Kliniken & Institute ... Institute Humangenetik Willkommen ausgewaehlte...

ausgewählte Publikationen C. R. Bartram

Rüdiger H.W., Kohl F.V., Mangels W., von Wichert P., Bartram C.R., Wöhler W., Passarge E.: Benzpyren induces sister chromatid exchanges. Nature 262, 290-292, 1976.

Bartram C.R., Rüdiger H.W., Schmidt-Preuss U., Passarge E.: Functional deficiency of fibroblasts heterozygous of Bloom syndrome as a specific manifestation of the pri­mary defect. Am. J. Hum. Genet. 33, 928-934, 1981.

De Klein A., Geurts van Kessel A., Grosveld G., Bartram C.R., Hagemeijer A., Bootsma D., Spurr N.K., Heisterkamp N., Groffen J., Stephenson J.R.: A cellular oncogene is translocated to the Phila­delphia chromosome in chronic myelocytic leukaemia. Nature 300, 765-767, 1982.

Heisterkamp N., Stephenson J.R., Groffen J., Hansen P.F., de Klein A., Bartram C.R., Grosveld G.: Localization of the c-abl oncogene adjacent to a trans­location breakpoint in chronic myelocytic leukaemia. Nature 306, 239-242, 1983.

Bartram C.R., de Klein A., Hagemeijer A., van Agthoven T., Geurts van Kessel A., Bootsma D., Grosveld G., Ferguson-Smith M.A., Davies T., Stone M., Heisterkamp N., Stephenson J.R., Groffen J.: Translocation of c-abl oncogene correlates with the pre­sence of a Philadelphia chromosome in chronic myelocytic leukaemia. Nature 306, 277-280, 1983.

Groffen J., Stephenson J.R., Heisterkamp N., de Klein A.,  Bartram C.R., Grosveld G.: Philadelphia chromosomal breakpoints are clustered within a limited region - bcr - on chromosome 22. Cell 36, 93-99, 1984.

Bartram C.R., Kleihauer E., de Klein A., Grosveld G., Teyssier J.R., Heisterkamp N., Groffen J.: C-abl and bcr are rearranged in a Ph-negative CML patient. EMBO J. 4, 683-686, 1985.

Bartram C.R.: Bcr rearrangement without juxtaposition of c-abl in chronic myelocytic leukemia. J. Exp. Med. 162, 2175, 2179, 1985.

Bartram C.R., Janssen J.W.G., Becher R., de Klein A., Grosveld G.: Persistence of chronic myelocytic leukemia despite dele­tion of rearranged bcr/c-abl sequen­ces in blast crisis. J. Exp. Med. 164, 1389-1396, 1986.

Janssen J.W.G., Steenvoorden A.C.M., Losekoot M., Bartram C.R.: Novel transforming sequences in human acute myelocytic leukemia cell lines. Oncogene 1, 175-179, 1987.

Janssen J.W.G., Steenvoorden A.C.M., Lyons J., Anger B., Böhlke J.U., Bos J.L., Seliger H., Bartram C.R.: Ras gene mutations in acute and chronic myelo­cytic leu­kemias, chronic myeloproliferative dis­orders and myelo­dysplastic syndromes. Proc. Natl. Acad. Sci. (USA) 84, 9228-9232, 1987.

Hansen-Hagge T.E., Yokota S., Bartram C.R.: Detection of minimal residual disease in acute lympho­blastic leukemia by in vitro amplification of rearranged T cell receptor d chain sequences.

Morgan G.J., Hughes T., Janssen J.W.G., Gow J., Guo A.P., Goldman J.M., Wiedemann L.M., Bartram C.: Polymerase chain reaction for detection of residual leukemia. Lancet I, 928-929, 1989.

Yokota S., Hansen-Hagge T.E., Ludwig W.D., Reiter A., Raghavachar A., Kleihauer E., Bartram C.R.: The use of polymerase chain reactions to monitor minimal residual disease in acute lymphoblastic leukemia patients. Blood 77 331-339, 1991.

Maurer J., Janssen J.W.G., Thiel E., van Denderen J., Ludwig W.D., Aydemir Ü., Heinze B., Fonatsch C., Harbott J., Reiter A., Riehm H., Hoelzer D., Bartram C.R.: Detection of chimeric BCR-ABL genes in acute lymphoblastic leukaemia by polymerase chain reac­tion. Lancet 337, 1055-1058, 1991.

Schwarz K., Hansen-Hagge T.E., Knobloch C., Friedrich W., Kleihauer E., Bartram C.R.:

Severe combined immunodeficiency in man: B- SCID patients exhibit an altered recombination pattern of the JH locus. J. Exp. Med. 174, 1039-1048, 1991.

Faust M., Ebensperger C., Schulz A.S., Schleit­hoff L., Hameister H., Bartram C.R., Janssen J.W.G.:

The murine ufo receptor: molecular cloning, chromoso­mal localization, and in-situ expression analy­sis. Oncogene 7, 1287-1293, 1992.

Hansen-Hagge T.E., Yokota S., Reuter H., Schwarz K., Bartram C.R.: Human common acute lymphoblastic leukemia derived cell lines are competent to recombine their T cell receptor d/a regions along a hierarchically ordered pathway. Blood 80, 2359-2362, 1992.

Wada M., Bartram C.R., Nakamura H., Hachiya M., Chen D.L., Borenstein J., Hansen-Hagge T.E., Ludwig W.D., Reiter A., Mizoguchi H., Koeffler H.P.: Analysis of p53 mutations in a large series of lymphoid hematological malignancies of childhood. Blood 82, 3163-3169, 1993.

Janssen J.W.G., Ludwig W.D., Borkhardt A., Spadinger U., Rieder H., Fonatsch C., Hossfeld D.K., Harbott J., Schulz A.S., Repp R., Sykora K.W., Hoelzer D., Bartram C.R.: Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complete remission. Blood 84, 3835-3842, 1994.

Takeuchi S., Bartram C.R., Seriu T., Miller C.W., Tobler A., Janssen J.W.G., Reiter A., Ludwig W.D., Zimmermann M., Schwaller J., Lee E., Miyoshi J., Koeffler H.P.: Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A and p18 genes in acute lymphoblastic leukemia (ALL) of childhood. Blood 86, 755-760, 1995.

Takeuchi S., Bartram C.R., Wada M., Reiter A., Hatta Y., Seriu T., Lee E., Miller C.W., Miyoshi I., Koeffler H.P.: Allelotype analysis of childhood acute lymphoblastic leukemia. Cancer Res. 55, 5377-5382, 1995.

Schwarz K., Bartram C.R.: V(D)J recombination pathology. Adv. Immunol. 61, 285-326, 1996.

Takeuchi S., Bartram C.R., Miller C.W., Seriu T., Reiter A., Mori N., Slatter J., Zimmermann M., Schrappe M., Koeffler H.P.: Acute lymphoblastic leukemia of childhood: identification of  two distinct regions of deletion on the short arm of chromosome 12 in the region of TEL and KJP1.

Blood 87, 3368-3374, 1996.

Schwarz K., Gauss G.H., Ludwig L., Pannicke U., Li Z., Lindner D., Friedrich W., Seger R.A., Hansen-Hagge T.E., Desiderio S., Lieber M.R., Bartram C.R. RAG mutations in human B cell-negative SCID. Science 274, 97-99, 1996.

Braunger J., Schleithoff L., Schulz A.S., Kessler H., Lammers R., Ullrich A., Bartram C.R., Janssen J.W.G.: Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multisubstrate docking-site. Oncogene 14, 2619-2631, 1997.

Van Dongen J.J.M., Seriu T., Panzer-Grümayer E.R., Biondi A., Pongers-Willemse M.J., Corral L., Stolz F., Schrappe M., Masera G., Kamps W.A., Gadner H., van Wering E.R., Ludwig W.D., Basso G., de Bruijn M.A.C., Cazzaniga G., Hettinger K., van der Does-van der Berg A., Hop W.C.J., Riehm H., Bartram C.R.: Prognostic value of minimal residual disease in acute lymphoblastic leukemia in childhood. Lancet 352, 1731-1738, 1998.

Janssen J.W.G., Vaandrager J.W., Heuser T., Jauch A., Kluin P.M., Geelen E., Bergsagel P.L., Kuehl W.M., Drexler H.G., Otsuki T., Bartram C.R., Schuuring E.: Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32). Blood 95, 2691-2698, 2000.

Nakao M., Janssen J.W.G., Flohr T., Bartram C.R.: Rapid and reliable quantification of minimal residual disease in acute lymphoblastic leukemia using rearranged immunoglobulin and T-cell receptor loci by LightCycler technology. Cancer Res. 60, 3281-3289, 2000.

Kulozik A.E., Hentze M.W., Hagemeier C., Bartram C.R.: Molekulare Medizin. Grundlagen – Pathomechanismen – Krankheitsbilder. Walter de Gruyter, 2000.

Bartram C.R., Beckmann J.P., Breyer F., Fey G.H., Fonatsch C., Irrgang B., Taupitz J., Seel K.M., Thiele F.: Humangenetische Diagnostik – Wissenschaftliche Grundlagen und gesellschaftliche Konsequenzen. Wissenschaftsethik und Technikfolgenbeurteilung Band 7, Springer Verlag, 2000.

Bartram C.R.: Vererbung und Umwelt bei Krebserkrankungen. In: Wink M. (Hsg), "Vererbung und Umwelt" Heidelberger Jahrbücher, XLV, Springer Verlag Heidelberg, pp. 29-44, 2001.

Takeuchi S., Seriu T., van Dongen J.J.M., Szczepanski T., Tsukasaki K., Takeuchi N., Fermin A.C., Seo H., Bartram C.R., Koeffler H.P.: Allelotype analysis in relapsed childhood acute lymphoblastic leukemia. Oncogene 22, 6970-6976, 2003.

Hiddemann W., Huber H., Bartram C.R. (Hsg.): Die Onkologie, Heidelberg: Springer Verlag (2004).

Schaaf C.P., Benzing J., Schmitt T.,Erz D.H.R., Tewes M.,  Bartram C.R., Janssen J.W.G.:

Novel interaction partners of the met-receptor  FASEB J. 19, 267-269, 2005

Cario G., Stanulla M., Fine B.M., Teuffel O., v. Neuhoff N., Schrauder A., Flohr T., Schäfer B.W., Bartram C.R., Welte K., Schlegelberger B.,  Schrappe M.: Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia. Blood 105, 821-826, 2005

Stanulla M., Schaeffeler E., Flohr T., Cario G., Schrauder A., Welte K., Ludwig W.D., Bartram C.R., Zanger U.M., Eichelbaum M., Schrappe M., Schwab M.: Thiopurine methyltransferase (TPMT) genotype is an independent modulator of early treatment response to 6-mercaptopurine in childhood acute lymphoblastic leukaemia. JAMA 293, 1485-1489, 2005