Kliniken & Institute ... Institute Medical Biometry Wir über uns Staff Scherer, Dominique ...

Dr. Dominique Scherer

Telefon: +49 (0)6221 56 7302

Telefax: +49 (0) 6221 56 4195

E-Mail: scherer@imbi.uni-heidelberg.de

Adresse: Im Neuenheimer Feld 130.3, 69120 Heidelberg

Research interests:

  • Pharmacogenetics in primary, secondary and tertiary cancer prevention
  • Personalized cancer prevention and treatment using genetic biomarkers
  • Effect of inflammation on cancer susceptibility and prognosis

Professional career:

2009-2010

Postdoctoral Fellow, Division of Molecular Genetic Epidemiology at the German Cancer Research Center, Heidelberg, Germany, in collaboration with the Clinic of Dermatology, Würzburg, Germany

2010-2011

Postdoctoral Fellow, Department of Genetics, Stanford University, USA

2011-2015

Postdoctoral Fellow and Deputy Group Leader, Molecular Epidemiology Group, Division of Preventive Oncology, National Center for Tumor Diseases, Heidelberg, Germany

Since 2015

Postdoctoral Fellow, Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Germany

Education:

2006

Diploma in Molecular Biology, Cell Biology and Pharmacology, Ruprecht Karls University, Heidelberg, Germany

2006-2009

PhD in Molecular Genetic Epidemiology, German Cancer Research Center/Ruprecht Karls University Heidelberg Medical Faculty, Germany

Research projects:

  • ERA-NET on Translational Cancer Research “Personalized prevention of colorectal neoplasia by use of genetic variability for the prediction of efficacy and symptoms/toxicity of treatment with COX-2 inhibitors and aspirin”
  • ERA-NET on Translational Cancer Research “A randomized, 2x2 biomarker prevention trial of low-dose aspirin and metformin in colon cancer patients.”

Selected publications:

Liesenfeld DB, Grapov , Fahrmann JF, Salou M, Scherer D, Toth R, Habermann N, Böhm J, Schrotz-King P, Gigic B, Schneider M, Ulrich A, Herpel E, Schirmacher P, Fiehn O, Lampe JW, Ulrich CM. Metabolomics and transcriptomics identify pathway differences between visceral and subcutaneous adipose tissue in colorectal cancer patients: the ColoCare study. American Journal of Clinical Nutrition - Epub ahead of print (2015)

Scherer D, Lisel M Koepl LM, Poole EM, Balavarca Y, Xiao L, Hsu L, Coghill AE, Campbell PT, Kleinstein SE, Figueiredo JC, Lampe JW, Buck K, Potter JD, Kulmacz RJ, J Baron JA, Jenkins MA, Hopper JL, Win AK, Newcomb PA, Ulrich CM*, Makar KM*. Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: Colon Cancer Family Registry. Genes, Chromosomes and Cancer. 53:568-78. (2014)

Kraus S*, Hummler S*, Toriola AT, Poole EM, Scherer D, Kotzmann J, Makar  KW, Kazanov  D, Galazan L, Naumov  I, Coghill A, Duggan D, Arber N*, Ulrich CM*. Impact of genetic polymorphisms on adenoma recurrence and toxicity in a cox-2 inhibitor (celecoxib) trial: Results from a pilot study. Pharmacogenetics and Genomics. 23:428-37. (2013)

Schrama D, Scherer D, Schneider M, Zapatka M, Bröcker EB, Schadendorf D, Ugurel S, Kumar R, Becker JC. ERCC5 p.Asp1104His and ERCC2 p.Lys751Gln Polymorphisms Are Independent Prognostic Factors for the Clinical Course of Melanoma.  Journal of Investigative Dermatology. 131: 1280–1290. (2011)

Scherer D, Rachakonda S, Angelini S, Mehnert F, Sucker A, Egberts F, Hauschild A, Hemminki K, Schadendorf D, Kumar R. Association between the Presence of MC1R Variants and Somatic BRAF/NRAS Mutations in Melanoma Tumors. Journal of Investigative Dermatology. 130: 2844-8. (2010)

Scherer D, Nagore E, Bermejo JL, Figl A, Botella-Estrada R, Thirumaran RK, Angelini S, Hemminki K, Schadendorf D, Kumar R. Melanocortin receptor 1 variants and melanoma risk: a study of 2 European populations. International Journal of Cancer. 125: 1868-75. (2009)

Gudbjartsson DF, Sulem P, Stacey SN, Goldstein AM, Rafnar T, Sigurgeirsson B, Benediktsdottir KR, Thorisdottir K, Ragnarsson R, Sveinsdottir SG, Magnusson V, Lindblom A, Kostulas K, Botella-Estrada R, Soriano V, Juberías P, Grasa M, Saez B, Andres R, Scherer D, Rudnai P, Gurzau E, Koppova K, Kiemeney LA, Jakobsdottir M, Steinberg S, Helgason A, Gretarsdottir S, Tucker MA, Mayordomo JI, Nagore E, Kumar R, Hansson J, Olafsson JH, Gulcher J, Kong A, Thorsteinsdottir U, Stefansson K. ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma. Nature Genetics. 40: 886-91. (2008)

Scherer D, Bermejo JL, Rudnai P, Gurzau E, Koppova K, Hemminki K, Kumar R. MC1R variants associated susceptibility to basal cell carcinoma of skin: interaction with host factors and XRCC3 polymorphism. International Journal of Cancer. 122: 1787-93. (2008)