Kliniken & Institute ... Kliniken Department of Neurology... Neurologie und... Research Neuroimmunology Molecular... MMN and CIDP

AUTOIMMUNE NEUROPATHIES

The role of peripheral T- and B-cells in the immunopathogenesis of MNM and CIDP

Autoantibody-related mechanisms are probably involved in the pathophysiology of chronic inflammatory demyelinating neuropathy (CIDP) and multifocal motor neuropathy (MMN). This project focuses on investigating the interaction of B cell-mediated und T cell-mediated autoimmune mechanisms in those disorders. To that end, immune cells from patients with NMO and CIDP are analyzed before and after therapy.

Selected publications

  • Korporal-Kuhnke M, Haas J, Schwarz A, Jarius S, Wildemann B. Plasmacytosis is a common immune signature in patients with MMN and CIDP and responds to treatment with IVIg. J Neuroimmunol 278 (2015) 60–68.
  • M. Korporal, J. Haas, A. Schwarz, B. Fritz, M. Milkova, C. Jacobi, B. Wildemann. Treatment with intravenous immunoglobulins restores B-Cell homeostasis in patients with chronic immune neuropathies.