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Systematic Reviews / Meta-Analyses

Staff

Dr. Katrin Jensen (Head of the Working Group)

Dr. Lorenz Uhlmann

Prof. Dr. Meinhard Kieser 

Tanja Proctor

Matthes Hackbusch

Svenja Seide

Dorothea Weber


Research topics:

  • multiple treatment comparisons (MTCs)
  • meta-analysis with survival data
  • sequential meta-analysis

Research projects (examples):

 

Cochrane Intervention Review: Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach, gastroesophageal junction and esophagus

 

Cooperation: Department of Surgery, University Medical Centre Mannheim, University of Heidelberg

 

Motivation of systematic review:

  • poor outcome for advanced disease even if resectable
  • several studies assessing perioperative chemotherapy
  • identify, appraise, select and synthesize all evidence

PICO-scheme:

 

Patients 

locoregionally advanced adenocarcinoma
resectable, previously untreated

absence of distant or peritoneal metastases

Intervention 

perioperative chemotherapy + surgery

Comparator  

surgery alone

Outcomes

overall survival, disease-free survival


Literature search: Medline, Embase, LILACS and others

 

14 randomized controlled trials included:

Publication: 

  • Ronellenfitsch U, Schwarzbach M, Hofheinz R, Kienle P, Kieser M, Slanger TE, Burmeister B, Ychou M, Kelsen D, Niedzwiecki D, Schuhmacher C, Urba S, van de Velde C, Walsh TN, Jensen K (2013): Preoperative chemo(radio)therapy versus primary surgery for gastroesophageal adeno­carcinoma: Systematic review with meta-analysis combining individual patient and aggregate data. European Journal of Cancer; online first: DOI
  • Ronellenfitsch U, Schwarzbach M, Hofheinz R, Kienle P, Kieser M, Slanger TE, Jensen K, GE and the Adenocarcinoma Meta-analysis Group (2013): Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach, gastroesophageal junction and lower esophagus (Review). Cochrane Database of Systematic Reviews, Issue 5. Art. No.: CD008107. DOI

 

Diagnostic Test Accuracy Review: Screening and diagnostic instruments for autism spectrum disorders (ASD)

 

Cooperation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Frankfurt am Main

 

Motivation of systematic review:

  • lack of comprehensive review on screening and diagnostic test
  • base for the development of a german guideline for clinicians, patients, and parents
  • stimulation to develop better diagnostic tools for adults with ASD

 

PICO-scheme:

Patients 

patients with diagnosis of ASD, control group without ASD

Intervention 

screening or diagnostic instrument

Comparator  

another screening or diagnostic instrument (if comparison available)

Outcomes

accurate diagnosis measured by sensitivity and specificity

 

Literature search: PubMed, Embase, Cochrane Library, PsychInfo, Psyndex, Hogrefe, WPS

 

 

About 60 screening and diagnostic instruments have to be assessed:

 

 

 

 

Publications