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TP3 Studies on adaptive therapy planning for prostate carcinoma and chordoma

In this project we focus on:

  • Studies to evaluate hypo-fractionated ion beam therapy in pelvic tumors with low α/β Establishing methods of plan adaptation for dominating inter-fractional organ movement (prostate, IPI-study) based on CT imaging
  • Clinical Implementation of the results above during application of ion boost in prostate carcinoma patients (IPI-study)
  • Development of methods for therapy planning and plan adaptation based on MRT- imaging only (prostate cancer)
  • Development of methods for plan adaptation for inter-fractional changes  of irradiation geometry (due to patient positioning) of sacral chordoma based on repeated CT- and MR- imaging

Selected publications

Uhl M, Welzel T, Jensen A, Ellerbrock M, Haberer T, Jäkel O, Herfarth K, Debus J. Carbon ion beam treatment in patients with primary and recurrent sacrococcygeal chordoma. Strahlenther Onkol. 2015 Jul;191(7):597-603

Rucinski A, Brons S, Richter D, Habl G, Debus J, Bert C, Haberer T, Jäkel O. Ion therapy of prostate cancer: daily rectal dose reduction by application of spacer gel. Radiat Oncol. 2015 Feb 27;10:56

Uhl M, Mattke M, Welzel T, Roeder F, Oelmann J, Habl G, Jensen A, Ellerbrock M, Jäkel O, Haberer T, Herfarth K, Debus J. Highly effective treatment of skull base chordoma with carbon ion irradiation using a raster scan technique in 155 patients: first long-term results Cancer. 2014 Nov 1;120(21):3410-7

Ruciński A, Bauer J, Campbell P, Brons S, Unholtz D, Habl G, Herfarth K, Debus J, Bert C, Parodi K, Jäkel O, Haberer T. Preclinical investigations towards the first spacer gel application in prostate cancer treatment during particle therapy at HIT. Radiat Oncol. 2013 Jun 6;8:134

Nikoghosyan AV, Schulz-Ertner D, Herfarth K, Didinger B, Münter MW, Jensen AD, Jäkel O, Hoess A, Haberer T, Debus J. Acute toxicity of combined photon IMRT and carbon ion boost for intermediate-risk prostate cancer - acute toxicity of 12C for PC. Acta Oncol. 2011 Aug;50(6):784-90

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