zurück zur Startseite
Zentrale Tel.: 06221-560

An integrated SYstems Medicine approach to Personalized And targeted THerapy in lYmphoma (SYMPATHY)

We are a Partner group of the European Molecular Biology Laboratory (EMBL) within the Molecular Medicine Partnership Unit (MMPU):

Our aim is to bring biology-based individualized treatment of lymphoma and leukemia into clinical practice. To achieve this ambitious aim, we establish a systems medicine program that integrates systematic functional assays, multi-omic profiling, bioinformatic analysis, mathematical modeling and setup towards a clinical exploitation. The basis of the program is a platform to map patient specific pathway activity and drug sensitivity of their primary tumor cells ex-vivo. By comparing drug responses across patients with detailed molecular characterization (e.g. whole exome- and RNA-sequencing) and the clinical parameters, we obtain a rich set of associations of drug sensitivity with biology, biomarkers and outcome. 



Figure 1) The general layout of our research program.


A particular focus of our research is on signals provided by the microenvironment, and  how these signals modify pathway activities targeted by drugs. We aim to generate a systems-level understanding of how the microenvironment and the individual genetic and molecular make-up of a tumor interact and modify drug response using a high throughput automated microscopy platform mimicking microenvironment conditions. In parallel, we investigate further dimensions of in-vivo drug response (3D-space, timing of drug response) with a hierarchy of increasingly complex culture models and readouts in suitable tumors.


Our group is funded by the eMed Programm of the BMBF. (http://www.sys-med.de/de/)


Group leader



Priv.-Doz. Dr. med. Sascha Dietrich

Facharzt für Hämatologie und Onkologie

Leiter des Lymphom-Programms
Molecular Medicine Partnership:
Systems medicine of Cancer Drugs
Personalisierte Lymhomtherapie (SYMPATHY)


Tel.: 06221-56 8030
E-Mail: sascha.dietrich@med.uni-heidelberg.de






Medizinische Klinik, Abt. Innere Medizin V
Hämatologie, Onkologie, Rheumatologie

Im Neuenheimer Feld 350
69120 Heidelberg


Tel.: 06221-56-39066




Group Members



Berit Johanna Brinkmann

PhD student


Tel.: +49 621 56-6539


Peter-Martin Bruch

MD Student

Tel.: + 49 6221 56-4043

Holly Giles

PhD student (EMBL International PhD Programme -
EIPP) Joint PhD with Huber Group, EMBL

Tel. + 49 6221 387 8823



Sarah Richter

Joint PhD with the group of Prof. Petra Knaup (IMBI)

Tel. + 49 6221 56-7398



Sophie-Alessa Rabe

Forschungslabor AG Dr. Dietrich


Phone: + 49 6221 56-6539
Opens window for sending emailsophie-alessa.Rabe@med.uni-heidelberg.de


Dr. med. Tobias Roider



Tel.: + 49 6221 56-6539 
Opens window for sending emailtobias.roider@med.uni-heidelberg.de

Xi Wang

Doctoral student


Tel.: +49 6221 56-6539


Carolin Kolb


Tel.: + 49 6221 56-39066


Angela Lenze


Tel.: 06221 - 56 39066

Mareike Knoll


Tel.: + 49 6221 56-39066


Selected Publication:


Drug-perturbation-based stratification of blood cancer. 
Dietrich S, Oleś M, Lu J, Sellner L, Anders S, Velten B, Wu B, Hüllein J, da Silva Liberio M, Walther T, Wagner L, Rabe S, Ghidelli-Disse S, Bantscheff M, Oleś AK, Słabicki M, Mock A, Oakes CC, Wang S, Oppermann S, Lukas M, Kim V, Sill M, Benner A, Jauch A, Sutton LA, Young E, Rosenquist R, Liu X, Jethwa A, Lee KS, Lewis J, Putzker K, Lutz C, Rossi D, Mokhir A, Oellerich T, Zirlik K, Herling M, Nguyen-Khac F, Plass C, Andersson E, Mustjoki S, von Kalle C, Ho AD, Hensel M, Dürig J, Ringshausen I, Zapatka M, Huber W, Zenz T. 
J Clin Invest. 2018 Jan 2;128(1):427-445. doi: 10.1172/JCI93801. Epub 2017 Dec 11.PMID:29227286


Multi-Omics factor analysis disentangles heterogeneity in blood cancer 
Ricard Argelaguet, Britta Velten, Damien Arnol, Sascha Dietrich, Thorsten Zenz, John C. Marioni, Florian Buettner, Wolfgang Huber, Oliver Stegle 
bioRxiv beta Nov. 10, 2017 doi.org/10.1101/217554


BRAF inhibition in hairy cell leukemia with low-dose vemurafenib. 
Dietrich S, Pircher A, Endris V, Peyrade F, Wendtner CM, Follows GA, Hüllein J, Jethwa A, Ellert E, Walther T, Liu X, Dyer MJ, Elter T, Brummer T, Zeiser R, Hermann M, Herold M, Weichert W, Dearden C, Haferlach T, Seiffert M, Hallek M, von Kalle C, Ho AD, Gaehler A, Andrulis M, Steurer M, Zenz T. 
Blood. 2016 Jun 9;127(23):2847-55. doi: 10.1182/blood-2015-11-680074. 
PMID: 26941398


Recurrent CDKN1B (p27) mutations in hairy cell leukemia. 
Dietrich S, Hüllein J, Lee SC, Hutter B, Gonzalez D, Jayne S, Dyer MJ, Oleś M, Else M, Liu X, Słabicki M, Wu B, Troussard X, Dürig J, Andrulis M, Dearden C, von Kalle C, Granzow M, Jauch A, Fröhling S, Huber W, Meggendorfer M, Haferlach T, Ho AD, Richter D, Brors B, Glimm H, Matutes E, Abdel Wahab O, Zenz T. 
Blood. 2015 Aug 20;126(8):1005-8. doi: 10.1182/blood-2015-04-643361. 
PMID: 26065650


Orchestrating high-throughput genomic analysis with Bioconductor. 
Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M. 
Nat Methods. 2015 Feb;12(2):115-21. doi: 10.1038/nmeth.3252. Review. 
PMID: 25633503


Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia. 
Dietrich S, Hüllein J, Hundemer M, Lehners N, Jethwa A, Capper D, Acker T, Garvalov BK, Andrulis M, Blume C, Schulte C, Mandel T, Meissner J, Fröhling S, von Kalle C, Glimm H, Ho AD, Zenz T. 
J Clin Oncol. 2013 Jul 1;31(19):e300-3. doi: 10.1200/JCO.2012.45.9495. No abstract available. 


BRAF inhibition in refractory hairy-cell leukemia. 
Dietrich S, Glimm H, Andrulis M, von Kalle C, Ho AD, Zenz T. 
N Engl J Med. 2012 May 24;366(21):2038-40. doi: 10.1056/NEJMc1202124. 



Print Diese Seite per E-Mail weiterempfehlen