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Recent Publications 2018

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Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.
Dittrich AS, Kühbandner I, Gehrig S, Rickert-Zacharias V, Twigg M, Wege S, Taggart CC, Herth F, Schultz C, Mall MA.
Eur Respir J. 2018 Mar 15. pii: 1701910. doi: 10.1183/13993003.01910-2017. [Epub ahead of print] PMID: 29545279

 

One time quantitative PCR detection of Pseudomonas aeruginosa to discriminate intermittent from chronic infection in cystic fibrosis.
Boutin S, Weitnauer M, Hassel S, Graeber SY, Stahl M, Dittrich AS, Mall MA, Dalpke AH.
J Cyst Fibros. 2018 Jan 11. pii: S1569-1993(18)30001-8. doi: 10.1016/j.jcf.2017.12.007.
[Epub ahead of print] PMID:29336943

 

Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization.
Heiss, K., Maier, M. I., Hoffmann, A., Frank, R., Bendszus, M., Mueller, A. K., Pfeil,
J. Scientific reports, 2018, 8(1), 3085.

Drug-perturbation-based stratification of blood cancer.
Dietrich S
, Oleś M, Lu J, Sellner L, Anders S, Velten B, Wu B, Hüllein J, da Silva Liberio M, Walther T, Wagner L, Rabe S, Ghidelli-Disse S, Bantscheff M, Oleś AK, Słabicki M, Mock A, Oakes CC, Wang S, Oppermann S, Lukas M, Kim V, Sill M, Benner A, Jauch A, Sutton LA, Young E, Rosenquist R, Liu X, Jethwa A, Lee KS, Lewis J, Putzker K, Lutz C, Rossi D, Mokhir A, Oellerich T, Zirlik K, Herling M, Nguyen-Khac F, Plass C, Andersson E, Mustjoki S, von Kalle C, Ho AD, Hensel M, Dürig J, Ringshausen I, Zapatka M, Huber W, Zenz T.
J Clin Invest. 2018 Jan 2;128(1):427-445. doi: 10.1172/JCI93801. Epub 2017 Dec 11.PMID:29227286

 

 

2017

Uncoupled iron homeostasis in type 2 diabetes mellitus.
Altamura S, Kopf S, Schmidt J, Müdder K, da Silva AR, Nawroth P, Muckenthaler MU.
J Mol Med (Berl). 2017 Dec;95(12):1387-1398. doi: 10.1007/s00109-017-1596-3. Epub 2017 Oct 3.PMID: 28971221

 

Performance of the Alere i RSV assay for point-of-care detection of respiratory syncytial virus in children.
Schnee SV, Pfeil J Ihling CM, Tabatabai J, Schnitzler P
BMC Infectious Diseases Dec 2017 17:767

 

Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component.
Bali KK, Kuner R.
Pain. 2017 Nov;158(11):2243-2258. doi: 10.1097/j.pain.0000000000001032. PMID: 28837503

 

High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer.
Janikovits J, Müller M, Krzykalla J, Körner S, Echterdiek F, Lahrmann B, Grabe N, Schneider M, Benner A, Doeberitz MVK, Kloor M.
Oncoimmunology. 2017 Nov 6;7(2):e1390640. doi: 10.1080/2162402X.2017.1390640. eCollection 2018. PMID:29308317

 

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages.
Costa da Silva M, Breckwoldt MO, Vinchi F, Correia MP, Stojanovic A, Thielmann CM, Meister M, Muley T, Warth A, Platten M, Hentze MW, Cerwenka A, Muckenthaler MU.
Front Immunol. 2017 Nov 8;8:1479. doi: 10.3389/fimmu.2017.01479. eCollection 2017. PMID: 29167669

 

A cross-sectional quantitative analysis of the natural history of Farber disease: an ultra-orphan condition with rheumatologic and neurological cardinal disease features.
Zielonka M, Garbade SF, Kölker S, Hoffmann GF, Ries M.
Genet Med. 2017 Oct 19. doi: 10.1038/gim.2017.133.
PMID:29048419

Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells.
Schweizer PA, Darche FF, Ullrich ND, Geschwill P, Greber B, Rivinius R, Seyler C, Müller-Decker K, Draguhn A, Utikal J, Koenen M, Katus HA, Thomas D.
Stem Cell Res Ther. 2017 Oct 16;8(1):229. doi: 10.1186/s13287-017-0681-4. PMID: 29037217

Fully digital data processing during cardiovascular implantable electronic device follow-up in a high-volume tertiary center.
Staudacher I, Nalpathamkalam AR, Uhlmann L, Illg C, Seehausen S, Akhavanpoor M, Buchauer A, Geis N, Lugenbiel P, Schweizer PA, Xynogalos P, Zylla MM, Scholz E, Zitron E, Katus HA, Thomas D.
Eur J Med Res. 2017 Oct 11;22(1):41. doi: 10.1186/s40001-017-0284-7. PMID:29020984

 

Chronic but not intermittent infection with Pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis
Sébastien Boutin, Simon Y. Graeber, Mirjam Stahl, A. Susanne Dittrich, Marcus A. Mall, Alexander H. Dalpke
Eur Respir J. 2017 Oct 5;50(4). pii: 1701086. doi: 10.1183/13993003.01086-2017. Print 2017 Oct. PMID:28982777

Dual function of UPF3B in early and late translation termination
Gabriele Neu-Yilik, Etienne Raimondeau, Boris Eliseev, Lahari Yeramala, Beate Amthor, Aurélien Deniaud, Karine Huard, Kathrin Kerschgens, Matthias W. Hentze, Christiane Schaffitzel, Andreas E. Kulozik
EMBO J. 2017 Sep 12. pii: e201797079. doi: 10.15252/embj.201797079. PMID:28899899

 

miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels.
Gandla J, Lomada SK, Lu J, Kuner R, Bali KK.
Pain. 2017 Sep;158(9):1765-1779. doi: 10.1097/j.pain.0000000000000971. PMID: 28614186

 

Low-iron diet and chelation therapy rescue severe atherosclerosis associated with high circulating iron levels
Francesca Vinchi, Richard Sparla, Andreas Simmelbauer, Sandro Altamura, Sebastian Speich, Bruno Galy, Matthias W. Hentze, Martina U. Muckenthaler
Atherosclerosis, Volume 263, August 2017, Pages e15-e16

 

Elevated systemic heme and iron levels as risk factor for vascular dysfunction and atherosclerosis: Evidence from a beta-thalassemia cohort study
Francesca Vinchi, Gregory M. Vercellotti, John D. Belcher, Richard Sparla, Eitan Fibach, Hala Zreid, Rushdy Rasras, Hussam Ghoti, Martina U. Muckenthaler, Eliezer A. Rachmilewitz
Atherosclerosis, August 2017, Volume 263, Pages e107–e108

 

Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain.
Paldy E, Simonetti M, Worzfeld T, Bali KK, Vicuña L, Offermanns S, Kuner R.
Nat Commun. 2017 Aug 2;8(1):176. doi: 10.1038/s41467-017-00341-w. PMID: 28765520

 

NOTCH1 mutation, TP53 alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of T-cell acute lymphoblastic leukemia.
Hof J, Kox C, Groeneveld-Krentz S, Bandapalli OR, Karawajew L, Schedel K, Kunz JB, Eckert C, Ludwig WD, Ratei R, Rhein P, Henze G, Muckenthaler MU, Kulozik AE, von Stackelberg A, Kirschner-Schwabe R.
Haematologica. 2017 Jul;102(7):e249-e252. doi: 10.3324/haematol.2016.157792. Epub 2017 Mar 30.PMID:28360149

No changes in heme synthesis in human Friedreich´s ataxia erythroid progenitor cells.
Steinkellner H, Singh HN, Muckenthaler MU, Goldenberg H, Moganty RR, Scheiber-Mojdehkar B, Sturm B.
Gene. 2017 Jul 20;621:5-11. doi: 10.1016/j.gene.2017.04.014. Epub 2017 Apr 12. PMID: 28412459

 

Imatinib and spironolactone suppress hepcidin expression.
Mleczko-Sanecka K, da Silva AR, Call D, Neves J, Schmeer N, Damm G, Seehofer D, Muckenthaler MU.
Haematologica. 2017 Jul;102(7):1173-1184. doi: 10.3324/haematol.2016.162917. Epub 2017 Apr 6.PMID:28385785

 

Acute loss of the hepatic endo-lysosomal system in vivo causes compensatory changes in iron homeostasis.
Metzendorf C, Zeigerer A, Seifert S, Sparla R, Najafi B, Canonne-Hergaux F, Zerial M, Muckenthaler MU.
Sci Rep. 2017 Jun 22;7(1):4023. doi: 10.1038/s41598-017-02898-4.PMID:28642463

 

Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease.
Neves J, Leitz D, Kraut S, Brandenberger C, Agrawal R, Weissmann N, Mühlfeld C, Mall MA, Altamura S, Muckenthaler MU.
EBioMedicine. 2017 Jun;20:230-239. doi: 10.1016/j.ebiom.2017.04.036. Epub 2017 Apr 29.PMID:28499927

WS02.2 Role of soluble and membrane-associated neutrophil elastase activity in cystic fibrosis sputum.
Dittrich, A. Susanne & Kühbandner, I & Gehrig, Stefanie & Rickert-Zacharias, V & Taggart, Cliff & Twigg, Matthew & Herth, Felix & Schultz, C & Mall, Marcus.
Journal of Cystic Fibrosis. June 2017 16. S3. 10.1016/S1569-1993(17)30163-7.

 

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
Hoffmann A, Helluy X, Fischer M, Mueller AK, Heiland S, Pham M, Bendszus M, Pfeil J
J. Vis. Exp. 2017 (124), e55334, doi:10.3791/55334

 

Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin.
da Silva AR, Neves J, Mleczko-Sanecka K, Tandon A, Sauer SW, Hentze MW, Muckenthaler MU.
J Mol Med (Berl). 2017 Jun 5. doi: 10.1007/s00109-017-1551-3. PMID: 28585096

 

Cdk6 contributes to cytoskeletal stability in erythroid cells.
Uras IZ, Scheicher RM, Kollmann K, Glösmann M, Prchal-Murphy M, Tigan AS, Fux DA, Altamura S, Neves J, Muckenthaler MU, Bennett KL, Kubicek S, Hinds PW, von Lindern M, Sexl V.
Haematologica. 2017 Jun;102(6):995-1005. doi: 10.3324/haematol.2016.159947. Epub 2017 Mar 2.
PMID:28255017

 

Systematic Cell-Based Phenotyping of Missense Alleles.
Thormählen AS, Runz H
.
Methods Mol Biol. 2017;1601:215-228. doi: 10.1007/978-1-4939-6960-9_17.PMID:28470529

 

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention.
Brings S, Fleming T, Freichel M, Muckenthaler MU, Herzig S, Nawroth PP.
Int J Mol Sci. 2017 May 5;18(5). pii: E984. doi: 10.3390/ijms18050984. Review.PMID:28475116

 

Pathophysiological consequences and benefits of HFE mutations: 20 years of research.
Hollerer I, Bachmann A, Muckenthaler MU.
Haematologica. 2017 May;102(5):809-817. doi: 10.3324/haematol.2016.160432. Epub 2017 Mar 9. Review.PMID:28280078

 

Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes - What We Know so Far and the Missing Links.
Groener JB, Oikonomou D, Cheko R, Kender Z, Zemva J, Kihm L, Muckenthaler M, Peters V, Fleming T, Kopf S, Nawroth PP.
Exp Clin Endocrinol Diabetes. 2017 Apr 13. doi: 10.1055/s-0043-106443.
PMID:28407670

 

A Distinct Cardiomyopathy: HCN4 Syndrome Comprising Myocardial Noncompaction, Bradycardia, Mitral Valve Defects, and Aortic Dilation.
Schweizer PA, Koenen M, Katus HA, Thomas D.
J Am Coll Cardiol. 2017 Mar 7;69(9):1209-1210. doi: 10.1016/j.jacc.2016.10.085. PMID:28254188

 

Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia.
Richter-Pechańska P, Kunz JB, Hof J, Zimmermann M, Rausch T, Bandapalli OR, Orlova E, Scapinello G, Sagi JC, Stanulla M, Schrappe M, Cario G, Kirschner-Schwabe R, Eckert C, Benes V, Korbel JO, Muckenthaler MU, Kulozik AE. Blood Cancer J. 2017 Feb 3;7(2):e523. doi: 10.1038/bcj.2017.3. PMID: 28157215

 

A Red Carpet for Iron Metabolism.
Muckenthaler MU, Rivella S, Hentze MW, Galy B.
Cell. 2017 Jan 26;168(3):344-361. doi: 10.1016/j.cell.2016.12.034. Review. PMID: 28129536

 

TREK-1 (K2P2.1) K+ channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control.
Lugenbiel P, Wenz F, Syren P, Geschwill P, Govorov K, Seyler C, Frank D, Schweizer PA, Franke J, Weis T, Bruehl C, Schmack B, Ruhparwar A, Karck M, Frey N, Katus HA, Thomas D.
Basic Res Cardiol. 2017 Jan;112(1):8. doi: 10.1007/s00395-016-0597-7. PMID: 28005193

 

Insights into the design and interpretation of iCLIP experiments.
Haberman N, Huppertz I, Attig J, König J, Wang Z, Hauer C, Hentze MW, Kulozik AE, Le Hir H, Curk T, Sibley CR, Zarnack K, Ule J.
Genome Biol. 2017 Jan 16;18(1):7. doi: 10.1186/s13059-016-1130-x. PMID: 28093074

 

Reverse-transcription loop-mediated isothermal amplification for rapid detection of respiratory syncytial virus directly from nasopharyngeal swabs.
Hoos J, Peters RM, Tabatabai J, Grulich-Henn J, Schnitzler P, Pfeil J.
J Virol Methods. 2017 Jan 16;242:53-57. doi: 10.1016/j.jviromet.2017.01.006. [Epub ahead of print] PMID: 28093275

 

Evaluation of Alere™ i RSV for rapid detection of respiratory syncytial virus in children hospitalized with acute respiratory tract infection.
Peters RM, Schnee SV, Tabatabai J, Schnitzler P, Pfeil J.
J Clin Microbiol. 2017 Jan 11. pii: JCM.02433-16. doi: 10.1128/JCM.02433-16. [Epub ahead of print] PMID: 28077700

 

Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms.
Enculescu M, Metzendorf C, Sparla R, Hahnel M, Bode J, Muckenthaler MU, Legewie S.
PLoS Comput Biol. 2017 Jan 9;13(1):e1005322. doi: 10.1371/journal.pcbi.1005322.
PMID: 28068331

 

 

 

2016

The structure and flexibility of conical HIV-1 capsids determined within intact virions.
Mattei S, Glass B, Hagen WJ, Kräusslich HG, Briggs JA.
Science. 2016 Dec 16;354(6318):1434-1437.
PMID: 27980210

 

Acetylated tubulin is essential for touch sensation in mice.
Morley SJ, Qi Y, Iovino L, Andolfi L, Guo D, Kalebic N, Castaldi L, Tischer C, Portulano C, Bolasco G, Shirlekar K, Fusco CM, Asaro A, Fermani F, Sundukova M, Matti U, Reymond L, De Ninno A, Businaro L, Johnsson K, Lazzarino M, Ries J, Schwab Y, Hu J, Heppenstall PA.
Elife. 2016 Dec 13;5. pii: e20813. doi: 10.7554/eLife.20813.

PMID: 27976998

 

Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease.
Wagner CJ, Schultz C, Mall MA.
Mol Cell Pediatr. 2016 Dec;3(1):25. doi: 10.1186/s40348-016-0053-7. Epub 2016 Jul 25. Review

 

Antiarrhythmic gene therapy - will biologics replace catheters, drugs and devices?
Lugenbiel P, Schweizer PA, Katus HA, Thomas D.
Eur J Pharmacol. 2016 Nov 15;791:264-273. doi: 10.1016 / j.ejphar.2016.09.001. Review.
PMID: 27593579

 

In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis.
Kirschbaum K, Sonner JK, Zeller MW, Deumelandt K, Bode J, Sharma R, Krüwel T, Fischer M, Hoffmann A, Costa da Silva M, Muckenthaler MU, Wick W, Tews B, Chen JW, Heiland S, Bendszus M, Platten M, Breckwoldt MO.
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13227-13232.
PMID: 27799546

Post-transplant cyclophosphamide-based haplo-identical transplantation as alternative to matched sibling or unrelated donor transplantation for non-Hodgkin lymphoma: a registry study by the European society for blood and marrow transplantation.
Dietrich S, Finel H, Martinez C, Tischer J, Blaise D, Chevallier P, Castagna L, Milpied N, Bacigalupo A, Corradini P, Mohty M, Sanz M, Hausmann A, Montoto S, Robinson S, Boumendil A, Sureda A, Dreger P.
Leukemia. 2016 Oct;30(10):2086-2089. doi: 10.1038/leu.2016.125

 

CTNNB1-mutant colorectal carcinomas with immediate invasive growth: a model of interval cancers in Lynch syndrome.
Ahadova A, von Knebel Doeberitz M, Bläker H, Kloor M.
Fam Cancer. 2016 Oct;15(4):579-86. doi: 10.1007/s10689-016-9899-z.

 

Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression.
Kim DK, Kim YH, Jung YS, Kim KS, Jeong JH, Lee YS, Yuk JM, Oh BC, Choy HE, Dooley S, Muckenthaler MU, Lee CH, Choi HS.
Sci Rep. 2016 Sep 30;6:34630. doi: 10.1038/srep34630.
PMID: 27688041

 

Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells.
Ebrahimi-Fakhari D, Wahlster L, Bartz F, Werenbeck-Ueding J, Praggastis M, Zhang J, Joggerst-Thomalla B, Theiss S, Grimm D, Ory DS, Runz H
.
Hum Mol Genet. 2016 Aug 15;25(16):3588-3599. doi: 10.1093/hmg/ddw204. Epub 2016 Jul 4.PMID:27378690

 

MOCAT2: a metagenomic assembly, annotation and profiling framework.
Kultima JR, Coelho LP, Forslund K, Huerta-Cepas J, Li SS, Driessen M, Voigt AY, Zeller G, Sunagawa S,
Bork P.
Bioinformatics. 2016 Aug 15;32(16):2520-3. doi: 10.1093/bioinformatics/btw183. Epub 2016 Apr 8.

 

The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia.
Song K, Wang H, Kamm GB, Pohle J, de Castro Reis F, Heppenstall P, Wende H, Siemens J.
Science. 2016 Aug 25. pii: aaf7537. [Epub ahead of print] PMID: 27562954

 

Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins.
Hauer C, Sieber J, Schwarzl T, Hollerer I, Curk T, Alleaume AM, Hentze MW, Kulozik AE.
Cell Rep. 2016 Aug 9;16(6):1588-603. doi: 10.1016/j.celrep.2016.06.096. Epub 2016 Jul 28.
PMID: 27475226

 

An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation.
Schur FK, Obr M, Hagen WJ, Wan W, Jakobi AJ, Kirkpatrick JM, Sachse C, Kräusslich HG, Briggs JA.
Science. 2016 Jul 29;353(6298):506-8. doi: 10.1126/science.aaf9620. Epub 2016 Jul 14.
PMID: 27417497

 

5-aza-2'-deoxycytidine (DAC) treatment downregulates the HPV E6 and E7 oncogene expression and blocks neoplastic growth of HPV-associated cancer cells.
Stich M, Ganss L, Puschhof J, Prigge ES, Reuschenbach M, Guiterrez A, Vinokurova S, von Knebel Doeberitz M.
Oncotarget. 2016 Jul 16. doi: 10.18632/oncotarget.10631. [Epub ahead of print]
PMID: 27447977

 

CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia.
Palmi C, Savino AM, Silvestri D, Bronzini I, Cario G, Paganin M, Buldini B, Galbiati M, Muckenthaler MU, Bugarin C, Mina PD, Nagel S, Barisone E, Casale F, Locatelli F, Nigro LL, Micalizzi C, Parasole R, Pession A, Putti MC, Santoro N, Testi AM, Ziino O, Kulozik AE, Zimmermann M, Schrappe M, Villa A, Gaipa G, Basso G, Biondi A, Valsecchi MG, Stanulla M, Conter V, Kronnie GT, Cazzaniga G.
Oncotarget. 2016 Jul 15. doi: 10.18632/oncotarget.10610.

 

The differential expression of alternatively polyadenylated transcripts is a common stress-induced response mechanism that modulates mammalian mRNA expression in a quantitative and qualitative fashion.
Hollerer I, Curk T, Haase B, Benes V, Hauer C, Neu-Yilik G, Bhuvanagiri M, Hentze MW, Kulozik AE.
RNA. 2016 Jul 12. [Epub ahead of print] PMID: 27407180

 

Human gut microbes impact host serum metabolome and insulin sensitivity.
Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, Forslund K, Hildebrand F, Prifti E, Falony G, Le Chatelier E, Levenez F, Doré J, Mattila I, Plichta DR, Pöhö P, Hellgren LI, Arumugam M, Sunagawa S, Vieira-Silva S, Jørgensen T, Holm JB, Trošt K; MetaHIT Consortium, Kristiansen K, Brix S, Raes J, Wang J, Hansen T,
Bork P, Brunak S, Oresic M, Ehrlich SD, Pedersen O.
Nature. 2016 Jul 21;535(7612):376-81.

 

High-Density Peptide Arrays for Malaria Vaccine Development.
Loeffler FF, Pfeil J, Heiss K.
Methods Mol Biol. 2016;1403:569-82. doi: 10.1007/978-1-4939-3387-7_32. PMID: 27076154

 

New hardware and workflows for semi-automated correlative cryo-fluorescence and cryo-electron microscopy/tomography.
Schorb M, Gaechter L, Avinoam O, Sieckmann F, Clarke M, Bebeacua C, Bykov YS, Sonnen AF, Lihl R, Briggs JA.
J Struct Biol. 2016 Jun 28. pii: S1047-8477(16)30135-6. doi: 10.1016/j.jsb.2016.06.020. [Epub ahead of print] PMID: 27368127

 

TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States.
Batti L, Sundukova M, Murana E, Pimpinella S, De Castro Reis F, Pagani F, Wang H, Pellegrino E, Perlas E, Di Angelantonio S, Ragozzino D, Heppenstall PA.
Cell Rep. 2016 Jun 21;15(12):2608-15. doi: 10.1016/j.celrep.2016.05.039. PMID: 27332874

 

Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes.
Chen S, Feng T, Vujić Spasić M, Altamura S, Breitkopf-Heinlein K, Altenöder J, Weiss TS, Dooley S,
Muckenthaler MU.
J Biol Chem. 2016 Jun 17;291(25):13160-74. doi: 10.1074/jbc.M115.691543. Epub 2016 Apr 27.

 

BRAF inhibition in hairy cell leukemia with low-dose vemurafenib.
Dietrich S, Pircher A, Endris V, Peyrade F, Wendtner CM, Follows GA, Hüllein J, Jethwa A, Ellert E, Walther T, Liu X, Dyer MJ, Elter T, Brummer T, Zeiser R, Hermann M, Herold M, Weichert W, Dearden C, Haferlach T, Seiffert M, Hallek M, von Kalle C, Ho AD, Gaehler A, Andrulis M, Steurer M, Zenz T.
Blood. 2016 Jun 9;127(23):2847-55. doi: 10.1182/blood-2015-11-680074.
PMID:
26941398

 

Dilation of the Aorta Ascendens Forms Part of the Clinical Spectrum of HCN4 Mutations.
Vermeer AM, Lodder EM, Thomas D, Duijkers FA, Marcelis C, van Gorselen EO, Fortner P, Buss SJ, Mereles D, Katus HA, Wilde AA, Bezzina CR, Boekholdt SM, Schweizer PA, Christiaans I.
J Am Coll Cardiol. 2016 May 17;67(19):2313-5. doi: 10.1016/j.jacc.2016.01.086.

 

Colorectal Cancer and the Human Gut Microbiome: Reproducibility with Whole-Genome Shotgun Sequencing.
Vogtmann E, Hua X, Zeller G, Sunagawa S, Voigt AY, Hercog R, Goedert JJ, Shi J, Bork P, Sinha R.
PLoS One. 2016 May 12;11(5):e0155362. doi: 10.1371/journal.pone.0155362. eCollection 2016.

 

A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression.
Stantcheva KK, Iovino L, Dhandapani R, Martinez C, Castaldi L, Nocchi L, Perlas E, Portulano C, Pesaresi M, Shirlekar KS, de Castro Reis F, Paparountas T, Bilbao D, Heppenstall PA.
EMBO Rep. 2016 Apr;17(4):585-600. doi: 10.15252/embr.201540983. Epub 2016 Feb 29. PMID: 26929027

 

Durable coexistence of donor and recipient strains after fecal microbiota transplantation.
Li SS, Zhu A, Benes V, Costea PI, Hercog R, Hildebrand F, Huerta-Cepas J, Nieuwdorp M, Salojärvi J, Voigt AY, Zeller G, Sunagawa S, de Vos WM, Bork P.
Science.
2016 Apr 29;352(6285):586-9. doi: 10.1126/science.aad8852.

 

Nucleic Acid Binding by Mason-Pfizer Monkey Virus CA Promotes Virus Assembly and Genome Packaging.
Füzik T, Píchalová R, Schur FK, Strohalmová K, Křížová I, Hadravová R, Rumlová M, Briggs JA, Ulbrich P, Ruml T.
J Virol. 2016 Apr 14;90(9):4593-603. doi: 10.1128/JVI.03197-15. Print 2016 May 1. PMID: 26912613

 

A saposin-lipoprotein nanoparticle system for membrane proteins.
Frauenfeld J, Löving R, Armache JP, Sonnen AF, Guettou F, Moberg P, Zhu L, Jegerschöld C, Flayhan A, Briggs JA, Garoff H, Löw C, Cheng Y, Nordlund P.
Nat Methods. 2016 Apr;13(4):345-51. doi: 10.1038/nmeth.3801. Epub 2016 Mar 7. PMID: 26950744

 

Cellular apoptosis susceptibility (CAS) is linked to integrin β1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC).
Winkler J, Roessler S, Sticht C, DiGuilio AL, Drucker E, Holzer K, Eiteneuer E, Herpel E, Breuhahn K, Gretz N, Schirmacher P, Ori A, Singer S.
Oncotarget. 2016 Mar 23. doi: 10.18632/oncotarget.8256. [Epub ahead of print] PMID: 27015362

 

miR-20a regulates expression of the iron exporter ferroportin in lung cancer.
Babu KR, Muckenthaler MU.
J Mol Med (Berl). 2016 Mar;94(3):347-59. doi: 10.1007/s00109-015-1362-3. Epub 2015 Nov 12

 

Retrovirus maturation-an extraordinary structural transformation.
Mattei S, Schur FK, Briggs JA.
Curr Opin Virol. 2016 Mar 21;18:27-35. doi: 10.1016/j.coviro.2016.02.008. [Epub ahead of print] Review. PMID: 27010119

 

Spatiotemporal variation of mammalian protein complex stoichiometries.
Ori A, Iskar M, Buczak K, Kastritis P, Parca L, Andrés-Pons A, Singer S, Bork P, Beck M.
Genome Biol. 2016 Mar 14;17:47. doi: 10.1186/s13059-016-0912-5. PMID: 26975353 

 

A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.
Eliava M, Melchior M, Knobloch-Bollmann HS, Wahis J, da Silva Gouveia M, Tang Y, Ciobanu AC, Triana del Rio R, Roth LC, Althammer F, Chavant V, Goumon Y, Gruber T, Petit-Demoulière N, Busnelli M, Chini B, Tan LL, Mitre M, Froemke RC, Chao MV, Giese G, Sprengel R, Kuner R, Poisbeau P, Seeburg PH, Stoop R, Charlet A, Grinevich V.
Neuron. 2016 Mar 16;89(6):1291-304. doi: 10.1016/j.neuron.2016.01.041.


Functional characterization of a mouse model for central post-stroke pain.
Gritsch S, Bali KK, Kuner R, Vardeh D.
Mol Pain. 2016 Mar 8;12. pii: 1744806916629049. doi: 10.1177/1744806916629049.

 

Proteomic analysis reveals branch-specific regulation of the unfolded protein response by nonsense-mediated mRNA decay
Sieber, J., Hauer, C., Bhuvanagiri, M., Leicht, S., Krijgsveld, J., Neu-Yilik, G., Hentze, M.W., Kulozik, A.E.
Molecular & Cellular Proteomics
2016 Feb 20 pii: mcp.M115.054056.

 

Mice with hepcidin-resistant ferroportin accumulate iron in the retina.
Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, Galy B, Hentze M, Muckenthaler MU, Dunaief JL.
FASEB J. 2016 Feb;30(2):813-23. doi: 10.1096/fj.15-276758. Epub 2015 Oct 27. PMID: 26506980

 

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.
Vinchi F, Costa da Silva M, Ingoglia G, Petrillo S, Brinkman N, Zuercher A, Cerwenka A, Tolosano E, Muckenthaler MU.
Blood. 2016 Jan 28;127(4):473-86. doi: 10.1182/blood-2015-08-663245. Epub 2015 Dec 16.

 

The orchestra of lipid-transfer proteins at the crossroads between metabolism and signaling. Chiapparino A, Maeda K, Turei D, Saez-Rodriguez J, Gavin AC.
Prog Lipid Res. 2016 Jan;61:30-9. doi: 10.1016/j.plipres.2015.10.004. Epub 2015 Dec 1. Review.PMID:26658141

 

Efficacy and safety of deferasirox in non-thalassemic patients with elevated ferritin levels after allogeneic hematopoietic stem cell transplantation.
Jaekel N, Lieder K, Albrecht S, Leismann O, Hubert K, Bug G, Kröger N, Platzbecker U, Stadler M, de Haas K, Altamura S, Muckenthaler MU, Niederwieser D, Al-Ali HK.
Bone Marrow Transplant. 2016 Jan;51(1):89-95. doi: 10.1038/bmt.2015.204. Epub 2015 Sep 14.

 

Gut Microbiota Linked to Sexual Preference and HIV Infection.
Noguera-Julian M, Rocafort M, Guillén Y, Rivera J, Casadellà M, Nowak P, Hildebrand F, Zeller G, Parera M, Bellido R, Rodríguez C, Carrillo J, Mothe B, Coll J, Bravo I, Estany C, Herrero C, Saz J, Sirera G, Torrela A, Navarro J, Crespo M, Brander C, Negredo E, Blanco J, Guarner F, Calle ML,
Bork P, Sönnerborg A, Clotet B, Paredes R.
EBioMedicine. 2016 Jan 28;5:135-46. doi: 10.1016/j.ebiom.2016.01.032. eCollection 2016 Mar.

 

eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences.
Huerta-Cepas J, Szklarczyk D, Forslund K, Cook H, Heller D, Walter MC, Rattei T, Mende DR, Sunagawa S, Kuhn M, Jensen LJ, von Mering C, Bork P.
Nucleic Acids Res. 2016 Jan 4;44(D1):D286-93. doi: 10.1093/nar/gkv1248. Epub 2015 Nov 17. PMID: 26582926

 

 

 

2015

The systematic analysis of protein-lipid interactions comes of age.
Saliba AE, Vonkova I, Gavin AC.
Nat Rev Mol Cell Biol. 2015 Dec;16(12):753-61. doi: 10.1038/nrm4080. Epub 2015 Oct 28. PMID: 26507169

 

BRAF inhibitor therapy in HCL.
Dietrich S
, Zenz T.
Best Pract Res Clin Haematol. 2015 Dec;28(4):246-52. doi: 10.1016/j.beha.2015.10.001. Epub 2015 Oct 20. Review. PMID:26614903

 

A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition.
Stockklausner C, Raffel S, Klermund J, Bandapalli OR, Beier F, Brümmendorf TH, Bürger F, Sauer SW, Hoffmann GF, Lorenz H, Tagliaferri L, Nowak D, Hofmann WK, Buergermeister R, Kerber C, Rausch T, Korbel JO, Luke B, Trumpp A, Kulozik AE.
Aging (Albany NY). 2015 Nov;7(11):911-27. PMID:
26546739

 

The Structure of Immature Virus-Like Rous Sarcoma Virus Gag Particles Reveals a Structural Role for the p10 Domain in Assembly.
Schur FK, Dick RA, Hagen WJ, Vogt VM, Briggs JA.
J Virol. 2015 Oct;89(20):10294-302. doi: 10.1128/JVI.01502-15. Epub 2015 Jul 29. PMID: 26223638

 

Low density of FOXP3-positive T cells in normal colonic mucosa is related to the presence of beta2-microglobulin mutations in Lynch syndrome-associated colorectal cancer.
Echterdiek F, Janikovits J, Staffa L, Müller M, Lahrmann B, Frühschütz M, Hartog B, Nelius N, Benner A, Tariverdian M, von Knebel Doeberitz M, Grabe N, Kloor M.
Oncoimmunology. 2015 Nov 11;5(2):e1075692. eCollection 2016 Feb.

 

Lipid Cooperativity as a General Membrane-Recruitment Principle for PH Domains.
Vonkova I, Saliba AE, Deghou S, Anand K, Ceschia S, Doerks T, Galih A, Kugler KG, Maeda K, Rybin V, van Noort V, Ellenberg J, Bork P, Gavin AC.
Cell Rep. 2015 Sep 1;12(9):1519-30. doi: 10.1016/j.celrep.2015.07.054.
Epub 2015 Aug 20. PMID: 26299969

 

Pediatric T-lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation.
Kunz JB, Rausch T, Bandapalli OR, Eilers J, Pechanska P, Schuessele S, Assenov Y, Stütz AM, Kirschner-Schwabe R, Hof J, Eckert C, von Stackelberg A, Schrappe M, Stanulla M, Koehler R, Avigad S, Elitzur S, Handgretinger R, Benes V, Weischenfeldt J, Korbel JO, Muckenthaler MU, Kulozik AE.
Haematologica. 2015 Aug 20. pii: haematol.2015.129692. [Epub ahead of print] PMID: 26294725

 

Improved binding site assignment by high-resolution mapping of RNA-protein interactions using iCLIP.
Hauer C, Curk T, Anders S, Schwarzl T, Alleaume AM, Sieber J, Hollerer I, Bhuvanagiri M, Huber W, Hentze MW, Kulozik AE.
Nat Commun. 2015 Aug 11;6:7921. doi: 10.1038/ncomms8921. PMID: 26260686

 

Recurrent CDKN1B (p27) mutations in hairy cell leukemia.
Dietrich S, Hüllein J, Lee SC, Hutter B, Gonzalez D, Jayne S, Dyer MJ, Oleś M, Else M, Liu X, Słabicki M, Wu B, Troussard X, Dürig J, Andrulis M, Dearden C, von Kalle C, Granzow M, Jauch A, Fröhling S, Huber W, Meggendorfer M, Haferlach T, Ho AD, Richter D, Brors B, Glimm H, Matutes E, Abdel Wahab O, Zenz T.
Blood. 2015 Aug 20;126(8):1005-8. doi: 10.1182/blood-2015-04-643361. Epub 2015 Jun 11. PMID: 26065650

 

Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E.
Díaz V, Peinado AB, Barba-Moreno L, Altamura S, Butragueño J, González-Gross M, Alteheld B, Stehle P, Zapico AG, Muckenthaler MU, Gassmann M.
Physiol Rep. 2015 Aug;3(8). pii: e12475. doi: 10.14814/phy2.12475.
PMID: 26243212

 

Adaptation of iron requirement to hypoxic conditions at high altitude.
Gassmann M, Muckenthaler MU.
J Appl Physiol (1985). 2015 Jul 16:jap.00248.2015. doi: 10.1152/japplphysiol.00248.2015. [Epub ahead of print] PMID: 26183475

 

RNA and nucleocapsid are dispensable for mature HIV-1 capsid core assembly.
Mattei S, Flemming A, Anders-Össwein M, Kräusslich HG, Briggs JA, Müller B.
J Virol. 2015 Jul 15. pii: JVI.00750-15. [Epub ahead of print] PMID:26178992

 

A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation.
Deniaud A, Karuppasamy M, Bock T, Masiulis S, Huard K, Garzoni F, Kerschgens K, Hentze MW, Kulozik AE, Beck M, Neu-Yilik G, Schaffitzel C.
Nucleic Acids Res. 2015 Jun 30. pii: gkv668.

 

A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain.
Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R.
Cancer Cell. 2015 Jun 8;27(6):780-96. doi: 10.1016/j.ccell.2015.04.017.

PMID:26058077

 

Retroviral proteases and their roles in virion maturation.
Konvalinka J, Kräusslich HG, Müller B.
Virology. 2015 May;479-480:403-17. doi: 10.1016/j.virol.2015.03.021. Epub 2015 Mar 26. Review. PMID: 25816761

 

Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs).
Mackmull MT, Iskar M, Parca L, Singer S, Bork P, Ori A, Beck M.
Mol Cell Proteomics. 2015 May;14(5):1350-60. doi: 10.1074/mcp.M114.042499.
Epub 2015 Mar 9. PMID: 25755299

 

Opens external link in new windowThe serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R.
Nat Med. 2015 May;21(5):518-23. doi: 10.1038/nm.3852. Epub 2015 Apr 27.
PMID:25915831 

 

The best of 25 years: mRNA 3'end processing.
Hollerer I, Kulozik AE.
RNA. 2015 Apr;21(4):640-1. doi: 10.1261/rna.050062.115

 

Quantitative mass spectrometry of posttranslational modifications: keys to confidence.
Hennrich ML, Gavin AC.
Sci Signal.
2015 Apr 7;8(371):re5. doi: 10.1126/scisignal.aaa6466. Review. PMID:25852188

 

Lymphocyte gene expression signatures from patients and mouse models of hereditary hemochromatosis reveal a function of HFE as a negative regulator of CD8+ T-lymphocyte activation and differentiation in vivo.
Costa M, Cruz E, Oliveira S, Benes V, Ivacevic T, Silva MJ, Vieira I, Dias F, Fonseca S, Gonçalves M, Lima M, Leitão C, Muckenthaler MU, Pinto J, Porto G.
PLoS One. 2015 Apr 16;10(4):e0124246. doi: 10.1371/journal.pone.0124246. eCollection 2015. PMID: 25880808

 

Opens external link in new windowA role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.
Lu J, Luo C, Bali KK, Xie RG, Mains RE, Eipper BA, Kuner R.
Nat Commun. 2015 Apr 13;6:6820. doi: 10.1038/ncomms7820.
PMID:25865668

 

Aqueous humor ferritin in hereditary hyperferritinemia cataract syndrome.
Lenzhofer M, Schroedl F, Trost A, Kaser-Eichberger A, Wiedemann H, Strohmaier C, Hohensinn M, Strasser M, Muckenthaler MU Grabner G, Aigner E, Reitsamer HA.
Optom Vis Sci. 2015 Apr;92(4 Suppl 1):S40-7. doi: 10.1097/OPX.0000000000000544. PMID:25756341

 

Temporal and technical variability of human gut metagenomes.
Voigt AY, Costea PI, Kultima JR, Li SS, Zeller G, Sunagawa S, Bork P.
Genome Biol. 2015 Apr 8;16:73. doi: 10.1186/s13059-015-0639-8. PMID: 25888008

 

Opens external link in new windowA novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia.
Guida C, Altamura S, Klein FA, Galy B, Boutros M, Ulmer AJ, Hentze MW, Muckenthaler MU.
Blood. 2015 Apr 2;125(14):2265-75. doi: 10.1182/blood-2014-08-595256. Epub 2015 Feb 6.
PMID:25662334


Dose-dependent effect of 2-deoxy-D-glucose on glycoprotein mannosylation in cancer cells.

Ahadova A, Gebert J, von Knebel Doeberitz M, Kopitz J,
Kloor M.
IUBMB Life. 2015 Mar;67(3):218-26. doi: 10.1002/iub.1364. Epub 2015 Apr 9. PMID:25854316

 

Association of high CD4-positive T cell infiltration with mutations in HLA class II-regulatory genes in microsatellite-unstable colorectal cancer.  
Surmann EM, Voigt AY, Michel S, Bauer K, Reuschenbach M, Ferrone S, von Knebel Doeberitz M, Kloor M.
Cancer Immunol Immunother. 2015 Mar;64(3):357-66. doi: 10.1007/s00262-014-1638-4. Epub 2014 Dec 2. PMID:25445815

 

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor.
Schimer J, Pávová M, Anders M, Pachl P, Šácha P, Cígler P, Weber J, Majer P, Řezáčová P, Kräusslich HG, Müller B, Konvalinka J.
Nat Commun. 2015 Mar 9;6:6461. doi: 10.1038/ncomms7461. PMID:25751579

 

Opens external link in new windowIron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency.
Martelli A, Schmucker S, Reutenauer L, Mathieu JR, Peyssonnaux C, Karim Z, Puy H, Galy B, Hentze MW, Puccio H.
Cell Metab. 2015 Feb 3;21(2):311-22. doi: 10.1016/j.cmet.2015.01.010.
PMID:25651183

 

Opens external link in new windowGenetic targeting of chemical indicators in vivo.
Yang G, de Castro Reis F, Sundukova M, Pimpinella S, Asaro A, Castaldi L, Batti L, Bilbao D, Reymond L, Johnsson K, Heppenstall PA.
Nat Methods. 2015 Feb;12(2):137-9. doi: 10.1038/nmeth.3207. Epub 2014 Dec 8.

Opens external link in new windowSystematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case for LDLR and Myocardial Infarction.
Thormaehlen AS, Schuberth C, Won HH, Blattmann P, Joggerst-Thomalla B, Theiss S, Asselta R, Duga S, Merlini PA, Ardissino D, Lander ES, Gabriel S, Rader DJ, Peloso GM, Pepperkok R, Kathiresan S, Runz H.
PLoS Genet. 2015 Feb 3;11(2):e1004855. doi: 10.1371/journal.pgen.1004855. eCollection 2015 Feb.PMID:25647241

 

Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution.
Schur FK, Hagen WJ, Rumlová M, Ruml T, Müller B, Kräusslich HG, Briggs JA.
Nature. 2015 Jan 22;517(7535):505-8. doi: 10.1038/nature13838. Epub 2014 Nov 2.
PMID: 25363765

 

 

2014

 Opens external link in new windowOligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice.
Gritsch S, Lu J, Thilemann S, Wörtge S, Möbius W, Bruttger J, Karram K, Ruhwedel T, Blanfeld M, Vardeh D, Waisman A, Nave KA, Kuner R
Nature Communications 2014 Dec 1;5:5472.

 

Opens external link in new windowPotential of fecal microbiota for early-stage detection of colorectal cancer.
Zeller G, Tap J, Voigt AY, Sunagawa S, Kultima JR, Costea PI, Amiot A, Böhm J, Brunetti F, Habermann N, Hercog R, Koch M, Luciani A, Mende DR, Schneider MA, Schrotz-King P, Tournigand C, Tran Van Nhieu J, Yamada T, Zimmermann J, Benes V, Kloor M, Ulrich CM, von Knebel Doeberitz M, Sobhani I, Bork P.
Mol Syst Biol. 2014 Nov 28;10:766.doi:10.15252/msb.20145645.PMID:25432777

 

 Opens external link in new windowAirway Mucus Obstruction Triggers Macrophage Activation and MMP12-dependent Emphysema.
Trojanek JB, Cobos-Correa A, Diemer S, Kormann M, Schubert SC, Zhou-Suckow Z, Agrawal R, Duerr J, Wagner CJ, Schatterny J, Hirtz S, Sommerburg O, Hartl D, Schultz C, Mall MA.

Am J Respir Cell Mol Biol. 2014 Nov;51(5):709-20.

 

Opens external link in new window5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.
Bhuvanagiri M, Lewis J, Putzker K, Becker JP, Leicht S, Krijgsveld J, Batra R, Turnwald B, Jovanovic B, Hauer C, Sieber J, Hentze MW, Kulozik AE.
EMBO Mol Med. 2014 Oct 15. pii: e201404461. doi: 10.15252/emmm.201404461.

 

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse.
Bandapalli OR, Schuessele S, Kunz JB, Rausch T, Stütz AM, Tal N, Geron I, Gershman N, Izraeli S, Eilers J, Vaezipour N, Kirschner-Schwabe R, Hof J, von Stackelberg A, Schrappe M, Stanulla M, Zimmermann M, Koehler R, Avigad S, Handgretinger R, Frismantas V, Bourquin JP, Bornhauser B, Korbel JO, Muckenthaler MU, Kulozik AE.
Haematologica. 2014 Oct;99(10):e188-92. doi: 10.3324/haematol.2014.104992.
Epub 2014 Jun 27. No abstract available. PMID:24972766

 

Opens external link in new windowDetection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors.
Woerner SM, Tosti E, Yuan YP, Kloor M, Bork P, Edelmann W, Gebert J.
Mol Carcinog. 2014 Sep 11. doi: 10.1002/mc.22213.

 

How mutant HFE causes hereditary hemochromatosis.
Muckenthaler MU.
Blood. 2014 Aug 21;124(8):1212-3. doi: 10.1182/blood-2014-07-581744. PMID:25147378

 

 Opens external link in new windowTransmembrane Protein 55B Is a Novel Regulator of Cellular Cholesterol Metabolism.
Medina MW, Bauzon F, Naidoo D, Theusch E, Stevens K, Schilde J, Schubert C, Mangravite LM, Rudel LL, Temel RE, Runz H, Krauss RM.
Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1917-23. doi: 10.1161/ATVBAHA.113.302806. Epub 2014 Jul 17. PMID:25035345

 

Opens external link in new windowNoncoding RNAs: key molecules in understanding and treating pain.
Bali KK, Kuner R.
Trends Mol Med. 2014 Aug;20(8):437-448. doi: 10.1016/j.molmed.2014.05.006. Epub 2014 Jun 28. Review.

 

Opens external link in new windowResistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload.
Altamura S, Kessler R, Gröne HJ, Gretz N, Hentze MW, Galy B, Muckenthaler MU.Cell Metab. 2014 Aug 5;20(2):359-67. doi: 10.1016/j.cmet.2014.07.007.

 

Opens external link in new windowA new player in the game: epithelial cathepsin S in early cystic fibrosis lung disease
Mall MA, Schultz C.
Am J Respir Crit Care Med. 2014 Jul 15;190(2):126-7. doi: 10.1164/rccm.201405-0935ED.

 

Opens external link in new windowWnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical
pathways
.
Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R.
Neuron. 2014 Jul 2;83(1):104-21. doi: 10.1016/j.neuron.2014.05.037.

 

Opens external link in new windowNovel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia.
Shochat C1, Tal N, Gryshkova V, Birger Y, Bandapalli OR, Cazzaniga G, Gershman N, Kulozik AE, Biondi A, Mansour MR, Twizere JC, Muckenthaler MU, Ben-Tal N, Constantinescu SN, Bercovich D, Izraeli S.
Blood. 2014 Jul 3;124(1):106-10.   

 

Opens external link in new windowStudying ongoing and spontaneous pain in rodents--challenges and opportunities.
Tappe-Theodor A, Kuner R.
Eur J Neurosci. 2014 Jun;39(11):1881-90. doi: 10.1111/ejn.12643. Epub 2014 May 29.

 

Opens external link in new windowCryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly.
Bharat, T.A., Castillo Menendez, L.R., Hagen, W.J., Lux, V., Igonet, S., Schorb, M., Schur, F.K., Krausslich, H.G. & Briggs, J.A.
Proc Natl Acad Sci U S A. 2014 May 19. pii: 201401455. Europe PMC

 

Opens external link in new windowAtherogenesis and iron: from epidemiology to cellular level.
Vinchi F, Muckenthaler MU, Da Silva MC, Balla G, Balla J, Jeney V.
Front Pharmacol. 2014 May 5;5:94. doi: 10.3389/fphar.2014.00094. eCollection 2014. Review

 

Opens external link in new windowThe NC domain of Gag is dispensable for actin incorporation into HIV-1 and for association of viral budding sites with cortical F-actin.
Stauffer S1, Rahman SA, de Marco A, Carlson LA, Glass B, Oberwinkler H, Herold N, Briggs JA, Müller B, Grünewald K, Kräusslich HG.
J Virol. 2014 Apr 30. [Epub ahead of print]

 

Opens external link in new windowLack of neutrophil elastase reduces inflammation, mucus hypersecretion and emphysema, but not mucus obstruction, in mice with CF-like lung disease.
Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA.
Am J Respir Crit Care Med. 2014 Mar 28. [Epub ahead of print]

 

Opens external link in new windowIron regulatory protein-1 protects against mitoferrin-1-deficient porphyria
Chung J, Anderson SA, Gwynn B, Deck KM, Chen MJ, Langer NB, Shaw GC, Huston NC, Boyer LF, Datta S, Paradkar PN, Li L, Wei Z, Lambert AJ, Sahr K, Wittig JG, Chen W, Lu W, Galy B, Schlaeger TM, Hentze MW, Ward DM, Kaplan J, Eisenstein RS, Peters LL, Paw BH.
J Biol Chem. 2014 Mar 14;289(11):7835-43. doi: 10.1074/jbc.M114.547778. Epub 2014 Feb 7. Erratum in: J Biol Chem. 2014 May 16;289(20):13707. PMID:24509859

 

Opens external link in new windowSequencing of a patient with balanced chromosome abnormalities and neurodevelopmental disease identifies disruption of multiple high risk loci by structural variation
Blake J, Riddell A, Theiss S, Gonzalez AP, Haase B, Jauch A, Janssen JW, Ibberson D, Pavlinic D, Moog U, Benes V, Runz H.
PLoS One. 2014 Mar 13;9(3):e90894. doi: 10.1371/journal.pone.0090894. eCollection 2014. PMID:24625750

 

Opens external link in new windowUnbiased RNAi screen for hepcidin regulators links hepcidin suppression to the proliferative Ras/RAF and the nutrient-dependent mTOR signaling pathways.
Mleczko-Sanecka, K., F. Roche, A.R. da Silva, D. Call, F. D’Allesio, A. Ragab, P.E. Lapinski, R. Ummanni, U. Korf, C. Oakes, G. Damm, L.A. D’Alessandro, U. Klingmüller, P.D. King, M. Boutros, M.W. Hentze and M.U. Muckenthaler. 
Blood. 2014 Mar 6;123(10):1574-85. doi: 10.1182/blood-2013-07-515957. Epub 2014 Jan 2. 

 

Opens external link in new windowFRET-based and other fluorescent proteinase probes.
Hu HY, Gehrig S, Reither G, Subramanian D, Mall MA, Plettenburg O, Schultz C.
Biotechnol J. 2014 Feb;9(2):266-81. doi: 10.1002/biot.201300201. Epub 2014 Jan 27.

 

Opens external link in new windowClinical significance of microsatellite instability in colorectal cancer.
Kloor M, Staffa L, Ahadova A, von Knebel Doeberitz M.
Langenbecks Arch Surg. 2014 Jan;399(1):23-31. doi: 10.1007/s00423-013-1112-3. Epub 2013 Sep 19.

 

Opens external link in new windowComparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations.
Sommerburg O, Krulisova V, Hammermann J, Lindner M, Stahl M, Muckenthaler M, Kohlmueller D, Happich M, Kulozik AE, Votava F, Balascakova M, Skalicka V, Stopsack M, Gahr M, Macek M Jr, Mall MA, Hoffmann GF.
J Cyst Fibros. 2014 Jan;13(1):15-23. doi: 10.1016/j.jcf.2013.06.003. Epub 2013 Jul 25.  

 

Opens external link in new windowA multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis.
Casanovas G, Banerji A, d'Alessio F, Muckenthaler MU, Legewie S.
PLoS Comput Biol. 2014 Jan;10(1):e1003421.doi:10.1371/journal.pcbi.1003421. Epub 2014 Jan2.

 

Opens external link in new windowThe activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse.
Bandapalli OR, Schuessele S, Kunz JB, Rausch T, Stütz AM, Tal N, Geron I, Gershman N, Izraeli S, Eilers J, Vaezipour N, Kirschner-Schwabe R, Hof J, von Stackelberg A, Schrappe M, Stanulla M, Zimmermann M, Koehler R, Avigad S, Handgretinger R, Frismantas V, Bourquin JP, Bornhauser B, Korbel JO, Muckenthaler MU, Kulozik AE.
Haematologica. 2014 Jun 27. pii: haematol.2014.104992. [Epub ahead of print]

 

Opens external link in new windowHigh CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol.
Cario G1, Rhein P, Mitlöhner R, Zimmermann M, Bandapalli OR, Romey R, Moericke A, Ludwig WD, Ratei R, Muckenthaler MU, Kulozik AE, Schrappe M, Stanulla M, Karawajew L.
Haematologica.
2014 Jan;99(1):103-10. doi: 10.3324/haematol.2013.090225. Epub 2013 Aug 2.

 

Opens external link in new windowmRNA 3'end processing: A tale of the tail reaches the clinic
Ina Hollerer, Kerstin Grund, Matthias W. Hentze, Andreas E. Kulozik
EMBO Mol Med. 2014 Jan 1;6(1):16-26. doi: 10.1002/emmm.201303300.

 

 

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