Kliniken & Institute … Institute Institute of Human… Research Department of Human… Research Group… Publications

Selected publications

Weber RG, Hoischen A, Ehrler M, Zipper P, Kaulich K, Blaschke B, Becker AJ, Weber-Mangal S, Jauch A, Radlwimmer B, Schramm J, Wiestler OD, Lichter P, Reifenberger G (2007). Frequent loss of chromosome 9, homozygous CDKN2/p14(ARF)/CDKN2B deletion and low TXC1 mRNA expression in pleomorphic xanthoastrocytomas. Oncogene, 26:1088-97.


Crabbe L, Jauch A, Naeger CM, Holtgreve-Grez H, Karlseder J. (2007):Telomere dysfunction as a cause of genomic instability in Werner syndrome. Proc Natl Acad Sci USA, 104:2205-2210.


Hensel M, Zoz M, Giesecke C, Benner A, Neben K, Jauch A, Stephan Stilgenbauer S, Ho AD, Krämer A (2007). High rate of centrosome aberrations and correlation with proliferative activity in patients with untreated B-cell chronic lymphocytic leukaemia. Int J Cancer, 12:978-83.


Balbach ST, Jauch A, Böhm-Steuer B, Cavaleri FM, Han YM, Boiani M (2007).   Chromosome stability differs in cloned mouse embryos and derivative ES cells. Dev Biol, 308:309-321.


Burnworth B, Arendt S, Muffler S, Steinkraus V, Brocker EB, Birek C, Hartschuh W, Jauch A, Boukamp P. (2007): The multi-step process of human skin carcinogenesis: A role for p53, cyclin D1, hTERT, p16, and TSP-1. Eur J Cell Biol., in press


Tsukasaki K, Lohr D, Sugahara K, Kamihira S, Tomonaga M, Bartram CR, Jauch A (2006). Comparative genomic hybridization analysis of Japanese B-cell chronic lymphocytic leukemia: correlation with clinical course. Leuk Lymphoma 47: 261-266.


Helbig I, Wirtenberger M, Jauch A, Hager HD, Tariverdian G, Hemminki K, Burwinkel B, Klaes R (2006). Trisomy 8q and partial trisomy 22 in a 43-year-old man with moderate intellectual disability, epilepsy and large cell non-Hodgkin lymphoma. Am J Med Genet 140:1658-62.


Gronwald J, Jauch A, Cybulski C, Schoell B, Bohm-Steuer B, Lener M, Grabowska E, Gorski B, Jakubowska A, Domagala W, Chosia M, Scott RJ, Lubinski J (2005). Comparison of genomic abnormalities between BRCAX and sporadic breast cancers studied by comparative genomic hybridization. Int J Cancer 114: 230-236.


Schmittwolf C, Kirchhof N, Jauch A, Durr M, Harder F, Zenke M, Muller AM (2005). In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents. EMBO J 24: 554-566.


Radujkovic A, Schad M, Topaly J, Veldwijk MR, Laufs S, Schultheis BS, Jauch A, Melo JV, Fruehauf S, Zeller WJ (2005). Synergistic activity of imatinib and 17-AAG in imatinib-resistant CML cells overexpressing BCR-ABL-Inhibition of P-glycoprotein function by 17-AAG. Leukemia 19: 1198-206.


Moreaux J, Cremer FW, Reme T, Raab M, Mahtouk K, Kaukel P, Pantesco V, DE Vos J, Jourdan E, Jauch A, Legouffe E, Moos M, Fiol G, Goldschmidt H, Rossi JF, Hose D, Klein B (2005). The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature. Blood 106: 1021-1030.


Cremer FW, Kartal M, Hose D, Bila J, Buck I, Bellos F, Raab MS, Brough M, Moebus A, Hager HD, Goldschmidt H, Moos M, Bartam CR, Jauch A (2005). High incidence and intraclonal heterogeneity of chromosome 11 aberrations in patients with newly diagnosed multiple myeloma detected by multiprobe interphase FISH. Cancer Genet Cytogenet 161: 116-124.


Cremer FW, Bila J, Buck I, Kartal M, Hose D, Ittrich C, Benner A, Raab MS, Theil AC, Moos M, Goldschmidt H, Bartram CR, Jauch A (2005). Delineation of distinct subgroups of multiple myeloma and a model for clonal evolution based on interphase cytogenetics. Genes Chromosomes Cancer 44: 194-203.


D`Haese JG, Tsukasaki K, Cremer FW, Fischer C, Bartram CR, Jauch A (2005). Chromosomal aberrations in follicular Non-Hodgkin-Lymphomas (NHL) of Japanese patients detected by CGH and PCR analysis. Cancer Genet Cytogenet 162: 107-14.


Guo J*, Jauch A*, Holtgreve-Grez H, Schoell B, Erz D, Schrank M, Janssen JWG (2005). Multicolor karyotype analyses of mouse embryonic stem cells. In Vitro Cell Dev Biol – Animal 41:287-283* both authors contributed equally to this work


Tsukasaki K, Tanosaki S, DeVos S, Hofmann WK, Wachsman W, Gombart AF, Krebs J, Jauch A, Bartram CR, Nagai K, Tomonaga M, Said JW, Koeffler HP (2004). Identifying progression-associated genes in adult T-cell leukemia/lymphoma by using oligonucleotide microarrays. Int J Cancer 109: 875-881.


Berlinghoff S, Veldwijk MR, Laufs S, Maser HP, Jauch A, Wenz F, Jens Zeller W, Fruehauf S (2004). Susceptibility of mesothelioma cell lines to adeno-associated virus 2 vector-based suicide gene therapy. Lung Cancer 46: 179-86.


Gamerdinger U, Teigler-Schlegel A, Pils S, Bruch J, Viehmann S, Keller M, Jauch A, Harbott J (2003). Cryptic chromosomal aberrations leading to an AML1/ETO Rearrangement are frequently caused by small insertions. Genes Chromosomes Cancer 36: 261-272.


Joos S, Granzow M, Holtgreve-Grez H, Siebert R, Harder L, Martin-Subero JI, Wolf J, Adamowicz M, Barth TFE, Lichter P, Jauch A (2003). Hodgkin`s lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2. Int J Cancer 103: 489-495.


Laufs S, Gentner B, Nagy KZ, Jauch A, Benner A, Naundorf S, Kuehlcke K, Schiedlmeier B, Ho AD, Zeller WJ, Fruehauf S (2003). Retroviral vector integration occurs into preferred genomic targets of human bone marrow repopulating cells. Blood 101: 2191-2198.



Tremmel S, Götte K, Popp S, Weber S, Hörmann K, Bartram CR, Jauch A (2003). Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization. Cancer Genet Cytogenet 144: 165-174.


Leotlela PD, Jauch A, Holtgreve-Grez H, Thakker RV (2003). Genetics of neuroendocrine and carcinoid tumours. Endocr Relat Cancer 10: 437-50.


Weber-Mangal S, Sinn HP, Popp S, Klaes R, Emig R, Bentz M, Mansmann U, Bastert G, Bartram CR, Jauch A (2003). Breast cancer in young women (< or = 35 years): Genomic aberrations detected by comparative genomic hybridization. Int J Cancer 107: 583-592.


Popp S, Schulze B, Granzow M, Keller M, Holtgreve-Grez H, Schoell B, Brough M, Hager H-D, Tariverdian G, Brown J, Kearney L, Jauch A (2002). Study of 30 patients with unexplained developmental delay and dysmorphic features or congenital abnormalities using conventional cytogenetics and multiplex FISH telomere (M-TEL) integrity assay. Hum Genet 111: 31-39.


Xie D, Jauch A, Miller CW, Bartram CR, Koeffler HP (2002). Discovery of over-expressed genes and genetic alterations in breast cancer cells using a combination of suppression subtractive hybridization, multiplex FISH and comparative genomic hybridization. Int J Oncol 21: 499-507.


Smogorzewska A, Karlseder J, Holtgreve-Grez H, Jauch A, de Lange T (2002). DNA Ligase IV-Dependent NHEJ of Deprotected Mammalian Telomeres in G1 and G2. Curr Biol 12: 1635-1644.


Granzow M, Popp S, Weber S, Schoell B, Holtgreve-Grez H, Senf L, Hager D, Boschert J, Scheurlen W, Jauch A (2001). Isochromosome 1q as an early genetic event in a child with intracranial ependymoma characterized by molecular cytogenetics. Cancer Genet Cytogenet 130: 79-83.