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Platelet Disorders

Stockklausner/Kulozik Research Group


I.  Regulation of thrombopoiesis: project description

Our working group examines the thrombopoietin receptor c-Mpl to find out how the function of integral membrane receptors is disrupted by a changed subcellular distribution. To this end we investigate new, but also known mutations in the thrombopoietin gene (THPO) and in its receptor c-Mpl that influence the activation of the pathway and receptor distribution within the cell.

 

Normal functioning of the THPO/c-Mpl pathway and receptor distribution are essential for the maintenance of a healthy number of platelets in the blood. Too many (thrombocytosis) or too few platelets (thrombocytopenia) per microliter of blood may cause severe hemorrhages and thromboses in humans. In addition, constant mutation-induced overstimulation of the THPO/cMpl pathway over long time periods can also lead to malignant myeloproliferative diseases.

 

With our work we want to improve our understanding of these disorders.

 

 

The Department of Pediatric Oncology of the University Medical Center for Children and Adolescents offers special consultation hours for children and adolescents with thrombocytopenias or thrombocytoses.

 

Special consultation hours: Tue 1 p.m. – 3 p.m.

Appointments: Phone: +49 6221 - 56 8381

 

 

 

 

II. Staff

 

Clemens Stockklausner - attending physician

Nicole Dickemann - technical assistant

 

Laboratory address:

Otto-Meyerhof-Zentrum
Im Neuenheimer Feld 350
69120 Heidelberg
Phone:  +49 6221 - 56 8214

 

Former staff members

Anne-Christine Klotter, cand. med. - medical student
Iabelle Nadine Kuhlee - mmedical student

Christin Duffert - medical student

 

 

 

 

III. Publications

Kuru TH, Roethke MC, Nyarangi-Dix J, Okouoyo S, Stockklausner C, Schenk JP, Debus J, Roth W, Teber D, Pahernik S, Schlemmer HP, Hohenfellner M, Hadaschik BA. (2013)
Pediatric case report on magnetic resonance imaging/transrectal ultrasound-fusion biopsy of rhabdomyosarcoma of the bladder/prostate: a new tool to reduce therapy-associated morbidity?
Urology. 2013 Feb;81(2):417-20. doi: 10.1016/j.urology.2012.10.043

 

Stockklausner, C., Echner, N., Klotter, A.C., Hegenbart, U., Dreger, P., Kulozik, A.E. (2012)

Opens external link in new windowHereditary thrombocythemia caused by a thrombopoietin (THPO) gain-of-function mutation associated with multiple myeloma and congenital limb defects

Ann Hematol. 91(7):1129-33

 

Günther P, Holland-Cunz S, Schupp CJ, Stockklausner C, Hinz U, Schenk JP. (2011)

Opens external link in new windowSignificance of Image-defined Risk Factors for Surgical Complications in Patients with Abdominal Neuroblastoma

Eur J Pediatr Surg. (5):314-7

 

Witt, O; Hämmerling, S.; Stockklausnerc, C.; Schenk, J.P.; Günther, P.; Behnisch, W.; Hamad, B.; Al Mulla, N.A.; Kulozik, A. (2009):

Opens external link in new window13-cis retinoic acid treatment of a patient with chemotherapy refractory nephroblastomatosis

J Pediatric Hematol Oncol 31(4):296-9.

 

Stockklausner, C., Behnisch, W., Mechtersheimer, G., Möller, P., Kulozik, A.E. (2008)

Opens external link in new windowLongterm Remission of Children with Relapsed and Secondary Anaplastic Large Cell Non-Hodgkin Lymphoma (ALCL) Following Treatment with Pulsed Dexamethasone and Low Dose Etoposide

Pediatr Blood  Cancer 50(1):126-9

 

Stockklausner, C., Gehring, N.H., Neu-Yilik, G., Hentze, M.W. and Kulozik, A.E. (2006)

Opens external link in new windowThe uORF-Containing Thrombopoietin mRNA Escapes Nonsense-Mediated Decay (NMD)

Nucleic Acids Res. 34(8):2355-63

 

Biskup, C., Kelbauskas, L., Zimmer, T., Benndorf, K., Bergmann, A., Becker, W., Ruppersberg, J.P., Stockklausner, C., Klöcker, N. (2004)

Opens external link in new windowInteraction of PSD-95 with potassium channels visualized by fluorescence-lifetime based resonance energy transfer imaging

J Biomed Opt. 9(4):753-9

 

Stockklausner, C., Klöcker, N. (2003)

Opens external link in new windowSurface expression of inward rectifier potassium channels is controlled by selective Golgi export

J Biol Chem. 278:17000-5

 

Stockklausner C., Ludwig J., Ruppersberg J.P., Klöcker N. (2001)

Opens external link in new windowA sequence motif responsible for ER export and surface expression of Kir2.0 inward rectifier K+ channels.

FEBS Lett. 493:129-133

 

 

 

Link to Pubmed:

Opens external link in new windowStockklausner - PubMed - NCBI