The Molecular Biology-Biochemistry Laboratory investigates the causes of variability in drug effects using pharmacological, molecular biological, biochemical, and cell biological methods. It develops biomarkers for individualization of drug therapy and supports clinical trials by isolation of cells (especially PBMCs) and genotyping of ADME-relevant genes.
Pharmacology and causes of variability of drugs are known in detail and thus lead to an effective and safe application.
Our Mission
We explore the mechanisms for pharmacokinetic and pharmacodynamic variability in order to detect, optimize or prevent desirable and undesirable drug effects in the individual patient at an early stage.
AREAS OF INTEREST
PBMC-IsolationPrompt isolation from whole blood samplesSterilely isolated vital PBMCs allow quantification of cellular immune response
Platelet IsolationRealtime isolation from whole blood samplesMeasurement of markers of platelet activation in isolated platelets or whole blood
PharmacogeneticsGenotyping of ADME relevant SNPs relevant SNPsDifferences in pharmacokinetics may be due to genetic causes
BiomarkerAppropriate biomarkers enable precision dosingDevelopment of PK/PD biomarkers for individualization of AM therapy
Intracellular PK/PDDrug concentration at the site of action is criticalElucidation of correlations between intracellular concentration and effect
Drug interactionsIn vitro testing of pharmacokinetic interactionsIn vitro assays for interaction with drug-metabolizing enzymes and transporters
