Allgemeine Pathologie
Pathologie

Publikationen


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Top Ten Publikationen


 

 

2016

First and Senior Authorship 

 

Raab MS, Lehners N, Xu J, Ho AD, Schirmacher P, Goldschmidt H, Andrulis M. Spatially divergent clonal evolution in multiple myeloma: overcoming resistance to BRAF inhibition. Blood. 2016;127(17):2155-7. (IF: 11.85)

 

Ploeger C, Waldburger N, Fraas A, Goeppert B, Pusch S, Breuhahn K, Wang XW, Schirmacher P, Roessler S. Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma. Hepatology. 2016;64(3):828-42. (IF: 11.71)

 

Samarin J, Laketa V, Malz M, Roessler S, Stein I, Horwitz E, Singer S, Dimou E, Cigliano A, Bissinger M, Falk CS, Chen X, Dooley S, Pikarsky E, Calvisi DF, Schultz C, Schirmacher P, Breuhahn K. PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells. Hepatology. 2016;63(3):813-26. (IF: 11.71)

 

Gdynia G, Sauer SW, Kopitz J, Fuchs D, Duglova K, Ruppert T, Miller M, Pahl J, Cerwenka A, Enders M, Mairbäurl H, Kamiński MM, Penzel R, Zhang C, Fuller JC, Wade RC, Benner A, Chang-Claude J, Brenner H, Hoffmeister M, Zentgraf H, Schirmacher P, Roth W. The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. Nat Commun. 2016;7:10764. (IF: 11.33)

 

Goyal A, Myacheva K, Groß M, Klingenberg M, Duran Arqué B, Diederichs S. Challenges of CRISPR/Cas9 applications for long non-coding RNA genes. Nucleic Acids Res. 2016;30. pii: gkw883. (IF: 9.20)

 

Link S, Grund SE, Diederichs S. Alternative splicing affects the subcellular localization of Drosha. Nucleic Acids Res. 2016;44(11):5330-43. (IF: 9.20)

 

Cooperative Contribution 

Al-Batran SE, Hofheinz RD, Pauligk C, Kopp HG, Haag GM, Luley KB, Meiler J, Homann N, Lorenzen S, Schmalenberg H, Probst S, Koenigsmann M, Egger M, Prasnikar N, Caca K, Trojan J, Martens UM, Block A, Fischbach W, Mahlberg R, Clemens M, Illerhaus G, Zirlik K, Behringer DM, Schmiegel W, Pohl M, Heike M, Ronellenfitsch U, Schuler M, Bechstein WO, Königsrainer A, Gaiser T, Schirmacher P, Hozaeel W, Reichart A, Goetze TO, Sievert M, Jäger E, Mönig S, Tannapfel A. Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial. Lancet Oncol. 2016;17(12):1697-1708. (IF: 26.51)

 

Halama N, Zoernig I, Berthel A, Kahlert C, Klupp F, Suarez-Carmona M, Suetterlin T, Brand K, Krauss J, Lasitschka F, Lerchl T, Luckner-Minden C, Ulrich A, Koch M, Weitz J, Schneider M, Buechler MW, Zitvogel L, Herrmann T, Benner A, Kunz C, Luecke S, Springfeld C, Grabe N, Falk CS, Jaeger D. Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients. Cancer Cell. 2016;29(4):587-601. (IF: 23.21)

 

Klapproth K, Lasitschka F, Rodewald HR. Multilayered ancestry of arterial macrophages. Nat Immunol. 2016;17(2):117-8. (IF: 19.38)

 

Noll EM, Eisen C, Stenzinger A, Espinet E, Muckenhuber A, Klein C, Vogel V, Klaus B, Nadler W, Rösli C, Lutz C, Kulke M, Engelhardt J, Zickgraf FM, Espinosa O, Schlesner M, Jiang X, Kopp-Schneider A, Neuhaus P, Bahra M, Sinn BV, Eils R, Giese NA, Hackert T, Strobel O, Werner J, Büchler MW, Weichert W, Trumpp A, Sprick MR. CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma. Nat Med. 2016;22(3):278-87. (IF: 30.36)

 

Ye QH, Zhu WW, Zhang JB, Qin Y, Lu M, Lin GL, Guo L, Zhang B, Lin ZH, Roessler S, Forgues M, Jia HL, Lu L, Zhang XF, Lian BF, Xie L, Dong QZ, Tang ZY, Wang XW, Qin LX. GOLM1 Modulates EGFR/RTK Cell-Surface Recycling to Drive Hepatocellular Carcinoma Metastasis. Cancer Cell. 2016;30(3):444-58. (IF: 23.21)

 


2015

First and Senior Authorship 

 

Alam MS*, Gaida MM*, Bergmann F, Lasitschka F, Giese T, Giese NA, Hackert T, Hinz U, Hussain SP, Kozlov SV, Ashwell JD. Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression. Nat Med. 2015 Nov;21(11):1337-43. (IF: 28.22)

 

Bickeböller M, Tagscherer KE, Kloor M, Jansen L, Chang-Claude J, Brenner H, Hoffmeister M, Toth C, Schirmacher P, Roth W, Bläker H. Functional characterization of the tumor-suppressor MARCKS in colorectal cancer and its association with survival. Oncogene. 2015 Feb 26;34(9):1150-9. (IF: 8.46)

 

Macher-Goeppinger S, Keith M, Tagscherer KE, Singer S, Winkler J, Hofmann TG, Pahernik S, Duensing S, Hohenfellner M, Kopitz J, Schirmacher P, Roth W. PBRM1 (BAF180) protein is functionally regulated by p53-induced protein degradation in renal cell carcinomas. J Pathol. 2015 Dec;237(4):460-71. (IF: 7.43)

 

Mogler C*, Wieland M*, König C, Hu J, Runge A, Korn C, Besemfelder E, Breitkopf-Heinlein K, Komljenovic D, Dooley S, Schirmacher P, Longerich T, Augustin HG. Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage. EMBO Mol Med. 2015 Feb 13;7(3):332-8. (IF: 8.67)

 

Müller B*, Bovet M*, Yin Y, Stichel D, Malz M, González-Vallinas M, Middleton A, Ehemann V, Schmitt J, Muley T, Meister M, Herpel E, Singer S, Warth A, Schirmacher P, Drasdo D, Matthäus F°, Breuhahn K°. Concomitant expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer (NSCLC) cells. J Pathol. 2015 Nov;237(3):390-401. (IF: 7.43)

 

Cooperative ContributionsGeorge J, Lim JS, Jang SJ, Cun Y, Ozretić L, Kong G, Leenders F, Lu X, Fernández-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Pützer B, Bos M, Michels S, Vlasic I, Seidel D, Pinther B, Schaub P, Becker C, Altmüller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castaños-Vélez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Köhler J, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansén S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt C, Perner S, Heukamp L, Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK. Comprehensive genomic profiles of small cell lung cancer. Nature. 2015 Aug 6;524(7563):47-53. (IF: 41.46)

 

Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van TM, Curth HM, Heise N, Weih F, Klein U, Schirmacher P, Kelliher M, Pasparakis M. NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. Cancer Cell. 2015 Nov 9;28(5):582-98. (IF: 23.52)

 

von Karstedt S, Conti A, Nobis M, Montinaro A, Hartwig T, Lemke J, Legler K, Annewanter F, Campbell AD, Taraborrelli L, Grosse-Wilde A, Coy JF, El-Bahrawy MA, Bergmann F, Koschny R, Werner J, Ganten TM, Schweiger T, Hoetzenecker K, Kenessey I, Hegedüs B, Bergmann M, Hauser C, Egberts JH, Becker T, Röcken C, Kalthoff H, Trauzold A, Anderson KI, Sansom OJ, Walczak H. Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis. Cancer Cell 2015;27(4):561-573. (IF: 23.52)

 

Das T, Safferling K, Rausch S, Grabe N, Boehm H, Spatz JP. A molecular mechanotransduction pathway regulates collective migration of epithelial cells. Nat Cell Biol. 2015 Mar;17(3):276-87. (IF: 18.70)

 

Denkert C, von Minckwitz G, Brase JC, Sinn BV, Gade S, Kronenwett R, Pfitzner BM, Salat C, Loi S, Schmitt WD, Schem C, Fisch K, Darb-Esfahani S, Mehta K, Sotiriou C, Wienert S, Klare P, André F, Klauschen F, Blohmer JU, Krappmann K, Schmidt M, Tesch H, Kümmel S, Sinn P, Jackisch C, Dietel M, Reimer T, Untch M, Loibl S. Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers. J Clin Oncol. 2015 Mar 20;33(9):983-91. (IF: 18.44)

 


2014

First and Senior Authorship 

 

Goeppert B, Konermann C, Schmidt CR, Bogatyrova O, Geiselhart L, Ernst C, Gu L, Becker N, Zucknick M, Mehrabi A, Hafezi M, Klauschen F, Stenzinger A, Warth A, Breuhahn K, Renner M, Weichert W, Schirmacher P, Plass C,  Weichenhan D. (2014)

Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway.

Hepatology. 59(2):544-54. (IF:11.19)

 

Gutschner T, Hammerle M, Pazaitis N, Bley N, Fiskin E, Uckelmann H, Heim A, Grobeta M, Hofmann N, Geffers R, Skawran B, Longerich T, Breuhahn K, Schirmacher P, Muhleck B, Huttelmaier S,  Diederichs S. (2014)

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma.

Hepatology. 59(5):1900-11. (IF:11.19)

 

Malz M, Bovet M, Samarin J, Rabenhorst U, Sticht C, Bissinger M, Roessler S, Bermejo JL, Renner M, Calvisi DF, Singer S, Ganzinger M, Weber A, Gretz N, Zornig M, Schirmacher P,  Breuhahn K. (2014)

Overexpression of far upstream element (FUSE) binding protein (FBP)-interacting repressor (FIR) supports growth of hepatocellular carcinoma.

Hepatology. 60(4):1241-50. (IF:11.19)

 

Pellegrino R, Calvisi DF, Neumann O, Kolluru V, Wesely J, Chen X, Wang C, Wuestefeld T, Ladu S, Elgohary N, Bermejo JL, Radlwimmer B, Zornig M, Zender L, Dombrowski F, Evert M, Schirmacher P,  Longerich T. (2014)

EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma.

Hepatology. 59(5):1886-99. (IF:11.19)

 

Winkler J, Ori A, Holzer K, Sticht C, Dauch D, Eiteneuer EM, Pinna F, Geffers R, Ehemann V, Andres-Pons A, Breuhahn K, Longerich T, Bermejo JL, Gretz N, Zender L, Schirmacher P, Beck M,  Singer S. (2014)

Prosurvival function of the cellular apoptosis susceptibility/importin-alpha1 transport cycle is repressed by p53 in liver cancer.

Hepatology. 60(3):884-95. (IF:11.19)

Cooperative Contribution 

 

 

Martins VC, Busch K, Juraeva D, Blum C, Ludwig C, Rasche V, Lasitschka F, Mastitsky SE, Brors B, Hielscher T, Fehling HJ,  Rodewald HR. (2014)

Cell competition is a tumour suppressor mechanism in the thymus.

Nature. 509(7501):465-70. (IF:42.35)

 

Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, Longerich T, Enikolopov G,  Lowe SW. (2014)

p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer.

Cell. 158(3):579-92. (IF:33.12)

 

Hu J, Srivastava K, Wieland M, Runge A, Mogler C, Besemfelder E, Terhardt D, Vogel MJ, Cao L, Korn C, Bartels S, Thomas M,  Augustin HG. (2014)

Endothelial cell-derived angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat.

Science. 343(6169):416-9. (IF:31.48)

 

Rudalska R, Dauch D, Longerich T, McJunkin K, Wuestefeld T, Kang TW, Hohmeyer A, Pesic M, Leibold J, von Thun A, Schirmacher P, Zuber J, Weiss KH, Powers S, Malek NP, Eilers M, Sipos B, Lowe SW, Geffers R, Laufer S,  Zender L. (2014)

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

Nat Med. 20(10):1138-46. (IF: 28.05)

 

Ertych N, Stolz A, Stenzinger A, Weichert W, Kaulfuss S, Burfeind P, Aigner A, Wordeman L,  Bastians H. (2014)

Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells.

Nat Cell Biol. 16(8):779-91. (IF:20.06)


 

2013

 

First and Senior Authorship

Tschaharganeh DF, Chen X, Latzko P, Malz M, Gaida MM, Felix K, Ladu S, Singer S, Pinna F, Gretz N, Sticht C, Tomasi ML, Delogu S, Evert M, Fan B, Ribback S, Jiang L, Brozzetti S, Bergmann F, Dombrowski F, Schirmacher P, Calvisi DF,  Breuhahn K. (2013)
Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma. Gastroenterology. 144(7):1530-42 e12. (IF:12.82)

Liu M, Roth A, Yu M, Morris R, Bersani F, Rivera MN, Lu J, Shioda T, Vasudevan S, Ramaswamy S, Maheswaran S, Diederichs S*,  Haber DA*. (2013)
The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. Genes & Development. 27(23):2543-8. (IF:12.44) *These two authors contributed equally to this work

Hämmerle M, Gutschner T, Uckelmann H, Ozgur S, Fiskin E, Gross M, Skawran B, Geffers R, Longerich T, Breuhahn K, Schirmacher P, Stoecklin G,  Diederichs S. (2013)
Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1). Hepatology. 58(5):1703-12. (IF:12.00)

Safferling K, Sutterlin T, Westphal K, Ernst C, Breuhahn K, James M, Jager D, Halama N,  Grabe N. (2013)
Wound healing revised: A novel reepithelialization mechanism revealed by in vitro and in silico models. J Cell Biol. 203(4):691-709. (IF:10.82)

Renner M, Wolf T, Meyer H, Hartmann W, Penzel R, Ulrich A, Lehner B, Hovestadt V, Czwan E, Egerer G, Schmitt T, Alldinger I, Renker EK, Ehemann V, Eils R, Wardelmann E, Buttner R, Lichter P, Brors B, Schirmacher PMechtersheimer G. (2013)
Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas. Genome Biol. 14(12):R137. (IF:10.29)



Cooperative Contribution

Baccelli I, Schneeweiss A*, Riethdorf S, Stenzinger A, Schillert A, Vogel V, Klein C, Saini M, Bauerle T, Wallwiener M, Holland-Letz T, Hofner T, Sprick M, Scharpff M, Marme F, Sinn HP, Pantel K*, Weichert W*,  Trumpp A. (2013)
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol. 31(6):539-44. (IF:32.44)

Wuestefeld T, Pesic M, Rudalska R, Dauch D, Longerich T, Kang TW, Yevsa T, Heinzmann F, Hoenicke L, Hohmeyer A, Potapova A, Rittelmeier I, Jarek M, Geffers R, Scharfe M, Klawonn F, Schirmacher P, Malek NP, Ott M, Nordheim A, Vogel A, Manns MP,  Zender L. (2013)
A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration. Cell. 153(2):389-401. (IF:31.96)

Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton JP, Athineos D, Kang TW, Lasitschka F, Andrulis M, Pascual G, Morris KJ, Khan S, Jin H, Dharmalingam G, Snijders AP, Carroll T, Capper D, Pritchard C, Inman GJ, Longerich T, Sansom OJ, Benitah SA, Zender L,  Gil J. (2013)
A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol. 15(8):978-90. (IF:20.76)

Dietrich S, Hullein J, Hundemer M, Lehners N, Jethwa A, Capper D, Acker T, Garvalov BK, Andrulis M, Blume C, Schulte C, Mandel T, Meissner J, Frohling S, von Kalle C, Glimm H, Ho AD,  Zenz T. (2013)
Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia. J Clin Oncol. 31(19):e300-3. (IF:18.04)

Kostareli E, Holzinger D, Bogatyrova O, Hielscher T, Wichmann G, Keck M, Lahrmann B, Grabe N, Flechtenmacher C, Schmidt CR, Seiwert T, Dyckhoff G, Dietz A, Hofler D, Pawlita M, Benner A, Bosch FX, Plinkert P, Plass C, Weichenhan D,  Hess J. (2013) 

HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas. J Clin Inest. 123(6):2488-501. (IF:12.81)

 

 

 

 


 

2012

First and Senior Authorship 

 

Kloor M, Huth C, Voigt AY, Benner A, Schirmacher P, von Knebel Doeberitz M,  Blaker H. (2012)

Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study.

Lancet Oncol. 13(6):598-606. (IF:22.59)

 

Warth A, Muley T, Meister M, Stenzinger A, Thomas M, Schirmacher P, Schnabel PA, Budczies J, Hoffmann H,  Weichert W. (2012)

The novel histologic International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification system of lung adenocarcinoma is a stage-independent predictor of survival.

J Clin Oncol. 30(13):1438-46. (IF:18.37)

 

Singer S, Zhao R, Barsotti AM, Ouwehand A, Fazollahi M, Coutavas E, Breuhahn K, Neumann O, Longerich T, Pusterla T, Powers MA, Giles KM, Leedman PJ, Hess J, Grunwald D, Bussemaker HJ, Singer RH, Schirmacher P,  Prives C. (2012)

Nuclear Pore Component Nup98 Is a Potential Tumor Suppressor and Regulates Posttranscriptional Expression of Select p53 Target Genes.

Mol Cell. 48(5):799-810. (IF:14.18)

 

Neumann O, Kesselmeier M, Geffers R, Pellegrino R, Radlwimmer B, Hoffmann K, Ehemann V, Schemmer P, Schirmacher P, Lorenzo Bermejo J,  Longerich T. (2012)

Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors.

Hepatology. 56(5):1817-27. (IF:11.67)

 

Malz M, Pinna F, Schirmacher P,  Breuhahn K. (2012)

Transcriptional regulators in hepatocarcinogenesis--key integrators of malignant transformation.

J Hepatol. 57(1):186-95. (IF:9.26)

 

Cooperative Contribution 

 

Dietrich S, Glimm H, Andrulis M, von Kalle C, Ho AD,  Zenz T. (2012)

BRAF inhibition in refractory hairy-cell leukemia.

N Engl J Med. 366(21):2038-40. (IF:53.30)

 

Has C, Sparta G, Kiritsi D, Weibel L, Moeller A, Vega-Warner V, Waters A, He Y, Anikster Y, Esser P, Straub BK, Hausser I, Bockenhauer D, Dekel B, Hildebrandt F, Bruckner-Tuderman L,  Laube GF. (2012)

Integrin alpha3 mutations with kidney, lung, and skin disease.

N Engl J Med. 366(16):1508-14. (IF:53.30)

 

Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R,  Nahrendorf M. (2012)

Myocardial infarction accelerates atherosclerosis.

Nature. 487(7407):325-9. (IF:36.28)

 

Peifer M, …..Schnabel P,…..  Thomas RK. (2012)

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Nat Genet. 44(10):1104-10. (IF:35.53)

 

Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, Konig R, Fackler OT,  Keppler OT. (2012)

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

Nat Med. 18(11):1682-9. (IF:22.46)

 

 

 


 

 

2011

First and Senior Authorship 

 

Kloor M, Voigt AY, Schackert HK, Schirmacher P, von Knebel Doeberitz M,  Blaeker H. (2011) 

Analysis of EPCAM protein expression in diagnostics of Lynch syndrome

J Clin Oncol. 29(2):223-7. (IF:18.97)

 

Gutschner T, Baas M, Diederichs S. (2011) Noncoding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases

Genome Res. 21(11):1944-54. (IF:13.59)

 

Straub BK, Rickelt S, Zimbelmann R, Grund C, Kuhn C, Iken M, Ott M, Schirmacher P,  Franke WW. (2011) E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells

J Cell Biol. 195(5):873-87. (IF:9.92)

 

Brauckhoff A, Malz M, Tschaharganeh D, Malek N, Weber A, Riener MO, Soll C, Samarin J, Bissinger M, Schmidt J, Longerich T, Ehemann V, Schirmacher P,  Breuhahn K. (2011) Nuclear expression of the ubiquitin ligase seven in absentia homolog (SIAH)-1 induces proliferation and migration of liver cancer cells

J Hepatol.  55(5):1049-57. (IF:9.33

Breinig M, Mayer P, Harjung A, Goeppert B, Malz M, Penzel R, Neumann O, Hartmann A, Dienemann H, Giaccone G, Schirmacher P, Kern MA, Chiosis G, Rieker RJ. (2011) Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors

Clin Cancer Res.17(8):2237-49. (IF:7.34)

Cooperative Contribution 

 

Haiman CA...., Sinn HP..... Couch FJ. (2011) A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer

Nat Genet. 43(12):1210-4. (IF: 36.38)

 

Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L. (2011) Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

Nature. 479(7374):547-51. (IF:36.10)

 

Dieter SM, Ball CR, Hoffmann CM, Nowrouzi A, Herbst F, Zavidij O, Abel U, Arens A, Weichert W, Brand K, Koch M, Weitz J, Schmidt M, von Kalle C,  Glimm H. (2011) Distinct types of tumor-initiating cells form human colon cancer tumors and metastases

Cell Stem Cell.  9(4):357-65. (IF:25.94)

 

Ozretic L, Rhiem K, Huss S, Wappenschmidt B, Markiefka B, Sinn P, Schmutzler RK, Buettner R. (2011) High Nuclear Poly (Adenosine Diphosphate-Ribose) Polymerase Expression Is Predictive for BRCA1- and BRCA2-Deficient Breast Cancer.

J Clin Oncol. 29(34):4586-8. (IF:18.97) 

 

Danckwardt S, Gantzert AS, Macher-Goeppinger S, Probst HC, Gentzel M, Wilm M, Grone HJ, Schirmacher P, Hentze MW, Kulozik AE. (2011) p38 MAPK controls prothrombin expression by regulated RNA 3' end processing

Mol Cell. 41(3):298-310. (IF:14.19)

 

 

 


 

2010 


First and Senior Authorship 

 

Goeppert B, Schmezer P, Dutruel C, Oakes C, Renner MBreinig MWarth A, Vogel MN, Mittelbronn M, Mehrabi A, Gdynia GPenzel RLongerich TBreuhahn K, Popanda O, Plass C, Schirmacher PKern MA. (2010)
Down-regulation of tumor suppressor a kinase anchor protein 12 in human hepatocarcinogenesis by epigenetic mechanisms. 

Hepatology. 52(6):2023-33.(IF:10.84)
 
Pellegrino R, Calvisi DF, Ladu S, Ehemann V, Staniscia T, Evert M, Dombrowski F, Schirmacher PLongerich T. (2010)
Oncogenic and tumor suppressive roles of polo-like kinases in human hepatocellular carcinoma. 

Hepatology. 51(3):857-68. (IF:10.84)
 
Gdynia GKeith MKopitz J, Bergmann MFassl A, Weber AN, George J, Kees T, Zentgraf HW, Wiestler OD, Schirmacher PRoth W. (2010)
danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria.

Cancer Res. 70(21):8558-68. (IF:7.54)
 
Andrulis MCapper DMeyer JPenzel RHartmann C, Zentgraf H, von Deimling A. (2010)
IDH1 R132H mutation is a rare event in MPN as determined by a mutation specific antibody.

Haematologica. 95(10):1797-8. (IF:6.42)
 
Böck BCTagscherer KEFassl AKrämer AOehme I, Zentgraf HW, Keith MRoth W. (2010)
The PEA-15 protein regulates autophagy via activation of JNK.

J Biol Chem. 285(28):21644-54. (IF:5.33)
 
Cooperative Contribution 


Surolia I, Pirnie SP, Chellappa V, Taylor KN, Cariappa A, Moya J, Liu H, Bell DW, Driscoll DR, Diederichs S, Haider K, Netravali I, Le S, Elia R, Dow E, Lee A, Freudenberg J, De Jager PL, Chretien Y, Varki A, Macdonald ME, Gillis T, Behrens TW, Bloch D, Collier D, Korzenik J, Podolsky DK, Hafler D, Murali M, Sands B, Stone JH, Gregersen PK, Pillai S. (2010)
Functionally defective germline variants of sialic acid acetylesterase in autoimmunity.

Nature. 466(7303):243-7. (IF:34.48)
 
Stolz A, Ertych N, Kienitz A, Vogel C, Schneider V, Fritz B, Jacob R, Dittmar G, Weichert W, Petersen I, Bastians H. (2010)
The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells. 

Nat Cell Biol. 12(5):492-9. (IF:19.53)
 
 
 

Feurle GE, Moos V, Schinnerling K, Geelhaar A, Allers K, Biagi F, Bläker H, Moter A, Loddenkemper C, Jansen A, Schneider T. (2010)
The immune reconstitution inflammatory syndrome in whipple disease: a cohort study. 

Ann Intern Med. 153(11):710-7. (IF:16.23)
 
Kossatz U, Breuhahn K, Wolf B, Hardtke-Wolenski M, Wilkens L, Steinemann D, Singer S, Brass F, Kubicka S, Schlegelberger B, Schirmacher P, Manns MP, Singer JD, Malek NP. (2010)
The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells. 

J Clin Invest. 120(11):3820-33. (IF:15.39)
 
Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch JSchirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiß K, Saftig P, Scheller J, Rose-John S. (2010)
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.

 

 


2009

 

First and Senior Authorship

 

Breinig M, Caldas-Lopes E, Goeppert B, Malz M, Rieker R, Bergmann F, Schirmacher P, Mayer M, Chiosis G, Kern MA. (2009)

Targeting heat shock protein 90 with non-quinone inhibitors: A novel chemotherapeutic approach in human hepatocellular carcinoma.

Hepatology. 50(1):102-112. (IF:11.36)

 

Malz M, Weber A, Singer S, Riehmer V, Bissinger M, Riener MO, Longerich T, Soll C, Vogel A, Angel P, Schirmacher P, Breuhahn K. (2009)

Overexpression of far upstream element binding proteins: A mechanism regulating proliferation and migration in liver cancer cells.

Hepatology. 50(4):1130-9. (IF:11.36)

 

Funke B, Autschbach F, Kim S, Lasitschka F, Strauch U, Rogler G, Gdynia G, Li L, Gretz N, Macher-Goeppinger S, Sido B, Schirmacher P, Meuer SC, Roth W. (2009)

Functional characterisation of decoy receptor 3 in Crohn's disease.

Gut. 58(4):483-91. (IF:9.77)

 

Singer S, Malz M, Herpel E, Warth A, Bissinger M, Keith M, Muley T, Meister M, Hoffmann H, Penzel R, Gdynia G, Ehemann V, Schnabel PA, Kuner R, Huber P, Schirmacher P, Breuhahn K. (2009)

Coordinated Expression of Stathmin Family Members by Far Upstream Sequence Element-Binding Protein-1 Increases Motility in Non-Small Cell Lung Cancer.

Cancer Res. 69(6):2234-43. (IF:7.51)

 

Macher-Goeppinger S, Aulmann S, Tagscherer KE, Wagener N, Haferkamp A, Penzel R, Brauckhoff A, Hohenfellner M, Sykora J, Walczak H, Teh BT, Autschbach F, Herpel E, Schirmacher P, Roth W. (2009)

Prognostic value of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors in renal cell cancer.

Clin Cancer Res. 15(2):650-9. (IF:6.49)

 

Cooperative Contribution

 

Begus-Nahrmann Y, Lechel A, Obenauf AC, Nalapareddy K, Peit E, Hoffmann E, Schlaudraff F, Liss B, Schirmacher P, Kestler H, Danenberg E, Barker N, Clevers H, Speicher MR, Rudolph KL. (2009)

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.

Nat Genet. 41(10):1138-43. (IF:30.26)

 

Schmitz R, Hansmann ML, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G, Klapper W, Vater I, Giefing M, Gesk S, Stanelle J, Siebert R, Küppers R. (2009)

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.

J Exp Med. 206(5):981-9. (IF:15.46)

 

Ceyhan GO, Bergmann F, Kadihasanoglu M, Altintas B, Demir IE, Hinz U, Müller MW, Giese T, Büchler MW, Giese NA, Friess H. (2009)

Pancreatic neuropathy and neuropathic pain-a comprehensive pathomorphological study of 546 cases.

Gastroenterology. 136(1):177-186. (IF:12.59)

 

Fortunato F, Bürgers H, Bergmann FRieger P, Büchler MW, Kroemer G, Werner J. (2009)

Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis.

Gastroenterology. 137(1):350-60. (IF:12.59) 

 

Németh J, Stein I, Haag D, Riehl A, Longerich T, Horwitz E, Breuhahn K, Gebhardt C, Schirmacher P, Hahn M, Ben-Neriah Y, Pikarsky E, Angel P, Hess J. (2009)

S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis.

Hepatology. 50(4):1130-9. (IF:11.36)

 


2008

 

First and Senior Authorship

 

Sido B, Lasitschka F, Giese T, Gassler N, Funke B, Schröder-Braunstein J, Brunnemer U, Meuer SC, Autschbach F. (2008)

A prominent role for mucosal cystine/cysteine metabolism in intestinal immunoregulation.

Gastroenterology.134(1):179-91. (IF: 11.67)

 

Nussbaum T, Samarin J, Ehemann V, Bissinger M, Ryschich E, Khamidjanov A, Yu X, Gretz N, Schirmacher P, Breuhahn K. (2008) 

Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis.

Hepatology. 48(1):146-56. (IF: 10.73)

Straub BK, Stoeffel P, Heid H, Zimbelmann R, Schirmacher P. (2008) 

Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis.

Hepatology. 47(6):1936-46. (IF: 10.73)

Schlaeger C, *Longerich T*, Schiller C, Bewerunge P, Mehrabi A, Toedt G, Kleeff J, Ehemann V, Eils R, Lichter P, Schirmacher P, Radlwimmer B. (2008)

Etiology-dependent molecular mechanisms in human hepatocarcinogenesis.

Hepatology. 47(2):511-520.  (IF: 10.73)  

* Equal Contribution*

 

Rabkin R, Awwad I, Chen Y, Ashley EA, Sun D, Sood S, Clusin W, Heidenreich P, Piecha G, Gross ML. (2008) 

Low-dose growth hormone is cardioprotective in uremia.

J Am Soc Nephrol. 19(9):1774-83. (IF: 7.1)

Cooperative Contribution

 
Zender L, Xue W, Zuber J, Semighini CP, Krasnitz A, Ma B, Zender P, Kubicka S, Luk JM, Schirmacher P, McCombie WR, Wigler M, Hicks J, Hannon GJ, Powers S,  (2008) 

Lowe SW. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.

Cell. 135(5):852-64. (IF: 29.9)


Xue W, Krasnitz A, Lucito R, Sordella R, Vanaelst L, Cordon-Cardo C, Singer S, Kuehnel F, Wigler M, Powers S, Zender L, Lowe SW. (2008) 

Genes Dev. 22(11):1439-44. (IF: 14.8)


Andrassy M, Volz HC, Igwe JC, Funke B, Eichberger SN, Kaya Z, Buss S, Autschbach F, Pleger ST, Lukic IK, Bea F, Hardt SE, Humpert PM, Bianchi ME, Mairbäurl H, Nawroth PP, Remppis A, Katus HA, Bierhaus A. (2008) 

Circulation. 117(25):3216-26. (IF: 12.8)

 

Zöllinger A, Stühmer T, Chatterjee M, Gattenlöhner S, Haralambieva E, Müller-Hermelink HK, Andrulis MGreiner A, Wesemeier C, Rath JC, Einsele H, Bargou RC. (2008) 

Blood. 112(8):3403-11. (IF: 10.9)

 

Gotthardt D, Runz H, Keitel V, Fischer C, Flechtenmacher C, Wirtenberger M, Weiss KH, Imparato S, Braun A, Hemminki K, Stremmel W, Rüschendorf F, Stiehl A, Kubitz R, Burwinkel B, Schirmacher P, Knisely AS, Zschocke J, Sauer P. (2008) 

Hepatology. 48(4):1157-66. (IF: 10.73)
 
 

 


2007

First and Senior Authorship
 
Gassler N, Roth W, Funke B, Schneider A, Herzog F, Tischendorf JJ, Grund K, Penzel R, Bravo IG, Mariadason J, Ehemann V, Sykora J, Haas TL, Walczak H, Ganten T, Zentgraf H, Erb P, Alonso A, Autschbach F, Schirmacher P, Knüchel R, Kopitz J. (2007)
Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing. 
Gastroenterology. 133(2):587-98. (IF:12.46)
Singer S, Ehemann V, Brauckhoff A, Keith M, Vreden S, Schirmacher P, Breuhahn K. (2007)
Protumorigenic overexpression of stathmin/Op18 by gain-of-function mutation in p53 in human hepatocarcinogenesis. 
Hepatology. 46(3):759-68. (IF:10.45)
 
Breinig M, Schirmacher P, Kern MA. (2007)

Cyclooxygenase-2 (COX-2) - a therapeutic target in liver cancer?

Curr Pharm Des. 13(32):3305-15. (IF:5.27)

 

Esposito I, Kayed H, Keleg S, Giese T, Sage EH, Schirmacher P, Friess H, Kleeff J. (2007)

Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer.
Neoplasia. 9(1):8-17. (IF:4.91)  

 

Gdynia G, Grund K, Eckert A, Böck BC, Funke B, Macher-Goeppinger S, Sieber S, Herold-Mende C, Wiestler B, Wiestler OD, Roth W. (2007)

Basal caspase activity promotes migration and invasiveness in glioblastoma cells.

Mol Cancer Res. 5(12):1232-40. (IF:4.76)
 
 Cooperative Contribution
 
Schaetzlein S, Kodandaramireddy NR, Ju Z, Lechel A, Stepczynska A, Lilli DR, Clark AB, Rudolph C, Kuhnel F, Wei K, Schlegelberger B, Schirmacher P, Kunkel TA, Greenberg RA, Edelmann W, Rudolph KL. (2007)
Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. 
Cell. 130(5):863-77. (IF:29.19)
 
Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL. (2007)
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. 
Nat Genet. 39(1):99-105. (IF:24.18)
 
Renner M, Bergmann G, Krebs I, End C, Lyer S, Hilberg F, Helmke B, Gassler N, Autschbach F, Bikker F, Strobel-Freidekind O, Gronert-Sum S, Benner A, Blaich S, Wittig R, Hudler M, Ligtenberg AJ, Madsen J, Holmskov U, Annese V, Latiano A, Schirmacher P, Amerongen AV, D'Amato M, Kioschis P, Hafner M, Poustka A, Mollenhauer J. (2007)
DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease. Gastroenterology. 133(5):1499-509. (IF:12.46) 
 
Protzer U, Seyfried S, Quasdorff M, Sass G, Svorcova M, Webb D, Bohne F, Hösel M, Schirmacher P, Tiegs G. (2007)
Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection. Gastroenterology. 133(4):1156-65. (IF:12.46)



Lechel A, Holstege H, Begus Y, Schienke A, Kamino K, Lehmann U, Kubicka S, Schirmacher P, Jonkers J, Rudolph KL. (2007)
Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease. 
Gastroenterology. 132(4):1465-75.  (IF:12.46)

 


2006

First and Senior Authorship
 
Müller-Decker K, Fürstenberger G, Annan N, Kucher D, Pohl-Arnold A, Steinbauer B, Esposito I, Chiblak S, Friess H, Schirmacher P, Berger I. (2006)
Preinvasive duct-derived neoplasms in pancreas of keratin 5-promoter cyclooxygenase-2 transgenic mice. 
Gastroenterology. 130(7):2165-78. (IF:12.39 )
 
Gassler N, Newrzella D, Böhm C, Lyer S, Li L, Sorgenfrei O, van Laer L, Sido B, Mollenhauer J, Poustka A, Schirmacher P, Gretz N. (2006)
Molecular characterisation of non-absorptive and absorptive enterocytes in human small intestine. 
Gut. 55(8):1084-9. (IF:7.69)
 
Kern MA, Haugg AM
, Koch AF, Schilling T, Breuhahn K, Walczak H, Fleischer B, Trautwein C, Michalski C, Schulze-Bergkamen H, Friess H, Stremmel W, Krammer PH, Schirmacher P, Müller M. (2006)
Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. 
Cancer Res. 66(14):7059-66. (IF:7.61)
 
Finis K, Sültmann H, Ruschhaupt M, Buness A, Helmchen B, Kuner R, Gross ML, Fink B, Schirmacher P, Poustka A, Berger I. (2006)
Analysis of pigmented villonodular synovitis with genome-wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches. 
Arthritis Rheum. 54(3):1009-19. (IF:7.42)
 
Breuhahn K, Longerich T, Schirmacher P.
 (2006)
Dysregulation of growth factor signaling in human hepatocellular carcinoma. 
Oncogene. 25(27):3787-800. (IF:6.87)
 
 Cooperative Contribution

 
Thuerigen O, Schneeweiss A, Toedt G, Warnat P, Hahn M, Kramer H, Brors B, Rudlowski C, Benner A, Schuetz F, Tews B, Eils R, Sinn HP, Sohn C, Lichter P. (2006)
Gene expression signature predicting pathologic complete response with gemcitabine, epirubicin, and docetaxel in primary breast cancer. 
J Clin Oncol. 24(12):1839-45. (IF:11.81)
 
 

Lenze D, Berg E, Volkmer-Engert R, Weiser AA, Greiner A, Knörr-Wittmann C, Anagnostopoulos I, Stein H, Hummel M. (2006)
Influence of antigen on the development of MALT lymphoma. 
Blood.107(3):1141-8. (IF:10.13)
 
 

Wursthorn K, Lutgehetmann M, Dandri M, Volz T, Buggisch P, Zollner B, Longerich T, Schirmacher P, Metzler F, Zankel M, Fischer C, Currie G, Brosgart C, Petersen J. (2006)
Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B. 
Hepatology.44(3):675-84. (IF:9.79)
 
Wenger T, Mattern J, Penzel R, Gassler N, Haas TL, Sprick MR, Walczak H, Krammer PH, Debatin KM, Herr I. (2006)
Specific resistance upon lentiviral TRAIL transfer by intracellular retention of TRAIL receptors. 
Cell Death Differ.13(10):1740-51. (IF:7.79)
 
di Mola FF, Friess H, Köninger J, Selvaggi F, Esposito I, Büchler MW, di Sebastiano P. (2006)
Haemorrhoids and transient receptor potential vanilloid 1.
Gut. 55(11):1665-6.(IF:7.69)

 


2005

First and Senior Authorship
 
Gross ML, Amann K, Ritz E.(2005)
Nephron number and renal risk in hypertension and diabetes. 
J Am Soc Nephrol.16 Suppl 1:S27-9. (IF:6.64)
 
 

Autschbach F, Eisold S, Hinz U, Zinser S, Linnebacher M, Giese T, Löffler T, Büchler MW, Schmidt J.(2005)
High prevalence of Mycobacterium avium subspecies paratuberculosis IS900 DNA in gut tissues from individuals with Crohn's disease. 
Gut. 54(7):944-9. (IF:6.60)
 
Gassler N, Herr I, Schneider A, Penzel R, Langbein L, Schirmacher P, Kopitz J.(2005) Impaired expression of acyl-CoA synthetase 5 in sporadic colorectal adenocarcinomas. 
J Pathol. 207(3):295-300. (IF:5.33)
 
Gross ML, Ritz E, Korsch M, Adamczak M, Weckbach M, Mall G, Berger I, Hansen A, Amann K.(2005)
Effects of estrogens on cardiovascular structure in uninephrectomized SHRsp rats. 
Kidney Int.67(3):849-57. (IF:4.79)
 
Moinzadeh P, Breuhahn K, Stützer H, Schirmacher P.(2005)
Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade-results of an explorative CGH meta-analysis. 
Br J Cancer. 92(5):935-41. (IF:3.74)
 
 Cooperative Contribution

 
Schneider A, Krüger C, Steigleder T, Weber D, Pitzer C, Laage R, Aronowski J, Maurer MH, Gassler N, Mier W, Hasselblatt M, Kollmar R, Schwab S, Sommer C, Bach A, Kuhn HG, Schäbitz WR.(2005)
The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. 
J Clin Invest.115(8):2083-98. (IF:14.20)
 
Nessling M, Richter K, Schwaenen C, Roerig P, Wrobel G, Wessendorf S, Fritz B, Bentz M, Sinn HP, Radlwimmer B, Lichter P.(2005)
Candidate genes in breast cancer revealed by microarray-based comparative genomic hybridization of archived tissue. 
Cancer Res.65(2):439-47. (IF:7.69)
 
Veltkamp C, Sartor RB, Giese T, Autschbach F, Kaden I, Veltkamp R, Rost D, Kallinowski B, Stremmel W.(2005) 
Regulatory CD4+CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TGepsilon26 mice leading to the prevention of colitis. 
Gut.54(2):207-14. (IF:6.60)
 
Sträter J, Hinz U, Hasel C, Bhanot U, Mechtersheimer G, Lehnert T, Möller P.(2005)
Impaired CD95 expression predisposes for recurrence in curatively resected colon carcinoma: clinical evidence for immunoselection and CD95L mediated control of minimal residual disease. 
Gut.54(5):661-5. (IF:6.60)
 
Stremmel W, Merle U, Zahn A, Autschbach F, Hinz U, Ehehalt R. (2005)
Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis. Gut. 54(7):966-71. (IF:6.60)

 


2004

First and Senior Authorship
 
Helmke BM, Mollenhauer J, Herold-Mende C, Benner A, Thome M, Gassler N, Wahl W, Lyer S, Poustka A, Otto HF, Deichmann M.(2004) 
BRAF mutations distinguish anorectal from cutaneous melanoma at the molecular level. Gastroenterology. 127(6):1815-20. (IF:13.09) 
 
Breuhahn K, Vreden S
, Haddad R, Beckebaum S, Stippel D, Flemming P, Nussbaum T, Caselmann WH, Haab BB, Schirmacher P.(2004)
Molecular profiling of human hepatocellular carcinoma defines mutually exclusive interferon regulation and insulin-like growth factor II overexpression.
Cancer Res. 64(17):6058-64. (IF:7.69) 
 
Gross ML, Adamczak M, Rabe T, Harbi NA, Krtil J, Koch A, Hamar P, Amann K, Ritz E. (2004)
Beneficial Effects of Estrogens on Indices of Renal Damage in Uninephrectomized SHRsp Rats. 
J Am Soc Nephrol. 15(2):348-58. (IF:6.64) 
 
Kern MA, Schöneweiss MM, Sahi D, Bahlo M, Haugg AM, Kasper HU, Dienes HP, Käferstein H, Breuhahn K, Schirmacher P. (2004) 
Cyclooxygenase-2 inhibitors suppress the growth of human hepatocellular carcinoma implants in nude mice. 
Carcinogenesis. 25(7):1193-9. (IF:5.38) 

Gassler N
, Kopitz J, Tehrani A, Ottenwälder B, Schnölzer M, Kartenbeck J, Lyer S, Autschbach F, Poustka A, Otto HF, Mollenhauer J.(2004) 
Expression of acyl-CoA synthetase 5 reflects the state of villus architecture in human small intestine. 
J Pathol. 202(2):188-96. (IF:5.33)

 


 Cooperative Contribution
 
Jüngst C, Cheng B, Gehrke R, Schmitz V, Nischalke HD, Ramakers J, Schramel P, Schirmacher P, Sauerbruch T, Caselmann WH. (2004) 
Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma. Hepatology. 39(6):1663-72. (IF:10.42) 
 
Schwarzbach MH, Koesters R, Germann A, Mechtersheimer G, Geisbill J, Winkler S, Niedergethmann M, Ridder R, Buechler MW, von Knebel Doeberitz M, Willeke F.(2004) Comparable transforming capacities and differential gene expression patterns of variant FUS/CHOP fusion transcripts derived from soft tissue liposarcomas. 
Oncogene. 23(40):6798-805. (IF:6.32) 
 
Barth TF, Müller S, Pawlita M, Siebert R, Rother JU, Mechtersheimer G, Kitinya J, Bentz M, Möller P. (2004) 
Homogeneous immunophenotype and paucity of secondary genomic aberrations are distinctive features of endemic but not of sporadic Burkitt's lymphoma and diffuse large B-cell lymphoma with MYC rearrangement.
J Pathol. 203(4):940-5. (IF:5.33) 
 
Bosch FX, Ritter D, Enders C, Flechtenmacher C, Abel U, Dietz A, Hergenhahn M, Weidauer H. (2004) 
Head and neck tumor sites differ in prevalence and spectrum of p53 alterations but these have limited prognostic value. 
Int J Cancer.111(4):530-8. (IF:4.41) 
 
Mollenhauer J, Helmke B, Medina D, Bergmann G, Gassler N, Müller H, Lyer S, Diedrichs L, Renner M, Wittig R, Blaich S, Hamann U, Madsen J, Holmskov U, Bikker F, Ligtenberg A, Carlén A, Olsson J, 

 



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