Kliniken & Institute … Institute Medical Biometry Research Klinische… Klinische… Systematic reviews /…


Network Meta-Analysis for the integrated evaluation of targeted therapies


Time scale: 2015-2018


Project staff: Dr. K. Jensen, Tanja Proctor, Prof. Dr. M. Kieser


Sponsor: BMBF




Systematic reviews and meta-analyses have become increasingly important in health care and can reach a high level of evidence if the included trials are of high quality. Network meta-analysis provide useful evidence for judiciously selecting the best treatment if more than one therapy option is available but each included trial only compares a subset of these treatment options. At present, a main focus in clinical research is set on targeted therapies in order to treat subgroups of patients taking into account their individual composition of disease, e.g. the presence or absence of a special biomarker. Meta-analysis methods have to be further developed to allow for the integrated evaluation of these new targeted therapies.


SR Cardiac Rehabilitation Outcome Study (CROS)

The prognostic effect of cardiac rehabilitation in the era of acute revascularization and statin therapy


Time scale: 2013-2015


Cooperation: Prof. Dr. B. Rauch for the Section of Cardiac Rehabilitation, European Association of Cardiovascular Prevention & Rehabilitation (EACPR)


Project staff: M.Sc. Saure, Dr. K. Jensen


Sponsor: German Society of Cardiovascular Prevention & Rehabilitation (DGPR), Pfizer



The objective of this systematic review is to show whether or not cardiovascular rehabilitation (CR) is effective in reducing total mortality and other clinical events during follow-up after coronary bypass grafting (CABG) in the era of intense medical therapy including statins. Furthermore, essential cardiac rehabilitation conditions and characteristics with respect to their influence on clinical outcome will be evaluated. These include timing of the start of CR after the index event (ACS or CABG), CR-duration and CR intensity.



PROSPERO 2014:CRD42014007084




Rauch B, Davos C.H, Doherty P, Saure D, Metzendorf M.I, Salzwedel A, Völler H, Jensen K, Schmidt J.P (2016). The prognostic effect of cardiac rehabilitation in the era of acute revascularization and statin therapy - a systematic review and meta-analysis of randomized and nonrandomized studies. The Cardiac Rehabilitation Outcome Study - CROS. European Journal of Preventive Cardiology (Epub ahead of print).




SR Diagnose Autism Spectrum Disorders (ASD)


Diagnostic test accuracy review: Screening and diagnostic instruments for autism spectrum disorders (ASD)


Time scale: 2013-2014


Cooperation: Prof. Dr. Ch. Freitag (Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Frankfurt am Main)


Project staff: Dr. K. Jensen


Sponsor: BMBF


Systematic diagnostic review in order to assess clinical utility and quality criteria of test accuracy studies, comparing different screening and diagnostic tests, reporting validity and reliability, and performing meta-analyses on test accuracy data




Vllasaliu L, Jensen K, Hoss S, Landenberger M, Ufniarz K, Kieser M, Freitag CM (2016):Diagnostic instruments for autism spectrum disorder (ASD): a systematic review and meta-analysis (Protocol).Cochrane Database of Systematic Reviews,2016/1:1-27



SR Placebo


Placebo controlled trials in surgery


Time-scale: 2011-2012


Cooperation: Dr. M. Diener (Study Centre of the German Surgical Society (SDGC), University Hospital of Heidelberg)


Project staff: Dr. K. Jensen, Prof. Dr. M. Kieser


Sponsor: BMBF


The objective of this systematic review is to identify available randomized surgical placebo-controlled trials in order to investigate whether the placebo control gives a reliable and valid effect estimate of effectiveness of the surgical intervention in question. By investigating this systematically, the potential suitability of sham surgery to serve as a research tool for identifying possibly useless surgical interventions can be verified. In addition, if surgical randomized controlled clinical trials comparing sham surgery with no treatment are available, the placebo effect will be quantified directly.




Probst P, Grummich K, Harnoss J.C, Hüttner F.J, Jensen K, Braun S, Kieser M, Ulrich A, Buechler M.W, Diener M.K (2016). Placebo-controlled trials in surgery: a systematic review and meta-analysis.Medicine 95/17:e3516.