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TP2 Implementation of heavy ion therapy of moved gastrointestinal tumors

Aims of TP2 are:

  • Optimizing radiotherapy with heavy ions of liver tumors –comparison of different radiation entities
  • Clinical Implementation of radiotherapy with scanned ion beams of pancreatic tumors
  • Exploiting individual statistic parameters for dose calculations with gating
  • Optimizing of therapy planning using tools for target volume definition and choosing robust planning parameters
  • Planning studies to address the question, if alternating therapy plans with varying parameters can increase robustness of dose application with gating
  • Durchführung einer Planungsstudie für Tumoren der Leber und Pankreas zur Auswahl geeigneter Einstrahlwinkel
  • Performing of planning studies for liver and pancreatic tumors to define suitable radiation angles
  • Evaluation of patient positioning tools (abdominal press) and implanted markers to optimize the precision of the beam application with gating
  • Establishing methods for slow plan adaptation in dominant inter-fractional changes of organ sizes based on weekly CT imaging and finally adaptation of the results into the clinical routine of pancreatic cancer treatment
  • Optimizing the methodology of dose verification when gating is applied Studies to optimize LET distributions in hypoxic areas of tumors in therapy planning

Selected publications

Richter D, Graeff C, Jäkel O, Combs SE, Durante M, Bert C. Residual motion mitigation in scanned carbon ion beam therapy of liver tumors using enlarged pencil beam overlap. Radiother Oncol. 2014 Nov;113(2):290-5

Richter D, Saito N, Chaudhri N, Härtig M, Ellerbrock M, Jäkel O, Combs SE, Habermehl D, Herfarth K, Durante M, Bert C. Four-dimensional patient dose reconstruction for scanned ion beam therapy of moving liver tumors. Int J Radiat Oncol Biol Phys. 2014 May 1;89(1):175-81

Habermehl D, Debus J, Ganten T, Ganten MK, Bauer J, Brecht IC,  Brons C,  Haberer T, Haertig M,  Jäkel O, Parodi K,  Welzel T, Combs SE. Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma – feasibility and clinical response Radiat Oncol. 2013; 8: 59

Combs SE, Habermehl D, Kieser M, Dreher C, Werner J, Haselmann R, Jäkel O, Jäger D, Büchler MW, Debus J. Phase I study evaluating the treatment of patients with locally advanced pancreatic cancer with carbon ion radiotherapy: the PHOENIX-01 trial. BMC Cancer. 2013 Sep 14;13:419

Habermehl D, Debus J, Ganten T, Ganten MK, Bauer J, Brecht IC, Brons S, Haberer T, Haertig M, Jäkel O, Parodi K, Welzel T, Combs SE. Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma - feasibility and clinical response. Radiat Oncol. 2013 Mar 13;8:59

Bassler N, Jäkel O, Søndergaard CS, Petersen JB. Dose- and LET-painting with particle therapy. Acta Oncol. 2010 Oct;49(7):1170-6

Combs SE, Habermehl D, Ganten T, Schmidt J, Edler L, Burkholder I, Jäkel O, Haberer T, Debus J. Phase i study evaluating the treatment of patients with hepatocellular carcinoma (HCC) with carbon ion radiotherapy: the PROMETHEUS-01 trial. BMC Cancer. 2011 Feb 12;11:67

Batista V, Richter D, Combs S, Jäkel,O. Inter- and Intra-fractional Motion Robustness for Pancreatic Patients Treated With Scanned Carbon Ion Therapy Int. J. Radiat. Oncol. Biol. Phys. 2014, Volume 90, Issue 1, Supplement, Page S921

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