Medizinische Informatik
Medizinische Biometrie und Informatik


Veröffentlichungen von Mitarbeitern der Sektion Medizinische Informatik:


Berger M., Kallus S., Nova I., Ristow O., Eisenmann U., Dickhaus H., Kuhle R., Hoffmann J., Seeberger R. (2015):
Approach to intraoperative electromagnetic navigation in orthognathic surgery: A phantom skull based trial. Journal of Cranio-Maxillo-Facial Surgery,43/9:1731-1736.


Firnkorn D., Ganzinger M., Muley T., Thomas M., Knaup P. (2015):
A Generic Data Harmonization Process for Cross-linked Research and Network Interaction. Construction and Application for the Lung Cancer Phenotype Database of the German Center for Lung Research. Methods of Information in Medicine,54/5:455-460.


Ganzinger, M., Knaup, P. (2015):
Requirements for data integration platforms in biomedical research networks: a reference model.
PeerJournal, 3:e755.


Günther, A., Harding, U., Gietzelt, M., Gradaus, F., Tute, E., and Fischer, M. (2015):
Ein städtischer Rettungsdienstbereich am Beginn eines sektorenübergreifenden Qualitätsmanagementsystems: Eine priorisierte Umsetzung der ERC Empfehlungen von 2010 und das Langzeitüberleben nach Herzkreislaufstillstand. Zeitschrift Für Evidenz, Fortbildung Und Qualität Im Gesundheitswesen.


Karmen, C., Hsiung, R. C., Wetter, T. (2015):
Screening Internet forum participants for depression symptoms by assembling and enhancing multiple NLP methods. Computer Methods and Programs in Biomedicine, 120(1), 27–36.


Song, B., Becker, M., Gietzelt, M., Haux, R., Kohlmann, M., Schulze, M., et al. (2015):
Feasibility Study of a Sensor-Based Autonomous Load Control Exercise Training System for COPD Patients. J Med Syst, 39(1), 150.


Stöllberger, C., Gerecke, B., Engberding, R., Grabner, B., Wandaller, C., Finsterer, J., Gietzelt, M., and Balzereit, A. (2015):
Interobserver Agreement of the Echocardiographic Diagnosis of LV Hypertrabeculation/Noncompaction. J Am Coll Cardiol Img 8, 1252–1257.


Wetter T. (2015):
Consumer Health Informatics. New services, roles, and responsibilities. Springer Verlag (Sept. 2015) ISBN 978-3-319-19589-6.


Winter A., Hilgers R. D., Hofestaedt R., Huebner U., Knaup-Gregori P., Ose C., Schmoor C., Timmer A., Wege D. (2015):
Good Medicine and Good Healthcare Demand Good Information (Systems). Methods of Information in Medicine,54/5:385-387.


Ammenwerth E., Haux R., Knaup-Gregori P. (2014):
IT-Projektmanagement im Gesundheitswesen: Lehrbuch und Projektleitfaden - Taktisches Management von Informationssystemen.
ISBN 978-3794530717, 2. Auflage, Schattauer Verlag, Stuttgart

Capurro D., Ganzinger M., Perez-Lu J., Knaup P. (2014):
Effectiveness of eHealth Interventions and Information Needs in Palliative Care: A Systematic Literature Review.
Journal of Medical Internet Research,16/3:e72.

Chang Y. T., Huang C. S., Yao C. T., Su S. L., Terng H. J., Chou H. L., Chou Y. C., Chen K. H., Shih Y. W., Lu C. Y., Lai C. H., Jian C. E., Lin C. H., Chen C. T., Wu Y. S., Lin K. S., Wetter T., Chang C. W., Chu C. M. (2014):
Gene expression profile of peripheral blood in colorectal cancer.
World Journal of Gastroenterology,20/39:14463-14471.

Chu C. M., Yao C. T., Chang Y. T., Chou H. L., Chou Y. C., Chen K. H., Terng H. J., Huang C. S., Lee C. C., Su S. L., Liu Y. C., Lin F. G., Wetter T., Chang C. W. (2014):
Gene Expression Profiling of Colorectal Tumors and Normal Mucosa by Microarrays Meta-Analysis Using Prediction Analysis of Microarray, Artificial Neural Network, Classification, and Regression Trees.
Disease Markers, ID 634123.

Dickhaus H., Knaup-Gregori P. (2014):
Medizinische Informatik. In: Biomedizinische Technik - Faszination, Einführung, Überblick.
Bd 1, S. 239-269, Hrsg.: Morgenstern Ute, Kraft Marc, de Gruyter Verlag, ISBN 978-311025198-2.

Dugas M, .Jöckel K. H., Gefeller O., Knaup-Gregori P., Friede T., Ammenwerth E., Kieser M., Prokosch H. U. (2014):
Freier Zugang zu Dokumentationsformularen und Merkmalskatalogen im Gesundheitswesen. Memorandum "Open Metadata".
GMS Medizinische Informatik, Biometrie und Epidemiologie,10/1: Doc01 (20140218).

Hartzler A., Wetter T. (2014):
Engaging Patients through Mobile Phones: Demonstrator Services, Success Factors, and Future Opportunities in Low and Middleincome Countries.
IMIA Yearbook of Medical Informatics 2014, 182-194.

Haux R., Ammenwerth E., Knaup P. (2014):
Reflections on health care in the information society - a prognosis for the year 2013.
Journal of Medical Systems,38/7:72.

Hofmann N. P., Dickhaus H., Katus H. A., Korosoglou G. (2014):
Quantitative assessment of myocardial blush grade in patients with coronary artery disease and in cardiac transplant recipients.
World Journal of Cardiology,6/10:1108-1112.

Knaup P., Ammenwerth E., Dujat C., Grant A., Hasman A., Hein A., Hochlehnert A., Kulikowski C., Mantas J., Maojo V., Marschollek M., Moura L., Plischke M., Röhrig R., Stausberg J., Takabayashi K., Ückert F., Winter A., Wolf K. H., Haux R. (2014):
Assessing the Prognoses on Health Care in the Information Society 2013 - Thirteen Years After.
Journal of Medical Systems,38/7:73.

Knaup P., Schöpe L. (2014):
Editorial: Using Data from Ambient Assisted Living and Smart Homes in Electronic Health Records.
Methods of Information in Medicine, 53/3:149-151.

Koch S. H.
, Proynova R., Paech B., Wetter T. (2014):
The perfectly motivated nurse and the others: workplace and personal characteristics impact of nursing tasks.
Journal of Nursing Management.

Kohl C. D. (2014):
AquaSim - Simulation zur Prüfung der Wirksamkeit eines Impfstoffs für Clownfische. Erschienen im Lehrbuch: Zeig mir Biostatistik! Ideen und Material für einen guten Biometrie-Unterricht, Rauch G., Muche R., Vontheim R. (Eds.),
ISBN 978-3-642-54335-7, Springer Verlag Berlin Heidelberg, Seite 95-100.

Kohl C. D., Bruns I., Freudigmann M., Scharf G., Schmücker P., Schwarz G., Semler S. C. (2014):
Vorstellung des Eckpunktepapiers „Digitale Archivierung papierbasierter Krankenakten von Studienpatienten“.
die pharmazeutische industrie,76/8:1204-1212.

Maier C., Dickhaus H. (2014):
Extraction of respiratory myogram interference from the ECG and its application to characterize sleep-related breathing disorders in atrial fibrillation.
Journal of Electrocardiology, 47/6:826-830.

Maier C.
, Wenz H., Dickhaus H. (2014):
Robust Detection of Sleep Apnea from Holter ECGs by Joint Assessment of Modulations in QRS Amplitude and Respiratory Myogram Interference.
Methods of Information in Medicine,53/4:303-307.

Malz M., Bovet M., Samarin J., Rabenhorst U., Sticht C., Bissinger M., Roessler S., Lorenzo Bermejo J., Renner M., Calvisi D. F., Singer S., Ganzinger M., Weber A., Gretz N., Zörnig M., Schirmacher P., Breuhahn K. (2014):
Overexpression of Far Upstream Element (FUSE) Binding Protein (FBP)-Interacting Repressor (FIR) Supports Growth of Hepatocellular Carcinoma.

Philippi H., Karch D., Kang K. S., Wochner K., Pietz J., Dickhaus H., Hadders-Algra M. (2014):
Computer-based analysis of general movements reveals stereotypies predicting cerebral palsy.
Developmental Medicine & Child Neurology,56/10:960-967.

Santos E., Schöll M., Sánchez-Porras R., Dahlem M.A., Silos H., Unterberg A.,
Dickhaus H., Sakowitz O. W. (2014):
Radial, spiral and reverberating waves of spreading depolarization occur in the gyrencephalic brain.

Storf H., Jedlitschka A., Knaup P., Dickhaus H. (2014):
Detection of physical helplessness at home using ambient sensor information.
Journal of Ambient Intelligence and Smart Environments, 6/2:137-155.

Trigo J. D., Kohl C. D., Eguzkiza A., Martínez-Espronceda M., Alesanco A., Serrano L., García J., Knaup P. (2014):
Detection of Physical Helplessness at Home Using Ambient Sensor Information.
IEEE Journal of Biomedical and Health Informatics.

Ückert F., Ammenwerth E., Dujat C., Grant A., Haux R., Hein A., Hochlehnert A., Knaup-Gregori P., Kulikowski C., Mantas J., Maojo V., Marschollek M., Moura L., Plischke M., Röhrig R., Stausberg J., Takabayashi K., Winter A., Wolf K. H., Hasman A. (2014):
Past and next 10 years of medical informatics.
Journal of Medical Systems,38/7:74.

Winter A., Hilgers R. D., Hofestädt R., Knaup-Gregori P., Ose C., Timmer A. (2014):
Editorial: How to Use Information Technology to Improve Medication
Methods of Information in Medicine,53/5:333-335.


Aamot H., Kohl C. D., Richter, D., Knaup-Gregori P. (2013):
Pseudonymization of patient identifiers for translational research.
BMC Medical Informatics and Decision Making, 13/75.

Koch S. H., Weir C., Westenskow D., Gondan M., Agutter J., Haar M., Görges M., Liu D., Staggers N. (2013):
Evaluation of the effect of information integration in displays for ICU nurses on situation awareness and task completion time: A prospective randomized controlled study.
International Journal of Medical Informatics, 82/10:665-675.

Hofman N. P., Voss A., Dickhaus H., Erbacher M., Doesch A., Ehlermann P.,
Gitsioudis G., Buss S. J., Giannitsis E., Katus H. A., Korosoglou G. (2013):
Long-Term Outcome After Heart Transplantation Predicted by Quantitative
Myocardial Blush Grade in Coronary Angiography.
American Journal of Transplantation 13/6:1491-1502.

Plotnicki L., Kohl C. D., Höcker B., Krupka K., Rahmel A., Pape L., Hoyer P., Marks S. D., Webb N. J. A., Söylemezoglu O., Topaloglu R., Szabo A. J., Seeman T., Marlies Cornelissen E. A., Knops N., Grenda R., Tönshoff B. (2013):
The CERTAIN Registry: A Novel, Web-Based Registry and Research Platform for Pediatric Renal Transplantation in Europe.
Transplantation Proceedings, 45/4:1414-1417.

Wicht A.
, Wetter T., Klein U. (2013):
A web-based system for clinical decision support and knowledge maintenance for deterioration monitoring of hematooncological patients.
Computer Methods and Programs in Biomedicine, 111/1:26-32.

Kohl C. D.
, Bruns I., Freudigmann M., Scharf G., Schmücker P., Schwarz G., Semler S. C. (2013):
GCP-compliant digital archiving of paper-based patient records of clinical trial subjects: a key issues paper.
Clinical Investigation, 3/5:451-465.

Kohl C. D., Bruns I., Freudigmann M., Scharf G., Schmücker P., Schwarz G., Semler S. C. (2013):
Digitale Archivierung papierbasierter Krankenakten von Studienpatienten - Eckpunktepapier des KKSN, der GMDS und der TMF unter
Mitwirkung des BfArM und der Landesüberwachungsbehörde Nordrhein-Westfalen.
GMS Medizinische Informatik, Biometrie und Epidemiologie,9/3.

Chiang C. H., Huang C. C., Chan W. L., Huang P. H., Chen Y. C., Chen T. J., Lin S. J., Chen J. W., Leu H. B. (2013):
Herpes simplex virus infection and risk of atrial fibrillation: A nationwide study.
International Journal of Cardiology, 164/2:201-204.

Chou H. L., Yao C. T., Su S. L., Lee C. Y., Hu K. Y., Terng H. J., Shih Y. W., Chang Y. T., Lu Y. F.., Chang C. W., Wahlqvist M. L., Wetter T., Chu C. M. (2013):
Gene expression profiling of breast cancer survivability by pooled cDNA microarray analysis using logistic regression, artificial neural networks and decision trees.
BMC Bioinformatics, 14/100.

Koch S. H., Proynova R., Paech B., Wetter T. (2013):
How to approximate user´s values preserving privacy: experiences with using attitudes towards work tasks as proxies for personal value elicitation.
Ethics and Information Technology,15/1:45-61.

Lahrmann B., Valous N. A., Eisenmann U., Wentzensen N., Grabe N. (2013):
Semantic Focusing Allows Fully Automated Single-Layer Slide Scanning of Cervical Cytology Slides.
PLoS ONE,8/4:e61441.

Reuner G., Fields A. C., Wittke A., Löpprich M., Pietz J. (2013):
Comparison of the developmental tests Bayley-III and Bayley-II in 7-month-old infants born preterms.
European Journal of Pediatrics,172/3:393-400.

Sütterlin T., Kolb C., Dickhaus H., Jäger D., Grabe N. (2013): Bridging the scales:
Semantic integration of quantitative SBML in graphical multi-cellular models and simulations with EPISIM and COPASI.

Valous N. A., Lahrmann B., Zhou W., Veltkamp R., Grabe N. (2013):
Multistage histopathological image segmentation of Iba1-stained murine microglias in a focal ischemia model: Methodological workflow and expert validation.
Journal of Neuroscience Methods,213/2:250-262.

Zhou W., Liesz A., Bauer H., Sommer C., Lahrmann B., Valous N., Grabe N., Veltkamp R. (2013):
Postischemic Brain Infiltration of Leukocyte Subpopulations Differs among Murine Permenant and Transient Focal Cerebral Ischemia Models.
Brain Pathology,23/1:34-44.

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Chiang C. H., Huang C. C., Chan W. L., Huang P. H., Chen Y. C., Chen T. J., Chung C. M., Lin S. J., Chen J. W., Leu H. B. (2012):
Letter to the Editor: Psoriasis and increased risk of ischemic stroke in Taiwan: A nationwide study.
Journal of Dermatology,39/3:279-281.

Fraiwan L., Lweesy K., Khasawneh N., Wenz H., Dickhaus H. (2012):
Automated sleep stage identification system based on time-frequency analysis of a single EEG channel and random forest classifier.
Computer Methods and Programs in Biomedicine,108/1:10-19.

Ganzinger M., He S., Breuhahn K., Knaup P. (2012):
On the Ontology Based Representation of Cell Lines.
PloS ONE,7/11:e48584.

Ganzinger M., Kesselmeier M., Fabian J., Knaup P. (2012):
An Encapsulated R Application for the Guided Analysis of Genomic Data.
Studies in Health Technology and Informatics,180:1144-1146.

Gupta S. K., Srivastava M., Akhoon B. A., Gupta S. K., Grabe N. (2012):
In silico accelerated identification of structurally conserved CD8+ and CD4+ T-cell epitopes in high-risk HPV types.
Infection, Genetics and Evolution,12/7:1513-1518.

Guziolowski C., Kittas A., Dittmann F., Grabe N. (2012):
Automatic generation of causal networks linking growth factor stimuli to functional cell state changes.
FEBS Journal,279/18:3462-3474.

Halama N., Zoernig I., Grabe N., Jaeger D. (2012):
The local immunological microenvironment in colorectal cancer as a prognostic factor for treatment decisions in the clinic. The way ahead.

He S., Ganzinger M., Kesselmeier M., Knaup P. (2012):
The Intellectual Property Management for Data Sharing in a German Liver Cancer Research Network.
Studies in Health Technology and Informatics,180:891-895.

Kahlert C., Gaitzsch E., Steinert G., Mogler C., Herpel E., Hoffmeister M., Jansen L., Benner A., Brenner H., Chang-Claude J., Rahbari N., Schmidt T., Klupp F., Grabe N., Lahrmann B., Koch M., Halama N., Büchler M., Weitz J.
Expression Analysis of Aldehyde Dehydrogenase 1A1 (ALDH1A1) in Colon and Rectal Cancer in Association with Prognosis and Response to Chemotherapy.
Annals of Surgical Oncology,19/13:4193-4201.

Karch D., Kang K. S., Wochner K., Philippi H., Hadders-Algra M., Pietz J., Dickhaus H. (2012):
Kinematic assessment of stereotypy in spontaneous movements in infants.
Gait & Posture,36/2:307-311.

Keim S., Zoernig I., Spille A., Lahrmann B., Brand K., Herpel E., Grabe N., Jäger D., Halama N. (2012):
Sequential metastases of colorectal cancer Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments.

Knaup P., Schöpe L. (2012):
IT as an Enabler of Sustainable Use of Data from Innovative Technical Components for Assisted Living.
Studies in Health Technology and Informatics,180:1132-1134.

Koch S. H., Weir C., Haar M., Staggers N., Agutter J., Görges M., Westenskow D. (2012):
Intensive care unit nurses' information needs and recommendations for integrated displays to improve nurses' situation awareness.

Schöll M., Gramer M., Santos E., Kentar M., Sanchez-Porras R., Zheng Z., Sakowitz O., Graf R., Dickhaus H. (2012):
Comparison of Laser Speckle Flowmetry and Intrinsic Optical Signal Imaging in Gyrencephalic Swine Brain during Cortical Spreading Depolarisations.
Biomedizinische Technik,57 (Suppl. 1): 323-326.
Schüle R., Dictus C., Campos B., Wan F., Felsberg J., Ahmadi R., Centner F. S., Grabe N., Reifenberger G., Lorenzo Bermejo J., Unterberg A., Herold-Mende C.
C. (2012):
Potential Canonical Wnt Pathway Activation in High-Grade Astrocytomas.
The Scientific World Journal,Article ID 697313.

Wu J. C., Chen Y. C., Liu L., Chen T. J., Huang W. C., Cheng H., Su T. P. (2012):
Effects of Age, Gender, and Socio-economic Status on the Incidence of Spinal Cord Injury: An Assessment Using the Eleven-Year Comprehensive Nationwide Database of Taiwan.
Journal of Neurotrauma,29/5:889-897.

Wu J. C., Liu L., Huang W. C., Chen Y. C., Ko C. C., Wu C. L., Chen T. J., Cheng H., Su T. P. (2012):
The Incidence of Adjacent Segment Disease Requiring Surgery after Anterior Cervical Discectomy and Fusion: Estimation Using an Eleven-Year Comprehensive Nationwide Database in Taiwan.


Knaup-Gregori P., Schöpe L. (2012):
Von eingebetteten zu soziotechnischen Systemen. Potenzial und Forschungsbedarf auf dem Gebiet der IT im AAL-Umfeld.
Positionspapier der AG Informationstechnik (IT) der BMBF/VDE Innovationspartnerschaft AAL (Hrsg.)
ISBN 978-3-8007-3420-7, VDE-Verlag, Berlin.

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Fraiwan L., Lweesy K., Khasawneh N., Wenz H., Dickhaus H. (2011):
Time frequency analysis for automated sleep stage identification in fullterm and preterm neonates.
Journal of Medical Systems,35/4:693-702.

Ganzinger M., Noack T., Diederichs S., Longerich T., Knaup P. (2011):
Service Oriented Data Integration for a Biomedical Research Network.
Studies in Health Technology and Informatics,169:867-871.

Lweesy K., Fraiwan L., Khasawneh N., Dickhaus H. (2011):
New automated detection method of OSA based on artificial neural networks using P-wace shape and time changes.
Journal of Medical Systems,35/4:703-734.

Halama N., Braun M., Kahlert C., Spille A., Quack C., Rahbari N., Koch M., Weitz J., Kloor M., Zoernig I., Schirmacher P., Brand K., Grabe N., Falk C. (2011):
Natural killer cells are scarce in colorectal carcinoma tissue despite high levels of chemokines & cytokines.
Clinical Cancer Research,17/4:678-689.

Halama N., Michel S., Kloor M., Zoernig I., Benner A., Spille A., Pommerencke T., von Knebel Doeberitz M., Folprecht G., Luber B., Feyen N., Martens U. M., Beckhove P.,
Gnjatic S., Schirmacher P., Herpel E., Weitz J., Grabe N., Jaeger D. (2011):
Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy.
Cancer Research,71/17:5670-5677.

Hasman A., Ammenwerth E., Dickhaus H., Knaup P., Lovis C., Mantas J., Maojo V., Martin-Sanchez F. J., Musen M., Patel V. L., Surjan G., Talmon J. L., Sarkar I. N. (2011):
Biomedical Informatics – A Confluence of Disciplines?
Methods of Information in Medicine,50/6:508-524.

Huang C. C., Chan W. L., Chen Y. C., Chen T. J, Lin S. J., Chen J. W., Leu H. B. (2011):
Angiotensin II receptor blockers and risk of cancer in patients with systemic hypertension.
American Journal of Cardiology,107/7:1028-1033.

Huang C. C., Chan W. L., Chen Y. C., Chen T. J., Chou K. T., Lin S. J., Chan W. L., Chen J. W. (2011):
Statin use in patients with asthma – a nationwide population-based study.
European Journal of Clinical Investigation,41/5:507-512.

Lahrmann B., Halama S., Sinn H. P., Schirmacher P., Jaeger D., Grabe N. (2011):
Automatic Tumor-Stroma Separation in Fluorescence TMAs Enables the Quantitative High-Throughput Analysis of Multiple Cancer Biomarkers.
PLoS ONE,6/12:e28048.

Paraskevopoulos D., Unterberg A., Metzner R., Dreyhaupt J., Eggers G., Wirtz C. R. (2011):
Comparative study of application accuracy of two frameless neuronavigation systems: experimental error assessment quantifying registration methods and clinically influencing factors.
Neurosurgical Review,34/2:217-228.

Wan F., Herold-Mende C., Campos B., Centner F. S., Dictus C., Becker N., Devens F., Mogler C., Felsberg J., Grabe N., Reifenberger G., Lichter P., Unterberg A., Lorenzo
Bermejo J., Ahmadi R. (2011):
Association of Stem Cell-Related Markers and Survival in Astrocytic Gliomas.

Wu J. C., Liu L., Chen Y. C., Huang W. C., Chen T. J., Cheng H. (2011):
Ossification of the posterior longitudinal ligament in the cervical spine: An 11-year comprehensive national epidemiology study.
Neurosurgical Focus,30/3:E5.

Wu J. C., Huang W. C., Chen Y. C., Tu T. H., Tsai Y. A., Huang S. F., Huang H. C., Cheng H. (2011):
Acidic fibroblast growth factor for repair of human spinal cord injury: a clinical trial.
Journal of Neurosurgery: Spine,15/3:216-227.

Wu J. C., Huang W. C., Chen Y. C., Tu T. H., Tsai Y. A., Huang S. F., Huang H. C., Cheng H. (2011):
Editorial Response: Repair of the injured human spinal cord.
Journal of Neurosurgery: Spine,15/3:214-215.

Yang K. Y., Liu K. T., Chen Y. C., Chen C. S., Lee Y. C., Perng R. P., Feng J.Y. (2011):
Plasma soluble vascular endothelial growth factor receptor-1 levels predict outcomes of pneumonia-related septic shock patients: a prospective observational study.
Critical Care,15:R11 (

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Adrenal Insufficiency in the Elderly: A Nationwide Study of Hospitalizations in Taiwan.
Tohoku Journal of Experimental Medicine,221/4:281-285.

Dickhaus H., Metzner R. (2010):
OP-Planung und OP-Unterstützung durch biomedizinische Technik.

Fraiwan L., Lweesy K., Khasawneh N., Fraiwan M., Wenz H., Dickhaus H. (2010):
Classification of Sleep Stages Using Multi-wavelet Time Frequency Entropy and LDA.
Methods of Information in Medicine,49/3:230-237.

Grabe N., Lahrmann B., Pommerencke T., von Knebel Doeberitz M., Reuschenberg M., Wentzensen N. (2010):
A virtual microscopy system to scan, evaluate and archive biomarker enhanced cervical cytology slides.
Cellular Oncology,32/1-2:109-119.

Halama N., Zoernig I., Spille A., Michel S., Kloor M., Grauling-Halama S., Westphal K., Schirmacher P., Jäger D., Grabe N. (2010):
Quantification of Prognostic Immune Cell Markers in Colorectal Cancer Using Whole Slide Imaging Tumor Maps.
Analytical and Quantitative Cytology and Histology,33/5:333-340.

Hildenbrand M., Rhiemeier V., Hartenstein B., Lahrmann B., Grabe N., Angel P., Hess J. (2010):
Impaired Skin Regeneration and Remodeling after Cutaneous Injury and Chemically Induced Hyperplasia in Taps-Transgenic Mice.
Journal of Investigative Dermatology,130/7:1922-1930.

Hoerbst A., Kohl C. D., Knaup P., Ammenwerth E. (2010):
Attitudes and behaviors related to the introduction of electronic health records among Austrian and German citizens.
International Journal of Medical Informatics,79/2:81-89.

Huang C. C., Chen Y. C., Leu H. B., Chen T. J., Lin S. J., Chan W. L., Chen J. W. (2010):
Risk of Adverse Outcomes in Taiwan Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors in Patients Who Received Percutaneous Coronary Intervention.
Amercian Journal of Cardiology,105/12:1705-1709.

Karch D., Kim K. S., Wochner K., Philippi H., Pietz J., Dickhaus H. (2010):
Compensation of large motion sensor displacements during long recordings of limb movements.
Journal of Biomechanics,43/9:1844-1848.

Karch D., Wochner K., Kim K. S., Philippi H., Hadders-Algra M., Pietz J., Dickhaus H. (2010):
Quantitative Score for the Evaluation of Kinematic Recordings in Neuropediatric Diagnostics.
Methods of Information in Medicine,49/5:526-530.

Korosoglou G., Riedle N., Erbacher M., Dengler T. J., Zugck C., Rottbauer W., Hardt S., Bekeredjian R., Kristen A., Giannitsis E., Osman N. F., Dickhaus H., Katus H. A. (2010):
Quantitative myocardial blush grade for the detection of cardiac allograft vasculopathy.
American Hearth Journal,159/4:643-651.

Lahrmann B., Halama N., Westphal K., Ernst C., Elsawaf Z., Sinn P., Bosch F. X., Dickhaus H., Jäger D., Schirmacher P., Grabe N. (2010):
Robust Gridding of TMAs After Whole-Slide Imaging Using Template Matching.
Cytometry A,77A/12:1169-1176.

Maier C., Dickhaus H. (2010):
Central Sleep Apnea Detection from ECG-derived Respiratory Signals.
Methods of Information in Medicine,49/5:462-466.

Pommerencke T.
, Westphal K., Ernst C., Safferling K., Dickhaus H., Steinberg T., Tomakidi P. and Grabe N. (2010):
Spatial quantification and classification of skin response following perturbation using organotypic skin cultures.

Yeh H. Y., Chen Y. C., Su I., Chou L. F., Chao H. T., Chen T. J., Hwang S. J. (2010):
Pattern and Consequences of First Visits to Obstetricians/gynecologists by: A nationwide study in Taiwan.
Journal of the Chinese Medical Association,73/3:144-149.

Ko C. C., Tsai H. W., Huang W. C., Wu J. C., Chen Y. C., Shih Y. H., Chen H. C., Wu C. L., Cheng H. (2010):
Srew loosening in the Dynesys stabilization system: radiographic evidence and effect on outcomes.
Neurosurgical Focus,28/6:E10.

Nach oben


Buck, J., S. Garde, C. D. Kohl and P. Knaup (2009). "Towards a comprehensive electronic patient record to support an innovative individual care concept for premature infants using the openEHR approach." International Journal of Medical Informatics 78(8): 521-531.

Grabe, N. and P. Schirmacher (2009). "From virtual microscopy to systems pathology: a meeting report of the 1st European workshop on tissue imaging and analysis, Heidelberg, Germany, 13-14 February 2009." Virchows Archiv 455(2): 193-196.

N. Halama, S. Michel, M. Kloor, I. Zoernig, T. Pommerencke, M. von Knebel Doeberitz, P. Schirmacher, J. Weitz, N. Grabe, D. Jäger. The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy. Cancer Immun.(2009) Feb 19;9:1.   

Heinrich, H. and H. Dickhaus (2009). Analysis of event-related potentials using wavelet networks. Advanced biosignal processing. A. Nait-Ali. Berlin, Springer: 183-199.

Knaup-Gregori, P. and H. Dickhaus (2009). "Perspectives of medical informatics: advancing health care requires interdisciplinarity and interoperability. Special topic on the occasion of the 35th anniversary of the Heidelberg/Heilbronn curriculum of medical informatics." Methods Inf Med 48(1): 1-3.

Knaup-Gregori, P., M. Haag, F. J. Leven and H. Dickhaus (2009). "Challenges in the evolution of the medical informatics program at Heidelberg/Heilbronn (Germany)." Methods Inf Med 48(1).

Korosoglou, G., H. Dickhaus and H. A. Katus (2009). "Quantitative automated assessment of myocardial perfusion at cardiac catheterization; the need for validation.[comment]." American Journal of Cardiology 103(6): 895-896.

Lweesy, K., L. Fraiwan, O. Al-Bataineh, N. Hamdi and H. Dickhaus (2009). "Optimization of ultrasound array designs for high intensity focused treatment of prostate cancer and benign prostatic hyperplasia." Med Biol Eng Comput.

Sütterlin, T., S. Huber, H. Dickhaus and N. Grabe (2009). "Modeling multi-cellular behavior in epidermal tissue homeostasis via finite state machines in multi-agent systems." Bioinformatics 25(16): 2057-2063.

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Grabe, N. (2008). "Virtuelle Mikroskopie in der Systempathologie." Pathologe 29: 259-263.

Karch, D., K. Kim, K. Wochner, J. Pietz, H. Dickhaus and H. Philippi (2008). "Quantification of the segmental kinematics of spontaneous infant movements." Journal of Biomechanics 41(13): 2860-2867.

Kohl, C. D., S. Garde and P. Knaup (2008). "Facilitating the openEHR approach - organizational structures for defining high-quality archetypes." Stud Health Technol Inform 136: 437-42.

Krockenberger, K., S. P. Luntz and P. Knaup (2008). "Usage and usability of standard operating procedures (SOPs) among the coordination centers for clinical trials (KKS)." Methods Inf Med 47(6): 505-10.

Maier, C., M. Khalil, H. Ulmer and H. Dickhaus (2008). "Precursors of syncope in linear and non-linear parameters of heart rate variability during pediatric head-up tilt test." Biomed Tech 53(3): 145-55.

Michel, S., A. Benner, M. Triverdian, N. Wentzensen, P. Hoefler, T. Pommerencke, N. Grabe, M. von Knebel Doeberitz and M. Kloor (2008). "High density of FOXP3-positive T cells infiltrating colorectal cancers with microsatellite instability." Brit J Cancer 99: 1867-1873.

E. Mussig, T. Steinberg, S. Schulz, J. Spatz, J. Ulmer, N. Grabe, A. Kohl, G. Komposch, P. Tomakidi. Connective Tissue Fibroblasts Established on Micropillar Interfaces are Pivotal for Epithelial Tissue Morphogenesis. Advanced Functional Materials (2008), 18, 1-11 (IF: 7.496)

Ndira, S., K. Rosenberger and T. Wetter (2008). "Assessment of data quality of and staff satisfaction with an electronic health records system in a developing country (Uganda) : a qualitative and quantitative comparative study." Method Inform Med 47(6): 489-98.

Pommerencke, T., T. Steinberg, H. Dickhaus, P. Tomakidi and N. Grabe (2008). "Nuclear staining and relative distance for quantifying epidermal differentiation in biomarker expression profiling." BMC Bioinformatics 9: 473.

Ranzinger, R., S. Herget, T. Wetter and C.-W. von der Lieth (2008). "GlycomeDB - integration of open-access carbohydrate structure databases." BMC Bioinformatics 9: 384.

Wetter, T. (2008). "Why is medical software so hard?" Computer Science - Research and Development 22(3): 185-99.

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Dickhaus H, Maier C Detection of Sleep Apnea Episodes from Multi-Lead ECGs Considering Different Physiological Influences. Method Inform Med 2007; 46(2):216-221 (2007)

Floca R, Dickhaus H: A Flexible Registration and Evaluation Engine (f.r.e.e.). Comput Meth Prog Bio 87, 81-92 (2007).

Garde S, Hovenga E, Buck J, Knaup P: Expressing Clinical Data Sets with openEHR Archetypes: A Solid Basis for Ubiquitous Computing. Int J Med Inform 76 (S3), S334-S341 (2007).

Garde S, Knaup P, Hovenga E, Heard S: Towards Semantic Interoperability for Electronic Health Records: Domain Knowledge Governance for openEHR Archetypes. Method Inform Med. 46 (3),332-343 (2007).

Grabe N, Neuber K. Simulating psoriasis by altering transit amplifying cells. Bioinformatics, Bioinformatics, Jun 1; 23(11):1309-12 (2007)

Grabe N, Pommerencke T, Tomakidi P, Steinberg T, Dickhaus H: „ Reconstructing protein networks of epithelial differentiation from histological sections”, Bioinformatics (2007) Dec 1; 23(23):3200-8 (2007)

Knaup P, Garde S, Haux R: Systematic planning of patient records for cooperative care and multicenter research. Int J Med Inform. 76 (1), 109-117 (2007).

Knaup P, Bott O, Kohl C, Lovis C, Garde S: Electronic Patient Records: Moving from Islands and Bridges towards Electronic Health Records for Continuitiy of Care. Method Inform Med, 46 Suppl 1, 34-46 (2007).

Haux R, Knaup P, Leiner  F: On Educating about Medical Data Management  - the Other Side of the Electronic Health Record. Method Inform Med. 46 (1). 74-79 (2007).

Ho S, Lukazc Z, Hoffmann GF, Lindner M, Wetter T: Feature Construction Can Improve Diagnostic Criteria for High-Dimensional Metabolic Data in Newborn Screening for Medium-Chain Acyl-CoA Dehydrogenase Deficiency; Clin Chem (2007)

Steinberg T, Schulz S, Spatz JP, Grabe N, Kohl A, Komposch G, Tomakidi P. Early Keratinocyte Differentiation on Micropillar Interfaces. Nano Lett. Feb; 7(2):287-94 (2007)

Weires M B, Tausch B, haug P J, Edwards C Q, Wetter T, Cannon-albright L A: Familiality of Diabetes Mellitus. Exp Clin Endocr Diab. 115:634-640 (2007).

Wetter, Th; To decay is system: The challenges of keeping a health information system alive; Int J Med Inform 76 (S1), pp. 252–260 (2007)

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2004 - 2006

Garde S, Knaup P: Requirements Engineering in Health Care: The Example of Chemotherapy-Planning in Paediatric Oncology. Requir Enl 11, 265-278 (2006)

Garde S, Wolff AC, Kutscha U, Wetter T, Knaup P; CSI-ISC: Concepts for Smooth Integration of Health Care Information System Components into Established Processes of Patient Care. Method Inform Med 45 (1): 10-18 (2006)

Hartge F, Wetter T, Haefeli WE; A similarity measure for case based reasoning modeling with temporal abstraction based on cross-correlation; Comput Meth Prog Bio 81(1), 41-8 (2006)

Haux R, Ammenwerth E, Häber A, Hübner-Bloder G, Knaup-Gregori P, Lechleitner G, Leiner F, Weber R, Winter A, Wolff AC: Medical Informatics Education Needs Information System Practicums in Health Care Settings - Experiences and Lessons Learned from 32 Practicums at Four Universities in Two Countries. Method Inform Med 46, 294-299 (2006).

Jaspers M, Knaup P, Schmidt D: The Computerized Patient Record: Where Do We Stand? Method Inform Med 45 Suppl 1, 29-39 (2006).

Knaup P, Pilz J , Kaltschmidt J, Ludt S, Szecsenyi J, Haefeli WE: Standardized Documentation of Drug Recommendations in Discharge Letters - A Contribution to Quality Management in Cooperative Care. Method Inform Med 45,  336-342 (2006).

Knaup P: Electronic Patient Records and their Benefit for Patient Care. Method Inform Med 45 Suppl 1, 40-42 (2006).

Kremer P, Tronnier V, Steiner HH, Metzner R, Ebinger F, Rating D, Hartmann M, Seitz A, Unterberg A, Wirtz CR: Intraoperative MRI for interventional neurosurgical procedures and tumor resection control in children. Child nerv syst 22, 674-678 (2006

Maier C, Dickhaus H. Recurrence analysis of nocturnal heart rate in sleep apnea patients. Biomed Tech; 51:224-228 (2006).

Bott OJ, Ammenwerth E, Brigl B, Knaup P, Lang E, Pilgram R, Pfeifer B, Ruderich F, Wolff AC, Haux R, Kulikowski C: The Challenge of Ubiquitous Computing in Health Care: Technology, Concepts and Solutions. Findings from the IMIA Yearbook of Medical Informatics (2005). Method Inform Med 44, 473-9.

Eggers G, Rieker M, Kress B, Fiebach J, Dickhaus H, Hassfeld S: Artefacts in magnetic resonance imaging caused by dental material. MAGMA 3:1-10 (2005)

Eggers G, Rieker M, , Fiebach J, Kress B, Dickhaus H, Hassfeld S: Geometric Accuracy of Magnetic Resonance Imaging of the Mandibular Nerve. Dentomaxillofac Rad 34(5):285-9 (2005)

Garde S, Kutscha U, Wetter Th, Wolff AC, Knaup P : CSI-ISC: Concepts for Smooth Integration of Health Care Information System Components into Established Processes of Patient Care. Method Inform Med 45, 10-18 (2005).

Grabe N, Neuber K: A multi-cellular systems biology model predicts epidermal morphology, kinetics, and Ca++ flow. Bioinformatics 21, 3541-7 (2005).

Knaup P, Garde S, Merzweiler A, Graf N, Schilling F, Weber R, Haux R: Towards shared patient records: An Architecture for Using Routine Data for Nationwide Research. Int J Med Inform, 75, 191-200 (2005).

Merzweiler A, Weber R, Garde S, Haux R, Knaup-Gregori P: TERMTrial – Terminologiy-based documentation systems for cooperative clinical trials. Comput Meth Prog Bio 78, 11-24 (2005)

Philipp, F., Jantke, M., Finkeissen, E., Beedgen, B., Linderkamp, O. Wetter, Th.; Introducing DoT-U2 – an XML based knowledge supported checklist software for documentation of a newborn screening investigation; Comput Meth Prog Bio. 77(2) 115-20 (2005)

Jaspers, M.W.M., Gardner R.M, L. Gatewood L.C., Haux R.,  Schmidt D., Wetter Th: Achievements after six years of IHPIE, the international partnership in health informatics education. Method Inform Med. 44 (1) 25-32 (2005)

van Quekelberghe PR, Jakob T, Hoffman D, Wetter T, Finkeissen E: Minimalist knowledge representation of primary care diseases in the knowledge base.Inform Prim Care 13(4): 239-247 (2005)

Bauer, A.M., Plaza, D. Wetter, T. Becker, M.D.; Computergestütztes System zur Verlaufskontrolle intraokularer Entzündungen; Ophtalmologe 102 1069-73 (2005)

Chevreux B, Pfisterer T, Drescher B, Driesel AJ, Werner EG, Müller WEG, Wetter Th, Suhai S: Using the miraEST assembler for reliable and automated mRNAtranscript assembly and SNP detection in sequenced ESTs. Gen Res 14 (2004) 1147 - 1159

Finkeissen E, Stamm I,Müssig M, Streicher J, Koke U, Helmstetter C, Hassfeld S, Wetter T: AIDA - Web Agents in Dental Treatment Planning. Adv Dent Res. Bethesda, MD, USA. Adv Dent Res 17 (2003) 74-6

Ganser KA, Dickhaus H, Metzner R, Wirtz CR. A deformable digital brain atlas system according to Talairach and Tournox. Medical Image Analysis. vol 8 pp. (2004) 3-22

Garde S, Baumgarten B, Basu O, Graf N, Haux R, Herold R, Kutscha U, Schilling F, Selle B, Spiess C, Wetter T, Knaup P (2003): A UML-based Meta-Model of Chemotherapy Planning in the Multi-Hospital / Multi-Trial-Center-Environment of Pediatric Oncology. Methods Inf Med 43(2) (2004) 171-183

Garde S, Knaup P, Herold R: Qumquad: a UML-based approach for remodeling of legacy systems in health care. Int J Med Inf 70(2-3) (2003) 183-194

Gatewood L, Limburg M, Gardner R, Haux RM, Jaspers M, Schmidt D, Wetter T: International Master Classes in health informatics. Int J Med Inf 73(2) (2004) 111-116

Gröschel J, Philipp F, Skonetzki St, Genzwürker H, Wetter Th, Ellinger K: Automated speech recognition for time recording in out-of-hospital emergency medicine – an experimental approach. Resuscitation 60(2) (2004) 205-212

Haux R, Ammenwerth E, Herzog W, Knaup P: Gesundheitsversorgung in der Informationsgesellschaft. Eine Prognose für das Jahr 2013. Informatik, Biometrie und Epidemiologie in Medizin und Biologie 35 (2004) 138-163

Knaup P, Ammenwerth E, Brandner R, Brigl B, Fischer G, Garde S, Lang E, Pilgram R, Ruderich F, Singer R, Wolff AC, Haux R, Kulikowski C: Towards Clinical Bioinformatics: Advancing Genomic Medicine with Informatics Methods and Tools. Findings from the IMIA Yearbook of Medical Informatics 2004. Methods Inf Med 43(3) (2004) 302-7

Knaup P, Frey W, Haux R, Leven FJ: Medical Informatics Specialists: What are their Job Profiles? Results of a Study on the First 1024 Medical Informatics Graduates of the Universities of Heidelberg and Heilbronn. Methods Inf Medicine 42 (2003) 578-587

Leven FJ, Knaup P, Schmidt D, Wetter T: Medical Informatics at Heidelberg/Heilbronn: Status – Evaluation – New Challenges in a Specialized Curriculum for Medical Informatics after Thirty Years of Evolution. International Journal of Medical Informatics 73 (2004) 117-125

Skonetzki S, Gausepohl HJ, van der Haak M, Knaebel S, Linderkamp O, Wetter T: HELEN, a modular framework for representing and implementing clinical practice guidelines. Methods Inf Med 43(4) (2004) 413-26

Wetter T: Modelle und Wirklichkeiten: Versuche einer Annäherung an eine vielschichtige Beziehung. eingeladener Kommentar zu Richter, M.M.; Einige Thesen: Logik versus Approximation; Künstliche Intelligenz 3 (2004) 65-66

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2001 - 2003

Ammenwerth E, Iller C, Mansmann U: Can evaluation studies benefit from triangulation? A case study. International Journal of Medical Informatics 70 (2003) 237-48

Ammenwerth E, Mansmann U, Iller C, Eichstaedter R: Factors Affecting and Affected by User Acceptance of Computer-based Nursing Documentation: Results of a Two-year Study. Journal of the American Medical Informatics Association 10 (2003) 69-84

Ammenwerth E, Haux R, Kulikowski C, Bohne A, Brandner R, Brigl B, Fischer G, Garde S, Knaup P, Ruderich F, Schubert R, Singer R, Wolff AC: Medical Informatics and the Quality of Health: New Approaches to Support Patient Care. Findings from the IMIA Yearbook of Medical Informatics 2003. Methods Inf Med 42(2) (2003) 185-189

Ammenwerth E, Wolff AC, Knaup P, Ulmer H, Skonetzki S, van Bemmel JH, McCray AT, Haux R, Kulikowski C: Developing and evaluating criteria to help reviewers of biomedical informatics manuscripts. J Am Med Inform Assoc 10(5) (2003) 512-4

Bludau B, Hochlehnert A, Wolff AC: Presenting XML-based medical discharge letters according to CDA. Methods Inf Med 42(5) (2003) 552-6

Brandner R, Pordesch U: Konzept zur signaturgesetzkonformen Erneuerung qualifizierter Signaturen. Datenschutz und Datensicherheit 27(6) (2003)354-359

Hollerbach A, Brandner R: Kriterien und Bewertung von Datenformaten für die beweiskräftige und sichere Langzeitspeicherung medizinischer Dokumente. Forum der Medizin-Dokumentation und Medizin-Informatik 5(4) (2003) 105-109

Garde S, Wolff AC, Kutscha U, Knaup P: Ein Vorgehensmodell für die Integration von Infor-mations-systemkomponenten des Gesundheitswesens in bestehende Behandlungs-pro-zesse. Informatik, Biometrie und Epidemiologie in Medizin und Biologie 34(3) (2003) 342-345

Keck HP, Wetter T: Functional Classification of Proteins Using a Nearest Neighbour Classification. In Silico Biology 3 (2003) 23-30

Roßnagel A, Fischer-Dieskau S, Pordesch U, Brandner R: Erneuerung elektronischer Signaturen - Grundfragen der Archivierung elektronischer Dokumente. CR 4 (2003) 301-306

van der Haak M, Wolff A, Brandner R, Drings P, Wannenmacher M, Wetter T: Data security and protection in cross-institutional electronic patient records. Int J Med Inf 70 (2003) 117-130

Wolff AC: Ein generisches XML-basiertes Informationsmodell zur Strukturierung patientenzentrierter onkologischer Patientenakten. Informatik, Biometrie und Epidemiologie in Medizin und Biologie 34(3) (2003) 271-274

Wolff AC, Kraus MJ, Leven FJ: Evaluation ärztlicher Fort- und Weiterbildung am Universitätsklinikum Heidelberg. Informatik, Biometrie und Epidemiologie in Medizin und Biologie 34(3) (2003) 571-574

Knaup, P., Frey, W., Haux, R., Leven, F.J. (2003). Medical Informatics Specialists: What are their Job Profiles?. Methods Inf Med. 42, 578-87.

Mludek, V., Wolff, A.C., van der Haak, M., Schweiger, R., Hölzer, S., Dudeck, J., Wetter, Th. (2002). Supporting Clinical Practice Guidelines: Lifecycles of Guidelines for Oncology within an XML-Based Guideline Framework; Stud Health Technol Inform 90, 466-470.

Wetter, T. (2002). Lessons learnt from bringing knowledge-based decision support into routine use. Artif Intell Med. 24, 195-203.

Ammenwerth, E., Eichstädter, R., Pohl, U., Rebel, S., Haux, R., Ziegler, S. (2001). A Randomized Evaluation of a Computer-Based Nursing Documentation System. Meth. Inform. Med. 40, 61-68.

Ammenwerth, E., Knaup, P., Meier, C., Mludek, V., Singer, R., Skonetzki, S., Wolff, A.C., Haux, R., Kulikowski, C. (2001). Digital Libraries and Recent Medical Informatics Research. Methods. Inf. Med. 40, 163-167.

Haux, R., Knaup, P., Herzog, W., Bauer, A.W., Reinhardt, E.R., Überla, K., van Eimeren, W., Wahlster, W. (2001). Information Processing in Health Care at the Start of the third Millenium - Potential and Limitations. Meth. Inform. Med. 40, 156-162.

Knaup, P., Harkener, S., Ellsässer, K.-H., Haux, R., Wiedemann, T. (2001). On the necessity of systematically planning clinical tumor documentation. Methods. Inf. Med. 40, 90-98.

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Ammenwerth, E., Buchauer, A., Bludau, H.-B., Haux, R. (2000).
Mobile Information and Communication Tools in the Hospital. Int. J. Med. Inform. 57, 21-40.

Mönnich, G., Wetter, Th. (2000).
Requirements for Speech Recognition to Support Medical Documentation. Methods of Information in Medicine 39(1):63-69

Ammenwerth, E., Buchauer, A., Bludau, H.-B., Haux, R. (2000).
Mobile Information and Communication Tools in the Hospital. Int. J. Med. Inform. 57, 21-40.

Wetter, T (2000).
Applications of expert systems in medicine. Acta Clin Belg 55(2): 55-67.

Ammenwerth, E., Haux, R. (2000).
A Compendium of Information Processing Functions in Nursing - Development and Pilot Study. Comp. in Nursing 18, 189-196.

Haux, R., Grant, A., Hasman, A., Hovenga, E., Knaup, P. (2000).
Recommendations of the International Medical Informatics Association (IMIA) on Education in Health and Medical Informatics. Meth. Inform. Med. 39, 267-277.

Knäbel S, Skonetzki S, Nelle M, Linderkamp O, Wetter T (2000).
Ergebnisse einer Umfrage zum Einsatz von Leitlinien in der Neonatologie. Z. ärtzl. Fort Qual.sich 39(1): 63-69.

Buchauer, A., Pohl, U., Kurzel, N., Haux, R. (1999).
Mobilizing a Health Professional Workstation - Results of an Evaluation Study.
Int. J. Med. Inform. 54, 105-114.

Haag, M., Maylein, L., Leven, F.J., Tönshoff, B., Haux, R. (1999).
Web-Based Training: A New Paradigm in Computer-Assisted Training in Medicine.
Int. J. Med. Inform. 53, 79-90.

Haux, R. (1999).
Zur Wissenschaftlichkeit in Medizin und Informatik.
Informatik-Spektrum 22, 276-283.

Knaup, P., Ball, M., Haux, R., Lun, K.C., Swinkels, W. (1999).
Necessity and Potential of Educating Medical Students, Physicians and Other Health Care Professionals in Medical Informatics.
Medical Teacher 21, 73-76.

Knaup, P., Wiedemann, T., Wolff, A., Creutzig, U., Haux, R., Schilling, F. (1999).
Rechnerunterstützte Dokumentation und Therapieplanung in der Pädiatrischen Onkologie: Vorstellung einer bundesweiten Lösung.
Klin. Pädiatr. 211, 189-191.

Rath, S., Heuer, C., Alle, W., Bach, A., Bischoff, B., Bonsanto, M.M., Borneff-Lipp, M., Brüssau, J., Haux, R., Kunze, S., Linderkamp, O., Middeke, M. (1999).
Integration of Generic Indicators for Quality Management in Hospital Information Systems.
Int. J. Med. Inform. 55, 179-188.

Winter, Al., Winter, An., Becker, K., Bott, O.J., Brigl, B., Gräber, S., Hasselbring, W., Haux, R., Jostes, C., Penger, O-S., Prokosch, H.-U., Ritter, J., Schütte, R., Terstappen, A. (1999).
Referenzmodelle für die Unterstützung des Managements von Krankenhausinformationssystemen.
Informatik, Biometrie und Epidemiologie in Med. u. Biol. 30, 173-189.

Brigl, B., Mendoza, G., Ringleb, P., Hacke, W., Haux, R. (1998).
Evaluation eines Daten- und Wissensbanksystems für die Neurologie in der klinischen Routine: Bewertung der Komponenten zur Dokumentation.
Informatik, Biometrie und Epidemiologie in Med. u. Biol. 29, 194-200.

Brigl, B., Ringleb, Steiner, T., P., Knaup, P., Hacke, W., Haux, R. (1998).
An Integrated Approach for a Knowledge-based Clinical Workstation: Architecture and Experience.
Meth. Inform. Med. 37, 16-25.

Buchauer, A., Ammenwerth, E., Bludau, H.-B., Haux, R. (1998).
Mobile Kommunikation und Informationsverarbeitung.
Management & Krankenhaus 12/98, 13-14.

Buchauer, A., Werner, R., Haux, R. (1998).
Cooperative Problem Solving with Personal Mobile Information Tools in Hospitals.
Meth. Inform. Med. 37, 8-15.

Haux, R. (1998).
Health and Medical Informatics Education: Perspectives for the Next Decade.
Int. J. Med. Inform. 50, 7-19.

Haux, R., Swinkels, W.,Ball, M., Knaup, P., Lun, K.C. (1998).
Transformation of Healthcare through Innovative Use of Information Technology:
Challenges for Health and Medical Informatics Education.
Int. J. Med. Inform. 50, 1-6.

Knaup, P., Budig, B., Haux, R., Schu, A. (1998).
Bewertung des Nutzens der rechnerunterstützten Essensanforderung am Universitätsklinikum Heidelberg.
Informatik, Biometrie und Epidemiologie in Med. u. Biol. 29, 201-208.

Knaup, P., Haux, R., Häber, A., Lagemann, A., Leiner, F. (1998).
Teaching the Fundamentals of Information Systems Management in Health Care:
Lecture and Practical Training For Students of Medical Informatics (Heidelberg/Heilbronn)
Int. J. Med. Inform. 50, 195-205.

Leven, F.J., Haux, R. (1998).
Twenty Five Years of Medical Informatics Education at Heidelberg/Heilbronn: Discussion of a Specialized Curriculum for Medical informatics
Int. J. Med. Inform. 50, 31-42.

Rais, S., Alle, W., Bach, A., Bischoff, B., Bonsanto, M.M., Borneff-Lipp, M., Brüssau, J., Haux, R., Heuer, C., Kunze, S., Linderkamp, O. Middeke, M. (1998).
Untersuchungen zur Patientenzufriedenheit über einen fachinvarianten standardisierten Fragebogen.
Das Krankenhaus 90, 86-90.

Schmücker, P., Ohr, C., Beß, A., Bludau, H.-B., Haux, R., Reinhard, O. (1998).
Die elektronische Patientenakte: Ziele, Strukturen, Präsentation und Integration.
Informatik, Biometrie und Epidemiologie in Med. u. Biol. 29, 221-241.

Viethen, G., Bach, A., Haux, R. (1998).
Drei Jahre Forschung zur Patientenunzufriedenheit - Von der Entwicklung und Erprobung eines Erhebungsinstruments.
Das Krankenhaus 90, 208-209.

Winter, A. F., Zimmerling, R., Bott, O.J., Gräber, S., Haas, P., Hasselbring, W., Haux, R., Heinrich, A., Jaeger, R., Kock, I., Kuhn, K., Möller, D.P.F., Penger, O.-S., Prokosch, H.-U., Ritter, J., Terstappen, A., Winter, A. (1998).
Das Management von Krankenhausinformationssystemen: eine Begriffsdefinition.
Informatik, Biometrie und Epidemiologie in Med. u. Biol. 29, 93-105.

Haux, R. (1997).
Aims and Tasks of Medical Informatics (with discussion).
Int. J. Med. Inform. 44, 9-87.

Haux, R., Frank, J., Knaup, P. (1997).
The IMIA WG1 Database on Health/Medical Informatics Programs and Courses :
A Call for Participation.
Meth. Inform. Med. 36, 233-234.

Haux, R., Brigl, B., Knaup, P., Wetter, T. (1997).
Wissensbasierte Entscheidungsunterstützung in der Medizin: Geleistetes und zu Leistendes.
KI 3/1997, 25-26.

Haux, R., Michaelis, J. (1997).
Investitionsschema zur Informationsverarbeitung in Krankenhäusern.
Das Krankenhaus 89, 425-426.

Überla, K., Haux, R., Tolxdorff, T. (1997).
Aufgaben, Organisation und Ausstattung der Servicebereiche für Medizinische Informationsverarbeitung (Klinische Rechenzentren) und der Institute für Medizinische Informatik in den Klinika der Bundesrepublik Deutschland.
Informatik, Biometrie und Epidemiologie in Med. u. Biol. 28, 25-45.

Hasman, A., Haux, R., Albert, A. (1996).
A Systematic View On Medical Informatics.
Comp. Meth. Progr. Biomed. 51, 131-139.

Haux, R. (1996).
Medical Informatics: Once More Towards Systematisation.
Meth. Inform. Med. 35, 189-192.

Haux, R. (1996).
Ziele und Aufgaben der Medizinischen Informatik (mit Diskussion).
Informatik, Biometrie und Epidemiologie in Med. u. Biol. 27, 149-173.

Haux, R., Dudeck, J., Pöppl, S. (1996).
Die zukünftige Entwicklung der Informationsverarbeitung in den Universitätsklinika.
Das Krankenhaus 88, 574-576.

Haux, R., Grothe, W., Runkel, M., Schackert, H.K., Windeler, J., Winter, A., Wirtz, R., Herfahrt, Ch., Kunze, S. (1996).
Knowledge Retrieval as One Type of Knowledge-Based Decision Support in Medicine: Results of an Evaluation Study.
Int. J. Bio-Med. Comp. 41, 69-85.

Haux, R., Schmücker, P., Winter, A. (1996).
Gesamtkonzept der Informationsverarbeitung im Krankenhaus.
Management & Krankenhaus 11/96, 45-50.
Nachdruck aus: Haas, al. (Hrsg.). Praxis der Informationsverarbeitung im Krankenhaus, 25-37. Landsberg: ecomed.

Lagemann, A., Haux, R., Winter, A. (1996).
Modellierung eines Anwendungssystems zur Unterstützung der Pflegedokumentation unter Berücksichtigung der Integration in ein Klinisches Arbeitsplatzsystem.
Informatik, Biometrie und Epidemiologie in Med. u. Biol. 27, 113-122.

Leiner, F., Haux, R. (1996).
Systematic Planning of Clinical Documentation.
Meth. Inform. Med. 35, 25-34.

Winter, A., Lagemann, A., Budig, B., Grothe, W., Haux, R., Herr, S., Pilz, J., Sawinski, R., Schmücker, P. (1996).
Health Professional Workstations and their Integration in a Hospital Information System: The Pragmatic Approach MEDIAS.
Comp. Meth. Progr. Biomed. 51, 193-209.

Brigl, B., Mieth, M., Haux, R., Glück, E. (1995).
The LBI-Method for Automated Indexing of Diagnoses by using SNOMED
Part 2: Evaluation.
Int. J. Bio-Med. Comp. 38, 101-108.

Brigl, B., Ringleb, P., Leiner, F., Steiner, T., Grau, A., Hacke, W., Haux, R. (1995).
Multiple Verwendbarkeit Klinischer Dokumentationen am Beispiel eines wissensbasierten klinischen Arbeitsplatzsystems in der Neurologie.
Informatik, Biometrie und Epidemiologie in Med. u. Biol. 26, 240-249.

Dujat, C., Haux, R., Schmücker, P., Winter, A. (1995).
Digital Optical Archiving of Medical Records in Hospital Information Systems -
A Practical Approach towards the Electronic Patient Record?
Meth. Inform. Med. 34, 489-497.

Haux, R. (1995).
Medical Informatics: A Key to the Future of Medicine and Health Care?
Meth. Inform. Med. 34, 454-457.

Winter, A., Haux, R. (1995).
A Three-Level Graph-Based Model for the Management of Hospital Information Systems.
Meth. Inform. Med. 34, 378-396.

Brigl, B., Mieth, M., Haux, R., Glück, E. (1994).
The LBI-Method for Automated Indexing of Diagnoses by using SNOMED
Part 1: Design and Realisation.Int. J. Bio-Med. Comp. 37, 237-247.

Fetter, M., Bastian, M., Mann, G., Haasis, R., Diener, H.C., Haux, R. (1994).
Einfluß einer antihypertensiven Therapie auf die Blutflußgeschwindigkeiten in extra- und intrakraniellen, hirnversorgenden Gefäßen unter Ruhebedingungen.
Akt. Neurol. 21, 177-182.

Frey, W., Haux, R., Leiner, F., Leven, F.J. (1994).
Medical Informatics Heidelberg/Heilbronn: Graduates‘ Experiences and Job Situation.
Meth. Inform. Med. 33, 290-298.

Haux, R., Leven, F.-J. (1994).
Twenty Years Medical Informatics Education at Heidelberg/Heilbronn: Evolution of a Specialized Curriculum for Medical Informatics.
Meth. Inform. Med. 33, 285-289.

Haux, R., Leven, F.J., Möhr, J.R., Protti, D.J. (1994).
Health and Medical Informatics Education
Meth. Inform. Med. 33, 246-249.

Leiner, F., Haux, R. (1994).
Prinzipien einer zielgerichteten Klinischen Dokumentation.
it + ti 36(6), 29-36.

Protti, D.J., van Bemmel, J.H., Gunzenhäuser, R., Haux, R., Warner, H., Douglas, J. V., Lang, E. (1994).
Can Health/Medical Informatics be Regarded as a Separate Discipline?
Meth. Inform. Med. 33, 318-326.

Stricker, H., Fuchs, S., Haux, R., Rößler, R., Rupprecht, B., Schmelmer, V., Wiegel, S. (1994).
Das Galenische Entwicklungs-System Heidelberg:
Systematische Rezepturentwicklung.
Pharm. Ind. 56, 641-647.

Zachariou, Z., Schiller, U., Leiner, F., Roth, H., Haux, R. (1994).
Das Heidelberger Modell - wissenschaftliche Falldokumentation in der Kinderchirurgie.
Zentralbl. Kinderchir. 3, 63-69.

Haux, R., Winter, A. (1993).
Medizinische Informatik im Krankenhaus.
Quintessenzen in der Medizin 1, 507-523.

Leiner, F., Haux, R., Glück, E. (1993).
Systematische Planung Medizinischer Basisdokumentationen im Krankenhaus.
Informatik, Biometrie und Epidemiologie in Med. u. Biol. 24, 199 - 213.

Mann, G., Haux, R. (1993).
Database Scheme Design for Clinical Studies Based on a Semantic Data Model.
Comp. Statist. & Data Analysis 15, 81-108.

Mieth, M., Brigl, B., Glück, E., Haux, R. (1993).
Zur automatischen Indexierung von Diagnosen nach SNOMED und Ihrer Anwendbarkeit in der Neurochirurgie.
Informatik, Biometrie und Epidemiologie in Med. u. Biol. 24, 101 - 109.

Sawinski, R., Hampl, J., Werner, R., Winter, A., Winkler, J., Haux, R., Kunze, S. (1993).
OP-Register und Arztbriefschreibung mit MDVS.
Informatik, Biometrie und Epidemiologie in Med. u. Biol. 24, 81 - 86.

Haux, R., Dudeck, J., Gaus, W., Leven, F.J., Kunath, H., Michaelis, J., Pretschner, D.P., Sonntag, H.-G., Thurmayr, R., Wolters, E. (1992).
Recommendations of the German Association for Medical Informatics, Biometry and Epidemiology for Education and Training in Medical Informatics.
Meth. Inform. Med. 31, 60-70.

Mann, G., Schleicher, C., Haux, R., Hennerici, M., Konietzko, M., Sliwka, U., Diener, H.-C., Nötzel, P. (1992).
Evaluation eines Daten- und Wissensbanksystems für die neurologische Ultraschalldiagnostik.
Biometrie und Informatik in Med. u. Biol. 23, 100-106.

Gerneth, F., Haux, R., Müller, C.A. (1992).
Data Modeling for Immunological and Clinical Data of Leukemia and Myasthenia Patients.
Meth. Inform. Med. 31, 136-146.

Diener, H.-C., Peters, C., Rudzio, M., Noe, A., Dichgans, J., Haux, R., Ehrmann, R., Tfelt-Hansen, P. (1991).
Ergotamine, Flunarizine and Sumatropan do not Change Cerebral Blood Flow Velocity in Normal Subjects and Miigraneurs.
J. Neurol. 238, 245-250.

Gerneth, F., Haux, R., Selbmann, H.K. (1991).
On Medical Research Subsystems and Their Integration in Hospital Information Systems.
Medical Informatics 16, 77-95.

Haux, R., Dudeck, J., Gaus, W., Leven, F.J., Kunath, H., Michaelis, J., Pretschner, D.P., Sonntag, H.-G., Thurmayr, R., Wolters, E. (1991).
Empfehlungen der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS) zur Bildung und Ausbildung in Medizinischer Informatik.
Biometrie und Informatik in Med. u. Biol. 22, 180-197.

Stricker, H., Haux, R., Wetter, T., Mann, G., Oberhammer, L., Flister, J., Fuchs, S., Schmelmer, V. (1991).
Das 'Galenische Entwicklungs-System Heidelberg' (GSH).
Pharm. Ind. 53, 571-578.

Fritz, H., Uhlig, K., Schunkert, H., Haux, R., Winter, A., Repges, R., Sieberth, H.-G. (1990).
Analyse des Informationssystems einer internistischen Klinik.
Biometrie und Informatik in Med. u. Biol. 21, 132-140.

Haux, R. (1989).
Expertensysteme in der Medizin - eine Einführung (Teil 2).
Softw. Kurier 2, 1-11.

Haux, R. (1989).
Knowledge-Based Decision Support for Diagnosis and Therapy: On the Multiple Usability of Patient Data.
Meth. Inform. Med. 28, 69-77.

Haux, R. (1989).
On Medical Informatics.
Meth. Inform. Med. 28, 66-68.

Haux, R. (1989).
Statistische Expertensysteme (eingelades Referat, mit Diskussion).
Biometrie und Informatik in Med. u. Biol. 20, 3-65.

Haux, R., Gerneth, F. (1989).
Non-Standard Data Models for Statistical Data Analysis (invited paper, with discussion).
Bulletin Int. Stat. Inst. 53, 3, 171-190 und 4, 247-256.

Haux, R. (1988).
On the Existence of Statistical Expert Systems.
Stat. Software Newsl. 14, 68-69.

Haux, R. (1988).
Expertensysteme in der Medizin - eine Einführung (Teil 1).
Softw. Kurier 1, 65-77.

Haux, R. (1988).
Wissensbasierte Diagnoseunterstützung mittels Mustererkennungsmethoden? (mit Diskussion)
Softw. Kurier 1, 78-86.

Haux, R., Immich, H., Schumacher, M. (1987).
Statistical Analysis of a Clinical Trial in Orthostatic Hypotension - a Nonparametric Approach.
Meth. Inform. Med. 26, 47-52.

Haux, R., Mattauch, V., Weckesser, G. (1987).
Rank Tests for the 2 x 2 Design with I Blocks.
Biom. J. 29, 507-524.

Haux, R., Unkelbach, H.D. (1987).
Biometrie und moderne Informationstechnologie - einführende Bemerkungen.
EDV in Med. u. Biol. 18, 65-66.

Schunkert, H., Emser, K., Haux, R., Winter, A., Kindler, J., Repges, R., Sieberth, H.-G. (1987).
Adaption eines Diagnosenschlüssels an die Erfordernisse einer medizinischen Klinik am Beispiel der Nephrologie.
Nieren- und Hochdruckkrankheiten 16, 417-422.

König, J., Giani, G., Haux, R. (1986).
Some Algorithms for Nonparametric Tests with two Independent Samples - Empirical and Complexity Investigations. Part 1: Permutation Tests.
Stat. Software Newsl. 12, 20-27.

Mollner, H., Haux, R., Schumacher, M. (1986).
Program Design of Tests for the Analysis of Right-Censored Data.
EDV in Med. u. Biol. 16, 134-139.

Haux, R. (1985).
Analysis of Profiles Based on Ordinal Classification Functions and Rank Tests.
Biom. J. 27, 607-622.

Haux, R. (1985).
Datenbankaspekte bei statistischen Auswertungssystemen.
EDV in Med. u. Biol. 16, 41-46.

Haux, R., Eckert, U. (1985).
Nondeterministic Dependencies in Relations: an Extension of the Concept of Functional Dependency.
Inform. Systems 10, 139-148.

Haux, R., Schumacher, M., Weckesser, G. (1985).
Asymptotic Relative Pitman Efficiencies of Rank Tests for Complete Block Designs.
Math. Operationsforsch. Statist., Ser. Statistics 16, 427-444.

Alle, M., Haux, R., Schumacher, M. (1984).
Rank Tests and Ties - some Properties of a Rank Test for Complete Block Designs -.
Commun. Statist. - Simula. Computa. 13, 183-212.

Haux, R. (1984).
Statistical Analysis Systems - Construction and Aspects of Method Design (Part 2).
Stat. Software Newsl. 10, 14-27.

Haux, R., Schumacher, M., Weckesser, G. (1984).
Rank Tests for Complete Block Designs.
Biom. J. 26, 567-582.

Haux, R. (1983).
Die Syntax der Kommandosprache von SAS - Überblick und Kritik -.
Stat. Software Newsl. B5, 28-37.

Haux, R. (1983).
How to Detect and Prevent Errors in Computer-Supported Statistical Analysis: an Example.
Meth. Inform. Med. 22, 87-92.

Haux, R. (1983).
Statistical Analysis Systems - Construction and Aspects of Method Design (Part 1).
Stat. Software Newsl. 9, 106-115.

Haux, R. (1982).
How to Store Hierarchical Structured Data Being Used for Statistical Analysis - Some Reflections about whether a Database System with Hierarchical Data Model Should Be Used.
Europ. Pol. Data Newsl. 43, 31-44.

Haux, R. (1981).
Einige Bemerkungen zur Frage: Soll man zur Speicherung hierarchischer Datenstrukturen ein Datenbanksystem mit hierachischem Datenmodell verwenden?
Stat. Software Newsl. 7, 58-63.

Haux, R. (1980).
Kriterien zur Programmentwicklung bei statistischen Auswertungen.
Stat. Software Newsl. 6, 85-96.

Kaboth, U., ..., Haux, R., ... (1980). (Studiengruppe Virushepatitisforschung der DFG).
Kooperative prospektive Studie 'Akute Virushepatitis' (DFG).
Verh. d. Dt. Ges. f. Innere Medizin 86, 749-776.

Kaboth, U., ..., Haux, R., ... (1980). (Studiengruppe Virushepatitisforschung der DFG).
Prospektive kooperative Studie 'Klinisch gesunde HBsAg-Träger' (DFG).
Verh. d. Dt. Ges. f. Innere Medizin 86, 744-749.

Kuhnert, A., Blomer, R., Haux, R., Zeh, T. (1980).
Möglichkeiten der Realisierung einer Schnittstelle bei Datenbanken und Statistischen Auswertungssystemen.
Stat. Software Newsl. 6, 22-26.

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