Kliniken & Institute … Kliniken Chirurgische Klinik… Herzchirurgie Forschung Publikationen 1997-1999


Publikationen 1997-1999










Bauernschmitt R, Schulz S, Schwarzhaupt A, Kiencke U, Vahl CF, Lange R, Hagl S (1999): 

Simulationof arterial hemodynamics after partial prosthetic repacement of the aorta. 

Ann Thorac Surg 67: 676-682



Bauernschmitt R, Mehmanesh H, Schulz S, Vahl C, Lange R, Hanfler M, Muller A, Hagl S (1999): 

Aortic input impedance and ventriculoarterial coupling following cardioversion/defibrillation. 

Pacing Clin Electrophysiol 22: 1047-53 



Bauernschmitt R, Naujokat E, Mehmanesh H, Schulz S, Vahl CF, Hagl S, Lange R (1999): 

Mathematical modelling of extracorporal circulation: simulation of different perfusion regiments. 

Perfusion 14:321-330 



Dengler TJ, Szabó G, Sido B, Nottmeyer W, Zimmermann R, Vahl CF, Hunig T, Meuer SC (1999): 

Prolonged allograft survival but no tolerance induction by modulating CD28 antibody JJ319 after high-responder rat heart transplantation. 

Transplantation 67: 392-398 



Dengler TJ, Zimmermann R, Meyer J, Sack FU, Girgsdies O, Kubler WE (1999) 

Vaccination against tick-borne encephalitis under therapeutic immunosuppression. Reduced efficacy in heart transplant recipients. 

Vaccine 17: 867-74 



De Simone R, Glombitza G, Vahl CF, Albers J, Meinzer HP, Hagl S (1999): 

Three-dimensional color-doppler: a new approach for quantitative assessment of mitral regurgitant jets. 

Am Soc Echocardiogr 12: 173-185 



De Simone R, Glombitza G, Vahl CF, Albers J, Meinzer HP, Hagl S (1999): 

Three-dimensional color-doppler for assessing mitral regurgitation during valvuloplasty. 

Eur J Cardio-Thoracic Surg 15: 127-133 



De Simone R, Glombitza G, Vahl CF, Albers J, Meinzer HP, Hagl S (1999): 

Three-dimensional color-doppler: a clinical study in patients with mitral regurgitation. 

J Am Coll Cardiol 33: 1646-1654 



De Simone R, Glombitza G, Vahl CF, Albers J, Meinzer HP, Hagl S (1999): 

Assessment of mitral regurgitant jets by three-dimensional color-doppler. 

Ann Thorac Surg 67: 494-499 



De Simone R, Glombitza G, Vahl CF, Meinzer HP, Hagl S (1999): 

A new diagnostic procedure for assessing intracardiac flow disturbances in patients with heart valve disease. 

Thorac Cardiovasc Surg 47: 369-375 



De Simone R, Glombitza G, Vahl CF, Meinzer HP, Hagl S (1999): 

Three-dimensional doppler techniques and clinical applications. 

Eur Heart J 20: 619-627 



De Simone R, Glombiza G, Vahl CF, Meinzer HP, Hagl S  (1999): 

Three-Dimensional Color Doppler, an Atlas of Intracardiac Imaging. 

CD und Buch: Futura Publishing Company - Armonk - New York 1999. ISBN 0-87993-429-8 



Glombitza G, De Simone R, Mende U, Merdes M, Krempien R, Zerfoski D, Vahl CF, Meinzer HP, Hagl S (1999): 

Neue klinische Anwendungen der dreidimensionalen Rekonstruktion in der echocardiographischen Diagnostik. 

Informatik Forsch Entw 14: 16-23 



Kranzhofer R, Schmidt J, Pfeiffer CA, Hagl S, Libby P, Kubler W (1999): 

Angiotensin induces inflammatory activation of human vascular smooth muscle cells. 

Arterioscler Thromb Vasc Biol 19: 1623-9. 



Kunst G, Martin E, Graf BM, Hagl S, Vahl CF (1999): 

Actions of Ketamine and its isomers on contractility and calcium transients in human myocardium. 

Anesthesiology 90: 1363-1371 



Mehmanesh H, Bauernschmitt R, Hagl S, Lange R (1999): 

Adjustable atrial and ventricular temporary electrode for low-energy termination of tachyarrhythmias early after cardiac surgery. 

Pacing Clin Electrophysiol 22: 1802-7 



Mehmanesh H, Bauernschmitt R, Lange R, Hagl S (1999): 

[A new concept for treatment of supraventricular tachycardia after heart operations: low energy internal cardioversion using a temporary atrial electrode] 

Z Kardiol 88: 434-41 



Mehmanesh H, Mieck U, Bauernschmitt R, Hagl S, Lange R (1999): 

[Temporary adjustable defibrillator electrodes: an alternative method for the treatment of postoperative arrhythmias after heart surgery] 

Anasthesiol Intensivmed Notfallmed Schmerzther 34: 758-62 



Osswald, BR, Blackstone EH, Tochtermann U, Thomas G, Vahl CF, Hagl S (1999): 

The meaning of early mortality after CABG. 

Eur J Cardio-Thorac Surg 15: 401-407 



Osswald, BR, Tochtermann U, Thomas G, Vahl CF, Hagl S (1999): 

The influence of follow-up response on risk factor analysis. 

Thorac Cardiovasc Surg 47: 32-37 



Schäffer L, Rosenberg M, Bonz A, Vahl CF, Hagl S (1999): 

Kontraktionsverhalten und intrazelluläre Calciumtransienten bei ischämischer

Kardiomyopathie: der Einfluss der Vorlast, der Nachlast und der Frequenz. 

Z Herz-, Thorax- und Gefäßchirurgie 13: 255-266 



Schulz S, Bauernschmitt R, Schwarzhaupt A, Vahl CF, Kiencke U (1999): 

Nonlinear dynamic analysis of hemodynamic signals for indentifying transition between ventriculoarterial coupling states. 

IEEE Comp cardiol 26: 517-510 



Sergi C, Serpi M, Muller-Navia J, Schnabel PA, Hagl S, Otto HF, Ulmer HE (1999): 

CATCH 22 syndrome: report of 7 infants with follow-up data and review of the recent advancements in the genetic knowledge of the locus 22q11. 

Pathologica 91: 166-72 Review 



Szabó G, Sebening C, Hackert T, Hoffmann L, Sonnenberg K, Hagl C, Tochtermann U, Vahl CF, Hagl S (1999): 

Influence of brain death and cardiac preservation on systolic and diastolic function and coronary circulation in the cross-circulated canine heart. 

World J Surg 23: 36-43 



Szabó G, Hackert T, Sebening C, Hagl C, Vahl CF, Hagl S (1999): 

Modulation of coronary perfusion pressure can reverse cardiac dysfunction after brain death. 

Ann Thorac Surg 67: 18-26 



Vahl CF, Kloss T, Yang X, Castell M, Mehrkens A, De Simone R, Schäffer L, Hagl S (1999): 

Surgical treatment of oligosymptomatic mitral valve incompetence? 

Eur J Cardio-Thorac Surg 16: 524-532 





Albers J, Schroeder A, Makabe M, Gaa J, De Simone R, Vahl CF, Hagl S (1998): 

Validierung digitaler Volumetrie und dreidimensionale Rekonstruktion kardialer magnetresonanz- und computertomographischer Bilddaten: Studie an explantierten Schweineherzen. 

Kardiovask Med 2: 79-87 



Bahrle S, Szabó G, Dengler TJ, Zimmermann R, Hagl S, Kubler W (1998): 

Immunosuppressive effects of ursodeoxycholic acid in heart-allografted rats 

Transplant Proc. 1998 May; 30(3): 864-5 



Bauernschmitt R, Bohrer H, Hagl S (1998):

Rescue therapy with C1-esterase inhibitor concentrate after emergency coronary surgery for failed PTCA 

Intensive Care Med. 1998 Jun; 24(6): 635-8 



Bauernschmitt R, Jakob HG, Vahl CF, Lange R, Hagl S (1998):

Operation for infective endocarditis: results after implantation of mechanical valves 

Ann Thorac Surg. 1998 Feb; 65(2): 359-64 



Bauernschmitt R, De Simone R, Lange R, Vahl CF, Thomas G, Hagl S (1998):

[Surgery of acute aortic valve endocarditis: prognosis in paravalvular abscess] 

Z Kardiol. 1998 Apr; 87(4): 276-82 



Bauernschmitt R, Schulz S, Hoffmann L, Schwarzhaupt A, Kiencke U, Vahl CF, Hagl S (1998): 

Mathematische Modellierung der Hämodynamik während extracorporaler Zirkulation 

Kardiotechnik 2: 39-43 



Bonz A, Siegmund B, Ladilov Y, Vahl CF, Piper HM (1998):

Metabolic recovery of isolated adult rat cardiomyocytes after energy depletion: existance of an ATP-threshold. 

J Mol Cell Cardiol 30: 2111-2119 



Dengler TJ, Szabó G, Amann K, Nottmeyer W, Vahl CF, Hagl S, Zimmermann R (1998): 

Induction therapy with an immunomodulatory CD2 antibody does not inhibit allograft vasculopathy after rat heart transplantation 

Transplant Proc. 1998 May; 30(3): 868-70 



Dengler TJ, Zimmermann R, Braun K, Muller-Bardorff M, Zehelein J, Sack FU, Schnabel PA, Kubler W, Katus HA (1998):

Elevated serum concentrations of cardiac troponin T in acute allograft rejection

after human heart transplantation 

J Am Coll Cardiol. 1998 Aug; 32(2): 405-12 



De Simone R, Glombitza G, Vahl CF, Albers J, Meinzer HP, Hagl S (1998) 

Three dimensional doppler for the assessment of mitral regurgitation. 

Computers in Cardiology 25: 617-620 



Gerber SH, Heyer C, Kruger C, Hagl S, Kubler W, Haass M (1998) 

Influence of Bretschneider's cardioplegia on norepinephrine release from isolated perfused guinea-pig hearts. 

J Mol Cell Cardiol 31: 89-99. 



Herold U, Jakob H, Kamler M, Thiele R, Tochtermann U, Weinmann J, Motsch J, Gebhard MM, Hagl S (1998):

Interruption of bronchial circulation leads to a severe decrease in peribronchial oxygen

tension in standard lung transplantation technique 

Eur J Cardiothorac Surg. 1998 Feb; 13(2): 176-83 



Mehmanesh H, Lange R, Hagl S (1998):

Temporary atrial electrode for the treatment of supraventricular tachycardia after cardiac operations 

Ann Thorac Surg. 1998 Mar; 65(3): 632-6 



Sack FU, Dollner R, Reidenbach B, Lange R, Gebhard MM, Hagl S (1998): 

In vivo fluorescence microscopy for the assessment of microvascular perfusion injury of small bowel during cardio-pulmonary bypass. 

Proceedings of the 20th European Conference on Microcirculation , 131-136. Edt. Carpentier PH, Vicaut E and Guilmot JL 



Sack FU, Hagl S (1998): 

Primäre und sekundäre Tumoren des Herzens. 

In: Thoraxtumoren, 2. Auflage Ed., 471-496. Edited by Drings P and Vogt-Moykopf I, Heidelberg, Springer 



Schulz S, Bauernschmitt R, Maar F, Schwarzhaupt A, Vahl CF, Kiencke U (1998) 

[Modeling of the baroreceptor reflex in a pulsatile model] 

Biomed Tech 43 Suppl: 310-1 



Szabó G, Bahrle S, Bátkai S, Stumpf N, Dengler TJ, Zimmermann R, Vahl CF, Hagl S (1998):

L-arginine: effect on reperfusion injury after heart transplantation 

World J Surg. 1998 Aug; 22(8): 791-7; discussion 797-8 



Szabó G, Bahrle S, Fazekas L, MacDonald D, Stumpf N, Vahl CF, Hagl S (1998) 

Endothelin-A receptor antagonist BQ123 protects against myocardial and

endothelial reperfusion injury 

Thorac Cardiovasc Surg 46: 232-236 



Szabó G, Bátkai S, Bahrle S, Dengler TJ, Vahl CF, Zimmermann R, Hagl S (1998):

Effects of nitric oxide synthesis on reperfusion injury and catecholamine responsiveness in a heterotopic rat heart-transplantation model 

J Cardiovasc Pharmacol. 1998 Feb; 31(2): 221-30 



Szabó G, Fazekas L, Bahrle S, MacDonald D, Stumpf N, Vahl CF, Hagl S (1998) 

Endothelin-A and -B antagonist protect myocardial and endothelial function

after ischemia/reperfusion in rat heart transplantation model 

Cardiovasc Res 39: 683-690 



Szabó G, Sebening C, Hackert T, Hagl C, Tochtermann U, Vahl CF, Hagl S (1998) 

Effects of brain death on myocardial function and ischemic tolerance of potential donor hearts. 

J Heart Lung Transplant 17: 921-930



Szabó G, Sebening C, Hackert T, Hoffmann L, Melnitchuk S, Vahl CF, Hagl S (1998) 

The role of coronary perfusion changes in cardiac dysfunction associated with brain death. 

Thorac Cardiovasc Surg 46: 339-43.



Szabó G, Sebening C, Hagl C, Tochtermann U, Vahl CF, Hagl S (1998):

Right ventricular function after brain death: response to an increased afterload 

Eur J Cardiothorac Surg. 1998 Apr; 13(4): 449-58; discussion 458-9 



Timek T, Bonz A, Dillmann R, Vahl CF, Hagl S (1998) 

The effect of triiodothyronine on myocardial contractile performance after

epinephrine exposure: implications for donor heart managemant. 

J Heart Lung Transplant 17: 931-940 



Thiele RI, Daniel V, Opelz G, Lange R, Sack FU, Jakob H, Hagl S (1998) 

Circulating interleukin-1 receptor antagonist (IL-1RA) serum levels in patients undergoing orthotopic heart transplantation. 

Transpl Int 11:443-8. 



Timek T, Vahl CF, Bonz A, Schäffer L, Rosenberg M, Hagl S (1998) 

Triiodothyronine reverses depressed contractile performance after exessive catecholamine stimulation. 

Ann Thorac Surg 66: 1618-1625



Vahl CF, Albers J, Makabe M, Meinzer HP, Ilg M, Fu X, Szabó G, Mühling J, Hagl S (1998): 

Heterogenity of myocardial edema in isolated pig hearts after perfusion with different types of cardioprotective solutions. 

Thorac Cardiovasc Surg 46: 285-292



Vahl CF, Timek T, Bonz A, Fuchs H, Dillmann R, Hagl S (1998):

Length dependence of calcium- and force-transients in normal and failing human myocardium 

J Mol Cell Cardiol. 1998 May; 30(5): 957-66 



Ziegler S, Vahl CF, Hagl S (1998): 

Freisetzung von Katecholaminen nach Exposition mit kadioplegischer Lösung:

Morphologische und biochemische Untersuchungen an rechtatrialem Myokardgewebe. 

Herz-, Thorax- und Gefäßchirurgie 12: 23-33 





Bauernschmitt R, Lange R, De Simone R, Hagl S (1997):

[Surgical treatment of acute endocarditis-

-which preoperative diagnosis does the surgeon need?] 

Langenbecks Arch Chir Suppl Kongressbd. 1997; 114: 1370-2 



Bauernschmitt R, Schulz S, Albers J, Riesenberg A, Schwarzhaupt A, Kiencke U, Vahl CF, Hagl S (1997):

Arterial hemodynamics during extracorporal circulation - a high time resolution mathematical model. 

Cardiovascular Engineering 2 (4), 1997: 236-243 



Bonz A, Vahl CF, Hagl S (1997):

Contractile behaviour and intracellular calcium during afterloaded contraction in mitral valve disease 

Thorac Cardiovasc Surg. 1997 Dec; 45(6): 280-6 



Hagl C, Szabó G, Sebening C, Tochtermann U, Vahl CF, Sonnenberg K, Hagl S (1997):

Is the brain death related endocrine dysfunction an indication for hormonal substitution therapy in the early period ? 

Eur J Med Res. 1997 Oct 30; 2(10): 437-40 



Hagl S, Jakob H, Sebening C, van Bodegom P, Schmidt K, Zilow E, Fleischer F, Ulmer H (1997):

External stabilization of long-segment tracheobronchomalacia guided by intraoperative bronchoscopy 

Ann Thorac Surg. 1997 Nov; 64(5): 1412-20; discussion 1421 



Haass M, Serf C, Gerber SH, Kruger C, Haunstetter A, Vahl CF, Nobiling R, Kubler W (1997):

Dual effect of digitalis glycosides on norepinephrine release from human atrial tissue

and bovine adrenal chromaffin cells: differential dependence on [Na+]i and [Ca2+]i 

J Mol Cell Cardiol. 1997 Jun; 29(6): 1615-27 



Jakob H, Kamler M, Hagl S (1997):

Doubly angled pleural drain circumventing the transcostal route relieves pain after cardiac surgery 

Thorac Cardiovasc Surg. 1997 Oct; 45(5): 263-4 



Jakob H, Kamler M, Vahl CF, Lange R, Tanzeem A, Hagl S (1997): 

Surgical alternatives in pulmonary embolism. 

Fibrinolysis and Proteolysis 11 (Suppl.2): 1-7 



Kamler M, Jakob H, Lehr HA, Gebhard MM, Hagl S (1997):

Direct visualization of leukocyte/endothelial cell interaction during extracorporeal circulation (ECC) in a new animal model 

Eur J Cardiothorac Surg. 1997 May; 11(5): 973-80 



Lange R, Hagl S (1997): 

Dynamic cardiomyoplasty: how well does it work? 

Eur Heart J. 1997 Feb; 18(2): 191-7 



Lange R, Sack FU (1997): 


In: Diagnostik und Therapie der Arrhythmien, 93-94. Edited by Brachmann J, Science Publishing 



Lange R, Sack FU, Hagl S (1997): 

Experience with isolated cardiomyoplasty in patients with contraindications for heart transplantation 

In: Cardiac Bioassist, 135-148. Edited by Carpentier A, Chachques JC, and Grandjean PA 



Lange R, Thielmann M, Hagl S (1997):

[Dynamic cardiomyoplasty] 

Herz. 1997 Oct; 22(5): 253-61 



Lange R, Thielmann M, Schmidt KG, Bauernschmitt R, Jakob H, Hasper B, Ulmer H, Hagl S (1997):

Spinal cord protection using hypothermic cardiocirculatory arrest in extended repair of recoarctation and persistent hypoplastic aortic arch 

Eur J Cardiothorac Surg. 1997 Apr; 11(4): 697-702 



Osswald BR, Vahl CF, Fleischer F, Hagl S (1997):

Successful revascularisation for unstable angina of a patient with asymptomatic bilateral internal carotid occlusion, 70% stenoses of the external carotid arteries, and other circulation disturbances 

Thorac Cardiovasc Surg. 1997 Aug; 45(4): 200-3 



Osswald BR, Vahl CF, Hagl S (1997): 

Increase of "high risk patients" untergoing CABG? 

Cardiovasc Eng 2: 228-230 



Sack FU, Lange R, Mehmanesh H, Amman K, Schnabel P, Zimmermann R, Dengler T, Otto HF, Hagl S (1997):

Transferral of extrathoracic donor neoplasm by the cardiac allograft 

J Heart Lung Transplant. 1997 Mar; 16(3): 298-301 



Schulz S, Bauernschmitt R, Albers J, Riesenberg A, Schwarzhaupt A, Vahl CF, Kiencke U (1997):

A mathematical high time resolution model of the arterial system under extracorporeal circulation 

Biomed Sci Instrum. 1997; 33: 406-11 



Schulz S, Bauernschmitt R, Schwarzhaupt A, Vahl CF, Kiencke U (1997):

Description of the ventriculoarterial interaction dynamics using recurrence plot strategies 

Biomed Sci Instrum. 1997; 34: 269-74 



Schulz S, Bauernschmitt R, Schwarzhaupt A, Vahl CF, Kiencke U (1997): 

Hemodynamic consequences of replacing the aorta by vascular grafts simulated in a mathematical model 

Biomed Sci Instrum. 1997; 34: 263-8 



Szabó G, Bahrle S, Dengler TJ, Bátkai S, Vahl CF, Hagl S (1997): 

[Reducing perfusion damage after heart transplantation with the nitric oxide donor L-arginine] 

Langenbecks Arch Chir Suppl Kongressbd. 1997; 114: 7-10 



Thiele RI, Jakob H, Hund E, Genzwuerker H, Herold U, Schweiger P, Hagl S (1997):

Critical illness polyneuropathy: a new iatrogenically induced syndrome after cardiac surgery? 

Eur J Cardiothorac Surg. 1997 Dec; 12(6): 826-35 



Thielmann M, Lange R, Bauernschmitt R, De Simone R, Richter G, Hagl S (1997): 

["Necessary" diagnostic procedures in traumatic aortic rupture, acute dissecting and chronic aortic aneurysms] 

Langenbecks Arch Chir Suppl Kongressbd. 1997; 114: 449-53 



Vahl CF, Carl I, De Simone R, Meinzer HP, Thomas G, Hagl S (1997):

[Calibration of clinical databanks with "virtual patients"] 

Z Kardiol. 1997 Jan; 86(1): 35-41



Vahl CF, Elkin M, Jung A, Schäffer L, Bonz A, Castell M, Albers J, De Simone R, Hagl S (1997): 

Intrazelluläre Calciumtransienten bei nachbelasteten Kontraktionen:

Untersuchungen am linksventrikulären Myokard von Patienten mit Aortenklappenstenosen. 

Z Kardiovask Med 1: 66-75



Vahl CF, Meinzer HP Thomas G, Jakob H, Hagl S (1997): 

Differenzierte Qualitätssicherung in der Herzchirurgie 

Deutsches Ärzteblatt 94: A369-A371



Vahl CF, Osswald BR, Meinzer HP, De Simone R, Thomas G, Hagl S (1997): 

[Internal quality assurance or Hawthorne effect?] 

Langenbecks Arch Chir Suppl Kongressbd. 1997; 114: 260-6 



Vahl CF, Timek T, Bonz A, Kochsiek N, Fuchs H, Schäffer L, Rosenberg M, Dillmann R, Hagl S (1997):

Myocardial length-force relationship in end stage dilated cardiomyopathy and normal human myocardium: analysis of intact and skinned left ventricular trabeculae obtained during 11 heart transplantations 

Basic Res Cardiol. 1997 Aug; 92(4): 261-70