Ortiz-Genga M, Crespo-Leiro MG, Deprez RH, Christiaans I, van Rijsingen IA, Wilde AA, Waldenstrom A, Bolognesi M, Bellazzi R, Mörner S, Bermejo JL, Monserrat L, Villard E, Mogensen J, Pinto YM, Charron P, Elliott P, Arbustini E, Katus HA, Meder B. Eur Heart J. 2014 Aug 27. pii: ehu301.

 

The Symptom Complex of Familial Sinus Node Dysfunction and Myocardial Noncompaction Is Associated With Mutations in the HCN4 Channel. Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, Buss SJ, Seyler C, Bruehl C, Draguhn A, Koenen M, Meder B, Katus HA, Thomas D. J Am Coll Cardiol. 2014 Aug 26;64(8):757-67. doi: 10.1016/j.jacc.2014.06.1155.

 

Influence of the Confounding Factors Age and Sex on MicroRNA Profiles from Per ipheral Blood. Meder B, Backes C, Haas J, Leidinger P, Stähler C, Großmann T, Vogel B, Frese K, Giannitsis E, Katus HA, Meese E, Keller A. Clin Chem. 2014 Jun 30. pii: clinchem.2014.224238. 

 

Systematic permutation testing in GWAS pathway analyses: identification of genetic networks in dilated cardiomyopathy and ulcerative colitis. Backes C, Rühle F, Stoll M, Haas J, Frese K, Franke A, Lieb W, Wichmann HE, Weis T, Kloos W, Lenhof HP, Meese E, Katus H, Meder B, Keller A. BMC Genomics. 2014 Jul 22;15(1):622.

 

The human miRNA repertoire of different blood compounds. Leidinger P, Backes C, Meder B, Meese E, Keller A. BMC Genomics. 2014 Jun 14;15(1):474. [Epub ahead of print]

 

Data-driven estimation of cardiac electrical diffusivity from 12-lead ECG signals. Zettinig O, Mansi T, Neumann D, Georgescu B, Rapaka S, Seegerer P, Kayvanpour E, Sedaghat-Hamedani F, Amr A, Haas J, Steen H, Katus H, Meder B, Navab N, Kamen A, Comaniciu D.Med Image Anal. 2014 Apr 26

 

Post cardiac injury syndrome after initially uncomplicated CRT-D implantation: a case report and a systematic review.Sedaghat-Hamedani F, Zitron E, Kayvanpour E, Lorenz HM, Katus HA, Meder B.Clin Res Cardiol. 2014 Apr 29. [Epub ahead of print] 

 

Fast data-driven calibration of a cardiac electrophysiology model from images and ECG.Zettinig O, Mansi T, Georgescu B, Kayvanpour E, Sedaghat-Hamedani F, Amr A, Haas J, Steen H,Meder B, Katus H, Navab N, Kamen A, Comaniciul D.Med Image Comput Comput Assist Interv. 2013;16(Pt 1):1-8. 

 

Renal sympathetic denervation therapy in the real world: results from the Heidelberg registry.Vogel B, Kirchberger M, Zeier M, Stoll F, Meder B, Saure D, Andrassy M, Mueller OJ, Hardt S, Schwenger V, Strothmeyer A, Katus HA, Blessing E.Clin Res Cardiol. 2014 Feb;103(2):117-24. doi: 10.1007/s00392-013-0627-5. Epub 2013 Oct 15. 

 

A blood based 12-miRNA signature of Alzheimer disease patients.Leidinger P, Backes C, Deutscher S, Schmitt K, Mueller SC, Frese K, Haas J, Ruprecht K, Paul F, Stähler C, Lang CJ, Meder B, Bartfai T, Meese E, Keller A.Genome Biol. 2013 Jul 29;14(7):R78. [Epub ahead of print] 

 

Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure.Vogel B, Keller A, Frese KS, Leidinger P, Sedaghat-Hamedani F, Kayvanpour E, Kloos W, Backe C, Thanaraj A, Brefort T, Beier M, Hardt S, Meese E, Katus HA, Meder B.Eur Heart J. 2013 Sep;34(36):2812-22. doi: 10.1093/eurheartj/eht256. Epub 2013 Jul 17. 

 

A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy.Meder B, Rühle F, Weis T, Homuth G, Keller A, Franke J, Peil B, Lorenzo Bermejo J, Frese K, Huge A, Witten A, Vogel B, Haas J, Völker U, Ernst F, Teumer A, Ehlermann P, Zugck C, Friedrichs F, Kroemer H, Dörr M, Hoffmann W, Maisch B, Pankuweit S, Ruppert V, Scheffold T, Kühl U, Schultheiss HP, Kreutz R, Ertl G, Angermann C, Charron P, Villard E, Gary F, Isnard R, Komajda M, Lutz M, Meitinger T, Sinner MF, Wichmann HE, Krawczak M, Ivandic B, Weichenhan D, Gelbrich G, El-Mokhtari NE, Schreiber S, Felix SB, Hasenfuß G, Pfeufer A, Hübner N, Kääb S, Arbustini E, Rottbauer W, Frey N, Stoll M, Katus HA.Eur Heart J. 2014 Apr;35(16):1069-77. doi: 10.1093/eurheartj/eht251. Epub 2013 Jul 12.

 

Comprehensive analysis of microRNA profiles in multiple sclerosis including next-generation sequencing.Keller A, Leidinger P, Steinmeyer F, Stähler C, Franke A, Hemmrich-Stanisak G, Kappel A, Wright I, Dörr J, Paul F, Diem R, Tocariu-Krick B, Meder B, Backes C, Meese E, Ruprecht K.Mult Scler. 2014 Mar;20(3):295-303. doi: 10.1177/1352458513496343. Epub 2013 Jul 8.   

 

Paleoproteomic study of the Iceman's brain tissue.Maixner F, Overath T, Linke D, Janko M, Guerriero G, van den Berg BH, Stade B, Leidinger P, Backes C, Jaremek M, Kneissl B, Meder B, Franke A, Egarter-Vigl E, Meese E, Schwarz A, Tholey A, Zink A, Keller A.Cell Mol Life Sci. 2013 Oct;70(19):3709-22. doi: 10.1007/s00018-013-1360-y. Epub 2013 Jun 6.

 

Genetic testing is superior to biopsy of the myocardium in cardiomyopathy - yes. Thanaraj A, Meder B. Dtsch Med Wochenschr. 2013 Mar;138(12):598. Epub 2013 Mar 12. German. 

 

Next-Generation Sequencing: From Understanding Biology to Personalized Medicine. Frese KS, Katus HA, Meder B. Biology 2013, 2(1), 378-398

 

CD26 Inhibition Enhances Perfusion Recovery in ApoE-/-Mice. Haverslag RT, de Groot D, Grundmann S, Meder B, Goumans MJ, Pasterkamp G, Hoefer IE, de Kleijn DP. Curr Vasc Pharmacol. 2013 Jan 1;11(1):21-8.

 

Stäehler CF, Keller A, Leidinger P, Backes C, Chandran A, Wischhusen J, Meder B, Meese E. Whole miRNome-wide Differential Co-expression of MicroRNAs. Genomics Proteomics Bioinformatics. 2012 Oct;10(5):285-94. doi: 10.1016/j.gpb.2012.08.003. Epub 2012 Aug 23.

 

Haas J, Frese KS, Park YJ, Keller A, Vogel B, Lindroth AM, Weichenhan D, Franke J, Fischer S, Bauer A, Marquart S, Sedaghat-Hamedani F, Kayvanpour E, Köhler D, Wolf NM, Hassel S, Nietsch R, Wieland T, Ehlermann P, Schultz JH, Dösch A, Mereles D, Hardt S, Backs J, Hoheisel JD, Plass C, Katus HA, Meder B. Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Mol Med. 2013 Jan 22. doi: 10.1002/emmm.201201553. [Epub ahead of print]

 

Vogel B, Keller A, Frese K, Kloos W, Kayvanpour E, Sedaghat-Hamedani F, Hassel S, Marquart S, Beier M, Giannitis E, Hardt S, Katus HA, Meder B. Refining Diagnostic MicroRNA Signatures by Whole-miRNome Kinetic Analysis in Acute Myocardial Infarction. Clin Chem. 2012 Dec 19. [Epub ahead of print]

 

Narula N, Favalli V, Tarantino P, Grasso M, Pilotto A, Bellazzi R, Serio A, Gambarin FI, Charron P, Meder B, Pinto Y, Elliott PM, Mogensen J, Bolognesi M, Bollati M, Arbustini E. Quantitative Expression of the Mutated Lamin A/C Gene in Patients With Cardiolaminopathy. J Am Coll Cardiol. 2012 Sep 28. pii: S0735-1097(12)04113-7.

 

Meder B, Frese KS, Katus HA. Die dilatative Kardiomyopathie – Ein Update. Aktuelle Kardiologie. 2012

 

Kloos W, Katus HA, Meder B. Genetic cardiomyopathies: Lessons learned from humans, mice, and zebrafish. Herz. 2012 Jul 7. [Epub ahead of print]

 

Meder B, Katus HA. Clinical and genetic aspects of hypertrophic and dilated cardiomyopathy. Der Internist 2012 [Epub ahead of print].

 

Laczny C, Leidinger P, Haas J, Ludwig N, Backes C, Gerasch A, Kaufmann M, Vogel B, Katus HA, Meder B, Stähler C, Meese E, Lenhof HP, Keller A. miRTrail – a comprehensive webserver for analyzing gene and miRNA patterns to enhance the understanding of regulatory mechanisms in diseases. BMC Bioinformatics 2012,13:56 (epub ahead)

   

Keller A, Graefen A, Ball M, Matzas M, Boisguerin V, Maixner F, Leidinger P, Backes C, Khairat R, Forster M, Stade B, Franke A, Mayer J, Spangler J, McLaughlin S, Shah M, Lee C, Harkins TT, Sartori A, Moreno-Estrada A, Henn B, Sikora M, Semino O, Chiaroni J, Rootsi S, Myres NM, Cabrera VM, Underhill PA, Bustamante CD, Vigl EE, Samadelli M, Cipollini G, Haas J, Katus H, O'Connor BD, Carlson MR, Meder B, Blin N, Meese E, Pusch CM, Zink A. New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing. Nat Commun. 2012 Feb 28;3:698. doi: 10.1038/ncomms1701.

 

Meder B, Katus HA. Clinical and genetic aspects of hypertrophic and dilated cardiomyopathy. Internist (Berl). 2012 Apr;53(4):408-14, 417-8. German.

 

Laczny C, Leidinger P, Haas J, Ludwig N, Backes C, Gerasch A, Kaufmann M, Vogel B, Katus HA, Meder B, Stähler C, Meese E, Lenhof HP, Keller A. miRTrail--a comprehensive webserver for analyzing gene and miRNA patterns to enhance the understanding of regulatory mechanisms in diseases. BMC Bioinformatics. 2012 Feb 22;13:36.

 

Keller A, Backes C, Leidinger P, Kefer N, Boisguerin V, Barbacioru C, Vogel B, Matzas M, Huwer H, Katus HA, Stähler C, Meder B, Meese E.
Next-generation sequencing identifies novel microRNAs in peripheral blood of lung cancer patients. Mol Biosyst. 2011 Dec;7(12):3187-99. Epub 2011 Oct 25.

   

Haas J, Katus HA, Meder B. Next-generation sequencing entering the clinical arena. Mol Cell Probes. 2011 Sep 8. [Epub ahead of print].

 

Keller A, Leidinger P, Bauer A, ElSharawy A, Haas J, Backes C, Wendschlag A, Giese N, Tjaden C, Ott K, Werner J, Hackert T, Ruprecht K, Huwer H, Huebers J, Jacobs G, Rosenstiel P, Dommisch H, Schaefer A, Müller-Quernheim J, Wullich B, Keck B, Graf N, Reichrath J, Vogel B, Nebel A, Jager S, Staehler P, Amarantos I, Boisguerin V, Staehler C, Beier M, Scheffler M, Büchler MW, Wischhusen J, Haeusler S, Dietl J, Hofmann S, Lenhof HP, Schreiber S, Katus HA, Rottbauer W, Meder B, Hoheisel J, Franke A, Meese E. Towards discovering the blood-born miRNome of human diseases. Nature Methods 2011.

 

Meder B, Huttner IG, Sedaghat-Hamedani F, Just S, Dahme T, Frese KS, Vogel B, Köhler D, Kloos W, Rudloff J, Marquart S, Katus HA, Rottbauer W. PINCH proteins regulate cardiac contractility by modulating ILK-PKB signaling. Molecular and Cellular Biology 2011 (epub ahead of print).

 

Just S, Berger IM, Meder B, Backs J, Marquart S, Eva Patzel, Gerd-Jörg Rauch; Tübingen 2000 Screen Consortium; Hugo A. Katus; Wolfgang Rottbauer. Protein kinase D2 controls cardiac valve formation in zebrafish by regulating HDAC5 activity. Circulation 2011 (epub ahead of print).

 

Meder B, Bergmann CE, Keller A, Just S, Katus HA, Hoefer IE, Buschmann IR. Quantification of Collateral Artery Growth by Automated Fluorescent Microsphere Perfusion. International Journal of Cardiology 2011 (epub ahead of print)

 

Just S*, Meder B*, Ina M. Berger, Christelle Etard, Nicole Trano, David Hassel, Sabine Marquart, Tillman Dahme, Alexander Hess, Britta Vogel, Mark C. Fishman, Uwe Strähle, Hugo A. Katus, Wolfgang Rottbauer. The myosin-interacting protein SMYD1 is essential for sarcomere organization. Journal of Cell Science 2011 (epub ahead of print) (*first and second author contributed equally)

 

Meder B, Scholz EP, Hassel D, Wolff C, Just S, Berger IM, Patzel E, Karle C, Katus HA, Rottbauer W. Reconstitution of Defective Protein Trafficking Rescues Long-QT Syndrome in Zebrafish. Biochem. Biophys. Res. Commun. 2011 (epub ahead of print)

 

Ehlermann P, Lehrke S, Papavassiliu T, Meder B, Borggrefe M, Katus HA, Schimpf R. Sudden cardiac death in a patient with lamin A/C mutation in the absence of dilated cardiomyopathy or conduction disease. Clin Res Cardiol. 2011 Feb 16. (epub ahead of print)

 

Meder B. MicroRNA Signaturen als neue Biomarker kardiovaskulärer Erkrankungen - Winzige Moleküle zeigen Herzinfarkt an. Lebendige Wissenschaft – Spitzenforschung Herz-Kreislauf-Medizin 2011

 

Keller A, Harz C, Matzas M, Meder B, Katus HA, Ludwig N, Fischer U, Meese E. Identification of novel SNPs in glioblastoma using targeted resequencing. PLoS One 2011 (in press)

 

Meder B, Haas J, Keller A, Heid C, Just S, Borries A, Boisguerin V, Scharfenberger-Schmeer M, Stähler P, Beier M, Weichenhan D, Strom T, Pfeufer A, Korn B, Katus HA, Rottbauer W. Targeted Next-Generation Sequencing for the Molecular Genetic Diagnostics of Cardiomyopathies. Circulation Cardiovascular Genetics 2011 (epub ahead of print)

 

Meder B, Keller A, Vogel B, Haas J, Sedaghat F, Kayvanpour E, Just S, Borries A, Rudloff J, Leidinger P, Meese E, Katus HA, Rottbauer W. MicroRNA Signatures in Total Peripheral Blood as Novel Biomarkers for Acute Myocardial Infarction. Basic Res Cardiol. 2010 (online first, DOI 10.1007/s00395-010-0123-2)

 

Meder B, Just S, Vogel B, Rudloff J, Gartner L, Dahme T, Huttner I, Zankl A, Katus HA, Rottbauer W. JunB-CBFß Signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure. J Cell Sci. 2010; 10.1242/jcs.067967

 

Hassel D*, Dahme T*, Erdmann J*, Meder B, Huge A, Stoll M, Just S, Hess A, Ehlermann P, Weichenhan D, Grimmler M, Liptau H, Hetzer R, Regitz-Zagrosek V, Fischer C, Nürnberg P, Schunkert H, Katus HA, Rottbauer W. Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Nat Med 2009;15:1281-8

 

Meder B, Laufer C, Hassel D, Just S, Marquart S, Vogel B, Hess A, Fishman MC, Katus HA, Rottbauer W. A single serine in the carboxyl terminus of cardiac essential myosin light chain-1 controls cardiomyocyte contractility in vivo. Circ Res 2009;104:650-659

 

Vogel B*, Meder B*, Just S, Laufer C, Berger I, Weber S, Katus HA, Rottbauer W. In Vivo Characterization of Human Dilated Cardiomyopathy Genes in Zebrafish. Biochem. Biophys. Res. Commun. 2009, doi:10.1016/j.bbrc.2009.09.129 (*first and second author contributed equally)

 

Meder B, Katus HA, Rottbauer W. Leichte Kette mit schweren Folgen - Der Zebrafish als Modell genetischer Herzschwäche. GenomXpress 2009;3.09

 

Friedrichs F, Zugck C, Rauch GJ, Ivandic B, Weichenhan D, Müller-Bardorff M, Meder B, El Mokhtari NE, Regitz-Zagrosek V, Hetzer R, Schäfer A, Schreiber S, Chen J, Neuhaus I, Ji R, Siemers NO, Frey N, Rottbauer W, Katus HA, Stoll M. HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy. Genome Res 2009;19:395-403

 

Meder B, Katus HA, Rottbauer, W. Genetik der hypertrophischen Kardiomyopathie. Journal für Kardiologie 2009;16 (7-8), 274-278

 

Hassel D, Scholz EP, Trano N, Friedrich O, Just S, Meder B, Weiss DL, Zitron E, Marquart S, Vogel B, Karle CA, Seemann G, Fishman MC, Katus HA, Rottbauer W. Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants. Circulation 2008;117:866-875

 

Meder B, Katus HA, Rottbauer W. Right into the heart of microRNA-133a. Genes Dev 2008;22:3227-3231

 

Bergmann C, Hoefer I, Meder B, Roth H, van Royen N, Breit SM, Jost MM, Aharinejad S, Hartmann S, Buschmann IR. Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op mice. J Leukoc Biol 2006;80:59-65

 

Hoefer I, Grundmann S, Schirmer S, van Royen N, Meder B, Bode C, Piek JJ, Buschmann IR. Aspirin, but not clopidogrel, reduces collateral conductance in a rabbit model of femoral artery occlusion. J Am Coll Cardiol 2005;46:994-1001

 

Jost MM*, Ninci E*, Meder B, Kempf C, van Royen N, Hua J, Berger B, Hoefer I, Modolell M, Buschmann I. Divergent effects of GM-CSF and TGFbeta1 on bone marrow-derived macrophage arginase-1 activity, MCP-1 expression, and matrix metalloproteinase-12: a potential role during arteriogenesis. FASEB J 2003;17:2281-2283

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