Personen

Prof. Dr. med. Gunhild Mechtersheimer

Oberärztin (Allgemeine Pathologie und Pathologische Anatomie)


06221 56-39909

Medical/professional background

seit 2006

German reference pathologist for soft tissue sarcomas of the European Organization for Research and Treatment of Cancer (EORTC)

seit 2002

Coordinator of research projects “molecular diagnostics” (FSPI) of the Tumorzentrum Heidelberg/Mannheim

1999

Habilitation

seit 1997

Scientific Research Group leader (Tumorzentrum Heidelberg/Mannheim, FSP I.1)

1996

Senior pathologist

1994

Board Certification Pathology

1987

MD-Thesis (summa cum laude, Institute of Pathology, University of Heidelberg)

seit 1986

Institute of Pathology, University of Heidelberg

1985 – 1986

Study of Medicine, Faculté de Médecine Broussais/Hôtel-Dieu, Paris, France

1980 – 1985

Study of Medicine, University of Heidelberg

Fields of Interest

Pathology and molecular genetics of soft tissue sarcomas. Surgical pathology and oncology including pediatric oncology and hematooncology. Molecular pathological diagnostics.

Selected Publications

Aulmann S, Longerich T, Schirmacher P, Mechtersheimer G, Penzel R (2006): Detection of the ASPSCR1/TFE3 gene fusion in paraffin embedded alveolar soft part sarcomas. Histopathol (in press)

Adamovicz M, Radlwimmer B, Rieker RJ, Mertens D, Schwarzbach M, Schraml P, Benner A, Lichter P, Mechtersheimer G, Joos S (2006): Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in softtissue sarcomas. Genes Chromosomes Cancer 45:829-838

Penzel R, Aulmann S, Moock M, Schwarzbach M, Rieker RJ, Mechtersheimer G (2005): The location of KIT and PDGFRA gene mutations in gastrointestinal stromal tumours is site- and phenotype-associated. J Pathol 58:634-639

Rieker RJ, Aulmann S, Penzel R, Schnabel PA, Blaeker H, Esposito I, Morresi-Hauf A, OttoHF,  Hecker E, Dienemann H, Schirmacher P, Mechtersheimer G (2005): Chromosomal imbalances in sporadic neuroendocrine tumours of the thymus. Cancer Lett 223:169-174

Rieker RJ, Penzel R, Aulmann S, Blaeker H, Morresi-Hauf A, Hecker E, Otto HF, Mechtersheimer G, von Heydebreck A (2005): Oncogenic tree models based on cytogenetic data: new insights into the development of epithelial tumors of the thymus. Cancer  Genet Cytogenet 158:75-80

Mechtersheimer G, Egerer G, Hensel M, Rieker RJ, Libicher M, Lehnert T, Penzel R (2004): Gastrointestinal stromal tumours and their response to  treatment with the tyrosine kinase inhibitor imatinib. Virchows Arch 444:108-118

Barth TF, Müller S, Pawlita M, Siebert R, Rother JU, Mechtersheimer G, Kitinya J, Bentz M, Möller P (2004): Homogeneous  immunophenotype and paucity of secondary genomic aberrations are distinctive features of endemic but not of sporadic Burkitt ́s lymphoma and diffuse large B-cell lymphoma with MYC rearrangement. J Pathol 203: 940-945

Mechtersheimer G, Lehnert T, Penzel R, Joos  S,  Egerer G, Otto HF (2003): Gastrointestinale Stromatumoren. Eine morphologisch und molekular eigenständige Tumorentität mit neuer therapeutischer Perspektive. Pathologe 24:182-191
 

Barth TF, Martin-Subero JI,  Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Möller P (2003): Gains of 2p involving the REL locus correlate withnuclear c-Rel protein accumulation in neoplasticcells of classical Hodgkinlymphoma. Blood101:3681-3686

Viardot A, Möller P, Högel J, Werner K, Mechtersheimer G, Ho AD, Ott G, Barth TF, Siebert R, Gesk S, Schlegelberger B, Döhner H, Bentz M (2002): Clinicopathologic correlations of genomic gains and losses in follicular lymphoma. J Clin Oncol 20: 4523-4530

Rieker RJ, Joos S, Bartsch C, Willeke F, Schwarzbach M, Otaño-Joos M, Ohl  , Högel J, Lehnert T, Lichter P, Otto HF, Mechtersheimer G (2002): Distinct chromosomal imbalances in pleomorphic and high-grade dedifferentiated liposarcomas. Int J Cancer 99: 68-73

Fritz B, Schubert F, Wrobel G, Schwaenen C, Wessendorf S, Nessling M, Korz C, Rieker RJ, Montgomery  K, Kucherlapati R, Mechtersheimer G, Eils R, Joos S, Lichter P (2002): Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma. Cancer Res 62:2993-2998

Joos S, Menz CK, Wrobel G, Siebert R, Gesk S, Ohl S, Mechtersheimer G, Trümper L,Möller P, Lichter P, Barth TFE (2002): Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm on chromosome 2. Blood 99:1381-1387

Wabisch M, Brüderlein S, Melzner I, Braun M, Mechtersheimer G, Möller P (2000): LiSa-2, a novel human liposarcoma cell line with a high capacity for terminal adipose differentiation. Int J Cancer 88: 889-894

Otaño-Joos M, Mechtersheimer G, Ohl S, Wilgenbus KK, Scheurlen W, Lehnert T, WillekeF, Otto HF, Lichter P, Joos S (2000): Detection of chromosomal imbalances in leiomyosarcoma by comparative genomic hybridization and interphase cytogenetics. Cytogenet Cell Genet 90:86-92