Research Group Molecular Cytogenetic
We have established multicolor fluorescence in situ hybridization methods (targeted FISH, subtelomere FISH, comparative genomic hybridization (CGH), human and mouse M-FISH) to analyze numerical and structural chromosome aberrations in metaphase and interphase nuclei.
Our research focus on the application of these methods in clinical and cancer cytogenetics. Major projects are:
- the identification of prognostically and pathogenetically relevant chromosome aberrations in multiple myeloma patients using interphase-FISH analysis of CD138 positive plasma cells,
- Chromothripsis as a mechanism of clonal evolution in acute myeloid leukemia (AML),
- SNP/CN analyses for the detection of recurrent genomic imbalances in systemic AL amyloidosis and Multiple Myeloma (MM).
- M-FISH for the detection and characterization of numeric and structural chromosomal aberrations in solid tumors, in cells with dysfunctional telomeres and in stem cell research (human and murine).
Dr. med. Martin Granzow Phone: +49 (0)6221-56-5076
Dr. med. Mutlu Kartal-Kaess Phone: +49 (0)6221-56-5063
Brigitte Schoell Phone: +49 (0)6221-56-5063