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Clinical medical physics in radiooncology

Our goal is to develop methods for high-precision irradiation of tumors within their three dimensional boundaries and at the same time spare the adjacent normal tissue as good as possible. To achieve this, the patient needs to be fixed precisely in the same position for each treatment fraction (session). The accuracy of patient positioning directly translates into the precision of the irradiation beam applied and thus the often required high doses needed to eradicate the tumor completely can be applied safely resulting in higher chances to cure the patient.

Du to constant progress in the field of radiotherapy we have today also the possibility

  • to perform radiotherapy during surgery (IORT),
  • to irradiate a tumor from various angles (stereotactic radiotherapy)
  • to vary the dose applied within the tumor individually
  • to use a therapy beam with different intensity distributions (intensity modulated  radiotherapy, IMRT)
  • to adapt the therapy beam with collimators to the contours of the tumors
  • to fix the patient precisely and reproducibly in position for the treatment
  • to use not only photons, but also protons and heavy ions for radiotherapy 

Computer scientists have developed radiotherapy planning software that allows to predict and to calculate the dose that will be deposited in the tissue prior to the irradiation. This also allows correction for inevitable motions of organs (such as breathing and heart beat) during the treatment.

Besides our duties in the clinical routine we are active in development and teaching in the following areas:

Implementation and development:

  • New treatment methods or devices
  • New treatment techniques and methods for quality assurance
  • Implementation and integration of new IT-systems; workflow-optimization

Lehrtätigkeiten an folgenden Einrichtungen (Kopie 1)

  • Online Master Advanced physical Methods in Radiooncology (APMR), Universität Heidelberg
  • Medizinische Physik für Physiker, Wissenschaftliche Weiterbildung Universität Heidelberg
  • Medizinische Physik und Technik für Radioonkologen, Wissenschaftliche Weiterbildung Universität Heidelberg
  • Lehrbeauftragung an der Dualen Hochschule Baden Württemberg (DHBW) Karlsruhe
  • MTRA Schule, Akademie für Weiterbildung
  • Strahlenschutzkurse am Fortbildungszentrum für Technik und Umwelt (FTU) am KIT Karlsruhe


  • Online Master Advanced physical Methods in Radiooncology (APMR),
    Heidelberg University
  • Medical physics for physicists, post gradual studies of Heidelberg University
  • Medical physics and technology for radiooncologists, post gradual studies of Heidelberg University
  • Teaching assignment Duale Hochschule Baden Württemberg (DHBW) Karlsruhe
  • Teaching assignment for MTRA -School (training of radiotherapists),
  • Teaching assignment radiation protection at Karlsruhe Institute of Technology (KIT)

Current projects

DHBW – bachelor theses
  • Laura Wolf  –  Eine Planungsstudie über den Vergleich von IMRT Bestrahlungsplänen in VMAT Technik mit und ohne Ausgleichsfilter in Bezug auf die Planqualität, Anzahl der Monitoreinheiten, Bestrahlungszeit und Ergebnis der dosimetrischen Verifikation. (2015)
  • Manuela Dehm  –  Vergleich von MVCT basierten Dosis-Nachberechnungen mit der Analyse von Online-Detektordaten (2015)    

APMR – master theses
  • Mark Delaperiere – Feasibility study of MLC (multi leaf collimator) virtual compensation for total body irradiation with lateral beams at large source axis distance (5m) (2014)
  • Frank Ahrenberg – Clinical Implementation of IMRT with flattening filter free photon beams (2013)


Technische Universität Kaiserslautern – master theses
  • Martina Schmauss – Vergleich der Dosisberechnung in Risikoorganen bei der IMRT mit Collapsed-Cone-Algorithmus versus konventioneller Bestrahlungsplanung mittels Pencil-Beam bzw. Collapsed-Cone-Algorithmus  (2014)
  • Xenia Wester – Einführung von einem 2D-Ionisationskammer-Array zur Planverifikation an einem Tomotherapie-Gerät (2014)
  • Matthias Seurig – Rekonstruktion von 3D-Dosisverteilungen aus 2D-Dosimessungen mit einem 2D-Ionisationskammer-Array zur dosimetrischen Verifikation in der IMRT (2013)

Selected publications

Dosimetriy:  Energy dosimetry

Rhein B, Hartmann G,  Bestimmung der Energiedosis in einem Medium dichter als Wasser bei 6MV Photonen mit einer zur Anzeige der Wasserenergiedosis kalibrierten Ionisationskammer. In: Tagungs CD 3 Ländertagung der ÖGMP, DGMP, SGSMP Wien  (2011) ISBN:3-925218-89-0.

Method for independent dose calculation for helical TomoTherapy

Klüter S, Schubert K, Lissner S, Sterzing F, Oetzel D, Debus J, Schlegel W, Oelfke W, Nill S (2014). Independent calculation of dose distributions for helical tomotherapy using a conventional treatment planning system. Medical Physics 41(8), 081709.

Integrated detector array for quality assurance of helical tomotherapy and develoment of a method to measure leave aperature

Lissner S, Schubert K, Klüter S, Oetzel D, Debus J (2013). A method for testing the performance and the accuracy of the binary MLC used in helical tomotherapy. Zeitschrift für Medizinische Physik 23, 153–161.

Peripheral doses in intensity modulated radiotherapy  (IMRT)

Lissner S, Schubert K, Wiezorek T, Sterzing F, Herfarth K, Sroka-Perez G, Debus J (2013). Investigations of peripheral dose for helical tomotherapy. Zeitschrift für Medizinische Physik 23(4), 324-31.

Wiezorek T, Schwahofer A, Schubert K (2009). The influence of different IMRT techniques on the peripheral dose: a comparison between sMLM-IMRT and helical tomotherapy. Strahlentherapie und Onkologie 185(10), 696-702.

Optimization  and quality assurance of IMRT techniqes

Klüter S, Sroka-Perez G, Schubert K, Debus J (2011). Leakage of the Siemens 160 MLC multileaf collimator on a dual energy linear accelerator. Physics in Medicine and Biology 56(2), N29-37.

Schubert K, Rhein B, Seurig M, Klüter S, Oetzel D, Debus J (2014). QA for rotational treatment delivery using the Octavius 4D Phantom. In: S. Klöck. Medizinische Physik. 44th Joint Conference of the SSRMP, DGMP, ÖGMP, Dreiländertagung für Medizinische Physik, Zürich, 159-160.  

Megavolt-computer tomography (MVCT) data sets for treatment planning

Prokesch H, Ecker S, Splinter M, Lampe C, Klüter S, Schubert K, Ellerbrock M, Jäkel O (2014). Combined Photon and Particle Radiotherapy Based on Megavoltage CT Data. In: Proceedings to the 53 Annual Meeting for the Particle Therapy Cooperative Group (PTCOG) 8-14 June 2014. International Journal of Particle Therapy 1(2), 636.

Schubert K, Maric T, Nill S, Sroka-Perez G, Herfarth K, Oelfke U, Debus J (2011). Tomotherapy MVCT in 3D-Conformal Treatment Planning. Radiotherapy and Oncology 99, S583. ESTRO Meeting, London.

Klüter S, Schubert K, Lissner S, Debus J (2011). Evaluation Of The Impact Of CT Hounsfield Unit Calibration on Dose Calculation in Helical Tomotherapy. International Journal of Radiation Oncology Biology Physics 81(2), S848-S849, Proceedings of the ASTRO 53rd Annual Meeting.

Bringing helical TomoTherapy into clinical routine,  implementation and development of methods for quality assurance

Schubert K, Klueter S, Lissner S, Wester X, Sterzing F, Oetzel D, Debus J (2013). SU-E-T-151: Evaluation of the Ability of the Seven29 Array to Measure Jaw Speeds On a TomoTherapy-System. AAPM 55th Annual Meeting. Medical Physics 40, 238.

K. Schubert, K. Wagenknecht, S. Lissner, G. Sroka-Perez and J. Debus (2009). Imaging QA Program for Image Guided RadioTherapy (IGRT). In: World Congress on Medical Physics and Biomedical Engineering, Munich. Springer Verlag Berlin Heidelberg, 457-459.

Schubert K, Nicholas D, Francois P, Lisbona A, Schmidt R, Tomsej M, Wagenknecht K, Sroka-Perez G, Debus J (2008). International Comparison of time-resolved Measurements on Helical Tomotherapy. International Journal of Radiation Oncology Biology Physics 72(1), S663, Proceedings of the 50th Annual ASTRO Meeting.

Schubert K, Sroka-Perez G, Wagenknecht K, Caprile-Etchart P, Sterzing F, Debus J (2007). QA for dynamic aspects of helical tomotherapy treatment delivery. Radiotherapy and Oncology 84, S1. 9th Biennial ESTRO Meeting on physics and radiation technology for clinical radiotherapy, Barcelona.