Molecular medicine is a scientific concept that focuses on the investigation of the molecular processes underlying disease and the resulting logical treatment strategies that are applicable to different conditions and organs. A number of research groups with various thematic priorities have specialized themselves on this concept:
Pediatric oncology: Clinical Cooperation Unit Pediatric Oncology (Olaf Witt Research Group, DKFZ)
The Clinical Cooperation Unit (CCU) Pediatric Oncology is a department of the German Cancer Research Center (DKFZ) that has been headed by Prof. Dr. Olaf Witt since 2008. The department aims at developing new and experimental methods of treating tumors of the nervous system in children and adolescents and testing these methods in clinical trials.
Pediatric neurooncology: Stefan Pfister Research Group
The Division of Pediatric Neurooncology at the DKFZ was created as a result of a long and intensive cooperation between the Department of Pediatric Oncology, Hematology, Immunology and Pulmonology (Prof. Dr. Andreas Kulozik), the Clinical Cooperation Unit Pediatric Oncology (Prof. Dr. Olaf Witt) and the Division of Molecular Genetics at the DKFZ (Prof. Dr. Peter Lichter). The research group has set itself the task of translating genetic and epigenetic information into clinical applications, whether as biomarkers or as new treatment options for children with brain tumors. The division is headed by Prof. Dr. Stefan Pfister.
Molecular Medicine Partnership Unit (MMPU) Research Group Diseases of mRNA metabolism (Andreas Kulozik/ Matthias Hentze)
This group investigates the mechanism of NMD (nonsense-mediated decay), one of the most important mRNA quality checks that cells perform to prevent the synthesis of wrong proteins. Another focus of research is the stress-related regulation of mRNA 3’ end processing. Both processes play an important role in diseases like thrombosis or thalassemia.
Molecular Medicine Partnership Unit (MMPU) Research Group Iron homeostasis in health and disease (Martina Muckenthaler/ Matthias Hentze)
The researchers in this group investigate the physiological regulation of the cellular and systemic iron metabolism that plays an important role in hereditary hemochromatosis, the most common disease in the western world.
Molecular Medicine Partnership Unit (MMPU) Research Group “Molecular Pediatric Oncology”(Andreas Kulozik/ Jan Korbel)
This Research Group investigates in unravelling the mechanisms that govern the transition from treatment sensitivity to treatment resistance in T-cell acute lymphoblastic leukemia (T-ALL) and to lay the foundation for the development of new treatment strategies.
For more information go to our Scientific Collaborations page.