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- The tumor stem cell hypothesis
- Experimental models of pancreatic tumor stem cells
- Fertilized chicken eggs as animal replacement method for therapy studies with patient tumors
- Bioactive agents from fruits and vegetables for tumor prevention and therapy
- Nutritional study with broccoli sprouts to support the efficacy of conventional therapy of pancreatic cancer
- Specific transfer of oncolytic adenoviruses via mesenchymal stem cells for elimination of pancreatic tumor stem cells
- The role of intercellular communication in the development of a tumor stem cell character
- Examination of tumor stem cells features in Giant Cell Tumor of Bone
- Talks and Congresses
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Experimental models of pancreatic tumor stem cells
Pancreatic CSCs are characterized according to specific features. These include (I) self-renewal potential (by symmetric and asymmetric cell division), (II) differentiation potential for conversion into various types of cells of the tumor, (III) the ability of serial passaging in immunodeficient mice with subsequent recapitulation of the original tumor, (IV) the expression of specific surface markers (CD24, CD44, c-Met, EpCAM/ESA, CD133, CXCR4), which allow an assured identification and purification of CSCs. Additionally there is an increased activity of the CSC marker enzyme aldehyde dehydrogenase isoform 1 (ALDH1), as well as a pronounced resistance to the induction of programmed cell death, along with enhanced signaling signaling by the master NF-kB transcription factor, which activates signaling pathways of epithelial-mesenchymal transduction with increased cell motility and migration potential of tumor cells. Using these markers, we have characterized cells of pancreatic cancer and use these primary and established cells now as models for therapeutic studies in the petri dish or in in vivo tumor xenografts.
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- Current Affaires
- Members
- For Patients
-
Projects
- The tumor stem cell hypothesis
- Experimental models of pancreatic tumor stem cells
- Fertilized chicken eggs as animal replacement method for therapy studies with patient tumors
- Bioactive agents from fruits and vegetables for tumor prevention and therapy
- Nutritional study with broccoli sprouts to support the efficacy of conventional therapy of pancreatic cancer
- Specific transfer of oncolytic adenoviruses via mesenchymal stem cells for elimination of pancreatic tumor stem cells
- The role of intercellular communication in the development of a tumor stem cell character
- Examination of tumor stem cells features in Giant Cell Tumor of Bone
- Talks and Congresses
- Poster presentations
- Publications
- Media
- Sponsors