Kliniken & Institute ... Interdisziplinäre... Heidelberger... Research Research Mesenchymal Stem Cell...

Mesenchymal Stem Cell Radiobiology Research Group

Our research group is interested in elucidating the radiobiological characteristics of mesenchymal stem cells. In this respect, we are examining biological mechanisms underlying the relative radiation resistance of these stem cells and are investigating potential uses of mesenchymal stem cells to treat radiation-induced organ and tissue lesions.

Mesenchymal stem cells (MSCs) are a heterogeneous group of multipotent stromal cells that were first isolated from bone marrow; they can also be found in various other human tissues including kidney, placenta, umbilical cord, bone and cartilage tissues. Due to their biological characteristics and physiological roles, they likely play an important part in the regeneration of damaged tissues.

We have shown that MSCs are relatively resistant against irradiation with photons and charged particles. Expression of characteristic cellular surface markers and functional stem cell properties were found not to be altered by radiotherapy using photon and 12C ion beams. Due to their radiobiological features, MSCs appear well suited to participate in the repair or regeneration of tissue damage induced by ionizing radiation. Apart from mechanistic examinations using cell culture and animal models, translational analyses using human biopsy specimens are in preparation within our research group.


 

 

 

Members/Contact

Group leaders:

Nils H. Nicolay, M.D., Ph.D.  nils.nicolay@med.uni-heidelberg.de
Peter E. Huber, M.D., Ph.D. (collaborator, German Cancer Research Center) p.huber@dkfz.de
Postdocs:Ramon Lopez Perez, Ph.D.

Doctoral students:

Ms Line Hoeltgen (M.D. student)
Mr Alexander Rühle (M.D. student)
Mr Oliver Xia (M.D. student)
Ms Franziska Muenz (M.D. student)
Mr Julius Schuster (M.D. Student)

Technicians

Ms Sylvia Trinh
Ms Ludmilla Frick