Scientific Collaborations of the Department of Pediatric Oncology, Hematology, Immunology and Pulmonology
Molecular Medicine Partnership Unit (MMPU)
Founded in 2002, the Molecular Medicine Partnership Unit (MMPU) is a joint venture of Heidelberg University Hospital and the EMBL. Eight international working groups consisting of medical and basic researchers address the molecular processes underlying common diseases, their pathogenesis, diagnosis and therapy. The MMPU is headed by Prof. Dr. Andreas Kulozik and Prof. Dr. Matthias Hentze. The website of the MMPU can be accessed here MMPU UniveritätsKlinikum, and here MMPU EMBL.
Staff members of the Department of Pediatric Oncology, Hematology, Immunology and Pulmonology are involved in four MMPU groups:
Clinical Cooperation Unit Pediatric Oncology
The Clinical Cooperation Unit (CCU) Pediatric Oncology is a department of the DKFZ that has strong structural ties to the Department of Pediatric Oncology, Hematology, Immunology and Pulmonology. The CCU has been headed by Prof. Dr. Olaf Witt since 2008. The department aims at developing new and experimental methods of treating tumors of the nervous system in children and adolescents and testing these methods in clinical trials.
Division of Pediatric Neurooncology
Headed by Prof. Dr. Stefan Pfister, the Division of Pediatric Neurooncology at the DKFZ is the result of a long and intensive cooperation between the Department of Pediatric Oncology, Hematology, Immunology and Pulmonology (Prof. Dr. Andreas Kulozik), the Clinical Cooperation Unit Pediatric Oncology (Prof. Dr. Olaf Witt) and the Division of Molecular Genetics at the DKFZ (Prof. Dr. Peter Lichter). The research group has set itself the task of translating genetic and epigenetic information into clinical applications, whether as biomarkers or as new treatment options for children with brain tumors.
Department of Translational Pulmonology
The Department of Translational Pulmonology is headed by Prof. Dr. Marcus A. Mall and was established in 2012 to strengthen lung research at Heidelberg University Hospital and at the Medical Faculty Heidelberg. The doctors and scientists of the department work together to investigate disease mechanisms and improve the diagnosis and treatment of chronic inflammatory lung diseases like cystic fibrosis, asthma and COPD. The department is housed in the Translational Lung Research Center (TLRC) and cooperates closely with the Pediatric Pulmonology & Allergology Unit, the Cystic Fibrosis Center, the Department of Pulmonary and Respiratory Critical Care Medicine of the Thoracic Center, and other medical institutions of Heidelberg University Hospital in order to develop clinical applications based on the research findings.
Translational Lung Research Center (TLRC)
The Translational Lung Research Center (TLRC) is an interdisciplinary research center that was founded in 2011 as a joint venture of the Medical Faculty Heidelberg, the Thoracic Center of Heidelberg University Hospital, the DKFZ and the EMBL. The TLRC is one of five locations of the German Center for Lung Research (DZL) funded by the Federal Ministry of Education and Research (BMBF) and is headed by Prof. Marcus A. Mall and his deputy Prof. Dr. Hans-Ulrich Kauczor. The TLRC currently consists of 23 research groups that investigate the mechanisms leading to the development of chronic inflammatory and malignant lung diseases like cystic fibrosis, asthma, COPD and lung cancer. The scientists work to find new therapeutic approaches, improve diagnostic possibilities and develop additional treatment options.
The Collaborative Research Center CRC 1036 is a joint project of the Faculty of Biosciences and Heidelberg University Hospital, the DKFZ and the EMBL that has been funded by the German Research Foundation (DFG) since 2012. The project aims at establishing a new focus of research at these institutions: Cellular Surveillance and Damage Response. The speaker of this CRC is ZMBH director Prof. Dr. Bernd Bukau, vice speakers are Prof. Dr. Andreas Kulozik and Prof. Dr. Frauke Melchior.
DFG FOR 855
The DFG Research Group 855, is a collaborative project of various national research groups in the area of "cytoplasmic regulation of gene expression" that has been supported by DFG funding since 2007; the speaker of the project is Prof. Dr. Elmar Wahle, Halle.
The working group of Prof. Martina Muckenthaler is involved in a BMBF-funded joint research project. Supported by partners in France, Italy and Spain, this group improves the diagnosis of rare congenital anemias and develops new treatment strategies. ERA-NET.
Center for Rare Diseases
The Center for Rare Blood Disorders headed by Prof. Muckenthaler and Prof. Andreas Kulozik is part of the Center for Rare Diseases of Heidelberg University Hospital. The purpose of the Center for Rare Blood Disorders is to diagnose and treat congenital blood disorders. These conditions include a wide range of very rare disorders that impair the functioning or formation of hemoglobin, of the coagulation factors in the plasma or of the blood cells themselves. Professor Muckenthaler also serves on the board of directors of the Center for Rare Diseases. BMBF:HMA-Iron.
The aim of the Cystic Fibrosis Center headed by Prof. Mall is to continue improving the patients' life expectancy and quality of life through early diagnosis and modern, individualized therapy.